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Victor T T Chan, Zihan Sun, Shumin Tang, Li Jia Chen, Adrian Wong, Clement C Tham, Tien Y Wong, Christopher Chen, M Kamran Ikram, Heather E Whitson, Eleonora M Lad, Vincent Mok, Carol Y Cheung
TOPIC: Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer's Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. CLINICAL RELEVANCE: Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD...
August 13, 2018: Ophthalmology
Giovanni Montesano, Susan R Bryan, David P Crabb, Paolo Fogagnolo, Francesco Oddone, Allison M McKendrick, Andrew Turpin, Paolo Lanzetta, Andrea Perdicchi, Chris A Johnson, David F Garway-Heath, Paolo Brusini, Luca M Rossetti
PURPOSE: To evaluate relative diagnostic precision and test retest variability of two devices, the Compass (CMP, CenterVue, Italy) fundus perimeter and the Humphrey Field Analyzer (HFA, Zeiss, Dublin), in detecting glaucomatous optic neuropathy (GON). DESIGN: Multicentre cross-sectional case-control study. SUBJECTS: We sequentially enrolled 499 glaucoma patients and 444 normal subjects to analyse relative precision. A separate group of 44 glaucoma patients and 54 normal subjects was analysed to assess test - retest variability...
August 13, 2018: Ophthalmology
Jacqueline Chua, Calvin Woon Loong Chin, Jimmy Hong, Miao Li Chee, Thu-Thao Le, Daniel Shu Wei Ting, Tien Yin Wong, Leopold Schmetterer
OBJECTIVE: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. METHODS: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]...
August 14, 2018: Journal of Hypertension
Yanin Suwan, Samantha Rettig, Sung Chul Park, Apichat Tantraworasin, Lawrence S Geyman, Keith Effert, Luis Silva, Ravivarn Jarukasetphorn, Robert Ritch
PURPOSE: In a myopic population, we investigated the occurrence of circumpapillary retinal nerve fiber layer (RNFL) segmentation errors that required manual correction in optical coherence tomography (OCT) and its effect on glaucoma diagnostic capability of OCT. MATERIALS AND METHODS: Myopic subjects (spherical equivalent refractive error <-3 diopters) with and without primary open-angle glaucoma were recruited. Three circumpapillary RNFL scans with diameters of 3...
August 14, 2018: Journal of Glaucoma
Kyoung Lae Kim, Sung Pyo Park
The objective of this study was to evaluate the association between serum vitamin D deficiency and age-related macular degeneration (AMD) in Koreans through a clinical case-control pilot study. The study included 96 patients: 30 with late AMD, 32 with early AMD, and 34 normal controls. The patients with late AMD were divided into 2 subgroups based on the presence or absence of subretinal fibrosis on optical coherence tomography (OCT) images. We measured 25-hydroxyvitamin D levels in the serum of all patients during the same season to rule out seasonal variation of serum vitamin D level...
August 2018: Medicine (Baltimore)
Luju Lai, Xiaoyun Shen, Haoqin Liang, Yingying Deng, Zhuandi Gong, Suocheng Wei
Mice of FRBI-1, FRBI-2, and FRBI-3 groups were intramuscularly injected with 20, 30, and 40mg/kg, respectively, for five consecutive days. Ovarian weights of three FRBI groups were reduced in comparison with FSH group. Ovarian cortex thicknesses (OCT) of the FRBI-3 group were less than that of the FSH group (P<0.05). As compared to FSH group, there were fewer numbers of secondary follicles (SFs) and mature follicles (MF) on the ovaries of FRBI-treated mice numbers of primary follicles (PFs) and SFs also decreased...
2018: BioMed Research International
Qihua Le, Daniel Cordova, Jianjiang Xu, Sophie X Deng
Purposes: To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods: Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian group) were included in this comparative cross-sectional study. The central cornea and the superior, inferior, nasal, and temporal limbal regions of each subject underwent Fourier-domain AS-OCT...
July 2018: Translational Vision Science & Technology
Annika W M Goorsenberg, Julia N S d'Hooghe, Daniel M de Bruin, Inge A H van den Berk, Jouke T Annema, Peter I Bonta
BACKGROUND: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. OBJECTIVE: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects of BT by OCT and compare these to the untreated right middle lobe (RML)...
