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Francesco Brigo, Franco Alessandrini, Giammario Ragnedda, Piera Canu, Veronica Tavernelli, Arianna Bratti, Raffaele Nardone
Ictal strabismus, sometimes associated with epileptic nystagmus, is an extremely rare epileptic phenomenon, suggestive of cortical involvement in monocular eye movement control. We describe a patient with ictal disconjugate contraversive horizontal eye deviation of cortical origin as the main clinical feature of a focal seizure. A 17-year-old, previously healthy woman had a seizure characterized by initial rightward conjugate eye deviation, followed by convergent strabismus due to adduction of the right eye towards the nose without conjugate left eye abduction (esotropia), forced leftward head deviation with impaired awareness, and subsequent evolution into a bilateral tonic-clonic seizure...
August 1, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
Rosa M Paragliola, Rosa M Lovicu, Giampaolo Papi, Ettore Capoluongo, Angelo Minucci, Giulia Canu, Alfredo Pontecorvi, Salvatore M Corsello
RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels...
2018: Frontiers in Endocrinology
Erica Dugnani, Valentina Pasquale, Paolo Marra, Daniela Liberati, Tamara Canu, Laura Perani, Francesco De Sanctis, Stefano Ugel, Francesca Invernizzi, Antonio Citro, Massimo Venturini, Claudio Doglioni, Antonio Esposito, Lorenzo Piemonti
Background: The widely-used genetically engineered mouse LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre, termed KPC, spontaneously develops pancreatic cancer mirroring all phases of the carcinogenesis but in asynchronous manner. Preclinical studies need defined criteria for the enrollment of the KPC sharing the same stage of carcinogenesis. Aim: To define a tumor staging criteria using magnetic resonance and ultrasound and then to correlate the imaging stage with overall survival of KPC mice...
July 24, 2018: Carcinogenesis
Yuchen Zhang, Shusheng Zhou
OBJECTIVES: Acinetobacter pittii carrying the blaNDM-1 gene is frequently reported in the world recently, however most of the blaNDM-1 genes are located on plasmids. Here we report a multidrug-resistant (MDR) A. pittii isolated in China co-harbouring blaNDM-1 , blaOXA-421 and blaAmpC in the genome. METHODS: Bacterial genomic DNA was extracted using the cetyl trimethylammonium bromide (CTAB) method. Whole-genome sequencing of A. pittii was performed using an Illumina MiSeq system (2×251bp) in combination with PacBio single-molecule real-time (SMRT) sequencing...
July 20, 2018: Journal of Global Antimicrobial Resistance
Federica Agosta, Gorana Mandic-Stojmenovic, Elisa Canu, Tanja Stojkovic, Francesca Imperiale, Francesca Caso, Elka Stefanova, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
This study identified structural and functional brain connectivity alterations in two independent samples of patients along the posterior cortical atrophy (PCA) disease course. Twenty-one PCA patients and 44 controls were recruited from two expert centres. Microstructural damage of white matter (WM) tracts was assessed using probabilistic tractography; resting state (RS) functional connectivity of brain networks was explored using a model free approach; grey matter (GM) atrophy was investigated using voxel-based morphometry...
2018: NeuroImage: Clinical
Umberto Arena, Morton Barlaz, Pinjing He, Ing I D'Adamo, Sergi Astals, Jean E Bogner, Stephanie C Bolyard, Jorge Manuel Caliço Lopes de Brito, Paolo S Calabrò, Paolo Canu, Christina Chroni, Bill Clarke, Hervé Corvellec, Giulia Costa, Malcolm Richard Gent, Antonio Gallardo Izquierdo, Jacek A Koziel, Nuno Lapa, Bo Leckner, Lidia Lombardi, Massimiliano Materazzi, Hans Oonk, Kostyantyn Pivnenko, Krishna R Reddy, Hans van der Sloot, Jan-Olov Sundqvist, Fabio Tatàno, Timothy Townsend, David Turner, Juergen Vehlow, Tianfeng Wang, Yongjiang Wang, Jim White, Yang Zeng, Christian Zurbrügg
No abstract text is available yet for this article.
