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https://www.readbyqxmd.com/read/29626805/evaluation-of-the-precision-id-whole-mtdna-genome-panel-for-forensic-analyses
#1
Christina Strobl, Mayra Eduardoff, Magdalena M Bus, Marie Allen, Walther Parson
Mitochondrial DNA (mtDNA) amplification and Massively Parallel Sequencing (MPS) using an early access version of the Precision ID Whole MtDNA Genome Panel (Thermo Fisher Scientific) and the Ion Personal Genome Machine (PGM) were evaluated using 15 forensically relevant samples. Samples were selected to represent typical forensic specimens for mtDNA analysis including hairs, hair shafts, swabs and ancient solid tissue samples (bones and teeth) that were stored in the freezer for up to several years after having been typed with conventional Sanger-type Sequencing and Capillary Electrophoresis...
March 29, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29594144/an-unexpected-case-of-scurvy-in-a-peritoneal-dialysis-patient
#2
Raymonda El Khoury, Mitchell Warren, Saba Ali, James L Pirkle
This case describes an obese adult male peritoneal dialysis patient who presented with a pruritic follicular rash. Nutrient deficiency was not suspected initially in this case because there was no history of protein-calorie malnutrition, but the patient reported a diet devoid of fruits and vegetables and had not been taking his dialysis vitamin as prescribed. Skin biopsy showed follicular hyperkeratosis with fragmented hair shafts and corkscrew hairs consistent with scurvy. After supplementation with ascorbic acid 500 mg twice daily for 2 weeks, the rash resolved completely...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29578625/detection-of-titanium-nanoparticles-in-the-hair-shafts-of-a-patient-with-frontal-fibrosing-alopecia
#3
Florence Brunet-Possenti, Lydia Deschamps, Hester Colboc, Andrea Somogyi, Kadda Medjoubi, Dominique Bazin, Vincent Descamps
Frontal fibrosing alopecia (FFA) is a lymphocyte-mediated primary cicatricial alopecia closely related to lichen planopilaris1 . Over time, the number of FFA reports has increased continuously, suggesting the implication of yet unidentified environmental factors. Several studies based on questionnaires have pointed out that leave-on facial skin care products, especially sunscreens, could be implicated in FFA2 . Here we report the detection of titanium dioxide (TiO2 ) along the hair shafts of a patient presenting FFA...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29574801/prevalence-and-characteristics-of-hair-plucking-in-captive-bonobos-pan-paniscus-in-north-american-zoos
#4
Colin M Brand, Linda F Marchant
When primates exhibit hair loss and are observed to engage in self or social hair plucking (a rapid jerking away of the hair shaft and follicle by the hand or mouth, often accompanied by inspection, and consumption) the altered appearance, and behavior patterns are thought to reflect individual physiological, and psychological well-being. Hair loss and hair plucking occur in many captive primate species, including all of the great apes. We present the first survey of this behavior among captive bonobos (N = 88; 50 females and 38 males) in seven zoos in the United States...
March 25, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29572801/hair-shaft-growth-in-gelfoam-%C3%A2-histoculture-of-skin-and-isolated-hair-follicles
#5
Robert M Hoffman, Lingna Li, Wenluo Cao
Human scalp skin with abundant hair follicles in various stages of the hair growth cycle was histocultured for up to 40 days on Gelfoam® at the air/liquid interface. The anagen hair follicles within the histoculture scalp skin produced growing hair shafts. Hair follicles could continue their cycle in histoculture; for example, apparent spontaneous catagen induction was observed both histologically and by the actual regression of the hair follicle. In addition, vellus follicles were shown to be viable at day 40 after initiation of culture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29554060/rare-report-of-unilateral-postauricular-dermoid-cyst
#6
Je Yeon Byeon, Hwan Jun Choi, Ji Hye Lee
Dermoid cysts are benign developmental anomalies that occurred as a result of the sequestration of the skin along the lines of embryonic closure. Those occurring in the cervicofacial region are uncommon, accounting for about 7% of all dermoids and its presence in postauricular region is further exceptionally rare. A healthy 19-year-old Asian boy presented with a unilateral postauricular cyst that had been present since childhood without any symptom. The computed tomography scan revealed an encapsulated tumor with no intracranial extension...
