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Carbapenem-resistant enterobacteriaceae

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https://www.readbyqxmd.com/read/28730149/review-of-antibiotic-resistance-in-the-indian-ocean-commission-a-human-and-animal-health-issue
#1
REVIEW
Noellie Gay, Olivier Belmonte, Jean-Marc Collard, Mohamed Halifa, Mohammad Iqbal Issack, Saindou Mindjae, Philippe Palmyre, Abdul Aziz Ibrahim, Harena Rasamoelina, Loïc Flachet, Laurent Filleul, Eric Cardinale
Antimicrobial resistance (AMR) is a major threat to human, animal health, and environment worldwide. For human, transmission occurred through a variety of routes both in health-care settings and community. In animals, AMR was reported in livestock, pets, and wildlife; transmission of AMR can be zoonotic with the probably most important route being foodborne transmission. The Indian Ocean Commission (IOC), composed of Comoros, Madagascar, Mauritius, Reunion (France), and Seychelles recognized the surveillance of AMR in both animal and human as a main public health priority for the region...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28723468/trends-in-antibiotic-resistance-in-urologic-practice
#2
REVIEW
Hala Kandil, Emma Cramp, Tejal Vaghela
CONTEXT: The significant global upsurge in antimicrobial resistance, particularly among Enterobacteriaceae, represents a serious threat to health care systems. The implications for urologic practice are of particular concern. OBJECTIVE: To review trends in antibiotic resistance in urologic practice. EVIDENCE ACQUISITION: We report current European trends of resistance in Gram-negative uropathogens. EVIDENCE SYNTHESIS: In addition to β-lactam resistance, Gram-negative pathogens are often resistant to multiple drug classes, including aminoglycosides, fluoroquinolones, and carbapenems, commonly used to treat urologic infections...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720159/carbapenem-resistant-enterobacteriaceae-a-strategic-roadmap-for-infection-control-corrigendum
#3
(no author information available yet)
No abstract text is available yet for this article.
July 19, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#4
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28711315/characterization-of-mobile-genetic-elements-carrying-vim-1-and-kpc-2-carbapenemases-in-citrobacter-freundii-isolates-in-madrid
#5
Jennifer Villa, David M Arana, Esther Viedma, Dafne Perez-Montarelo, Fernando Chaves
Carbapenemase producing Citrobacter freundii (CPCF) infections are still uncommon in European countries. Here we report a molecular study conducted in a tertiary care facility in southern Madrid, Spain, from 2009 to 2014 to investigate the epidemiology of CPCF. The blaIMP-1,blaIMP-2,blaKPC,blaNDM,blaOXA-48,blaVIM-1 and blaVIM-2 genes were screened by PCR. Molecular typing was carried out by Pulsed-field gel electrophoresis analysis (PFGE) and multilocus sequence typing (MLST). Whole genome sequencing (WGS) was performed to characterize the resistome and the mobile genetic elements associated with the carbapenems resistance of CPCF...
July 8, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28709901/multicenter-collaboration-study-on-the-%C3%AE-lactam-resistant-enterobacteriaceae-in-japan-the-65th-anniversary-public-interest-purpose-project-of-the-japanese-society-of-chemotherapy
#6
Yoshikazu Ishii, Kotaro Aoki, Kazuhiro Tateda, Hiroshi Kiyota
This study was conducted using the same method of the "1-day multicenter collaborative research for Clostridium difficile infectious". This surveillance study was performed by 38 participating medical facilities across Japan. Of the 268 fecal specimens collected in this study, 5 (1.9%) carbapenem-resistant Enterobacteriaceae (CRE) were judged carbapenem resistant by the criteria of the Infectious Disease Act, Japan (2 mg/L or more and 64 mg/L or more MICs for imipenem and cefmetazole, respectively). However, no isolate was shown to have a meropenem MIC of 2 mg/L or more...
July 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28706391/utility-of-a-novel-chromogenic-medium-as-a-screening-method-in-the-detection-of-carbapenemase-producing-enterobacteriaceae
#7
Anusha Chaturvedi, Gunjiganur Shankarappa Banashankari
INTRODUCTION: With the emergence of multidrug resistant Gram-negative bugs, there is an urgent need for rapid detection of these resistant organisms. AIM: This study was performed to assess the utility of a novel chromogenic medium in the detection of carbapenemase producing Enterobacteriaceae from various clinical specimens. MATERIALS AND METHODS: A total of 202 isolates of Enterobacteriaceae, which were resistant to meropenem (10 μg) disc by standard disc diffusion method, were analyzed over a period of 6 months...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28705201/genotypic-diversity-among-multidrug-resistant-pseudomonas-aeruginosa-and-acinetobacter-species-at-mulago-hospital-in-kampala-uganda
#8
David P Kateete, Ritah Nakanjako, Moses Okee, Moses L Joloba, Christine F Najjuka
BACKGROUND: Multidrug resistant Pseudomonas aeruginosa and Acinetobacter species are common causes of nosocomial infections worldwide. Recently we reported the occurrence of carbapenem resistant Enterobacteriaceae, P. aeruginosa and Acinetobacter species at Mulago National Referral Hospital in Kampala, Uganda, but the isolates were not analyzed for genetic relatedness. Herein we report the intra-species genotypic diversity among P. aeruginosa and Acinetobacter baumannii isolated from hospitalized patients and the environment at Mulago Hospital, using repetitive elements-based PCR (Rep-PCR) genotyping...
