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https://www.readbyqxmd.com/read/30336201/effects-of-ethanol-on-human-periodontal-ligament-fibroblasts-subjected-to-static-compressive-force
#1
Agnes Schröder, Erika Calvano Küchler, Marjorie Omori, Gerrit Spanier, Peter Proff, Christian Kirschneck
Consumption of toxic substances like alcohol is widespread in the general population and thus also in patients receiving orthodontic treatment. Since human periodontal ligament (hPDL) fibroblasts play a key role in orthodontic tooth movement (OTM) by expressing cytokines and chemokines, we wanted to clarify, whether ethanol modulates the physiological activity and expression pattern of hPDL fibroblasts during static compressive force application. We pre-incubated hPDL fibroblasts for 24h with different ethanol concentrations, corresponding to casual (0...
October 15, 2018: Alcohol
https://www.readbyqxmd.com/read/30335777/factors-associated-with-unsuccessful-treatment-outcome-in-tuberculosis-patients-among-refugees-and-their-surrounding-communities-in-gambella-regional-state-ethiopia
#2
Eyasu Ejeta, Getenet Beyene, Getu Balay, Zegeye Bonsa, Gemeda Abebe
BACKGROUND: Tuberculosis (TB) is a leading cause of public health challenges among immigrant refugees and their surrounding communities in developing countries. Evaluating the treatment outcome of TB patients is one of the key indicators to understand the performance of TB control program. Hence, this study aims to assess profile, treatment outcome and factors associated with unsuccessful outcome of TB patients treated under the TB control program among refugees and their surrounding communities (SCs) in Gambella Regional State, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/30334801/design-and-test-of-a-biomechanical-model-for-the-estimation-of-knee-joint-angle-during-indoor-rowing-implications-for-fes-rowing-protocols-in-paraplegia
#3
Taian Vieira, Giacinto Luigi Cerone, Laura Gastaldi, Stefano Pastorelli, Liliam F Oliveira, Marco Gazzoni, Alberto Botter
Functional electrical stimulation of lower limb muscles during rowing provides a means for the cardiovascular conditioning in paraplegia. The possibility of shaping stimulation profiles according to changes in knee angle, so far conceived as changes in seat position, may help circumventing open issues associated with muscle fatigue and movement coordination. Here we present a subject-specific biomechanical model for the estimation of knee joint angle during indoor rowing. Anthropometric measurements and foot and seat position are inputs to the model...
October 17, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/30334690/clinical-indicators-that-identify-risk-of-deteriorating-and-dying-in-people-with-a-hematological-malignancy-a-case-control-study-with-multivariable-analysis
#4
Elise Button, Nicole C Gavin, Raymond J Chan, Shirley Chambers, Jason Butler, Patsy Yates
BACKGROUND: Identifying people who are at risk of deteriorating and dying is essential to inform goals of care, appropriate treatment decisions, patient autonomy, and effective end-of-life care. Limited literature exists on predicting survival near the end of life for people with a hematological malignancy. OBJECTIVE: To identify the key clinical indicators that signal a person with a hematological malignancy is at high risk of deteriorating and dying. DESIGN, SETTING, PARTICIPANTS: Eleven clinical indicators identified in a Delphi approach were tested via a retrospective case-control study...
