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https://www.readbyqxmd.com/read/28437719/matrix-assisted-laser-desorption-ionization-mass-spectrometric-imaging-of-olanzapine-in-a-single-hair-using-esculetin-as-a-matrix
#1
Hang Wang, Ying Wang, Ge Wang, Lizhi Hong
Matrix-assisted laser desorption/ionization-mass spectrometric imaging (MALDI-MSI) for the analysis of intact hair is a powerful tool for monitoring changes in drug consumption. The embedding of a low drug concentration in the hydrophobic hair matrix makes it difficult to extract and detect, and requires an improved method to increase detection sensitivity. In this study, an MSI method using MALDI-Fourier transform ion cyclotron resonance was developed for direct identification and imaging of olanzapine in hair samples using the positive ion mode...
April 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28413121/characterisation-of-cell-cycle-arrest-and-terminal-differentiation-in-a-maximally-proliferative-human-epithelial-tissue-lessons-from-the-human-hair-follicle-matrix
#2
Talveen S Purba, Lars Brunken, Michael Peake, Asim Shahmalak, Asuncion Chaves, Enrique Poblet, Ralf Paus
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member proteins (p21(CIP1), p27(KIP1) and p57(KIP2)) regulate cell cycle progression/arrest, endoreplication, differentiation and apoptosis. Since they have not yet been adequately characterized in the human HF, we asked whether and where CIP/KIP proteins localise in the human hair matrix and pre-cortex in relation to cell cycle activity and HF-specific epithelial cell differentiation that is marked by keratin 85 (K85) protein expression...
April 2, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28391141/development-and-validation-of-a-novel-multiplexed-dna-analysis-system-innotyper-%C3%A2-21
#3
Hiromi Brown, Robyn Thompson, Gina Murphy, Dixie Peters, Bobby La Rue, Jonathan King, Anne H Montgomery, Marion Carroll, James Baus, Sid Sinha, Frank R Wendt, Bing Song, Ranajit Chakraborty, Bruce Budowle, Sudhir K Sinha
We report here a novel multiplexed DNA analysis system consisting of 20 Alu markers and Amelogenin for analysis of highly degraded forensic biological samples. The key to the success of the system in obtaining results from degraded samples is the primer design yielding small amplicon size (60-125bp) for all 20 markers. The markers included in the InnoTyper(®) 21 system are bi-allelic, having two possible allelic states (insertion or null) and thus termed INNULs. The markers are short interspersed nuclear elements (SINEs), a category of retrotransposable elements (REs) which are non-coding genomic DNA repeat sequences, or "mobile insertion elements," comprising approximately 40% of the human genome...
March 18, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28381806/arachidonate-12-lipoxygenase-inhibitors-promote-s100a3-citrullination-in-cultured-sw480-cells-and-isolated-hair-follicles
#4
Kenji Kizawa, Takeshi Fujimori, Tomomitsu Kawai
The human hair shaft is covered with multiple scale-like cuticular layers. During the terminal differentiation stage of immature cuticular cells within the hair follicle, cysteine-rich calcium binding S100A3 protein is predominantly translated, and its arginine residues are converted to citrullines by peptidylarginine deiminases (PADI). In this study, we found several naturally occurring compounds (e.g., hinokitiol, escletin, and quercetin) elevate S100A3 citrullination in a human colorectal adenocarcinoma cell line (SW480)...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28345791/trichoscopic-diagnosis-of-cutaneous-pelodera-strongyloides-infestation-in-a-dog
#5
Rareş G M Căpitan, Chiara Noli
BACKGROUND: Pelodera strongyloides infestation has rarely been reported in dogs. It is a saprophytic free-living nematode, found in moist decaying organic matter, whose L3 larval stages occasionally can invade the skin of dogs and humans. Larvae penetrate the follicular infundibula causing an erythematous and pruritic dermatitis. The disease is usually diagnosed by deep skin scraping or histopathology, with large numbers of parasites readily identified in hair follicles. CASE REPORT: Pelodera strongyloides dermatitis was diagnosed in a six-year-old mixed breed dog presenting with alopecia, erythema and severe pruritus on the ventrum and limbs...
