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JOURNAL ARTICLE
Marco Panizzolo, Francesco Barbero, Federica Ghelli, Giacomo Garzaro, Valeria Bellisario, Irina Guseva Canu, Ivana Fenoglio, Enrico Bergamaschi, Roberto Bono
The widespread and increasing use of nanomaterials has resulted in a higher likelihood of exposure by inhalation for nanotechnology workers. However, tracking the internal dose of nanoparticles deposited at the airways level, is still challenging. To assess the suitability of particle number concentration determination as biomarker of internal dose, we carried out a cross sectional investigation involving 80 workers handling nanomaterials. External exposure was characterized by portable counters of particles DISCminiTM (Testo, DE), allowing to categorize 51 workers as exposed and 29 as non-exposed (NE) to nanoparticles...
April 28, 2024: Chemosphere
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JOURNAL ARTICLE
Miriam Pepponi, Valentina Berti, Elsa Fasciglione, Flavio Montanini, Letizia Canu, Fabrice Hubele, Elisabetta Abenavoli, Vittorio Briganti, Elena Rapizzi, Anne Charpiot, David Taieb, Karel Pacak, Bernard Goichot, Alessio Imperiale
PURPOSE: To investigate the [68 Ga]DOTATOC PET radiomic profile of head and neck paragangliomas (HNPGLs) and identify radiomic characteristics useful as predictors of succinate dehydrogenase genes (SDHx) pathogenic variants. METHODS: Sporadic and SDHx HNPGL patients, who underwent [68 Ga]DOTATOC PET/CT, were retrospectively included. HNPGLs were analyzed using LIFEx software, and extracted features were harmonized to correct for batch effects and confronted testing for multiple comparison...
April 30, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#3
JOURNAL ARTICLE
Zhao Chen, Christopher J Grim, Padmini Ramachandran, Jianghong Meng
Oxford Nanopore sequencing is one of the high-throughput sequencing technologies that facilitates the reconstruction of metagenome-assembled genomes (MAGs). This study aimed to assess the potential of long-read assembly algorithms in Oxford Nanopore sequencing to enhance the MAG-based identification of bacterial pathogens using both simulated and mock communities. Simulated communities were generated to mimic those on fresh spinach and in surface water. Long reads were produced using R9.4.1+SQK-LSK109 and R10...
April 30, 2024: Microbiology Spectrum
#4
Eleonora Faccioli, Federica Grosso, Andrea Dell'Amore, Sara Delfanti, Giovanni Zambello, Luigi Cerbone, Gianluca Canu, Antonina De Angelis, Viola Sambataro, Federica Pezzuto, Paola Barbieri, Giulia Pasello, Fiorella Calabrese, Federico Rea
The role of immunotherapy in the multimodal treatment for pleural mesothelioma (PM) is still under investigation, particularly in the preoperative setting. Pathological complete response (pCR) has been previously described after chemotherapy and immunotherapy; however, there is no prior experience reported with immunotherapy alone before surgery. We report the case of a 58-year-old male with biphasic PM treated with immunotherapy, resulting in a major clinical partial response. Following a multidisciplinary evaluation between thoracic surgeons, medical oncologists, pathologists, radiologists and radiation oncologists, the patient underwent surgery with radical intent through a right extended pleurectomy/decortication (eP/D)...
2024: Frontiers in Oncology
#5
JOURNAL ARTICLE
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme asparagine synthetase (ASNS). Here, we used antisense oligonucleotides (ASO) against Asns in orthologous and slowly progressive PKD murine models and show that treatment leads to a drastic reduction of total kidney volume (measured by MRI) and a prominent rescue of renal function in the mouse...
April 29, 2024: EMBO Molecular Medicine
#6
JOURNAL ARTICLE
Silvia Basaia, Matteo Zavarella, Giulia Rugarli, Giacomo Sferruzza, Camilla Cividini, Elisa Canu, Laura Cacciaguerra, Marco Bacigaluppi, Gianvito Martino, Massimo Filippi, Federica Agosta
Neurogenesis decline with aging may be associated with brain atrophy. Subventricular zone neuron precursor cells possibly modulate striatal neuronal activity via the release of soluble molecules. Neurogenesis decay in the subventricular zone may result in structural alterations of brain regions connected to the caudate, particularly to its medial component. The aim of this study was to investigate how the functional organization of caudate networks relates to structural brain changes with aging. One hundred and fifty-two normal subjects were recruited: 52 young healthy adults (≤35 years old), 42 middle-aged (36 ≤ 60 years old) and 58 elderly subjects (≥60 years old)...
2024: Brain communications
#7
JOURNAL ARTICLE
Yigit Baysal, Nastassja Goy, Sonja Hartnack, Irina Guseva Canu
OBJECTIVES: The mental health of veterinary and other animal health professionals is significantly impacted by the psychological stressors they encounter, such as euthanasia, witnessing animal suffering and moral distress. Moral distress, initially identified in nursing, arises when individuals are aware of the right action but are hindered by institutional constraints. We aimed to review existing research on moral distress scales among animal care workers by focusing on the identification and psychometric validity of its measurement...