July 2018: Waste Management
Jacques-Olivier Coq, Maxime Delcour, Yuko Ogawa, Julie Peyronnet, Francis Castets, Nathalie Turle-Lorenzo, Valérie Montel, Laurence Bodineau, Phillipe Cardot, Cécile Brocard, Sylvie Liabeuf, Bruno Bastide, Marie-Hélène Canu, Masahiro Tsuji, Florence Cayetanot
Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads to white matter injury (WMI), encephalopathy of prematurity (EP), and often to cerebral palsy (CP), but the related pathophysiological mechanisms remain unclear. In prior studies, we used mild intrauterine hypoperfusion (MIUH) in rats to successfully reproduce the diversity of clinical signs of EP, and some CP symptoms. Briefly, MIUH led to inflammatory processes, diffuse gray and WMI, minor locomotor deficits, musculoskeletal pathologies, neuroanatomical and functional disorganization of the primary somatosensory and motor cortices, delayed sensorimotor reflexes, spontaneous hyperactivity, deficits in sensory information processing, memory and learning impairments...
2018: Frontiers in Neurology
Daniele Bernardeschi, Giuseppina Canu, Daniele De Seta, Francesca Yoshie Russo, Evelyne Ferrary, Isabelle Mosnier, Olivier Sterkers
No abstract text is available yet for this article.
July 4, 2018: Clinical Otolaryngology
Loïc Djaileb, Adrien Jankowski, Marjorie Canu, Alex Calizzano, Laurent Riou, Alexis Broisat, Daniel Fagret, Catherine Ghezzi, Gerald Vanzetto, Gilles Barone-Rochette
No abstract text is available yet for this article.
June 26, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Fei Gao, Xue Wang, Xuming Li, Mingyue Xu, Huayun Li, Merhaba Abla, Huigai Sun, Shanjun Wei, Jinchao Feng, Yijun Zhou
Background: Ammopiptanthus nanus is a rare broad-leaved shrub that is found in the desert and arid regions of Central Asia. This plant species exhibits extremely high tolerance to drought and freezing and has been used in abiotic tolerance research in plants. As a relic of the tertiary period, A. nanus is of great significance to plant biogeographic research in the ancient Mediterranean region. Here, we report a draft genome assembly using the Pacific Biosciences (PacBio) platform and gene annotation for A...
July 1, 2018: GigaScience
Francesco Brigo, Giammario Ragnedda, Piera Canu, Raffaele Nardone
We describe a patient with pseudoradial nerve palsy caused by acute ischaemic stroke ('cortical hand') to emphasise how preserved synkinetic wrist extension following fist closure can distinguish this from peripheral causes of wrist drop.
June 12, 2018: Practical Neurology
G Rosati, L E Heimbürger, D Melaku Canu, C Lagane, L Laffont, M J A Rijkenberg, L J A Gerringa, C Solidoro, C N Gencarelli, I M Hedgecock, H J W De Baar, J E Sonke
Redox conditions and organic matter control marine methylmercury (MeHg) production. The Black Sea is the world's largest and deepest anoxic basin and is thus ideal to study Hg species along the extended redox gradient. Here we present new dissolved Hg and MeHg data from the 2013 GEOTRACES MEDBlack cruise (GN04_leg2) that we integrated into a numerical 1-D model, to track the fate and dynamics of Hg and MeHg. Contrary to a previous study, our new data show highest MeHg concentrations in the permanently anoxic waters...
April 2018: Global Biogeochemical Cycles
Julie Fourneau, Marie-Hélène Canu, Caroline Cieniewski-Bernard, Bruno Bastide, Erwan Dupont
In human, a chronic sensorimotor perturbation (SMP) through prolonged body immobilization alters motor task performance through a combination of peripheral and central factors. Studies performed on a rat model of SMP have shown biomolecular changes and a reorganization of sensorimotor cortex through events such as morphological modifications of dendritic spines (number, length, functionality). However, underlying mechanisms are still unclear. It is well known that phosphorylation regulates a wide field of synaptic activity leading to neuroplasticity...
