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https://www.readbyqxmd.com/read/30540996/the-difficult-colorectal-polyps-and-adenomas-practical-aspects
#1
REVIEW
László Herszényi
BACKGROUND: Colonoscopy is the gold standard for adenoma detection. All endoscopists who perform colonoscopy must by mandate be skilled to perform polypectomy. However, there are significant differences between endoscopists in terms of the polyp detection rate and in the effectiveness of polypectomy. SUMMARY: Most polyps identified can be managed by conventional polypectomy and do not pose a significant challenge for resection to an adequately skilled and trained endoscopist...
December 12, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/30539859/tracking-significant-modules-and-key-genes-for-esophageal-squamous-cell-carcinoma-based-on-differential-modules
#2
Meng-Li Zheng, Nai-Kang Zhou, Cheng-Hua Luo
Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved. Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data. Materials and Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC...
December 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30539675/re-thinking-performance-assessment-for-primary-care-opinion-of-the-expert-panel-on-effective-ways-of-investing-in-health
#3
Dionne Kringos, Sabina Nuti, Christian Anastasy, Margaret Barry, Liubove Murauskiene, Luigi Siciliani, Jan De Maeseneer
BACKGROUND: In 2017, the European Commission (EC) identified as a policy priority the performance assessment of primary care systems, which relates to a country's primary care structure, services delivery and outcomes. The EC requested its Expert Panel on Effective Ways of Investing in Health (Expert Panel) to provide an opinion on ways for improving performance assessment of primary care. OBJECTIVES: To provide an overview of domains and dimensions to be taken into consideration in assessing primary care and specific indicators to be collected and analysed to improve understanding of primary care performance...
December 12, 2018: European Journal of General Practice
https://www.readbyqxmd.com/read/30539375/combing-both-simulated-and-field-measured-data-to-develop-robust-hyperspectral-indices-for-tracing-canopy-transpiration-in-drought-tolerant-plant
#4
Jia Jin, Quan Wang, Jinlin Wang
Transpiration plays a key role in water and energy fluxes at various scales. While in recent remote sensing offers a fast and convenient method for tracing transpiration at multiple scales, the approach is mostly indirect and relies on energy balance. Although several hyperspectral indices have been reported to show potentials for tracing transpiration directly, both at leaf and canopy scales, they remain in pioneer stages and need extensive validations. In this study, we used the Soil, Canopy Observation, Photochemistry and Energy fluxes (SCOPE) model calibrated to arid ecosystems in Central Asia, to generate a simulated dataset for validation...
December 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/30539111/does-metabolic-rate-increase-linearly-with-running-speed-in-all-distance-runners
#5
Matthew E Batliner, Shalaya Kipp, Alena M Grabowski, Rodger Kram, William C Byrnes
Running economy (oxygen uptake or metabolic rate for running at a submaximal speed) is one of the key determinants of distance running performance. Previous studies reported linear relationships between oxygen uptake or metabolic rate and speed, and an invariant cost of transport across speed. We quantified oxygen uptake, metabolic rate, and cost of transport in 10 average and 10 sub-elite runners. We increased treadmill speed by 0.45 m · s -1 from 1.78 m · s -1 (day 1) and 2.01 m · s -1 (day 2) during each subsequent 4-min stage until reaching a speed that elicited a rating of perceived exertion of 15...
January 2018: Sports Med Int Open
https://www.readbyqxmd.com/read/30538673/somatotropic-axis-regulation-unravels-the-differential-effects-of-nutritional-and-environmental-factors-in-growth-performance-of-marine-farmed-fishes
#6
REVIEW
Jaume Pérez-Sánchez, Paula Simó-Mirabet, Fernando Naya-Català, Juan Antonio Martos-Sitcha, Erick Perera, Azucena Bermejo-Nogales, Laura Benedito-Palos, Josep Alvar Calduch-Giner
The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make this association variable throughout season and life cycle, and the present minireview aims to better define the nutritional and environmental regulation of the endocrine growth cascade over precisely defined groups of fishes, focusing on Mediterranean farmed fishes...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30538594/to-test-or-not-occurrence-of-sickle-cell-trait-and-assessment-of-the-awareness-toward-its-screening-among-patients-attending-magale-health-center-iv-namisindwa-district-eastern-uganda
#7
Keneth Mandu, Sharifu K Tusuubira, Bashir Mwambi, Fred Webbo, Christine Atuhairwe, Ivan Mugisha Taremwa
Purpose: To evaluate the occurrence of sickle cell trait (SCT), assess patient awareness and evaluate the performance of a sickle cell hemoglobin-S (dithionate-qualitative solubility) point-of-care test among patients seeking care at Magale Health Center IV, Namisindwa District, Eastern Uganda. Materials and methods: We conducted a cross sectional study, in which we consecutively enrolled participants aged ≥18 years at Magale Health Center IV. Four milliliters of EDTA blood were collected by venipuncture and screened for SCT using solubility testing, and confirmed with hemoglobin (Hb) electrophoresis at Central Public Health Laboratory (CPHL), Kampala, Uganda...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/30538262/bretschneider-solution-induced-alterations-in-the-urine-metabolome-in-cardiac-surgery-patients
#8
Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Tao Huan, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen
The development of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution represented a major advancement in cardiac surgery, offering significant myocardial protection. However, metabolic changes induced by this additive in the whole body have not been systematically investigated. Using an untargeted mass spectrometry-based method to deeply explore the urine metabolome, we sought to provide a holistic and systematic view of metabolic perturbations occurred in patients receiving HTK...
