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Topical supplements

Stacey L Sheridan, Katrina E Donahue, Alison T Brenner
OBJECTIVE: To create a shared vision for the content, delivery, measurement, and sustainment of patient-centered high value care. METHODS: We performed a scoping review and translated findings into toolkit for system leaders. For our scoping review, we searched Medline, 2005-November 2015, for literature on patient-centered care (PCC) and its relationship to a high value care change model. We supplemented searches with key author, Google Scholar, and key website searches...
May 20, 2018: Patient Education and Counseling
Rebecca Y Du, Melissa A LoPresti, Caroline C Hadley, Sandi Lam
PURPOSE: In lower-income populations, high rates of neural tube defects (NTDs) are a concern. Nutritional folate deficiencies and mycotoxins in contaminated food supplies increase risk of NTDs. As physicians in public health and involved in the care of children with NTDs, pediatric neurosurgeons have an interest in the treatment and prevention of NTDs. We aimed to evaluate the literature to assess the awareness and the existence of best practices/educational materials on this issue to better guide management...
December 14, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Andrew R Jagim, Richard A Stecker, Patrick S Harty, Jacob L Erickson, Chad M Kerksick
Creatine has been extensively researched and is well-supported as one of the most effective dietary supplements available. There is overwhelming support within the literature regarding the ability of creatine to augment performance following short term (5-7 days) and long-duration supplementation periods. There is also strong support for creatine regarding its safety profile and minimal risk for adverse events or any negative influence on markers of clinical health and safety. Recent research has also highlighted the ability of creatine to confer several health-related benefits in select clinical populations in addition to offering cognitive benefits...
2018: Frontiers in Nutrition
Adam C Lieber, Estee Hong, David Putrino, Dominic A Nistal, Jonathan S Pan, Christopher P Kellner
While significant research has been performed regarding the use of thrombolytic agents and thrombectomy in the setting of acute stroke, other factors, such as nutritional status of stroke patients, is a less explored topic. The topic of nutrition is critical to the discussion of stroke, as up to half of stroke survivors may be considered malnourished at discharge. Dysphagia, old age, restricted upper limb movement, visuospatial impairment, and depression are all important risk factors for malnutrition in this cohort...
December 7, 2018: Brain Sciences
Kam Lun Hon, Kin Fon Leong, Theresa Nh Leung, Alexander Kc Leung
Background: Eczema or atopic dermatitis (AD) is a common relapsing childhood dermatologic illness. Treatment of AD is primarily topical with emollients and corticosteroid/calcineurin inhibitor, which is efficacious for the majority of patients. However, AD is often complicated and difficult to manage in many Asian cities. Effective therapy is impeded by fallacies in the following aspects: (1) mistrust and unrealistic expectations about Western medicine, (2) skin care and allergy treatment, (3) ambiguity about optimal bathing and moisturizing, (4) hesitation and phobias about the usage of adequate topical corticosteroid and immunomodulatory therapies, (5) food and aeroallergen avoidance and dietary supplementation, and (6) complementary and alternative therapies...
2018: Drugs in Context
Jin Sun Hwang, Yoon Pyo Lee, Young Joo Shin
PURPOSE: To investigate the efficacy of topical carbomer-based lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D) supplementation. METHODS: A total of 116 patients with DED from June 2015 to June 2016 were included. The participants were divided into the vitamin D deficiency (VDD) group and the non-VDD group according to their serum 25HD levels...
December 7, 2018: Cornea
Naoki Ito, Shinobu Seki, Fumitaka Ueda
Aging-associated changes of skin conditions are a major concern for maintaining quality of life. Therefore, the improvement of skin conditions by dietary supplementation is a topic of public interest. In this study, we hypothesized that a composite supplement containing fish derived-collagen peptide and ornithine (CPO) could improve skin conditions by increasing plasma growth hormone and/or insulin-like growth factor-1 (IGF-1) levels. Twenty-two healthy Japanese participants were enrolled in an 8-week double-blind placebo-controlled pilot study...
