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Carbapenem-resistant enterobacteriaceae

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https://www.readbyqxmd.com/read/28642846/decreased-fitness-and-virulence-in-st10-escherichia-coli-harboring-blandm-5-and-mcr-1-against-a-st4981-strain-with-blandm-5
#1
Yawei Zhang, Kang Liao, Hua Gao, Qi Wang, Xiaojuan Wang, Henan Li, Ruobing Wang, Hui Wang
Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28642140/emergence-of-carbapenem-resistant-enterobacteriaceae-isolated-from-patients-in-a-university-hospital-in-saudi-arabia-epidemiology-clinical-profiles-and-outcomes
#2
Fawzia E Alotaibi, Elham E Bukhari, Maha M Al-Mohizea, Taghreed Hafiz, Eman Bin Essa, Yasmeen I AlTokhais
Carbapenemase-producing Enterobacteriaceae have been steadily spreading worldwide during the last decade. Nine patients were identified prospectively and were followed during their hospitalization course to identify the epidemiology, clinical profiles and outcomes. These patients had one or more cultures positive for a CRE isolate, contributing to a total of eleven positive cultures from various sites without including duplicates of isolates obtained from the same site. Isolates from these patients included five Klebseilla pneumoniae, three Escherichia coli, and one Enterobacter aerogenes...
June 19, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28639165/molecular-characterization-of-intestinal-carriage-of-carbapenem-resistant-enterobacteriaceae-among-inpatients-at-two-iranian-university-hospitals-first-report-of-co-production-of-bla-ndm-7-and-bla-oxa-48
#3
H Solgi, F Badmasti, Z Aminzadeh, C G Giske, M Pourahmad, F Vaziri, S A Havaei, F Shahcheraghi
Gastrointestinal colonization of carbapenem-resistant Enterobacteriaceae (CRE) could serve as a reservoir for the transmission of these pathogens in the clinical setting. The aim of this study was to investigate the intestinal carriage of CRE and to analyze risk factors for CRE carriage. Rectal swabs were collected from 95 patients at two Iranian university hospitals. CRE screening was performed using selective media (CHROMagar and MacConkey agar). Polymerase chain reaction (PCR) was used to detect carbapenemase-encoding genes...
June 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28637265/importance-of-carbapenemase-production-detection-in-carbapenem-resistant-enterobacteriaceae-looking-beyond-epidemiological-purposes
#4
Adriana Jimenez, Lilian Abbo, Merhawi T Gebrezgi
No abstract text is available yet for this article.
June 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28636666/molecular-and-microbiological-report-of-a-hospital-outbreak-of-ndm-1-carrying-enterobacteriaceae-in-mexico
#5
Paola Bocanegra-Ibarias, Elvira Garza-González, Rayo Morfín-Otero, Humberto Barrios, Licet Villarreal-Treviño, Eduardo Rodríguez-Noriega, Ulises Garza-Ramos, Santiago Petersen-Morfin, Jesus Silva-Sanchez
OBJECTIVES: To characterize the microbiological, molecular and epidemiological data of an outbreak of carbapenem-resistant Enterobacteriaceae (CRE) in a tertiary-care hospital in Mexico. METHODS: From September 2014 to July 2015, all CRE clinical isolates recovered during an outbreak in the Hospital Civil "Fray Antonio Alcalde" in Jalisco, Mexico were screened for antimicrobial susceptibility, carbapenemase production, carbapenemase-encoding genes, and plasmid profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28630686/fecal-carriage-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-enterobacteriaceae-in-egyptian-patients-with-community-onset-gastrointestinal-complaints-a-hospital-based-cross-sectional-study
#6
H M Abdallah, N Alnaiemi, E A Reuland, B B Wintermans, A Koek, A M Abdelwahab, A Samy, K W Abdelsalam, C M J E Vandenbroucke-Grauls
OBJECTIVES: The aim of this study was to determine the prevalence of extended-spectrum β-lactamase (ESBL) and carbapenemase production among Enterobacteriaceae isolated from ambulatory patients with gastrointestinal complaints admitted to El-Ahrar General Hospital, Zagazig, Egypt in the period between January 2013 and May 2013. METHODS: One hundred and thirteen Enterobacteriaceae isolates were recovered from 100 consecutive Egyptian patients with community-onset gastrointestinal complaints...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28630202/identifying-spectra-of-activity-and-therapeutic-niches-for-ceftazidime-avibactam-and-imipenem-relebactam-against-carbapenem-resistant-enterobacteriaceae