December 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30538041/a-data-driven-ground-fault-detection-and-isolation-method-for-main-circuit-in-railway-electrical-traction-system
#9
Zhiwen Chen, Xueming Li, Chao Yang, Tao Peng, Chunhua Yang, H R Karimi, Weihua Gui
Due to the complex and harsh operation conditions, like corrosion, aging cable and static electricity, of electrical traction drive system, ground fault will generate large short circuit current to harm the key components. Effective fault diagnosis is important, but also challenging. The conventional method used for ground fault detection only takes advantage of voltage measurements of DC-link. Other measurements onboard are also available, which are correlated with the voltage measurements. Taking the correlation into account will improve the detection performance...
December 4, 2018: ISA Transactions
https://www.readbyqxmd.com/read/30537925/regulatory-motifs-found-in-the-small-heat-shock-protein-shsp-gene-family-in-tomato
#10
Debora Arce, Flavio Spetale, Flavia Krsticevic, Paolo Cacchiarelli, Javier De Las Rivas, Sergio Ponce, Guillermo Pratta, Elizabeth Tapia
BACKGROUND: In living organisms, small heat shock proteins (sHSPs) are triggered in response to stress situations. This family of proteins is large in plants and, in the case of tomato (Solanum lycopersicum), 33 genes have been identified, most of them related to heat stress response and to the ripening process. Transcriptomic and proteomic studies have revealed complex patterns of expression for these genes. In this work, we investigate the coregulation of these genes by performing a computational analysis of their promoter architecture to find regulatory motifs known as heat shock elements (HSEs)...
December 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30537747/stromal-cell-derived-ccl20-promotes-tumor-progression-and-osteolysis-in-giant-cell-tumor-of-bone
#11
Chenglong Zhao, Dongsheng Wang, Liang Tang, Zhichao Zhang, Song Li, Ming Qian, Zhipeng Wu, Wang Zhou, Mingyao Liu, Jian Luo, Tielong Liu, Zhenxi Li, Jianru Xiao
BACKGROUND/AIMS: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. METHODS: We explored the expression of CCL20 in stromal cells (GCTSCs) using microarray. Clinical analyses of the role of CCL20 in tumor progression were performed based on the patient cohort of our institution...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30537038/downregulation-of-microrna-23b-protects-against-ischemia-reperfusion-injury-via-p53-signaling-pathway-by-upregulating-mdm4-in-rats
#12
Zhi Zhao, Jian-Zhong Guan, Min Wu, Gui-Hua Lai, Zhong-Lian Zhu
Total knee arthroplasty is a commonly performed safe procedure and typically executed in severe knee arthritis, but it also triggers ischemia-reperfusion injury (IRI). More recently, microRNAs (miRs) have been reported to play a contributory role in IRI through the key signaling pathway. Hence, the current study aimed to investigate the effect and specific mechanism of microRNA-23b (miR-23b), murine double minute 4 (MDM4), and the p53 signaling pathway in IRI rat models. First, the IRI model was established, and the expression pattern of miR-23b, MDM4, and the p53 signaling pathway-related genes was characterized in cartilaginous tissues...
December 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30536655/the-p-class-pentatricopeptide-repeat-protein-ppppr_21-is-needed-for-accumulation-of-the-psbi-ycf12-dicistronic-mrna-in-physcomitrella-chloroplasts
#13
Tetsuo Ebihara, Takuya Matsuda, Chieko Sugita, Mizuho Ichinose, Hiroshi Yamamoto, Toshiharu Shikanai, Mamoru Sugita
Chloroplast gene expression is controlled by numerous nuclear-encoded RNA-binding proteins. Among them, pentatricopeptide repeat (PPR) proteins are known to be key players of posttranscriptional regulation in chloroplasts. However, the functions of many PPR proteins remain unknown. In this study, we characterized the function of a chloroplast-localized P-class PPR protein PpPPR_21 in Physcomitrella patens. Knockout (KO) mutants of PpPPR_21 exhibited reduced protonemata growth and lower photosynthetic activity...
December 7, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/30535879/identification-of-phosphorylation-proteins-in-response-to-water-deficit-during-wheat-flag-leaf-and-grain-development
#14
Fei Luo, Xiong Deng, Yue Liu, Yueming Yan
BACKGROUND: Wheat (Triticum aestivum L.) serves as important grain crop widely cultivated in the world, which is often suffered by drought stress in natural conditions. As one of the most important post translation modifications, protein phosphorylation widely participates in plant abiotic stress regulation. In this study, we performed the first comparative analysis of phosphorylated protein characterization in flag leaves and developing grains of elite Chinese bread wheat cultivar Zhongmai 175 under water deficit by combining with proteomic approach and Pro-Q Diamond gel staining...