July 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28702469/comparison-between-carbapenems-and-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-in-the-treatment-for-bloodstream-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-a-systematic-review-and-meta-analysis
#9
Maged Muhammed, Myrto Eleni Flokas, Marios Detsis, Michail Alevizakos, Eleftherios Mylonakis
BACKGROUND: Carbapenems are widely used for the management of bloodstream infections (BSIs) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE). However, the wide use of carbapenems has been associated with carbapenem-resistant Enterobacteriaceae development. METHODS: We searched the PubMed and Scopus databases (last search date was on June 1, 2016) looking for studies that reported mortality in adult patients with ESBL-PE BSIs that were treated with carbapenems or β-lactam/β-lactamase inhibitors (BL/BLIs)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28702005/insights-into-a-novel-blakpc-2-encoding-incp-6-plasmid-reveal-carbapenem-resistance-circulation-in-several-enterobacteriaceae-species-from-wastewater-and-a-hospital-source-in-spain
#10
Yancheng Yao, Fernando Lazaro-Perona, Linda Falgenhauer, Aránzazu Valverde, Can Imirzalioglu, Lucas Dominguez, Rafael Cantón, Jesús Mingorance, Trinad Chakraborty
Untreated wastewater, particularly from hospitals and other healthcare facilities, is considered to be a reservoir for multidrug-resistant bacteria. However, its role in the spread of antibiotic resistances in the human population remains poorly investigated. We used whole genome sequencing to analyze 25 KPC-2-producing Enterobacteriaceae isolates from sewage water collected during a 3-year period and three clinical Citrobacter freundii isolates from a tertiary hospital in the same collection area in Spain...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28697720/early-onset-pneumonia-after-liver-transplant-microbial-causes-risk-factors-and-outcomes-mansoura-university-egypt-experience
#11
Mohammad Khairy El-Badrawy, Raed El-Metwaly Ali, Amr Yassen, Mohammad Ahmad AbouElela, Rehab Ahmad Elmorsey
OBJECTIVES: Pneumonia has a negative effect on the outcome of liver transplant. Our aim was to analyze early-onset pneumonia that developed within the first month after transplant. MATERIALS AND METHODS: This prospective single-center study included 56 adult living-donor liver transplant recipients; those who developed early-onset pneumonia based on clinical and radiologic criteria were investigated as to causative pathogens and then followed up and compared with other recipients without pneumonia to illustrate risk factors, outcomes, and related mortality of posttransplant pneumonia...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28693493/comparison-of-in-house-and-commercial-real-time-pcr-based-carbapenemase-gene-detection-methods-in-enterobacteriaceae-and-non-fermenting-gram-negative-bacterial-isolates
#12
M Smiljanic, M Kaase, P Ahmad-Nejad, B Ghebremedhin
BACKGROUND: Carbapenemase-producing gram-negative bacteria are increasing globally and have been associated with outbreaks in hospital settings. Thus, the accurate detection of these bacteria in infections is mandatory for administering the adequate therapy and infection control measures. This study aimed to establish and evaluate a multiplex real-time PCR assay for the simultaneous detection of carbapenemase gene variants in gram-negative rods and to compare the performance with a commercial RT-PCR assay (Check-Direct CPE)...
July 10, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28687975/prevalence-and-drug-resistance-characteristics-of-carbapenem-resistant-enterobacteriaceae-in-hangzhou-china
#13
Yan Yang, Jian Chen, Di Lin, Xujian Xu, Jun Cheng, Changgui Sun
With the abuse of antimicrobial agents in developing countries, increasing number of carbapenem-resistant Enterobacteriaceae (CRE) attracted considerable public concern. A retrospective study was conducted based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drug resistance characteristics of CRE in southeast China. Bacterial species were identified. Antimicrobial susceptibility was examined by broth microdilution method or epsilometer test. Resistant β-lactamase genes were identified by polymerase chain reaction and sequencing...
July 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28681083/a-novel-protocol-obviates-endoscope-sampling-for-carbapenem-resistant-enterobacteriaceae-experience-of-a-center-with-a-prior-outbreak
#14
Zachary L Smith, Arshish Dua, Kia Saeian, Nathan A Ledeboer, Mary Beth Graham, Murad Aburajab, Darren D Ballard, Abdul H Khan, Kulwinder S Dua
BACKGROUND: Numerous published outbreaks, including one from our institution, have described endoscope-associated transmission of multidrug-resistant organisms (MDROs). Individual centers have adopted their own protocols to address this issue, including endoscope culture and sequestration. Endoscope culturing has drawbacks and may allow residual bacteria, including MDROs, to go undetected after high-level disinfection. AIM: To report the outcome of our novel protocol, which does not utilize endoscope culturing, to address our outbreak...