#7
Ghady Haidar, Cornelius J Clancy, Liang Chen, Palash Samanta, Ryan K Shields, Barry N Kreiswirth, M Hong Nguyen
We determined imipenem, imipenem-relebactam, ceftazidime and ceftazidime-avibactam minimum inhibitory concentrations (MICs) against 100 CRE isolates that underwent whole genome sequencing. KPCs were the most common carbapenemases. Forty-six isolates carried ESBLs. With the addition of relebactam, imipenem susceptibility increased from 8% to 88%. With the addition of avibactam, ceftazidime susceptibility increased from 0% to 85%. Neither imipenem-relebactam nor ceftazidime-avibactam was active against MBL-producers...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28630192/in-vitro-activity-of-aztreonam-avibactam-against-enterobacteriaceae-and-pseudomonas-aeruginosa-isolated-by-clinical-laboratories-in-40-countries-from-2012-to-2015
#8
James A Karlowsky, Krystyna M Kazmierczak, Boudewijn L M de Jonge, Meredith A Hackel, Daniel F Sahm, Patricia A Bradford
The combination of the monobactam, aztreonam, and the non-β-lactam β-lactamase inhibitor, avibactam, is currently in clinical development for the treatment of serious infections caused by metallo-β-lactamase (MBL)-producing Enterobacteriaceae, a difficult to treat subtype of carbapenem-resistant Enterobacteriaceae for which therapeutic options are currently very limited. The present study tested clinically significant isolates of Enterobacteriaceae (n=51,352) and Pseudomonas aeruginosa (n=11,842) collected from hospitalized patients in 208 medical center laboratories from 40 countries from 2012 to 2015 for in vitro susceptibility to aztreonam-avibactam, aztreonam, and comparator antimicrobial agents using standard broth microdilution methodology...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28618764/what-is-the-rectal-colonization-rate-of-carbapenem-resistant-enterobacteriaceae-cre-infected-patients-what-is-the-decolonization-rate-of-cre-colonized-patients-in-the-hospital
#9
Fatma Feriha Çilli, Bilgin Arda, Ayşe Uyan, Münevver Kayin, Demet Dikiş, Nilay Korkmaz, Nilgün Deniz Küçükler, Nurhayat Kepeli, Behiye Ulusoy, Şükran Akşit Barik, Mehmet Ali Özinel, Sercan Ulusoy, Oğuz Reşat Sipahi
No abstract text is available yet for this article.
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28615687/multi-drug-resistant-klebsiella-pneumoniae-strains-circulating-in-hospital-setting-whole-genome-sequencing-and-bayesian-phylogenetic-analysis-for-outbreak-investigations
#10
Eleonora Cella, Massimo Ciccozzi, Alessandra Lo Presti, Marta Fogolari, Taj Azarian, Mattia Prosperi, Marco Salemi, Michele Equestre, Francesca Antonelli, Alessia Conti, Marina De Cesaris, Silvia Spoto, Raffaele Antonelli Incalzi, Roberto Coppola, Giordano Dicuonzo, Silvia Angeletti
Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in the epidemiological surveillance of multi-drug resistant nosocomial pathogens. Between January 2012 and February 2013, twenty-one multi-drug resistant K. pneumoniae strains, were collected from patients hospitalized among different wards of the University Hospital Campus Bio-Medico...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615088/healthcare-antibiotic-resistance-prevalence-dc-harp-dc-a-regional-prevalence-assessment-of-carbapenem-resistant-enterobacteriaceae-cre-in-healthcare-facilities-in-washington-district-of-columbia
#11
Jacqueline Reuben, Nancy Donegan, Glenn Wortmann, Roberta DeBiasi, Xiaoyan Song, Princy Kumar, Mary McFadden, Sylvia Clagon, Janet Mirdamadi, Diane White, Jo Ellen Harris, Angella Browne, Jane Hooker, Michael Yochelson, Milena Walker, Gary Little, Gail Jernigan, Kathleen Hansen, Brenda Dockery, Brendan Sinatro, Morris Blaylock, Kimary Harmon, Preetha Iyengar, Trevor Wagner, Jo Anne Nelson
OBJECTIVE Carbapenem-resistant Enterobacteriaceae (CRE) are a significant clinical and public health concern. Understanding the distribution of CRE colonization and developing a coordinated approach are key components of control efforts. The prevalence of CRE in the District of Columbia is unknown. We sought to determine the CRE colonization prevalence within healthcare facilities (HCFs) in the District of Columbia using a collaborative, regional approach. DESIGN Point-prevalence study. SETTING This study included 16 HCFs in the District of Columbia: all 8 acute-care hospitals (ACHs), 5 of 19 skilled nursing facilities, 2 (both) long-term acute-care facilities, and 1 (the sole) inpatient rehabilitation facility...