August 15, 2018: Respiration; International Review of Thoracic Diseases
Sinisa D Grozdanic, Tatjana Lazic, Helga Kecova, Kabhilan Mohan, Markus H Kuehn
OBJECTIVE: To perform detailed analysis of retinal changes in dogs with SARDS using optical coherence tomography (OCT), funduscopy, and molecular analysis. ANIMALS: Subjects were 29 dogs from 12 US states and Canada diagnosed with SARDS by 8 ophthalmologists. An additional 7 eyes from 5 deceased SARDS dogs were used for molecular and histological analysis. PROCEDURES: Dogs were evaluated using chromatic pupil light reflex testing (cPLR), and electroretinography (ERG); subjects underwent complete ophthalmic examination, including funduscopy, retinal photography, and OCT, in addition to complete laboratory analysis, blood pressure evaluation, abdominal and thoracic radiographs, and computerized tomography (CT) imaging to assess possible systemic abnormalities...
August 15, 2018: Veterinary Ophthalmology
L Y Qiao, X G Cai, X X Li, J X Tan, Z Guan, Y Zhang, S Z Li, K Cao, N L Wang
Objective: To assess the retinal image quality of the normal northern rural Chinese adult population. Methods: A normal population-based, cross-sectional study. From Oct, 2012 to Jan 2013, a clustered, random sampling procedure was used to select normal population who visual acuity≤ 0(LogMAR) and 30-69 years old from 2 villages. All eligible subjects were invited to undergo a comprehensive eye examination, and the retinal image quality related index were examined with pupil 4 mm using objective optical quality analysis systemⅡ(OQAS Ⅱ, Visiometrics, Spain), including MTFcutoff, VA20, VA9, PSF50, PSF10, OSI, SR...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Bihai Tong, Han Wang, Man Chen, Shixiong Zhou, Yuanyuan Hu, Qianfeng Zhang, Gufeng He, Lianshe Fu, Huatian Shi, Long Jin, Huidong Zhou
A series of steric phenylpyridazine based homoleptic iridium(iii) complexes (1-3) have been synthesized with novel one-pot methods. Single X-ray structural analyses are conducted on complexes 1 and 2 to reveal their coordination arrangement. These complexes exhibit a very strong green phosphorescence emission with high quantum yields of over 64%. The relationship between photophysical properties and the substituent nature of the complexes is discussed by density functional theory (DFT) and time-dependent DFT...
August 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Lucas A Torres, Jayme R Vianna, Faisal Jarrar, Glen P Sharpe, Makoto Araie, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Masanori Hangai, Aiko Iwase, Jeffrey M Liebmann, Christian Y Mardin, Toru Nakazawa, Harry A Quigley, Alexander F Scheuerle, Kazuhisa Sugiyama, Hidenobu Tanihara, Goji Tomita, Yasuo Yanagi, Claude F Burgoyne, Balwantray C Chauhan
PURPOSE: To determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinal rim measurements. METHODS: Ninety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used. For each of the 48 minimum rim width (MRW) measurement points, we determined whether PRL were present, absent or indeterminate...
June 2018: Acta Ophthalmologica
M Maier, S Bohnacker, J Klein, J Klaas, N Feucht, A Nasseri, C P Lohmann
BACKGROUND: In large full thickness macular holes (FTMH) the closure rate after vitrectomy and conventional internal limiting membrane (ILM) peeling is less than 90%. The aim of this study was to examine the visual acuity and anatomical success rate with high-resolution optical coherence tomography (OCT) after transconjunctival sutureless 23-gauge pars plana vitrectomy as well as intraoperative OCT (iOCT) and Brilliant Peel (BP)-assisted ILM peeling using the inverted ILM flap technique in patients with large FTMHs...
August 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Manas R Biswal, Howard M Prentice, George W Smith, Ping Zhu, Yao Tong, C Kathleen Dorey, Alfred S Lewin, Janet C Blanks
Aberrant growth of blood vessels in the choroid layer of the eye, termed choroidal neovascularization (CNV), is the pathological hallmark of exudative age-related macular degeneration (AMD), causing irreversible blindness among the elderly. Co-localization of proangiogenic factors and hypoxia inducible factors (HIF) in neovascular membranes from AMD eyes suggests the role of hypoxia in pathogenesis of CNV. In order to utilize hypoxic conditions in RPE for therapeutic purposes, we developed an optimized hypoxia regulated, RPE cell-specific gene therapy to inhibit choroidal neovascularization...