October 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/30334610/collateral-benefits-how-the-practical-application-of-good-participatory-practice-can-strengthen-hiv-research-in-sub-saharan-africa
#5
Deborah Baron, Thandekile Essien, Sinazo Pato, Miliswa Magongo, Nomthandazo Mbandazayo, Fiona Scorgie, Helen Rees, Sinead Delany-Moretlwe
INTRODUCTION: The Good Participatory Practice (GPP): Guidelines for Biomedical HIV Prevention Trials, second edition (2011) were developed to provide clinical trial sponsors and implementers with a formal stakeholder engagement framework. As one of the largest African research institutes, Wits Reproductive Health and HIV Institute (Wits RHI) became an early adopter of GPP by implementing its principles within large-scale national and regional clinical trials. This article examines Wits RHI's lessons learned from implementing GPP, its ongoing efforts to institutionalize GPP, and the yet to be realized potential in creating fully sustainable structures for meaningful stakeholder engagement in HIV prevention research, implementation science and beyond...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334468/-18-f-fdg-pet-uptake-in-non-infected-total-hip-prostheses
#6
Stefan J Gelderman, Paul C Jutte, Ronald Boellaard, Joris J W Ploegmakers, David Vállez García, Greetje A Kampinga, Andor W J M Glaudemans, Marjan Wouthuyzen-Bakker
Background and purpose - 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used in the diagnostic work-up of a patient with suspected periprosthetic joint infection (PJI) but, due to a lack of accurate interpretation criteria, this technique is not routinely applied. Since the physiological uptake pattern of FDG around a joint prosthesis is not fully elucidated, we determined the physiological FDG uptake in non-infected total hip prostheses. Patients and methods - Patients treated with primary total hip arthroplasty (1995-2016) who underwent a FDG-PET/CT for an indication other than a suspected PJI were retrospectively evaluated...
October 18, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/30334225/large-de-novo-microdeletion-in-epilepsy-with-intellectual-and-developmental-disabilities-with-a-systems-biology-analysis
#7
Kai Gao, Yujia Zhang, Ling Zhang, Weijing Kong, Han Xie, Jingmin Wang, Ye Wu, Xiru Wu, Xiaoyan Liu, Yuehua Zhang, Feng Zhang, Albert Cheung-Hoi Yu, Yuwu Jiang
Epilepsy is one of the most common complex neurological diseases. It is frequently associated with intellectual and developmental disabilities (ID/DD). In recent years, copy number variation (CNV), especially microdeletion, was proven to be a potential key factor of genetic epilepsy. In this paper, the authors tested the hypothesis that the large de novo rare CNV is an important cause of epilepsy with ID/DD. We performed a custom array comparative genomic hybridization (aCGH) to detect the CNVs of 96 Chinese epileptic patients with ID/DD...
2018: Advances in Neurobiology
https://www.readbyqxmd.com/read/30334224/synaptic-plasticity-and-synchrony-in-the-anterior-cingulate-cortex-circuitry-a-neural-network-approach-to-causality-of-chronic-visceral-pain-and-associated-cognitive-deficits
#8
Ying Li
Human brain imaging studies have demonstrated the importance of cortical neuronal networks in the perception of pain in patients with functional bowel disease such as irritable bowel syndrome (IBS).Studies have identified an enhanced response in the anterior cingulate cortex (ACC) to colorectal distension in viscerally hypersensitive (VH) rats. Electrophysiological recordings show long-lasting potentiation of local field potential (LFP) in the medial thalamus (MT)-ACC synapses in VH rats. Theta burst stimulation in the MT reliably induced long-term potentiation (LTP) in the MT-ACC pathway in normal rats, but was occluded in the VH state...
2018: Advances in Neurobiology
https://www.readbyqxmd.com/read/30334013/surgical-complications-of-presurgical-systemic-therapy-for-renal-cell-carcinoma-a-systematic-review
#9
Barrett McCormick, Matthew A Meissner, Jose A Karam, Christopher G Wood
Background: Locally advanced and metastatic renal cell carcinoma (RCC) is associated with poor survival outcomes. The integration of presurgical systemic therapy with targeted molecular agents prior to surgical resection of RCC tumors has been utilized to improve on these outcomes. These agents may be associated with an increased risk of perioperative complications due to their action on angiogenesis and cell proliferation. Objective: To examine the evidence for the incidence and severity of perioperative complications following presurgical targeted therapy for locally advanced or metastatic RCC...