December 3, 2018: Marine Drugs
Sonia L Ramírez-Garza, Emily P Laveriano-Santos, María Marhuenda-Muñoz, Carolina E Storniolo, Anna Tresserra-Rimbau, Anna Vallverdú-Queralt, Rosa M Lamuela-Raventós
The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe...
December 3, 2018: Nutrients
Darryn Willoughby, Susan Hewlings, Douglas Kalman
With over two-thirds (71.6%) of the US adult population either overweight or obese, many strategies have been suggested for weight loss. While many are successful, the weight loss is often accompanied by a loss in lean body mass. This loss in lean body mass has multiple negative health implications. Therefore, weight loss strategies that protect lean body mass are of value. It is challenging to consume a significant caloric deficit while maintaining lean body mass regardless of macronutrient distribution. Therefore, the efficacy of various dietary supplements on body weight and body composition have been a topic of research interest...
December 3, 2018: Nutrients
Tsuyoshi Chiba
Along with an increase in self-care and self-medication practices, the use of health foods as primary and secondary methods of disease prevention has increased. Consumers are aware only of the health benefits of dietary ingredients, although the potential risks associated with most ingredients are unknown. Adverse events associated with the use of health foods have been reported, and in some cases they were due to inappropriate use such as the concomitant use of several health foods or health foods and drugs...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Uma Padhye Phatak, Arik Alper, Dinesh S Pashankar
Complementary and Alternative Medicine (CAM) consists of products and practices that are not considered to be a part of conventional medicine. This article reviews pediatric studies on CAM in Inflammatory Bowel Disease (IBD) along with relevant adult studies. Prevalence of CAM use ranges from 22 to 84% in children with IBD all over the world. CAM use in IBD includes diet changes, supplements, herbals, botanicals and mind-body therapies. Common reasons for using CAM include severe disease and concern for adverse effects of conventional medicines...
November 27, 2018: Journal of Pediatric Gastroenterology and Nutrition
Omid Eslami, Farzad Shidfar, Maryam Akbari-Fakhrabadi
BACKGROUND: Up to now, the association between vitamin D and cardiorespiratory fitness (CRF) is still inconsistent and there is a lack of a comprehensive review on this topic. AIM: To systematically review the literature including both observational studies and randomized controlled trials (RCTs) on the association between vitamin D and CRF in the general population. METHODS: The literature was investigated by exploring databases of PubMed, EMBASE, Scopus and ISI Web of Science as well as a manual search up to April 2017 by using related MeSH terms and key words...
November 30, 2018: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
E Dent, J E Morley, A J Cruz-Jentoft, H Arai, S B Kritchevsky, J Guralnik, J M Bauer, M Pahor, B C Clark, M Cesari, J Ruiz, C C Sieber, M Aubertin-Leheudre, D L Waters, R Visvanathan, F Landi, D T Villareal, R Fielding, C W Won, O Theou, F C Martin, B Dong, J Woo, L Flicker, L Ferrucci, R A Merchant, L Cao, T Cederholm, S M L Ribeiro, L Rodríguez-Mañas, S D Anker, J Lundy, L M Gutiérrez Robledo, I Bautmans, I Aprahamian, J M G A Schols, M Izquierdo, B Vellas
OBJECTIVES: Sarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR). METHODS: To develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia...
2018: Journal of Nutrition, Health & Aging
Eva Cunha, Tiago Trovão, Ana Pinheiro, Telmo Nunes, Raquel Santos, Jorge Moreira da Silva, Berta São Braz, Luís Tavares, Ana Salomé Veiga, Manuela Oliveira
BACKGROUND: Periodontal disease (PD) is caused by the development of a microbial biofilm (dental plaque) in the periodontium, affecting approximately 80% of dogs. Several bacterial species present in the canine oral cavity can be implicated in the development of this disease, including Enterococcus spp. To decrease antibiotic administration, a possible control strategy for dog's enterococcal PD may involve the use of the antimicrobial peptide (AMP) nisin. Nisin's inhibitory activity was evaluated against a collection of previously characterized enterococci obtained from the oral cavity of dogs with PD (n = 20), as well as the potential of a guar-gum gel and a veterinary toothpaste as topical delivery systems for this AMP...
