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Bi-Cheng Wang, Chen Fu, Jun-Li Liu, Yu-Ting Li, Tao Zhang, Gang Wu, Quentin Liu, Jun Xue
Metastatic cystic lesions may be considered as target lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. However, cystic lesions are considered as non-measurable according to RECIST 1.0. Krukenberg tumors are cystic metastases from gastric cancer. The aim of the present case report was to address the question of whether a Krukenberg tumor can be considered as a target lesion. A 30-year-old female patient was diagnosed with stage IV gastric cancer 6 months after parturition. Subsequently, the patient received two courses of oxaliplatin/capecitabine plus trastuzumab (OCT) treatment...
December 2018: Molecular and Clinical Oncology
Junwon Lee, Christopher Seungkyu Lee, Min Kim, Sung Chul Lee
BACKGROUND: Changes in retinal fluid patterns associated with circumscribed choroidal hemangioma (CCH) have not been investigated yet. A long-term follow-up study was performed to evaluate the changes of retinal fluid patterns and treatment responses. METHODS: We retrospectively reviewed medical records of all CCH patients diagnosed between November 2005 and March 2017. Enrolled patients had visual symptoms, were treatment-naïve, and had been followed-up for more than 2 years...
December 13, 2018: BMC Ophthalmology
Lisa A Ostrin, Christianne E Strang, Kevin Chang, Ashutosh Jnawali, Li-Fang Hung, Baskar Arumugam, Laura J Frishman, Earl L Smith, Paul D Gamlin
Purpose: Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. The goal of this study was to develop and validate a targeted ipRGC immunotoxin to ultimately examine the role of ipRGCs in macaque monkeys. Methods: An immunotoxin for the macaque melanopsin gene ( OPN4 ), consisting of a saporin-conjugated antibody directed at the N-terminus, was prepared in solutions of 0...
2018: Frontiers in Neurology
J Lešták, Š Pitrová, M Žáková
Nerve Fiber Layer (RNFL) measurements in the same altitudinal half of the eye in hyper-tension (HTG) and normal-tension glaucomas (NTG). MATERIALS AND METHODS: We examined both eyes in altogether 50 patients (100 eyes). The cohort was divided into two groups, in each of them; there were 25 patients with average age of 55.4 in the NTG group and 54.6 years in the HTG group. The NTG group consisted of 17 women of the average age of 55.35 (range, 25-75) years, and 8 men of the average age of 55...
2018: Ceská a Slovenská Oftalmologie
J Valašková, I Popov, V Krásnik
PURPOSE: functional and anatomical results after combination of intravitreal dexamethasone implant with anti-VEGF bevacizumab in macular edema secondary to retinal vein occlusion. METHODS: Retrospective analysis of 50 patients, average age 72 years, 15 men and 35 women. Inclusion criteria for treatment were retinal vein occlusion, best corrected visual acuity (BCVA) more than 20/200 and macular edema more than 250 μm. Algorithm of treatment was dexamethason, anti-VEGF (bevacizumab), dexamethason...
2018: Ceská a Slovenská Oftalmologie
M Kováčová, M Meliška, B Kalvodová
PURPOSE: To evaluate OCT findings and long-term follow-up results in patient with optic disc pit (ODP) and associated maculopathy treated with pars plana vitrectomy (PPV). METHODS: Six eyes of 6 patients (3 females, 3 males) were included in a retrospective study. We excluded patients with ODP without maculopathy. Patients were followed in years 2008-2017. Mean age at the first examination was 40,3 years (15-70 years). Duration of worsening of the best corrected visual acuity (BCVA) ranged from 2 days to few years...
2018: Ceská a Slovenská Oftalmologie
Erel İçel, Halil İbrahim İmamoğlu, Adem Türk, Aykut İçel, Nurettin Akyol
Background/aim: This study aimed to investigate the effects of two different medical treatment options on choroidal thickness (CT) in patients with primary hypertension. Materials and methods: Forty newly diagnosed primary hypertension patients and 21 healthy volunteers were included. The patients were randomly divided into two subgroups. Group I started on perindopril arginine and Group II started on amlodipine. Submacular CT using optical coherence tomography (OCT) was measured before treatment and at the third and sixth months after treatment...