November 27, 2017: Kidney cancer
https://www.readbyqxmd.com/read/30333742/non-vitamin-k-antagonist-oral-anticoagulants-and-cognitive-impairment-in-atrial-fibrillation-insights-from-the-meta-analysis-of-over-90-000-patients-of-randomized-controlled-trials-and-real-world-studies
#10
Chi Zhang, Zhi-Chun Gu, Long Shen, Mang-Mang Pan, Yi-Dan Yan, Jun Pu, Xiao-Yan Liu, Hou-Wen Lin
Background: The relationship between the use of non-vitamin K antagonist oral anticoagulants (NOACs) and the impairment of cognition in atrial fibrillation (AF) remains unknown. Methods: A comprehensive database search of Medline, Embase, Cochrane Library databases, and ClinicalTrials.gov Website was performed for randomized controlled trials (RCTs) reporting cognitive impairment events and observational nationwide database studies reporting adjusted hazard ratio (HR) in AF patients with NOACs. The primacy outcome was a composite of any cognitive impairment...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30333718/adiponectin-mediates-running-restored-hippocampal-neurogenesis-in-streptozotocin-induced-type-1-diabetes-in-mice
#11
Suk-Yu Yau, Thomas Ho-Yin Lee, Ang Li, Aimin Xu, Kwok-Fai So
Streptozotocin (STZ)-induced diabetes impairs learning and memory performance and reduces adult hippocampal neurogenesis. Physical exercise brings beneficial effects. We have previously shown that adiponectin, an adipocyte-secreted hormone critically involved in the pathology of diabetes, is a key mediator for exercise-enhanced adult hippocampal neurogenesis. Here, we tested whether adiponectin is required for exercise to restore adult hippocampal neurogenesis in an animal model of diabetes. The findings showed that a single injection of 195 mg/kg STZ-induced diabetes significantly increased serum levels of corticosterone and reduced hippocampal adiponectin levels in adult mice...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30332826/low-dose-radiotherapy-has-no-harmful-effects-on-key-cells-of-healthy-non-inflamed-joints
#12
Lisa Deloch, Michael Rückert, Rainer Fietkau, Benjamin Frey, Udo S Gaipl
Low-dose radiotherapy (LD-RT) for benign inflammatory and/or bone destructive diseases has been used long. Therefore, mechanistic investigations on cells being present in joints are mostly made in an inflammatory setting. This raises the question whether similar effects of LD-RT are also seen in healthy tissue and thus might cause possible harmful effects. We performed examinations on the functionality and phenotype of key cells within the joint, namely on fibroblast-like synoviocytes (FLS), osteoclasts and osteoblasts, as well as on immune cells...
October 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30332510/long-noncoding-rna-linc01133-inhibits-oral-squamous-cell-carcinoma-metastasis-through-a-feedback-regulation-loop-with-gdf15
#13
Jianlu Kong, Wenjie Sun, Wenyuan Zhu, Chuanxia Liu, Honghe Zhang, Huiming Wang
BACKGROUND AND OBJECTIVES: Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS: The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC cell lines were tested by real-time quantitative polymerase chain reaction (RT-qPCR). SPSS20.0 was used to perform statistical analysis of LINC01133 expression in clinical samples and correlate expression of LINC01133 and GDF15...
October 17, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30328153/effects-of-commercial-premix-vitamin-level-on-sternum-growth-calcification-and-carcass-traits-in-meat-duck
#14
Huaiyong Zhang, Hang Liao, Qiufeng Zeng, Jianping Wang, Xuemei Ding, Shiping Bai, Keying Zhang
The present study was conducted to investigate the effects of dietary vitamin level on sternum growth, calcification and carcass traits in meat duck. A total of 432 1-d-old mixed-sex Cherry Valley ducks (216 males and 216 females) were randomly allocated and fed low-vitamin level diet (70% NRC vitamin regimen), high-vitamin level diet (DSM vitamin regimen) or medium-vitamin level diet (50% low-vitamin level diet and 50% high-vitamin level diet). Sternum and serum were harvested after 49 d of feeding. Compared with the low-vitamin level group, dietary high-vitamin level increased body weight (BW) at d 49 (p = 0...