November 29, 2018: BMC Veterinary Research
Norihiko Yokoi, Georgi As Georgiev
In December 2010 and January 2012, 3% diquafosol sodium ophthalmic solution and 2% rebamipide ophthalmic suspension, respectively, appeared first in Japan as prescription drugs for the treatment of dry eye (DE). Since then, not only the diagnosis and treatment but also the understanding of the pathophysiology of DE have greatly advanced, and a new concept of layer-by-layer diagnosis and treatment for DE, respectively termed "tear-film-oriented diagnosis" (TFOD) and "tear-film-oriented therapy" (TFOT) was born...
November 1, 2018: Investigative Ophthalmology & Visual Science
Joseph Dadabo, Julia Fram, Prakash Jayabalan
The goal of the practitioner managing a patient with knee osteoarthritis (OA) is to minimize pain and optimize their function. Several noninterventional (noninjectable) therapies are available for these individuals, each having varying levels of efficacy. An individualized approach to the patient is most beneficial in individuals with knee OA and the treatment plan the practitioner chooses should be based on this principle. The focus of this article is to provide an up-to-date overview of the treatment strategies available, evidence to support them, and in whom these treatments would be most appropriate...
November 26, 2018: Journal of Knee Surgery
Joanne Neale, Caral Brown, Aimee N C Campbell, Jermaine D Jones, Verena E Metz, John Strang, Sandra D Comer
BACKGROUND AND AIMS: Providing take-home naloxone (THN) to people who use opioids is an increasingly common strategy for reversing opioid overdose. However, implementation is hindered by doubts regarding the ability of people who use opioids to administer naloxone and respond appropriately to overdoses. We aimed to increase understanding of the competencies required and demonstrated by opioid users who had recently participated in a THN program and were subsequently confronted with an overdose emergency...
November 26, 2018: Addiction
Sanchta, Ritu Trivedi, Mehar Hasan Asif, Prabodh Kumar Trivedi
Cross-kingdom gene regulation by microRNAs (miRNAs) initiated a hot debate on the effective role of orally acquired plant miRNAs on human gene expression. It resulted in the expansion of gene regulation theories and role of plant miRNAs in cross-kingdom regulation of gene expression. This opened up the discussion that "Whether we really get what we eat?" and "Whether the orally acquired miRNAs really have a biologically important consequences after entering our digestive and circulatory system?" The reports of orally acquired plant miRNAs inside human alimentary canal have been a topic of discussion in the scientific community...
November 26, 2018: RNA Biology
Xiaoyan Ding, Wei Sun, Jinglong Chen
Background: Sorafenib is the standard targeted drug used to treat hepatocellular carcinoma (HCC), but the therapeutic response between individuals varies markedly. Recently, cytokine-based immunotherapy has been a topic of intense discussion in the fight against cancer. The aim of this study was to explore whether cytokine IL-2 could augment the anti-tumour effects of sorafenib on HCC. Methods: HepG2 and Huh7 cells were co-treated with sorafenib and IL-2 in vitro, and cellular viability and death were analysed through the MTT assay, TUNEL staining, LDH release assay, and western blotting...
2018: Cancer Cell International
Urs-Vito Albrecht, Gerd Hasenfuß, Ute von Jan
BACKGROUND: In the app stores of mobile platforms, consumers are confronted with an enormous number of mobile apps. Over the past few years, considerable research has been undertaken into to identifying, characterizing, and evaluating apps, be it in health-related or other contexts. However, many of these projects are restricted to specific areas of application and offer little flexibility in adapting the applied criteria. OBJECTIVE: This paper presents an adaptable method for selecting and characterizing mobile apps listed in a mobile App Store (the Apple App Store)...
November 20, 2018: JMIR MHealth and UHealth
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