August 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Yasmine Maher Shaaban, Tamer Abdel Fattah Badran
Purpose: The purpose of this study was to compare the effects of three different corneal refractive surgeries: microkeratome laser in situ keratomileusis (LASIK), femtosecond laser in situ keratomileusis (FS-LASIK) and femtosecond small incision lenticule extraction (FS-SMILE) on 6-month postoperative stability of tear film to provide a basis for selection of operative procedures. Patients and methods: This is a prospective, randomized, comparative study that included 90 eyes of three equal groups of patients...
2018: Clinical Ophthalmology
Tiew-Hwa K Teng, Jasper Tromp, Wan Ting Tay, Inder Anand, Wouter Ouwerkerk, Vijay Chopra, Gurpreet S Wander, Jonathan Jl Yap, Michael R MacDonald, Chang Fen Xu, Yvonne Mf Chia, Wataru Shimizu, A Mark Richards, Adriaan Voors, Carolyn Sp Lam
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), β blockers, and mineralocorticoid receptor antagonists (MRAs) are of proven benefit and are recommended by guidelines for management of patients with heart failure and reduced ejection fraction (HFrEF). We aimed to examine the first prospective multinational data from Asia on prescribing patterns of guideline-directed medical therapies and analyse its effect on outcomes. METHODS: In the prospective multinational ASIAN-HF registry (with enrolment from 46 centres in 11 countries in Asia), we enrolled patients aged 18 years or older, with symptomatic heart failure (stage C, with at least one episode of decompensated heart failure in the past 6 months that resulted in admission to hospital or was treated in an outpatient clinic) and left ventricular systolic dysfunction (ejection fraction ≤40% on baseline echocardiography, consistent with 2016 European Society of Cardiology guidelines)...
September 2018: Lancet Global Health
Juan Lu, Nannan Li, Yaochun Gao, Nan Li, Yifei Guo, Haitao Liu, Xi Chen, Chunyan Zhu, Zhengqi Dong, Akira Yamamoto
The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0⁻G3) and concentrations (0.1⁻1.0%) on the pulmonary absorption of macromolecules. The absorption-enhancing mechanisms were elucidated by microarray, western blotting analysis, and PCR. Fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs of poorly absorbable drugs...
August 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
R Lanzillo, G Cennamo, M Moccia, C Criscuolo, A Carotenuto, N Frattaruolo, F Sparnelli, A Melenzane, A Lamberti, G Servillo, F Tranfa, G De Crecchio, V Brescia Morra
BACKGROUND: Vascular pathology is increasingly acknowledged as a risk factor of multiple sclerosis (MS). Vascular density (VD) is reduced in MS patients' eyes on optical coherence tomography (OCT) angiography (A). OBJECTIVE: We performed a one-year prospective study to estimate VD variations over time and possible clinical correlates. METHODS: Fifty MS patients underwent spectral domain (SD)-OCT and OCT angiography at baseline and after 1-year follow-up...
August 13, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Kunliang Qiu, Binyao Chen, Jianling Yang, Ce Zheng, Haoyu Chen, Mingzhi Zhang, Nomdo M Jansonius
PURPOSE: To determine the influence of the optic disc-fovea distance (DFD) on the normative classifications based on thickness measurements of macular inner retinal layers with spectral-domain optical coherence tomography (OCT) in healthy subjects. METHODS: A total of 182 eyes from 182 healthy subjects were included (mean (SD) spherical equivalent -0.8 (1.9) dioptres). We performed macula and optic disc imaging with the Topcon 3D OCT 2000. The thickness of the macular inner retinal layers (macular retinal nerve fibre layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL) and both combined (ganglion cell complex; GCC)) and the corresponding classifications based on the built-in normative database were recorded...
August 12, 2018: British Journal of Ophthalmology
Won June Lee, Kyeong Ik Na, Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To evaluate patterns of glaucomatous structural progression using the combined retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) event-based progression analysis feature provided by spectral-domain optical coherence tomography (SD-OCT)'s Guided Progression Analysis (GPA) software. DESIGN: Retrospective observational case series. METHODS: Seventy-nine (79) patients with open-angle glaucoma (OAG) showing clinically confirmed structural progression within a minimum 3-year follow-up period...
August 9, 2018: American Journal of Ophthalmology
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