June 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28614760/abundance-of-carbapenemase-genes-blakpc-blandm-and-blaoxa-48-in-wastewater-effluents-from-tunisian-hospitals
#12
Emna Nasri, Jessica Subirats, Alexandre Sànchez-Melsió, Hedi Ben Mansour, Carles M Borrego, José Luis Balcázar
Carbapenems are β-lactam antibiotics with a broad spectrum of activity and are usually considered the last resort for the treatment of severe infections caused by multidrug-resistant pathogens. The clinically most significant carbapenemases are KPC, NDM, and OXA-48-like enzymes, whose genes have been increasingly reported worldwide in members of the family Enterobacteriaceae. In this study, we quantified the abundance of these genes in wastewater effluents from different Tunisian hospitals. The blaNDM and blaOXA-48-like genes were detected at similar concentrations in all hospital wastewater effluents...
June 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28613981/detection-of-new-delhi-metallo-%C3%AE-lactamase-variants-ndm-4-ndm-5-and-ndm-7-in-enterobacter-aerogenes-isolated-from-a-neonatal-intensive-care-unit-of-a-north-india-hospital-a-first-report
#13
Nayeem Ahmad, Syed Manazir Ali, Asad U Khan
A total 402 Enterobacteriaceae isolates were recovered from blood and rectal swabs of 1,000 infants admitted to the Neonatal Intensive Care Unit (NICU) of the Jawaharlal Medical College and Hospital Aligarh, India. Carbapenamase producers were determined by Carba NP phenotype biochemical assay. Out of 402 isolates, it was the first time three of the isolates were identified as Enterobacter aerogenes carrying blaNDM-4, blaNDM-5, and blaNDM-7 genes. These genes were identified by polymerase chain reaction (PCR) and sequence analysis...
June 14, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28610832/comparison-of-antimicrobial-activity-between-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-multidrug-resistant-isolates-of-escherichia-coli-klebsiella-pneumoniae-and-pseudomonas-aeruginosa
#14
Adnan Alatoom, Hashim Elsayed, Karen Lawlor, Laila AbdelWareth, Rania El-Lababidi, Lysettee Cardona, Mohammad Mooty, Maria-Fernanda Bonilla, Ahmad Nusair, Imran Mirza
OBJECTIVE: We compared the activity of ceftolozane-tazobactam and ceftazidime-avibactam against 120 strains including extended spectrum β-lactamase (ESBL) producers, carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa isolated from patients admitted to Cleveland Clinic Abu Dhabi, United Arab Emirates. METHODS: The in-vitro susceptibility was tested using E-strip MIC method and PCR was used to characterize the carbapenemase enzymes produced by CRE strains...
June 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28608133/frequency-associated-factors-and-outcome-of-multi-drug-resistant-intensive-care-unit-acquired-pneumonia-among-patients-colonized-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#15
Keyvan Razazi, Armand Mekontso Dessap, Guillaume Carteaux, Chloé Jansen, Jean-Winoc Decousser, Nicolas de Prost, Christian Brun-Buisson
BACKGROUND: We assessed prevalence, associated factors and prognosis of extended-spectrum beta-lactamase-producing Enterobacteriaceae pneumonia acquired in intensive care unit (ESBL-PE pneumonia) among carriers. Variables associated with nosocomial pneumonia caused by carbapenem-resistant bacteria (CRB) were also assessed. METHODS: A 6-year prospective study (May 2009-March 2015) in the medical ICU of an 850-bed university-affiliated hospital was conducted. RESULTS: Of the 6303 patients admitted, 843 (13...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28607027/carbapenemase-producing-enterobacteriaceae-isolates-from-edo-state-nigeria
#16
Christiana Jesumirhewe, Burkhard Springer, Sarah Lepuschitz, Franz Allerberger, Werner Ruppitsch
The emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) is a global health problem which is of great concern to public health services (1, 2).….