April 19, 2024: BMJ Open
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JOURNAL ARTICLE
Mariya Cherenko, Natasha M Appelman-Dijkstra, Ana Luisa Priego-Zurita, N R Biermasz, Olaf Dekkers, F A Klok, Nicole Reisch, Anna Aulinas, Betina Biagetti, Salvatore Cannavo, Letizia Canu, Mario Detomas, France Devuyst, Henrik Falhammar, Richard A Feelders, Francesco Ferrau, F Gatto, Chiara Grasselli, Pepijn van Houten, Charlotte Hoybye, Andrea M Isidori, Aglaia Kyrilli, Paola Loli, Dominique Maiter, Elisabeth Dorothea Susanne Nowak, Rosario Pivonello, Oskar Ragnarsson, Rebecca V Steenaard, Nicole Unger, Annenienke C Van de Ven, Susan M Webb, Diego Yeste, S Faisal Ahmed, Alberto M Pereira
BACKGROUND: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). OBJECTIVE: To evaluate current management of new cases of CS with a focus on VTE and thromboprophylaxis. DESIGN AND METHODS: A survey was conducted within those that report in electronic reporting tool (e-REC) of The European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG's) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 until July 2022...
April 1, 2024: Endocrine Connections
#9
JOURNAL ARTICLE
Orlane Dupuis, Julien Girardie, Mélanie Van Gaever, Philippe Garnier, Jacques-Olivier Coq, Marie-Hélène Canu, Erwan Dupont
Interaction with the environment appears necessary for the maturation of sensorimotor and cognitive functions in early life. In rats, a model of sensorimotor restriction (SMR) from postnatal day 1 (P1) to P28 has shown that low and atypical sensorimotor activities induced the perturbation of motor behavior due to muscle weakness and the functional disorganization of the primary somatosensory and motor cortices. In the present study, our objective was to understand how SMR affects the muscle-brain dialogue. We focused on irisin, a myokine secreted by skeletal muscles in response to exercise...
March 31, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Giacomo Di Filippo, Gian Luigi Canu, Giovanni Lazzari, Dorin Serbusca, Eleonora Morelli, Paolo Brazzarola, Leonardo Rossi, Benard Gjeloshi, Mariangela Caradonna, George Kotsovolis, Ioannis Pliakos, Efthymios Poulios, Theodosios Papavramidis, Federico Cappellacci, Pier Francesco Nocini, Pietro Giorgio Calò, Gabriele Materazzi, Fabio Medas
Obesity's role in thyroid cancer development is still debated, as well as its association with aggressive histopathological subtypes (AHSs). To clarify the link between Body Mass Index (BMI) and AHS of differentiated thyroid carcinoma (DTC), we evaluated patients who underwent thyroidectomy for DTC from 2020 to 2022 at four European referral centres for endocrine surgery. Based on BMI, patients were classified as normal-underweight, overweight, or obese. AHSs were defined according to 2022 WHO guidelines. Among 3868 patients included, 34...
April 7, 2024: Cancers
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JOURNAL ARTICLE
Alma Ghirelli, Edoardo Gioele Spinelli, Elisa Canu, Silvia Basaia, Veronica Castelnovo, Giordano Cecchetti, Elisa Sibilla, Teuta Domi, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Giacomina Rossi, Lucio Tremolizzo, Ildebrando Appollonio, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Massimo Filippi, Federica Agosta
BACKGROUND: Semantic behavioral variant frontotemporal dementia (sbvFTD) is a neurodegenerative condition presenting with specific behavioral and semantic derangements and predominant atrophy of the right anterior temporal lobe (ATL). The objective was to evaluate clinical, neuropsychological, neuroimaging, and genetic features of an Italian sbvFTD cohort, defined according to recently proposed guidelines, compared to semantic variant primary progressive aphasia (svPPA) and behavioral variant FTD (bvFTD) patients...
April 10, 2024: Journal of Neurology
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MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Federico Emanuele Pozzi, Vittoria Aprea, Ginevra Giovannelli, Francesca Lattuada, Cinzia Crivellaro, Francesca Bertola, Veronica Castelnovo, Elisa Canu, Massimo Filippi, Ildebrando Appollonio, Carlo Ferrarese, Federica Agosta, Lucio Tremolizzo
We present an in-depth clinical and neuroimaging analysis of a family carrying the MAPT K298E mutation associated with frontotemporal dementia (FTD). Initial identification of this mutation in a single clinical case led to a comprehensive investigation involving four affected siblings allowing to elucidate the mutation's phenotypic expression.A 60-year-old male presented with significant behavioral changes and progressed rapidly, exhibiting speech difficulties and cognitive decline. Neuroimaging via FDG-PET revealed asymmetrical frontotemporal hypometabolism...