March 27, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28344061/compartmentation-of-mitochondrial-and-oxidative-metabolism-in-growing-hair-follicles-a-ring-of-fire
#6
John J Lemasters, Venkat K Ramshesh, Gregory L Lovelace, John Lim, Graham D Wright, Duane Harland, Thomas L Dawson
Little is known about the energetics of growing hair follicles, particularly in the mitochondrially abundant bulb. Here, mitochondrial and oxidative metabolism was visualized by multiphoton and light sheet microscopy in cultured bovine hair follicles and plucked human hairs. Mitochondrial membrane potential (ΔΨ), cell viability, reactive oxygen species (ROS) and secretory granules were assessed with parameter-indicating fluorophores. In growing follicles, lower bulb epithelial cells had high viability, and mitochondria were polarized...
March 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28324847/species-identification-in-forensic-samples-using-the-spindel-approach-a-ghep-isfg-inter-laboratory-collaborative-exercise
#7
Cíntia Alves, Rui Pereira, Lourdes Prieto, Mercedes Aler, Cesar R L Amaral, Cristina Arévalo, Gabriela Berardi, Florencia Di Rocco, Mariela Caputo, Cristian Hernandez Carmona, Laura Catelli, Heloísa Afonso Costa, Pavla Coufalova, Sandra Furfuro, Óscar García, Anibal Gaviria, Ana Goios, Juan José Builes Gómez, Alexis Hernández, Eva Del Carmen Betancor Hernández, Luís Miranda, David Parra, Susana Pedrosa, Maria João Anjos Porto, Maria de Lurdes Rebelo, Matteo Spirito, María Del Carmen Villalobos Torres, António Amorim, Filipe Pereira
DNA is a powerful tool available for forensic investigations requiring identification of species. However, it is necessary to develop and validate methods able to produce results in degraded and or low quality DNA samples with the high standards obligatory in forensic research. Here, we describe a voluntary collaborative exercise to test the recently developed Species Identification by Insertions/Deletions (SPInDel) method. The SPInDel kit allows the identification of species by the generation of numeric profiles combining the lengths of six mitochondrial ribosomal RNA (rRNA) gene regions amplified in a single reaction followed by capillary electrophoresis...
March 7, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28299823/monilethrix-in-monozygotic-twins-with-very-rare-mutation-in-krt-86-gene
#8
B Nedoszytko, Z Lewicka-Potocka, A Szczerkowska-Dobosz, J Gleń, B Bykowska, J Świątecka-Czaj, R Nowicki
Monilethrix is a heretitary disorder, characterized by abnormal hair shafts with nodes and narrow internodes [1], typically caused by autosomal dominant mutations in type II hair keratin genes KRT 81, KRT 83 and KRT 86 [2-8]. Rarely, autosomal recessive mutation in desmoglein 4 gene may be responsible for the disease [9,10]. Among affected family members, symptoms may vary from almost normal scalp to alopecia, moreover the severity of the disease may change during patient life. This article is protected by copyright...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28273976/trichoadenoma-of-nikolowski-a-rare-tumour-with-unusual-presentation-over-vulva
#9
Ashok Sangwaiya, Shilpa Bairwa, Shivani Kalhan, Puja Sharma, Rahul N Satarkar
Trichoadenoma is a rare benign, slowly growing, cutaneous tumour of the hair follicle first described by Nikolowski in 1958. It presents as a non-specific nodule over the face or buttocks. However, unusual sites such as the neck, upper arm, thigh, shoulder, and shaft of the penis may also be affected. The tumour is less mature than a trichofolliculoma and is more differentiated than a trichoepithelioma with a differentiation towards the infundibular portion of the pilosebaceous canal. Histologically, it consists of numerous infundibulocystic structures present throughout the dermis, few of which are lined by eosinophilic epidermal cells with attempted glandular formation and contain laminated keratin, without evidence of hair follicle formation...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28232922/-road-dividing-line-like-pigmentation-of-hair-as-a-diagnostic-clue-for-griscelli-syndrome
#10
Alexandros C Katoulis, Dimitra Daskari, Aikaterini I Liakou, Evangelia Bozi, Dimitra Lianou, Dimitris Rigopoulos
We report a case of a 5-year-old girl with physical and psychomotor retardation, acquired microcephaly, and history of recurrent infections. Dermoscopic and microscopic hair examination revealed a "road-dividing line"-like pigmentation of hair shafts. The combination of history, clinical findings, and hair examination led to the diagnosis of Griscelli syndrome type II. The picture of "road-dividing line" on hair microscopic and dermoscopic examination is highly characteristic for Griscelli syndrome, and in this framework, dermatologic examination may be of high importance for the diagnosis...
