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Xiang Fan, Ling-Ling Wu, Xia Di, Tong Ding, Ai-Hua Ding
Background: Standard automated perimetry does not sufficiently detect early open-angle glaucoma (OAG) in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential (icVEP) could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors. Methods: This was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss (mean deviation ≥ -6...
October 20, 2018: Chinese Medical Journal
Dong Hui Cho, Seok Jung Jo, Jae Hoon Lee, Tae Jun Song, Do Hyun Park, Sung Koo Lee, Myung-Hwan Kim, Sang Soo Lee
BACKGROUND AND AIMS: Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is increasingly accepted as an effective treatment option in patients who require drainage for acute cholecystitis. A newly designed lumen-apposing metal stent (LAMS) has been introduced recently in this procedure. In this study, we evaluated the feasibility and safety of the newly designed LAMS in patients with acute cholecystitis who were unsuitable for cholecystectomy. METHODS: Between Mar 2017 and Oct 2017, 22 patients with acute cholecystitis who were unsuitable for cholecystectomy underwent EUS-GBD with the newly designed LAMS...
October 17, 2018: Surgical Endoscopy
Maddipatla Reddikumar, Joel Cervantes, Yukitoshi Otani, Barry Cense
As data acquisition for retinal imaging with optical coherence tomography (OCT) becomes faster, efficient collection of photons becomes more important to maintain image quality. One approach is to use a larger aperture at the eye's pupil to collect more photons that have been reflected from the retina. A 2.8-mm beam diameter system with only 7 reflecting surfaces was developed for low-loss retinal imaging. The larger beam size requires defocus and astigmatism correction, which was done in a closed loop adaptive optics method using a Shack-Hartmann wavefront sensor and a deformable mirror with 140 actuators and a +/-2...
October 16, 2018: Journal of Biophotonics
Myong Hwa Yamamoto, Akiko Maehara, Sung Sik Kim, Kohei Koyama, Song-Yi Kim, Masaru Ishida, Akiko Fujino, Elizabeth S Haag, Dragos Alexandru, Allen Jeremias, Fernando A Sosa, Keyvan Karimi Galougahi, Ajay J Kirtane, Jeffrey W Moses, Ziad A Ali, Gary S Mintz, Richard A Shlofmitz
OBJECTIVES: We sought to assess plaque modification and stent expansion following orbital atherectomy (OA) for calcified lesions using optical coherence tomography (OCT). BACKGROUND: The efficacy of OA for treating calcified lesions is not well studied, especially using intravascular imaging in vivo. METHODS: OCT was performed preprocedure, post-OA, and post-stent (n = 58). Calcium modification after OA was defined as a round, concave, polished calcium surface...
October 17, 2018: Catheterization and Cardiovascular Interventions
Krzysztof Jeziorny, Anna Niwald, Agnieszka Moll, Katarzyna Piasecka, Aleksandra Pyziak-Skupien, Arleta Waszczykowska, Dobromiła Baranska, Beata Malachowska, Agnieszka Szadkowska, Wojciech Mlynarski, Agnieszka Zmyslowska
AIMS: Some patients with diabetic ketoacidosis develop cerebral edema (CE) in the course of type 1 diabetes mellitus (T1D), which may result in central nervous system disorders and high mortality. The imperfection of existing neuroimaging techniques for early recognition of CE forces us to search for the new and non-invasive methods. The aim of the study was to assess the usefulness of new methods (pachymetry, transorbital ultrasonography-USG, optical coherence tomography-OCT study) in the assessment of the risk of CE occurrence in children with newly diagnosed T1D...
October 16, 2018: Acta Diabetologica
Josef Guber, Max Vieregge, Hendrik P N Scholl, Christophe Valmaggia
PURPOSE: To evaluate the technique and the long-term outcomes after autologous internal limiting membrane flap surgery for refractory macular holes. METHODS: The free ILM flap technique was used as a secondary procedure for non-closing macular holes after failed initial standard procedure. SD-OCT images were taken to assess the anatomical outcome of surgery while best corrected visual acuity (BCVA) was used to evaluate the functional outcome during a one-year follow-up...
October 16, 2018: Klinische Monatsblätter Für Augenheilkunde
Yusuf Yazici, Lin Xie, Adesuwa Ogbomo, Lorie A Ellis, Kavitha Goyal, Amanda Teeple, Ece A Mutlu, Ismail Simsek
Purpose: Biosimilar IFX (CT-P13) received marketing approval in Turkey for treatment of rheumatologic diseases, including ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis. Population data on real-world treatment patterns of CT-P13 following marketing approval in European countries are largely unreported. This study examined the prescribing and medication utilization patterns of innovator infliximab (IFX) and CT-P13 in Turkey for patients with RA or IBD naïve to either IFX...
2018: Biologics: Targets & Therapy
Shuang Gao, Yingming Zhou, Xiaolong Jin, Zhongjing Lin, Yisheng Zhong, Xi Shen
A 50-year-old woman developed recurrent vitreous opacities in her left eye. The first diagnostic vitrectomy revealed no significant abnormality. OCT showed multiple high-density reflective nodules. The ratio of Interleukin 6 to 10 was over 1 in her aqueous humor, and Epstein-Barr virus was present. Conventional immunohistochemistry examination of vitrectomy specimens was diffusely positive for CD2, CD3, Ki67. Highly-metabolic nodules were found in her right breast on PET-CT scan. Immunohistochemistry of the breast biopsy was suggestive of NK/T cell lymphoma...
