Tomohiro Kagi, Aya Inoue, Takuya Noguchi, Wakana Suzuki, Saya Takano, Kohei Otani, Rio Naganuma, Yuto Sekiguchi, Yusuke Hirata, Sawako Shindo, Gi-Wook Hwang, Atsushi Matsuzawa
Drug-induced acute renal failure (ARF) is a public health concern that hinders optimal drug therapy. However, pathological mechanisms of drug-induced ARF remain to be elucidated. Here, we show that a pathological process of drug-induced ARF is mediated by proinflammatory cross-talk between kidney tubular cells and macrophages. Both polymyxin B and colistin, polypeptide antibiotics, frequently cause ARF, stimulated the ERK and NF-κB pathways in kidney tubular cells, and thereby upregulated M-CSF and MCP-1, leading to infiltration of macrophages into the kidneys...
April 19, 2024: Journal of Immunology