October 17, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/30327849/development-of-quality-outcome-indicators-to-improve-the-quality-of-urinary-and-faecal-continence-care
#15
Adrian Wagg, Dianne Gove, Kai Leichsenring, Joan Ostaszkiewicz
INTRODUCTION AND HYPOTHESIS: Despite the range of treatment options available, relatively few people with incontinence find a total cure. The importance of daily management with toileting and containment cannot be underestimated. To our knowledge, there are no outcome measures to benchmark good care. The aim of this study was to create a set of key performance indicators (KPIs) to measure outcomes for toileting and containment. METHODS: An expert panel (EP) defined a set of KPIs using evidence from a scoping review, stakeholder engagement, and expert consensus...
October 16, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/30327356/prediabetes-is-associated-with-structural-brain-abnormalities-the-maastricht-study
#16
Marnix J M van Agtmaal, Alfons J H M Houben, Vera de Wit, Ronald M A Henry, Nicolaas C Schaper, Pieter C Dagnelie, Carla J van der Kallen, Annemarie Koster, Simone J Sep, Abraham A Kroon, Jacobus F A Jansen, Paul A Hofman, Walter H Backes, Miranda T Schram, Coen D A Stehouwer
OBJECTIVE: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. RESEARCH DESIGN AND METHODS: We used data from 2,228 participants (1,373 with normal glucose metabolism [NGM], 347 prediabetes, and 508 type 2 diabetes (oversampled); mean age 59...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30326995/the-impact-of-10-years-of-human-papillomavirus-hpv-vaccination-in-australia-what-additional-disease-burden-will-a-nonavalent-vaccine-prevent
#17
Cyra Patel, Julia Ml Brotherton, Alexis Pillsbury, Sanjay Jayasinghe, Basil Donovan, Kristine Macartney, Helen Marshall
BACKGROUND: A National human papilloma virus (HPV) Vaccination Programme for the prevention of HPV infection and associated disease using the quadrivalent HPV vaccine (4vHPV) has been funded and implemented in Australia since 2007, initially for girls only and extended to boys in 2013, with uptake rates among the highest observed worldwide. AIM: We report on the impact of this national programme on HPV prevalence and associated disease burden and estimate the potential impact of adopting a nonavalent HPV (9vHPV) vaccine...
October 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/30326825/hepatitis-b-virus-downregulates-vitamin-d-receptor-levels-in-hepatoma-cell-lines-thereby-preventing-vitamin-d-dependent-inhibition-of-viral-transcription-and-production
#18
Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran, Ziv Ben-Ari
BACKGROUND: Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV) replication. Our study aimed to assess the in-vitro relationship between HBV production and Vitamin D signaling pathway and to explore the associated mechanism(s). METHODS: HBV transcription and replication was evaluated by qRT-PCR of the HBV-RNA and covalently closed circular DNA (cccDNA)...
October 16, 2018: Molecular Medicine
https://www.readbyqxmd.com/read/30326483/significance-of-hyperbaric-oxygenation-in-the-treatment-of-fournier-s-gangrene-a-comparative-study
#19
Petra Anheuser, Sandra Mühlstädt, Jennifer Kranz, Laila Schneidewind, Joachim Steffens, Paolo Fornara
INTRODUCTION: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene. PATIENTS AND METHODS: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017...
October 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30325928/prevalence-of-and-reasons-for-women-s-family-members-and-health-professionals-preferences-for-cesarean-section-in-china-a-mixed-methods-systematic-review
#20
Qian Long, Carol Kingdon, Fan Yang, Michael Dominic Renecle, Shayesteh Jahanfar, Meghan A Bohren, Ana Pilar Betran
BACKGROUND: China has witnessed a rapid increase of cesarean section (CS) rates in recent years. Several non-clinical factors have been cited as contributing to this trend including maternal request and perceived convenience. We aimed to assess preferences for mode of delivery and reasons for preferences for CS in China to inform the development of future interventions to mitigate unnecessary CSs, which are those performed in the absence of medical indications. METHODS AND FINDINGS: We conducted a mixed-methods systematic review and included longitudinal, cross-sectional, and qualitative studies in mainland China, Hong Kong, and Taiwan that investigated preferences for mode of delivery among women and family members and health professionals, and the reasons underlying such preferences...
October 2018: PLoS Medicine
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