April 9, 2024: Neurogenetics
#14
JOURNAL ARTICLE
Serena Martinelli, Giulia Cantini, Arianna Pia Propato, Daniele Bani, Daniele Guasti, Patrizia Nardini, Laura Calosi, Tommaso Mello, Nicole Bechmann, Giovanna Danza, Fabio Villanelli, Letizia Canu, Mario Maggi, Massimo Mannelli, Elena Rapizzi, Michaela Luconi
The crosstalk between the chromaffin and adrenocortical cells is essential for the endocrine activity of the adrenal glands. This interaction is also likely important for tumorigenesis and progression of adrenocortical cancer and pheochromocytoma. We developed a unique in vitro 3D model of the whole adrenal gland called Adrenoid consisting in adrenocortical carcinoma H295R and pheochromocytoma MTT cell lines. Adrenoids showed a round compact morphology with a growth rate significantly higher compared to MTT-spheroids...
April 5, 2024: Scientific Reports
#15
JOURNAL ARTICLE
Romain Freund, Jean-Jacques Sauvain, Guillaume Suarez, Pascal Wild, Thomas Charreau, Amélie Debatisse, Kirushanthi Sakthithasan, Valérie Jouannique, Jacques A Pralong, Irina Guseva Canu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients. METHODS: Three hundred three participants were randomly selected from a 15,000-transit worker cohort within the Respiratory disease Occupational Biomonitoring Collaborative Project (ROBoCoP)...
April 4, 2024: Journal of Occupational Medicine and Toxicology
#16
JOURNAL ARTICLE
Oksana A Korzhavina, Natalia V Gubareva, Andrey V Kitashov, Temir A Britayev, Viatcheslav N Ivanenko
Crinoids (Echinodermata) exhibit unique morphological and behavioral characteristics that facilitate a wide range of symbiotic relationships with diverse organisms. Our comprehension of their interactions with microscopic copepod crustaceans is, however, still in a nascent and fragmented state. Here, we review and discuss the 166 literature records to date in which a total of 39 copepod species in 6 families have been reported in association with 33 species of the crinoid order Comatulida. Many of these associations have been reported just once...
March 13, 2024: Animals: An Open Access Journal From MDPI
#17
JOURNAL ARTICLE
Marko Gerić, Gordana Pehnec, Katarina Matković, Jasmina Rinkovec, Ivana Jakovljević, Ranka Godec, Silva Žužul, Ivan Bešlić, Ante Cvitković, Luka Delić, Pascal Wild, Irina Guseva Canu, Nancy B Hopf, Goran Gajski
More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world's population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM10 exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants)...
March 13, 2024: Journal of Xenobiotics
#18
JOURNAL ARTICLE
Serena Martinelli, Alessandro Rolfo, Carlotta Pace, Letizia Canu, Anna Maria Nuzzo, Domenica Giuffrida, Pietro Gaglioti, Tullia Todros
OBJECTIVE: The aim of this study was to demonstrate the establishment of adrenal sparing in intrauterine growth restricted (IUGR) human fetuses. IUGR fetuses are a subgroup of small for gestational age (SGA) fetuses that are unable to reach their own growth potential because of chronic hypoxia and undernutrition. We hypothesized that in IUGR fetuses the adrenal gland is relatively larger and secretion of noradrenaline (NA), adrenaline (A), and cortisol is increased. STUDY DESIGN: This is a prospective observational study including 65 singleton pregnancies (42 IUGR and 23 controls)...
March 26, 2024: International Journal of Gynaecology and Obstetrics
#19
JOURNAL ARTICLE
Jean-Jacques Sauvain, Maud Hemmendinger, Thomas Charreau, Valérie Jouannique, Amélie Debatisse, Guillaume Suárez, Nancy B Hopf, Irina Guseva Canu
OBJECTIVE: In this pilot study on subway workers, we explored the relationships between particle exposure and oxidative stress biomarkers in exhaled breath condensate (EBC) and urine to identify the most relevant biomarkers for a large-scale study in this field. METHODS: We constructed a comprehensive occupational exposure assessment among subway workers in three distinct jobs over 10 working days, measuring daily concentrations of particulate matter (PM), their metal content and oxidative potential (OP)...
March 20, 2024: International Archives of Occupational and Environmental Health
#20
JOURNAL ARTICLE
Anastasiya Muntyanu, Raymond Milan, Mohammed Kaouache, Julien Ringuet, Wayne Gulliver, Irina Pivneva, Jimmy Royer, Max Leroux, Kathleen Chen, Qiuyan Yu, Ivan V Litvinov, Christopher E M Griffiths, Darren M Ashcroft, Elham Rahme, Elena Netchiporouk
BACKGROUND: Psoriasis is a major global health burden affecting ~ 60 million people worldwide. Existing studies on psoriasis focused on individual-level health behaviors (e.g. diet, alcohol consumption, smoking, exercise) and characteristics as drivers of psoriasis risk. However, it is increasingly recognized that health behavior arises in the context of larger social, cultural, economic and environmental determinants of health. We aimed to identify the top risk factors that significantly impact the incidence of psoriasis at the neighborhood level using populational data from the province of Quebec (Canada) and advanced tree-based machine learning (ML) techniques...
March 18, 2024: American Journal of Clinical Dermatology
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