March 16, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29512247/a-61-year-old-man-with-erythematous-forearm-papules-three-months-after-liver-transplantation
#7
Mesrop Ayrapetyan, Paul Googe, Puneet Jolly, Kara Levinson, Elena Popowitch, Anne M Lachiewicz
A 61-year-old Caucasian man presented with papules on his left forearm and hand three months after liver transplantation: images from physical exam, pathology and microbiology are presented. Skin biopsy confirmed the presence of fungal elements within the hair shaft, which is consistent with Majocchi granuloma, also known as nodular granulomatous perifolliculitis. A combination of fungal culture, microscopic morphology, and gene sequencing was used to identify the causative organism. The patient recovered with appropriate systemic antifungal therapy...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29488689/morphological-changes-of-hair-melanosomes-by-aging
#8
Takashi Itou
Various changes appear in hair by aging and graying is the most remarkable one. Changes in melanocytes have been well studied as the cause, however, little is known about the change of melanosomes which have a role of carrying melanin pigments into hair shafts. Using pigmented hairs of Japanese females from their age of 4 to 75, I isolated melanosomes and observed them. As a result, I found a significant change in the morphology of hair melanosomes with age. They were ellipsoidal on the whole and there was no age dependence in the major axis, while the minor axis significantly increased and its frequency distribution broadened with age...
February 28, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29482481/intradermal-injections-of-a-hair-growth-factor-formulation-for-enhancement-of-human-hair-regrowth-safety-and-efficacy-evaluation-in-a-first-in-man-pilot-clinical-study
#9
Rinky Kapoor, Debraj Shome
BACKGROUND: Research has shown the efficacy of hair growth factors in hair regrowth. We describe the intradermal injections of a recombinant, bioengineered hair formulation, containing growth factors, into the scalp skin, for enhancement of hair regrowth and evaluate its efficacy. OBJECTIVES: The objective of this study was to assess the efficacy and safety of the hair growth factor formulation in reducing hair loss and enhancing hair growth. MATERIALS AND METHODS: This was an open-label, prospective, single-arm interventional pilot study in which 1000 patients were given intradermal injections of a hair formulation into the scalp skin...
February 26, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29476262/beveled-incisions-what-is-the-evidence
#10
REVIEW
Shelby Brown, Michael Mirmanesh, Ping Song, Demetrius Coombs, David Rengifo, Lee L Q Pu
BACKGROUND: Although many aesthetic surgeons believe that beveling the angle of an incision improves the aesthetic outcome with regard to scaring, the literature remains scarce largely because few studies have been conducted. OBJECTIVE: This systematic review therefore aims to identify whether using a beveled incision adds an aesthetic benefit, to determine whether there is a specific angle that yields a superior outcome, and for the first time, to present a complete discussion of this subject for practicing surgeons...
February 23, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29469711/value-of-dermoscopy-for-the-diagnosis-of-monilethrix
#11
T Baltazard, F Dhaille, G Chaby, C Lok
Monilethrix is a rare genodermatosis characterized by a hair shaft dysplasia responsible for hypotrichosis. We report the case of a child with monilethrix with no associated cases in the family. Trichoscopy facilitated the diagnosis. A 2-year-old boy presented with diffuse alopecia and persistent fragile hair for several months. Clinical examination revealed alopecia with hairs broken several millimeters from the scalp. Trichoscopy revealed zones of dystrophic constriction of the hair shaft, separated at regular intervals by elliptical nodes of normal thickness, giving a "necklace" appearance...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468283/activation-of-wnt-%C3%AE-catenin-signaling-is-involved-in-hair-growth-promoting-effect-of-655-nm-red-light-and-led-in-in-vitro-culture-model
#12
Le Han, Ben Liu, Xianyan Chen, Haiyan Chen, Wenjia Deng, Changsheng Yang, Bin Ji, Miaojian Wan
Activation of the Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis and hair growth. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth in numerous clinical studies, in which 655-nm red light was found to be most effective and practical for stimulating hair growth. We evaluated whether 655-nm red light + light-emitting diode (LED) could promote human hair growth by activating Wnt/β-catenin signaling. An in vitro culture of human hair follicles (HFs) was irradiated with different intensities of 655-nm red light + LED, 21 h7 (an inhibitor of β-catenin), or both...
February 21, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29457017/distinct-trichoscopic-features-of-the-sideburns-in-frontal-fibrosing-alopecia-compared-to-the-frontotemporal-scalp
#13
Jessica Cervantes, Mariya Miteva
The trichoscopic features of frontal fibrosing alopecia (FFA) have been described in the frontotemporal area, yet there is no data detailing the trichoscopic features of the sideburns, which can be the initial or exclusive area of involvement. In this retrospective cohort study, 236 trichoscopic images of the frontotemporal and sideburn area obtained via dry trichoscopy from patients with biopsy-proven FFA were examined by two independent researchers to determine the trichoscopic features of FFA in the sideburns...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29441770/-determination-of-hair-shafts-by-innotyper%C3%A2-21-kit
#14
F Li, M Zhang, Y X Wang, J J Shui, M Yan, X P Jin, X J Zhu
OBJECTIVES: To explore the application value of InnoTyper® 21 kit in forensic practice. METHODS: Samples of hair shafts and saliva were collected from 8 unrelated individuals. Template DNA was extracted by AutoMate Express™ forensic DNA automatic extraction system. DNA was amplified by InnoTyper® 21 kit and AmpFℓSTR™ Identifiler™ Plus kit, respectively, and then the results were compared. RESULTS: After the amplification by InnoTyper® 21 kit, complete specific genotyping could be detected from the saliva samples, and the peak value of genotyping profiles of hair shafts without sheath cells was 57-1 219 RFU...