January 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28229231/hair-follicle-changes-following-intense-pulsed-light-axillary-hair-reduction-histometrical-histological-and-immunohistochemical-evaluation
#11
Moetaz El-Domyati, Wael Hosam, Noha H Moftah, Hamza Abdel Raouf, Selwet M Saad
Intense pulsed light (IPL) has been used for years in hair reduction; however, no previous studies discussed quantitative histological and immunohistochemical changes of hair follicles after IPL. Accordingly, this study aims to objectively quantify histological and immunohistochemical changes of hair follicles after IPL hair reduction. Right axillae of 21 volunteers were subjected to 6 IPL sessions using Quanta system IPL and evaluated at 1 week and 1 month after last session (i.e., 3 and 4 months from the start of treatment, respectively) in comparison to baseline and left control axillae...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28220862/induction-of-hair-follicle-dermal-papilla-cell-properties-in-human-induced-pluripotent-stem-cell-derived-multipotent-lngfr-thy-1-mesenchymal-cells
#12
Ophelia Veraitch, Yo Mabuchi, Yumi Matsuzaki, Takashi Sasaki, Hironobu Okuno, Aki Tsukashima, Masayuki Amagai, Hideyuki Okano, Manabu Ohyama
The dermal papilla (DP) is a specialised mesenchymal component of the hair follicle (HF) that plays key roles in HF morphogenesis and regeneration. Current technical difficulties in preparing trichogenic human DP cells could be overcome by the use of highly proliferative and plastic human induced pluripotent stem cells (hiPSCs). In this study, hiPSCs were differentiated into induced mesenchymal cells (iMCs) with a bone marrow stromal cell phenotype. A highly proliferative and plastic LNGFR(+)THY-1(+) subset of iMCs was subsequently programmed using retinoic acid and DP cell activating culture medium to acquire DP properties...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211089/icariin-promotes-mouse-hair-follicle-growth-by-increasing-insulin-like-growth-factor-1-expression-in-dermal-papillary-cells
#13
Y-S Su, Z-X Fan, S-E Xiao, B-J Lin, Y Miao, Z-Q Hu, H Liu
BACKGROUND: Icariin is a major flavonoid isolated from Epimedium spp. leaves (Epimedium Herba), and has multiple pharmacological functions, including anti-angiogenesis, anti-oxidant, anti-inflammatory and immunoprotective effects. AIM: To investigate whether icariin can stimulate growth of hair follicles in mice and the underlying mechanism. METHODS: In vitro, the effect of icariin on hair growth was assessed by using a vibrissae hair follicle (VHF) organ-culture model...
February 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28203534/comparison-of-methanol-and-isopropanol-as-wash-solvents-for-determination-of-hair-cortisol-concentration-in-grizzly-bears-and-polar-bears
#14
Thomas Kroshko, Luciene Kapronczai, Marc R L Cattet, Bryan J Macbeth, Gordon B Stenhouse, Martyn E Obbard, David M Janz
Methodological differences among laboratories are recognized as significant sources of variation in quantification of hair cortisol concentration (HCC). An important step in processing hair, particularly when collected from wildlife, is the choice of solvent used to remove or "wash" external hair shaft cortisol prior to quantification of HCC. The present study systematically compared methanol and isopropanol as wash solvents for their efficiency at removing external cortisol without extracting internal hair shaft cortisol in samples collected from free-ranging grizzly bears and polar bears...
