Lihong Wen, Zhexiang Fan, Weichang Huang, Yong Miao, Jiarui Zhang, Bingcheng Liu, Decong Zhu, Damao Dai, Jiaxian Zhang, Demengjie Le, Yufan Zhang, Qian Qu, Zhiqi Hu, Ruosi Chen
BACKGROUND: Depletion or permanent quiescence of the hair follicle stem cell (HFSC) pool underlies pathogenesis in androgenetic alopecia (AGA). Reactivation of quiescent HFSCs is considered an efficient treatment strategy for hair loss. The retinoic acid (RA) is critical to ensure stem cell homeostasis and function. However, little is known about whether RA regulates HFSC homeostasis. We aimed to investigate the impact of RA on HFSC homeostasis and the underlying mechanisms, in order to provide new potential targets for medical therapies of AGA...
April 17, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV