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Saeed Tarabichi, Michelle DeLeon, Nicole Krumrei, Joseph Hanna, Nell Maloney Patel
OBJECTIVE: To determine the effectiveness of competition on education conference attendance rate with a secondary goal of increased performance on in-service examination performance within a single academic general surgery residency. DESIGN: By using a competition-based model of learning, we aimed to increase the overall resident attendance to weekly education conference as well as performance on in-service examination. Residents were given weekly reading assignments which were supplemented with lectures from faculty with expert knowledge of a given topic on a weekly basis...
October 10, 2018: Journal of Surgical Education
Gregory E Kaebnick
What are the boundaries of bioethics? Where does bioethics give way to other kinds of ethics-organizational ethics, environmental ethics, social ethics, or just ethics? According to one commonly cited account of the origin of bioethics, the field always had a relatively broad remit; it was supposed to be about the ethics of the life sciences in general. In the early days of bioethics, however, the topic that seemed most in need of critical attention was the encounter between experts in medicine and the laity-doctors or medical researchers on the one hand and patients or medical research subjects on the other...
September 2018: Hastings Center Report
Irena Sailer, Sven Mühlemann, Ralf J Kohal, Benedikt C Spies, Bjarni E Pjetursson, Niklaus P Lang, Klaus L Gotfredsen, Jan E Ellingsen, Helena Francisco, Mutlu Özcan, Bassam Hassan, Guillem E Pardo, Javier A Bardaji, Riccardo D Kraus, Ann Wennerberg
OBJECTIVES: The tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all-ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions. METHODS: Four reviews were available analyzing the current literature on the respective topics...
October 2018: Clinical Oral Implants Research
Molly A Martin, Helen H Lee, Jazmin Landa, Mark Minier, David Avenetti, Anna Sandoval
Background: The COordinated Oral health Promotion (CO-OP) Chicago trial will test the efficacy of a community health worker (CHW) intervention to improve oral health behaviors for children at high risk for early childhood caries. Before implementing the cluster-randomized controlled trial, we conducted a formative assessment to determine the final design. We used qualitative methods to assess the feasibility and acceptability of the proposed recruitment, data collection, and intervention plan...
2018: Pilot and Feasibility Studies
Gregory L King, David J Sandgren, Jennifer M Mitchell, David L Bolduc, William F Blakely
We developed a clinical assessment tool for use in an NHP radiation model to 1) quantify severity responses for subsyndromes of the acute radiation syndrome (ARS; that is, hematopoietic and others) and 2) identify animals that required enhanced monitoring. Our assessment tool was based primarily on the MEdical TREatment ProtocOLs for Radiation AccidentVictims (METREPOL) scoring system but was adapted for NHP to include additional indices (for example, behaviors) for usein NHP studies involving limited medical intervention...
October 10, 2018: Comparative Medicine
Jozo Grgic, Pavle Mikulic, Brad J Schoenfeld, David J Bishop, Zeljko Pedisic
This paper aims to critically evaluate and thoroughly discuss the evidence on the topic of caffeine supplementation when performing resistance exercise, as well as provide practical guidelines for the ingestion of caffeine prior to resistance exercise. Based on the current evidence, it seems that caffeine increases both maximal strength and muscular endurance. Furthermore, power appears to be enhanced with caffeine supplementation, although this effect might, to a certain extent, be caffeine dose- and external load-dependent...
October 8, 2018: Sports Medicine
Shu Hu, Gianni Belcaro, Morio Hosoi, Beatrice Feragalli, Roberta Luzzi, Mark Dugall
BACKGROUND: This registry study evaluates the effects of oral Centellicum®, a new preparation of Centella asiatica (CA) on cutaneous stretchmarks (SMs) on the lower abdominal wall in comparison with the topical treatment with a specific antistretch cream. This cream is used for pregnancy SMs. The aim of the management was to give back to the structurally damaged skin areas (apparent as SMs) a normal elasticity and resistance and improving the local microcirculation. METHODS: We selected 78 healthy women with SMs at least 6 months postpartum available to follow the registry plan...