December 12, 2018: Turkish Journal of Medical Sciences
C Elhardt, S G Priglinger, Y Karakolova, W J Mayer, C Wertheimer
BACKGROUND: Corneal optical coherence tomography (anterior segment OCT, AS-OCT) is described in the current IC3D classification of corneal dystrophies to be a method for improvement of clinical diagnostics and treatment. OBJECTIVE: In this case series AS-OCT images of corneal dystrophies were analyzed with respect to morphological changes. MATERIAL AND METHODS: This was a retrospective imaging and morphological case series with 38 eyes. For image acquisition the corneal module of the high-resolution spectral-domain OCT Zeiss Cirrus HD-5000 platform (Oberkochen, Germany) was employed...
December 11, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Vincent M Borderie, Sara Touhami, Cristina Georgeon, Otman Sandali
Objective: Big bubble (BB)-deep anterior lamellar keratoplasty (DALK) has become the reference transplantation technique for corneal stromal disorders. Type 1 BB is the desired aspect but it is not constant. We aimed to determine the predictive factors of type 1 BB success. Methods: Observational cohort study including 77 consecutive eyes of 77 patients undergoing DALK by one surgeon at a single reference center without any selection. Clinical and spectral domain optical coherence tomography data were collected pre- and postoperatively...
2018: Journal of Ophthalmology
Angela Ariza de Schellenberger, Wolfram C Poller, Verena Stangl, Ulf Landmesser, Eyk Schellenberger
Background: Optical coherence tomography (OCT) is an intravascular, high-resolution imaging technique that is used to characterize atherosclerotic plaques. However, the identification of macrophages as important markers of inflammation and plaque vulnerability remains difficult. Here, we investigate whether the uptake of very small iron oxide particles (VSOP) in macrophages, that cluster in phagolysosomes and allow high-quality magnetic resonance imaging (MRI) of atherosclerotic plaques, and uptake of ferumoxytol nanoparticles enhance detection of macrophages by OCT...
2018: International Journal of Nanomedicine
Ricardo A Arbizu, Samuel Nurko, Nicole Heinz, Maureen Amicangelo, Leonel Rodriguez
BACKGROUND: We evaluated the changes in antroduodenal manometry (ADM) parameters and interpretation when the test is performed the day of catheter placement and the following day. METHODS: Catheter was placed endoscopically under anesthesia and recorded on day 1 and repeated on day 2. Study parameters including antrum and small bowel motility index (MI) during fasting, meal, postprandial, erythromycin (EES), and octreotide (OCT) challenge phases, the presence of the phase III of the migrating motor complex (MMC), visual postprandial response, and study interpretation were compared between both days...
December 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Salomon Y Cohen, Sandrine Tabary, Ala El Ameen, Sarah Mrejen, Gabriel Quentel, Audrey Giocanti-Auregan
PURPOSE: To investigate morphological changes in myopic choroidal neovascularization (mCNV) using optical coherence tomography-angiography (OCT-A) after treatment with ranibizumab. METHODS: Retrospective analysis of consecutive patients over a 24-month period. All treatment-naïve mCNV were imaged at baseline with color pictures, spectral-domain OCT and OCT-A, and fluorescein angiography in selected cases. CNV morphology was classified at baseline and at 6 months...
December 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Chanda Gupta, Roy Tan, Chitaranjan Mishra, Neha Khandelwal, Rajiv Raman, Ramasamy Kim, Rupesh Agrawal, Parveen Sen
PURPOSE: To evaluate structural changes in the choroid among patients with diabetic macular edema (DME), with varying grades of diabetic retinopathy (DR), using enhance depth imaging spectral domain optical coherence tomography (EDI SD-OCT) scans. METHODS: A cross-sectional study was conducted on 82 eyes with DR and DME and 86 healthy control eyes. Eyes with DME were classified according to the severity of DR as per the international DR severity scale. Sub foveal choroidal thickness (SFCT)was obtained using EDI SD-OCT scans...