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28594170/pharmaceutical-approaches-to-target-antibiotic-resistance-mechanisms
#17
Domenico Schillaci, Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Patrizia Diana, Girolamo Cirrincione, Stella Cascioferro
There is urgent need for new therapeutic strategies to fight the global threat of antibiotic resistance. The focus of this Perspective is on chemical agents that target the most common mechanisms of antibiotic resistance such as enzymatic inactivation of antibiotics, changes in cell permeability, and induction/activation of efflux pumps. Here we assess the current landscape and challenges in the treatment of antibiotic resistance mechanisms at both bacterial cell and community levels. We also discuss the potential clinical application of chemical inhibitors of antibiotic resistance mechanisms as add-on treatments for serious drug-resistant infections...
June 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28592552/colistin-and-polymyxin-b-susceptibility-testing-for-carbapenem-resistant-and-mcr-positive-enterobacteriaceae-comparison-of-sensititre-microscan-vitek-2-and-etest-with-broth-microdilution
#18
Ka Lip Chew, My-Van La, Raymond T P Lin, Jeanette W P Teo
Colistin and polymyxin B remain part of the last line of antibiotics for multi-drug-resistant Gram negative bacteria such as carbapenem-resistant-Enterobacteriaceae Current EUCAST-CLSI joint recommendations are for broth microdilution to be performed for MIC testing of colistin. Commercial susceptibility testing methods were evaluated and compared against reference broth microdilution (BMD), using a susceptible breakpoint of ≤2mg/L for both colistin and polymyxin B. Seventy-six Enterobacteriaceae were included, of which twenty-one were mcr-1 positive...
June 7, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28585170/rapid-and-simple-identification-of-carbapenemase-genes-bla-ndm-bla-oxa-48-bla-vim-bla-imp-14-and-bla-kpc-groups-in-gram-negative-bacilli-by-in-house-loop-mediated-isothermal-amplification-with-hydroxynaphthol-blue-dye
#19
Arpasiri Srisrattakarn, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Lumyai Wonglakorn, Pimjai Saenjamla, Prajuab Chaimanee, Jureerut Daduang, Aroonwadee Chanawong
Carbapenem-resistant Enterobacteriaceae isolates by carbapenemase production are being reported globally with increasing frequency, leading to limited therapeutic options. We therefore developed a loop-mediated isothermal amplification method with hydroxynaphthol blue dye (LAMP-HNB) for rapid confirmation of bla NDM, bla OXA-48, bla VIM, bla IMP-14 and bla KPC groups. Sixty-two Enterobacteriaceae and Pseudomonas spp. isolates carrying various carbapenemase genes (28 bla NDM-1, 9 bla IMP-14a, 2 bla IMP-48, 1 bla IMP-1, 1 bla IMP-4, 1 bla IMP-9, 1 bla IMP-15, 4 bla VIM-2, 1 bla VIM-1, 1 bla IMP-14a & bla VIM-2, 7 bla KPC-2, 3 bla OXA-48 and 3 bla OXA-181) and 37 non-carbapenemase-producing Enterobacteriaceae isolates as confirmed by the PCR methods were included...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28584849/carbapenem-resistant-enterobacteriaceae-infections-results-from-a-retrospective-series-and-implications-for-the-design-of-prospective-clinical-trials
#20
Elizabeth L Alexander, Jeffery Loutit, Mario Tumbarello, Richard Wunderink, Tim Felton, George Daikos, Karen Fusaro, Dan White, Shu Zhang, Michael N Dudley
BACKGROUND: The increasing incidence of multidrug-resistant Gram negatives, such as carbapenem-resistant Enterobacteriaceae (CRE), has resulted in a critical need for new antimicrobials. Most studies of new antimicrobials have been performed in patients with nondrug-resistant pathogens. We performed a retrospective analysis of patients with CRE infections to inform the design of phase 3 clinical trials. METHODS: This was a retrospective study at 22 centers in 4 countries...
2017: Open Forum Infectious Diseases
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