December 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29440852/rare-variant-of-ankyloblepharon-ectodermal-defect-cleft-lip-cleft-palate-syndrome-curly-hair-ankyloblepharon-nail-disease-syndrome
#15
Ajay Chopra, Debdeep Mitra, Renu Kandpal, Reetu Agarwal
Ankyloblepharon-ectodermal defect-cleft lip/cleft palate (AEC) syndrome is one of the variants of ectodermal dysplasia. It is an autosomal dominant disorder comprising of ankyloblepharon, ectodermal dysplasia, and cleft palate or cleft lip. In 1976, it wasfirst described by Hay and Wells, therefore also known as Hay-Wells syndrome. The characteristic feature of this syndrome is "ankyloblepharon filiforme adnatum", which refers to the partial thickness fusion of the eyelid margins. The "curly hair-ankyloblepharon-nail disease (CHAND) syndrome" is a clinical variant of AEC syndrome...
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29390202/-clinical-trial-regeneration-of-skin-perception-after-deep-degree-burns-in-childhood
#16
Stephan Fuchs, Gunter Klohs, Malte Kornhuber, Rainer Finke
BACKGROUND:  Cutaneous aesthesia is frequently impaired following thermal injury. The perception of pressure and touch is compromised. METHODS:  We analysed 352 patient files retrospectively and tested the perception in deep burn-damaged skin of children. The skin regions examined were classified into groups according to treatment: group 1: necrosectomy + split-thickness skin graft; group 2: epifascial necrosectomy + split-thickness skin graft; group 3: epifascial necrosectomy + Integra® + split- thickness skin graft...
February 1, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29371649/studies-on-the-proteome-of-human-hair-identification-of-histones-and-deamidated-keratins
#17
Sunil S Adav, Roopa S Subbaiaih, Swat Kim Kerk, Amelia Yilin Lee, Hui Ying Lai, Kee Woei Ng, Siu Kwan Sze, Artur Schmidtchen
Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichment of keratin, keratin-associated proteins (KAPs), and intermediate filament proteins, which were part of protein networks associated with response to stress, innate immunity, epidermis development, and the hair cycle...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29364454/circular-hairs-nomenclature-and-meanings
#18
Ana Luiza Valle Esteves, Natália Battisti Serafini, Luciana Rodino Lemes, Daniel Fernandes Melo
Trichoscopy has become an essential tool for the diagnosis of various diseases that affect the hair and scalp. Through dermatoscopy we identified a set of findings that share a circular shape of hair shafts. The objective of this study is to distinguish among the various forms of circular hairs in order to identify their peculiarities and to describe in which skin disorders they can be found.
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29360892/long-term-pubic-dermatitis-diagnosed-as-white-piedra
#19
James Landero
The case of a 58-year-old man with a pruritic rash involving the pubic area that had been undiagnosed for 30 years is presented. At least 15 different primary care physicians and dermatologists evaluated the patient during this time period. Multiple treatments were unsuccessful and a definitive diagnosis was not rendered. Wood lamp evaluation of the pubic area revealed hair shaft concretions that were confirmed on histologic evaluation to be white piedra (WP). The patient was successfully treated with topical ketoconazole and the eruption completely resolved...
December 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29334164/clinical-evaluation-of-a-novel-fractional-radiofrequency-device-for-hair-growth-fractional-radiofrequency-for-hair-growth-stimulation
#20
Ines Verner, Torello Lotti
AGA is a common disorder. Different treatments are available to prevent hair loss and achieve hair growth with variable results. The purpose of the present study was to evaluate the efficacy and safety of a novel fractional radiofrequency (RF) device (HairLux, Innogen Technologies Ltd., Yokneam, Israel), to prevent hair loss and induce hair growth. Twenty-five patients received 10 fractional RF treatments every 2 weeks, and were followed up 2 months after the last treatment. All patients were evaluated by global photography...
January 15, 2018: Dermatologic Therapy
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