2018: PloS One
Hae Min Kang, Hyoung Jun Koh, Sung Chul Lee
BACKGROUND: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). METHODS: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behçet uveitis...
2018: PloS One
Kyeong Ik Na, Ahnul Ha, Sung Uk Baek, Won June Lee, Dai Woo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
PURPOSE: To evaluate the clinical efficacy of a novel screening sign (i.e., the Triple Hump [TH] sign) for prediction of laser peripheral iridotomy (LPI)'s intraocular pressure (IOP)-lowering effectiveness in subjects with asymptomatic narrow angles. METHODS: This cross-sectional study was conducted from 2010 to 2015 in a hospital setting. Eighty-four (84) eyes of 84 primary angle-closure suspect (PACS) patients were imaged before LPI using anterior-segment optical coherence tomography (AS-OCT)...
December 10, 2018: Journal of Glaucoma
Shady T Awwad, Maamoun Abdul Fattah, Manal Shokr, Ahmad R Dhaini
PURPOSE: To evaluate the role of a novel automated detection software as compared to human operators in assessing the presence and depth of stromal demarcation line on optical coherence tomography (OCT) in keratoconus eyes post cross-linking Design: This was a reliability analysis study. METHODS: Two independent operators and an automated detection software examined corneal OCTs of 25 eyes of 25 patients post corneal cross-linking using the Dresden protocol, at 3 months postoperatively...
December 5, 2018: American Journal of Ophthalmology
Henrietta Ho, Yih-Chung Tham, Miao Li Chee, Yuan Shi, Nicholas Y Q Tan, Kah-Hie Wong, Shivani Majithia, Carol Y Cheung, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain OCT (SD-OCT) in a multi-ethnic Asian population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Ethnic Chinese, Malay and Indian adults, aged greater than 48 years without glaucoma, recruited from the Singapore Epidemiology of Eye Diseases (SEED) Study. METHODS: All participants underwent standardized systemic and ocular examinations...
December 4, 2018: Ophthalmology
G Y Su, P P Zheng, Y D Su, K Cao, C Gao, Y Zhang, B Li, Q F Liang
Objective: To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Methods: Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Forty-four rabbits that successfully established the model were randomly divided into four groups: corneal collagen cross-linking (CXL) group, antibiotic group, CXL+ antibiotic group and untreated group, with 11 rabbits in each group...
December 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Badr O Alahmadi, Amro A Omari, Maria Fernanda Abalem, Chris Andrews, Dana Schlegel, Kari H Branham, Naheed W Khan, Abigail Fahim, Thiran Jayasundera
BACKGROUND: Patients with retinal diseases frequently complain of poor visual function even when visual acuity is relatively unaffected. This clinical finding has been attributed to deficits in contrast sensitivity (CS). The purpose of our study was to evaluate the CS in patients with clinical and genetic diagnosis of inherited retinal degeneration (IRD) and relatively preserved visual acuity. METHODS: Seventeen patients (30 eyes) with IRD and visual acuity of 20/40 or better, and 18 controls (18 eyes) without any ocular condition underwent slit lamp examination, visual acuity testing via standard Snellen chart testing, CS testing via the Quick Contrast Sensitivity Function (QCSF), and Spectral Domain Optical Coherence Tomography (SD-OCT)...
December 7, 2018: BMC Ophthalmology
Shunsuke Konishi, Naoki Mori, Hirosato Takikawa, Hidenori Watanabe
The monoterpene isolated from Mentha haplocalyx, 3,3,5-trimethyl-2-oxabicyclo[2.2.2]oct-5-en-4-ol, was synthesized according to its proposed structure. However, the NMR data of the synthetic sample were not in agreement with those reported for the natural product. After considerable efforts, the genuine structure was confirmed as (1R*,2R*)-4-(1'-hydroxy-1'-methylethyl)-1-methylycyclohex-3-ene-1,2-diol.
December 10, 2018: Bioscience, Biotechnology, and Biochemistry
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