July 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28670639/extended-spectrum-beta-lactamase-producing-gram-negative-bacteria-in-iran-a-review
#15
Hamed Ebrahimzadeh Leylabadlo, Tala Pourlak, Abed Zahedi Bialvaei, Mohammad Aghazadeh, Mohammad Asgharzadeh, Hossein Samadi Kafil
BACKGROUND: The emergence and spread of extended spectrum β-lactamase (ESBL)-producing Gram- negative bacteria (GNB), particularly in Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, have increased all over the world. ESBLs are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. The rate of nosocomial infections caused by ESBL-producing GNB in Asia Pacific has increased and several studies have identified their prevalence in the region...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28670570/in-vitro-pharmacokinetics-pharmacodynamics-evaluation-of-fosfomycin-combined-with-amikacin-or-colistin-against-kpc2-producing-klebsiella-pneumoniae
#16
Wei Yu, Kai Zhou, Lihua Guo, Jinru Ji, Tianshui Niu, Tingting Xiao, Ping Shen, Yonghong Xiao
Objectives: The emergence of carbapenem-resistant Enterobacteriaceae, especially Klebsiella pneumoniae, has become a major concern in clinic settings. Combination therapy is gaining momentum to counter the secondary resistance and potential suboptimal efficacy of monotherapy. The aim of this study was to evaluate the bactericidal effect of fosfomycin (FM), amikacin (AMK), or colistin (COL) alone and combinations against KPC2-producing K. pneumoniae using dynamic model by simulating human pharmacokinetics in vitro...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28666753/first-report-of-an-e-coli-strain-from-swine-carrying-an-oxa-181-carbapenemase-and-colistin-resistance-determinant-mcr-1
#17
Sandra Pulss, Torsten Semmler, Ellen Prenger-Berninghoff, Rolf Bauerfeind, Christa Ewers
Plasmid-mediated resistance in Enterobacteriaceae against carbapenems and colistin represents an emerging threat for public health. Although animals have been identified as a relevant source of multidrug-resistant (MDR) bacteria, there are only few reports about the presence of carbapenemases in animal isolates. Using Mueller-Hinton agar with meropenem, 7,850 fecal E. coli isolates obtained from 2,160 pigs were screened for carbapenem non-susceptibility. Eleven isolates showed growth on meropenem agar but only two proved positive for a carbapenemase gene, namely blaOXA-48-like, by PCR...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28660131/successful-treatment-of-multidrug-resistant-klebsiella-pneumoniae-using-dual-carbapenem-regimen-in-immunocompromised-patient
#18
Wasim S El Nekidy, Mohamed Y Mooty, Nizar Attallah, Lyssette Cardona, Maria Fernanda Bonilla, Islam M Ghazi
This report describes a longitudinal case of immunocompromised patient post kidney transplant who was admitted to our institution repeatedly for treatment of various infections caused by multi-drug resistant Klebsiella pneumoniae. The patient was successfully treated with a combination of ertapenem/meropenem on multiple occasions despite the elevated MICs. Our observations corroborate previous preclinical studies and case reports showing the efficacy of double carbapenem regimens against resistant Enterobacteriaceae...
2017: IDCases
https://www.readbyqxmd.com/read/28655675/emergence-and-spread-of-antibiotic-resistance-in-west-africa%C3%A2-contributing-factors-and-threat-assessment
#19
A S Ouedraogo, H Jean Pierre, A L Bañuls, R Ouédraogo, S Godreuil
The emergence and spread of antibiotic resistance present a major public health issue in both developed (DC) and less developed countries (LDC). Worldwide, its main cause is the uncontrolled and unjustified use of antibiotics. In countries with limited resources, such as West African nations, other features, more specifically socioeconomic and behavioral factors, contribute to exacerbate this problem. The objective of this review is to give an update of the common and specific factors involved in the amplification of antibiotic resistance phenomena in LCD, particularly in West African countries...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28652234/meropenem-vaborbactam-tested-against-contemporary-gram-negative-isolates-collected-worldwide-during-2014-including-carbapenem-resistant-kpc-producing-multidrug-resistant-and-extensively-drug-resistant-enterobacteriaceae
#20
Mariana Castanheira, Michael D Huband, Rodrigo E Mendes, Robert K Flamm
We evaluated the activity of meropenem-vaborbactam against contemporary non-fastidious gram-negative clinical isolates, including resistant phenotypes and carbapenemase genotypes of Enterobacteriaceae Meropenem-vaborbactam (inhibitor at 8 μg/ml) and comparators were susceptibility tested using reference broth microdilution methods against 14,304 gram-negative clinical isolates collected worldwide during 2014. Carbapenemase encoding genes were screened by PCR/sequencing. Meropenem-vaborbactam (MIC50/90, ≤0...
June 26, 2017: Antimicrobial Agents and Chemotherapy
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