October 2018: Minerva Ginecologica
Alberto Gil de la Fuente, Federico Traldi, Jitka Siroka, Adam Kretowski, Michal Ciborowski, Abraham Otero, Coral Barbas, Joanna Godzien
The biological role of oxidized glycerophosphocholines (oxPCs) is a current topic of research importantly contributing to the understanding of health and disease. Global non-targeted metabolomics offers an interesting approach to expand current knowledge and link oxPCs to new biological functions. Although this strategy is successful, it also has some limitations which are clearly noticeable during the identification process. For this reason, clear rules related to the identification of each group of metabolites are needed...
December 11, 2018: Analytica Chimica Acta
Jie Chen, Chao-Min Wan, Si-Tang Gong, Feng Fang, Mei Sun, Yuan Qian, Ying Huang, Bao-Xi Wang, Chun-Di Xu, Li-Yan Ye, Mei Dong, Yu Jin, Zhi-Hua Huang, Qin-Bing Wu, Chao-Min Zhu, You-Hong Fang, Qi-Rong Zhu, Yong-Sui Dong
BACKGROUND: The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population. DATA SOURCES: The experts group of evidence development put forward clinical problems, collects evidence, forms preliminary recommendations, and then uses open-ended discussions to form recommendations. The literature review was done for developing this guideline in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to June 2013...
October 2018: World Journal of Pediatrics: WJP
Sharnie Wu, Kong Chan Tang
PURPOSE: Ocular regional blocks generally require blind instrumentation to the posterior orbit, leading to rare but serious complications. However, topical anesthesia does not suppress eye or lid movements and may lead to more surgical complications. Advanced subconjunctival anesthesia (ASCAN) is a technique developed to provide reliable akinesia and anesthesia without anterior dissection or blind intrusion into the posterior orbit, while allowing visualization of the needle-tip position...
September 28, 2018: Asia-Pacific Journal of Ophthalmology
Shoukat H Qari, Mary R Leinhos, Tracy N Thomas, Eric G Carbone
We provide an overview of a Centers for Disease Control and Prevention-funded public health preparedness and response (PHPR) research and training initiative to improve public health practice. Our objectives were to accelerate the translation, dissemination, and implementation (TDI) of promising PHPR evidence-based tools and trainings developed by the Preparedness and Emergency Response Research Centers (PERRC) or the Preparedness and Emergency Response Learning Centers (PERLC) between 2008 and 2015. Nine competitive awards were made to seven academic centers to achieve predetermined TDI objectives...
September 27, 2018: American Journal of Public Health
Karla Alejandra Mora Rodríguez, Selim R Benbadis
PURPOSE OF REVIEW: The purpose of this review is to summarize and discuss available information on the management of epilepsy patients on renal replacement therapy. Older and newer antiepileptic drugs (AEDs) pharmacology will be reviewed, as well as the need to supplement dosages during or after hemodialysis, peritoneal dialysis, and continuous renal replacement treatment. RECENT FINDINGS: The great majority of anticonvulsants have been studied in patients with renal failure...
September 27, 2018: Current Treatment Options in Neurology
Marianna Donnarumma, Claudio Marasca, Maria Palma, Maria Vastarella, Maria Carmela Annunziata, Gabriella Fabbrocini
BACKGROUND: Over recent years, the link between obesity, metabolic syndrome and Hidradenitis Suppurativa (HS) has been explored. It has been demonstrated that HS patients have a high prevalence of the metabolic syndrome and an increased frequency of insulin resistance. The objective of our study is to estimate the effectiveness of an oral supplementation based on myo- inositol (MI), folic acid and liposomal magnesium (LEVIGON®) on the clinical and metabolic profile of patients affected by HS...
September 20, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Suzanna Maria Zick, Christina Czuhajewski, Judith M Fouladbakhsh, Heather Greenlee, Richard Edmund Harris, Norah Lynn Henry, Shruti Jolly, Tohfa Khabir, Jane Perlmutter, Tami Remington, Detrick Snyder, Lisa Spratke, Brad Zebrack, Erin Zettell, Rita Benn
OBJECTIVES: Oncology providers are often confronted by patients who use complementary or alternative therapies, but have limited knowledge or confidence on how to advise patients on appropriate use. Despite this, there are few opportunities for oncology providers to learn about complementary or alternative therapies, while at the same time there is a high demand for integrative oncology (IO) training. To address a gap in IO educational opportunities, and particularly for nonphysicians, we created the Integrative Oncology Scholars (IOS) Program...