May 28, 2018: Journal of Neurochemistry
Enrico Erdas, Fabio Medas, Claudia Salaris, Gian L Canu, Silvia Sanna, Luca Gordini, Giuseppe Pisano, Pietro G Calò
No abstract text is available yet for this article.
May 24, 2018: Minerva Chirurgica
Joshua J Broman-Fulks, Chelsea M Abraham, Kelsey Thomas, Will H Canu, David C Nieman
The anxiolytic and antidepressant effects of regular physical exercise have been well documented, though the mechanisms through which exercise alleviates symptoms of emotion disorders require further investigation. Mounting research indicates that exercise reduces anxiety sensitivity, a known vulnerability factor for the development and maintenance of psychological disorders, presumably via repeated exposure to feared somatic sensations. The purpose of the present study was to examine whether anxiety sensitivity mediates the relation between exercise frequency and symptoms of anxiety and depression...
May 23, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
Stefano Cappai, Federica Loi, Annamaria Coccollone, Marino Contu, Paolo Capece, Michele Fiori, Simona Canu, Cipriano Foxi, Sandro Rolesu
Bluetongue (BT) is a vector-borne disease transmitted by species of Culicoides midges (Diptera: Ceratopogonidae). Many studies have contributed to clarifying various aspects of its aetiology, epidemiology and vector dynamic; however, BT remains a disease of epidemiological and economic importance that affects ruminants worldwide. Since 2000, the Sardinia region has been the most affected area of the Mediterranean basin. The region is characterised by wide pastoral areas for sheep and represents the most likely candidate region for the study of Bluetongue virus (BTV) distribution and prevalence in Italy...
July 1, 2018: Preventive Veterinary Medicine
Massimo Filippi, Silvia Basaia, Elisa Canu, Francesca Imperiale, Giuseppe Magnani, Monica Falautano, Giancarlo Comi, Andrea Falini, Federica Agosta
The aim of this study was two-fold: (i) to investigate structural and functional brain network architecture in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), stratified in converters (c-aMCI) and non-converters (nc-aMCI) to AD; and to assess the relationship between healthy brain network functional connectivity and the topography of brain atrophy in patients along the AD continuum. Ninety-four AD patients, 47 aMCI patients (25 c-aMCI within 36 months) and 53 age- and sex-matched healthy controls were studied...
May 9, 2018: Molecular Psychiatry
Valentina Sposato, Nadia Canu, Elena Fico, Salvatore Fusco, Giulia Bolasco, Maria Teresa Ciotti, Matteo Spinelli, Delio Mercanti, Claudio Grassi, Viviana Triaca, Pietro Calissano
Basal forebrain cholinergic neurons (BFCN) are key modulators of learning and memory and are high energy-demanding neurons. Impaired neuronal metabolism and reduced insulin signaling, known as insulin resistance, has been reported in the early phase of Alzheimer's disease (AD), which has been suggested to be "Type 3 Diabetes." We hypothesized that BFCN may develop insulin resistance and their consequent failure represents one of the earliest event in AD. We found that a condition reminiscent of insulin resistance occurs in the medial septum of 3 months old 3×Tg-AD mice, reported to develop typical AD histopathology and cognitive deficits in adulthood...
May 7, 2018: Molecular Neurobiology
Halshka Graczyk, Nancy B Hopf, Zakia Mediouni, Irina Guseva-Canu, Olivier Sanvido, Kaspar Schmid, Aurelie Berthet
AIMS: There is currently no centralised database on workers' exposures to plant protection products (PPPs) in Switzerland, nor a national register for negative health effects linking them to occupational PPP exposure. This lack of basic data makes it difficult to implement either epidemiological research or prevention campaigns for the agricultural sector. The first objective was to understand the level of information and flow of data on occupational PPP exposures and health effects in the Canton of Vaud, Switzerland...
2018: Swiss Medical Weekly
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
June 2018: Acta Biomaterialia
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