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tet1 melanoma

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https://www.readbyqxmd.com/read/29938218/immunity-drives-tet1-regulation-in-cancer-through-nf-%C3%AE%C2%BAb
#1
Evelyne Collignon, Annalisa Canale, Clémence Al Wardi, Martin Bizet, Emilie Calonne, Sarah Dedeurwaerder, Soizic Garaud, Céline Naveaux, Whitney Barham, Andrew Wilson, Sophie Bouchat, Pascale Hubert, Carine Van Lint, Fiona Yull, Christos Sotiriou, Karen Willard-Gallo, Agnès Noel, François Fuks
Ten-eleven translocation enzymes (TET1, TET2, and TET3), which induce DNA demethylation and gene regulation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are often down-regulated in cancer. We uncover, in basal-like breast cancer (BLBC), genome-wide 5hmC changes related to TET1 regulation. We further demonstrate that TET1 repression is associated with high expression of immune markers and high infiltration by immune cells. We identify in BLBC tissues an anticorrelation between TET1 expression and the major immunoregulator family nuclear factor κB (NF-κB)...
June 2018: Science Advances
https://www.readbyqxmd.com/read/29383037/interferon-gamma-an-important-marker-of-response-to-immune-checkpoint-blockade-in-non-small-cell-lung-cancer-and-melanoma-patients
#2
Niki Karachaliou, Maria Gonzalez-Cao, Guillermo Crespo, Ana Drozdowskyj, Erika Aldeguer, Ana Gimenez-Capitan, Cristina Teixido, Miguel Angel Molina-Vila, Santiago Viteri, Maria De Los Llanos Gil, Salvador Martin Algarra, Elisabeth Perez-Ruiz, Ivan Marquez-Rodas, Delvys Rodriguez-Abreu, Remedios Blanco, Teresa Puertolas, Maria Angeles Royo, Rafael Rosell
Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or can be upregulated via interferon gamma (IFN-γ). We have explored whether the expression of IFNG, the gene encoding IFN-γ, is associated with clinical response to the immune checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma patients. The role of inflammation-associated transcription factors STAT3, IKBKE, STAT1 and other associated genes has also been examined. Methods: Total RNA from 17 NSCLC and 21 melanoma patients was analyzed by quantitative reverse transcription PCR...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/25179374/loss-of-5-hydroxymethylcytosine-in-cancer-cause-or-consequence
#3
REVIEW
Gabriella Ficz, John G Gribben
Discovery of the enzymatic activity that catalyses oxidation of 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) mediated by the MLL (KMT2A) fusion partner TET1 has sparked intense research to understand the role this new DNA modification has in cancer. An unambiguous picture has emerged where tumours are depleted of 5hmC compared to corresponding normal tissue, but it is not known whether lack of 5hmC is a cause or a consequence of tumourigenesis. Experimental data reveals a dual tumour-suppressive and oncogenic role for TET proteins...
November 2014: Genomics
https://www.readbyqxmd.com/read/25089631/a-novel-cancer-germline-transcript-carrying-pro-metastatic-mir-105-and-tet-targeting-mir-767-induced-by-dna-hypomethylation-in-tumors
#4
Axelle Loriot, Aurélie Van Tongelen, Jordi Blanco, Simon Klaessens, Julie Cannuyer, Nicolas van Baren, Anabelle Decottignies, Charles De Smet
Genome hypomethylation is a common epigenetic alteration in human tumors, where it often leads to aberrant activation of a group of germline-specific genes, commonly referred to as "cancer-germline" genes. The cellular functions and tumor promoting potential of these genes remain, however, largely uncertain. Here, we report identification of a novel cancer-germline transcript (CT-GABRA3) displaying DNA hypomethylation-dependent activation in various tumors, including melanoma and lung carcinoma. Importantly, CT-GABRA3 harbors a microRNA (miR-105), which has recently been identified as a promoter of cancer metastasis by its ability to weaken vascular endothelial barriers following exosomal secretion...
August 2014: Epigenetics: Official Journal of the DNA Methylation Society
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