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Amir Almatlouh, Daniella Bach-Holm, Line Kessel
Surgical outcome after trabeculectomy depends on maintaining a functional bleb which requires a delicate balance between incomplete wound healing to prevent fibrosis and enough wound healing to prevent hyperfiltration. Thus, controlling the inflammatory response is essential. We conducted a systematic review and meta-analysis to compare the effectiveness of different formulations of steroids (topical, systemic and depot) and nonsteroidal anti-inflammatory drugs (NSAIDs) in achieving long-term pressure control with fewer antiglaucomatous medications, preserving visual acuity and visual fields while considering surgical and postoperative complications...
September 21, 2018: Acta Ophthalmologica
R Douglas Wilson, Aaron B Caughey, Stephen L Wood, George A Macones, Ian J Wrench, Jeffrey Huang, Mikael Norman, Karin Pettersson, William J Fawcett, Medhat M Shalabi, Amy Metcalfe, Leah Gramlich, Gregg Nelson
OBJECTIVE: This ERAS Guideline for perioperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for pre-operative, intra-operative, and post-operative phases with primarily, a maternal focus. The 'focused' pathway process for scheduled and unscheduled CD, for this ERAS CD guideline will consider, from 'decision to operate (starting with the 30 - 60 minutes prior to skin incision) to hospital discharge'. METHODS: The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Section", "Cesarean Section Delivery" and all pre- and intra-operative ERAS® items...
September 18, 2018: American Journal of Obstetrics and Gynecology
Karen Sánchez-Armendáriz, Ana García-Gil, Cesar A Romero, José Contreras-Ruiz, Marcia Karam-Orante, Denek Balcazar-Antonio, Judith Domínguez-Cherit
BACKGROUND: Vitamin D has immunomodulatory effects both in the innate and adaptive immune systems, and there is growing scientific evidence demonstrating its relevance in inflammatory processes such as AD. HYPOTHESIS: If vitamin D3 promotes the skin immune system, then it should improve the response to treatment of patients with AD. METHODS: A randomized, double-blind placebo-controlled clinical trial was conducted, which included 65 patients with AD according to Hanifin-Rajka criteria and the severity scale (SCORAD)...
September 20, 2018: International Journal of Dermatology
Jenny J Ly, Mabel Crescioni, Sonya Eremenco, Serge Bodart, Mario Donoso, Adam J Butler, Susan M Dallabrida
Electronic capture of patient-reported outcome (PRO) data has many advantages over paper-based data collection. Regulatory agencies have consistently supported the use of electronic PRO (ePRO) data capture and recommended participant and site staff training on the correct use of electronic data capture systems. The objective of this paper is to outline best practice recommendations for training end users, including site staff and study participants, on the use of ePRO technology in clinical trials to enable consistent, accurate, and complete data collection...
September 16, 2018: Therapeutic Innovation & Regulatory Science
Laura G González-Ortiz, Stefano Calciolari, Nick Goodwin, Viktoria Stein
Objective: As part of the EU-funded Project INTEGRATE, the research sought to develop an evidence-based understanding of the key dimensions and items of integrated care associated with successful implementation across varying country contexts and relevant to different chronic and/or long-term conditions. This paper identifies the core dimensions of integrated care based on a review of previous literature on the topic. Methodology: The research reviewed literature evidence from the peer-reviewed and grey literature...
August 8, 2018: International Journal of Integrated Care
Justine Fenner, Nanette B Silverberg
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder. The disease is typified by chronic pruritus, a series of signs and symptoms associated with immune dysfunction (eg, increased immunoglobulin E mediated allergies), and abnormal skin barrier dysfunction (eg, increased response to irritants). Due to the chronic itch and reactivity, patients and parents of affected children will seek therapy. Therapies range from emollients to topical medicaments, including topical corticosteroids, and immunosuppressive agents...
September 2018: Clinics in Dermatology
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