December 8, 2018: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/30535618/neurons-in-rat-orbitofrontal-cortex-and-medial-prefrontal-cortex-exhibit-distinct-responses-in-reward-and-strategy-update-in-a-risk-based-decision-making-task
#15
Dan-Dan Hong, Wen-Qiang Huang, Ai-Ai Ji, Sha-Sha Yang, Hui Xu, Ke-Yi Sun, Aihua Cao, Wen-Jun Gao, Ning Zhou, Ping Yu
The orbitofrontal cortex (OFC) and the medial prefrontal cortex (mPFC) are known to participate in risk-based decision-making. However, whether neuronal activities of these two brain regions play similar or differential roles during different stages of risk-based decision-making process remains unknown. Here we conducted multi-channel in vivo recordings in the OFC and mPFC simultaneously when rats were performing a gambling task. Rats were trained to update strategy as the task was shifted in two stages. Behavioral testing suggests that rats exhibited different risk preferences and response latencies to food rewards during stage-1 and stage-2...
December 8, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30535560/spinal-cord-ultrasonography-of-the-newborn
#16
REVIEW
Iacopo Valente, Alessandro Pedicelli, Martina Piacentini, Marco Di Serafino, Gianfranco Vallone, Stefania Speca, Cesare Colosimo
Ultrasound represents the first-line survey for the assessment of spinal cord development abnormalities. In fact, within 6 months of life, the non-ossification of neuronal arcs provides an excellent acoustic window that allows a detailed depiction of the spinal canal, its content and of the surrounding soft tissues. Nevertheless, an accurate ultrasound examination requires a complete knowledge of the anatomy, the condition of normality, the frequent anatomical variants and the main pathologies involved. This review is intended to briefly summarize the US technique, the main clinical indication and the key notions that could help to properly perform this type of ultrasound examination...
December 7, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/30535493/genetic-epigenetic-and-transcriptional-comparison-of-esophagus-tumor%C3%A2-associated-and-adjacent-normal-myofibroblasts
#17
Ildikó Huliák, László Bodai, Mátyás Czepán, Dávid Kovács, Anikó Szabó, László Tiszlavicz, György Lázár, Zoltán Rakonczay, Péter Hegyi, Imre Miklós Boros, Mónika Kiricsi
Myofibroblasts (MFs) are present in healthy tissues and are also key components of the tumor microenvironment. In the present study a comparative analysis of MFs obtained from various gastrointestinal tumor tissues and from tumor‑adjacent normal tissues of cancer patients was performed, with the aim to evaluate differences in MF morphology, gene expression profile and function. The goal was to correlate the observed morphological and functional variations with the underlying genetic and epigenetic backgrounds...
December 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30535433/ten-genes-associated-with-mgmt-promoter-methylation-predict-the-prognosis-of-patients-with-glioma
#18
Yang Zhang, Junwei Zhu
Glioma originates from the glial cells of the spine or brain, and promoter methylation of O6‑methylguanine‑DNA methyltransferase (MGMT) can promote the chemosensitivity of glioma. The present study aimed to reveal the key genes implicated in MGMT promoter methylation in patients with glioma. RNA‑sequencing data and methylation data for glioma were extracted from The Cancer Genome Atlas database. Following expression characteristic analysis and differential expression analysis using unsupervised hierarchical clustering and a rank sum test, the feature genes were identified between high and low methylation groups...
December 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30534171/assessing-the-quality-of-dental-services-using-servqual-model
#19
Nooredin Dopeykar, Mohammadkarim Bahadori, Parisa Mehdizadeh, Ramin Ravangard, Mahmood Salesi, Seyed Mojtaba Hosseini
Background: The measurement of service quality had an important role in managing service provided, diagnosing the problem, and assessing service performance. Patient satisfaction is one of the key indicators of quality in health-care organizations. This study aimed to measure the service quality gap of patients' perceptions and expectations in five dimensions at a military Specialized Dental Clinic in Iran using SERVQUAL tool. Materials and Methods: This was a cross-sectional and descriptive-analytical study conducted at a Specialized Dental Clinic affiliated to the Armed Forces of Islamic Republic of Iran in Tehran in 2013...
November 2018: Dental Research Journal
https://www.readbyqxmd.com/read/30534053/triclosan-impairs-hippocampal-synaptic-plasticity-and-spatial-memory-in-male-rats
#20
Alejandra Arias-Cavieres, Jamileth More, José Miguel Vicente, Tatiana Adasme, Jorge Hidalgo, José Luis Valdés, Alexis Humeres, Ismael Valdés-Undurraga, Gina Sánchez, Cecilia Hidalgo, Genaro Barrientos
Triclosan, a widely used industrial and household agent, is present as an antiseptic ingredient in numerous products of everyday use, such as toothpaste, cosmetics, kitchenware, and toys. Previous studies have shown that human brain and animal tissues contain triclosan, which has been found also as a contaminant of water and soil. Triclosan disrupts heart and skeletal muscle Ca2+ signaling, damages liver function, alters gut microbiota, causes colonic inflammation, and promotes apoptosis in cultured neocortical neurons and neural stem cells...
2018: Frontiers in Molecular Neuroscience
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