2017: MethodsX
https://www.readbyqxmd.com/read/28164458/comparison-of-hair-removal-efficacy-and-side-effect-of-neodymium-yttrium-aluminum-garnet-laser-and-intense-pulsed-light-systems-18-month-follow-up
#15
Georgina Zita Szima, Eszter Anna Janka, Anikó Kovács, Blanka Bortély, Edina Bodnár, Irina Sawhney, Éva Szabó, Éva Remenyik
BACKGROUND: Photothermal destruction of hair shaft melanin with intense pulsed light (IPL) and neodymium:yttrium-aluminum-garnet (Nd:YAG) laser has become an effective treatment of hair removal. AIMS: Our aim was to compare efficacy, satisfactory levels, safety, and side effects of Nd:YAG and IPL in hair reduction. METHODS: This was a prospective randomized intrapatient, right-left, assessor-blinded comparison of Nd:YAG vs IPL. There were 38 volunteers recruited...
February 6, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28155238/dickkopf-1-is-involved-in-dexamethasone-mediated-hair-follicle-regression
#16
Mi Hee Kwack, Jun Ho Lee, Chang Hoon Seo, Jung Chul Kim, Moon Kyu Kim, Young Kwan Sung
The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs) and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice...
February 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28099203/evaluation-of-gene-expression-patterns-in-micrografts-demonstrate-induction-of-catagen-like-processes-during-storage
#17
Walter Krugluger, Karl Stiefsohn, Karl Moser, Claudia Moser, Katarina Laciak
BACKGROUND: Alterations of gene expression patterns may contribute to the commonly observed transient reduction of hair shaft elongation in hair restoration surgery. OBJECTIVE: To elucidate the molecular causes, we evaluated changes in gene expression patterns in hair follicle micrografts during storage. MATERIALS AND METHODS: Micrografts with different amounts of adjacent connective tissue (regular, skinny, and chubby) were stored for different periods, and the expression of key genes was determined: dermal papilla (DP): FGF7, alkaline phosphatase (ALP), versican; outer root sheath: Krt15; inner root sheath: Krt 25; cuticula: Krt85; Henle layer: filaggrin; genes related to apoptosis and growth/differentiation: Caspase 3, Ovol1, and Foxo1...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28078444/mps-analysis-of-the-mtdna-hypervariable-regions-on-the-miseq-with-improved-enrichment
#18
Mitchell M Holland, Laura A Wilson, Sarah Copeland, Gloria Dimick, Charity A Holland, Robert Bever, Jennifer A McElhoe
The non-coding displacement (D) loop of the human mitochondrial (mt) genome contains two hypervariable regions known as HVR1 and HVR2 that are most often analyzed by forensic DNA laboratories. The massively parallel sequencing (MPS) protocol from Illumina (Human mtDNA D-Loop Hypervariable Region protocol) utilizes four sets of established PCR primer pairs for the initial amplification (enrichment) step that span the hypervariable regions. Transposase adapted (TA) sequences are attached to the 5'-end of each primer, allowing for effective library preparation prior to analysis on the MiSeq, and AmpliTaq Gold DNA polymerase is the enzyme recommended for amplification...
January 11, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28074524/trichoscopic-clues-for-diagnosis-of-alopecia-areata-and-trichotillomania-in-asians
#19
Saranya Khunkhet, Vasanop Vachiramon, Poonkiat Suchonwanit
BACKGROUND: Trichoscopy has become a useful diagnostic tool for various hair and scalp diseases, including alopecia areata (AA) and trichotillomania (TTM), which are sometimes difficult to distinguish clinically. OBJECTIVES: To describe trichoscopic findings of AA and TTM in an Asian population and to establish diagnostic clues for these conditions. METHODS: Trichoscopy was performed with a handheld dermoscope in 52 patients diagnosed with AA and 23 patients diagnosed with TTM...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27976432/trichobacteriosis-axillaris-caused-by-dermabacter-hominis
#20
Jorge Larrondo, Lorena Porte, Marianne Gosch, Raúl Cabrera, Thomas Weitzel
Trichobacteriosis is a frequent superficial bacterial infection of the hair, mainly affecting sweat gland bearing areas such as axillae and genital region, and also rarely the scalp.(1-3) The disease is characterized by bacterial overgrowth forming nodular concretions, usually of yellow color (infrequently black or reddish), which are firmly attached to the hair shaft.(1,4) Clinical hallmarks are rancid, acidic odor, unpleasant "dirty" sensation, and staining of clothes. Although most cases have been associated to different species of corynebacteria, the full etiologic spectrum of this infection is uncertain ...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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