Evelyne Collignon, Annalisa Canale, Clémence Al Wardi, Martin Bizet, Emilie Calonne, Sarah Dedeurwaerder, Soizic Garaud, Céline Naveaux, Whitney Barham, Andrew Wilson, Sophie Bouchat, Pascale Hubert, Carine Van Lint, Fiona Yull, Christos Sotiriou, Karen Willard-Gallo, Agnès Noel, François Fuks
Ten-eleven translocation enzymes (TET1, TET2, and TET3), which induce DNA demethylation and gene regulation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are often down-regulated in cancer. We uncover, in basal-like breast cancer (BLBC), genome-wide 5hmC changes related to TET1 regulation. We further demonstrate that TET1 repression is associated with high expression of immune markers and high infiltration by immune cells. We identify in BLBC tissues an anticorrelation between TET1 expression and the major immunoregulator family nuclear factor κB (NF-κB)...
June 2018: Science Advances