October 12, 2018: Survey of Ophthalmology
Aaron Jamison, Paul Cauchi, David F Gilmour
Purpose: The aim of this study was to evaluate the safety and efficacy of photodynamic therapy (PDT) with verteporfin as a treatment for circumscribed choroidal haemangioma (CCH). Procedures: This is a retrospective cohort study of all treatment-naïve patients undergoing PDT with verteporfin for CCH in a single centre between April 1, 2007, and September 30, 2016. Best corrected visual acuity (BCVA; using ETDRS letter score), optical coherence tomography (OCT) measurements and a subjective measurement of visual function were recorded before treatment, at 3-month follow-up and at each annual follow-up...
September 2018: Ocular Oncology and Pathology
Sandra Wagner, Eberhart Zrenner, Torsten Strasser
The purpose of this study was to provide an in-depth analysis of the ciliary muscle's (CM) morphological changes during accommodation by evaluating CM thickness (CMT) profiles. The CM of 15 near-emmetropic subjects (age 20-39) was imaged via optical coherence tomography (OCT) during far (0 D) and near vision (3 D). A custom-made Java-based program was used for semi-automatic CM segmentation and thickness measurements. CMT profiles were generated to determine regions of the largest shape changes. The results revealed on average a thinning within the first 0...
October 1, 2018: Biomedical Optics Express
Talal F Al-Azemi, Mickey Vinodh, Abdirahman A Mohamod, Fatemeh H Alipour
Crystals of 1-(1,4-dihy-droxy)-2,3,4,5-(1,4-dioct-yloxy)-pillar[5]arene, C99 H158 O10 ·C2 H4 Cl2 , were grown from a 1,2-dicholoro-ethane/ n -hexane solvent system. In the crystal, the encapsulated 1,2-di-chloro-ethane solvent is stabilized by C-H⋯π inter-actions and mediates the formation of an inter-locked supra-molecular polymer via C-H⋯Cl inter-actions.
October 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Vincenza Bonfiglio, Michele Reibaldi, Alessandra Pizzo, Andrea Russo, Iacopo Macchi, Giuseppe Faro, Teresio Avitabile, Antonio Longo
PURPOSE: To analyse the effects of intravitreal dexamethasone implant (DEX) in patients with diabetic macular oedema (DME) unresponsive to ranibizumab treatment, in relation to the inflammatory optical coherence tomography (OCT) retinal features, subfoveal neuroretinal detachment (SND) and hyperreflective retinal spots (HRS). METHODS: Patients with DME poorly responsive to three injections of ranibizumab were treated with DEX. Best-corrected visual acuity (BCVA) and central macula thickness (CMT, measured by Spectralis SD-OCT) were assessed at baseline and at 1, 3, and 6 months...
October 14, 2018: Acta Ophthalmologica
Xingzhou Peng, Marc Behl, Pengfei Zhang, Magdalena Mazurek-Budzyn Ska, Yakai Feng, Andreas Lendlein
Well-defined dihydroxy telechelic oligodepsipeptides (oDPs), which have a high application potential as building blocks for scaffold materials for tissue engineering applications or particulate carrier systems for drug delivery applications are synthesized by ring-opening polymerization (ROP) of morpholine-2,5-diones (MDs) catalyzed by 1,1,6,6-tetra-n-butyl-1,6-distanna-2,5,7,10-tetraoxacyclodecane (Sn(IV) alkoxide). In contrast to ROP catalyzed by Sn(Oct)2 , the usage of Sn(IV) alkoxide leads to oDPs, with less side products and well-defined end groups, which is crucial for potential pharmaceutical applications...
October 14, 2018: Macromolecular Bioscience
Chinmoy Sarkar, Chris Webster, John Gallacher
BACKGROUND: Rapid urbanisation and associated socioeconomic transformations have modified current lifestyles, shifting dietary preferences towards ready-to-eat, calorie-dense food of poor nutritional quality. The effect of ready-to-eat food environments that sell food for instant consumption on the risk of type 2 diabetes has received scant attention. We therefore aimed to examine the association between exposure to ready-to-eat food environments and type 2 diabetes in a large and diverse population sample...
October 2018: Lancet. Planetary Health
Jie Hu, Yang Peng, Tongzhang Zheng, Bin Zhang, Wenyu Liu, Chuansha Wu, Minmin Jiang, Joseph M Braun, Simin Liu, Stephen L Buka, Aifen Zhou, John Pierce Wise, Yiming Zhang, Yangqian Jiang, Chen Hu, Xiaomei Chen, Zheng Huang, Dan Zheng, Kunchong Shi, Xichi Zhang, Ashley Truong, Zhengmin Qian, Wei Xia, Yuanyuan Li, Shunqing Xu
BACKGROUND: Identification of windows of heightened vulnerability to environmental factors has substantial public health implications. Prenatal exposure to vanadium has been linked to adverse birth outcomes; however, critical windows for such exposure during fetal growth remain unknown. We aimed to assess trimester-specific associations of vanadium exposure with ultrasound measures of fetal growth and birth size in a Chinese longitudinal cohort. METHODS: The present study was embedded in our ongoing prospective prenatal cohort study at the Wuhan Women and Children Medical Care Center (Wuhan, Hubei, China)...
October 2018: Lancet. Planetary Health
Ayisha Kausar, Nadia Akhtar, Farooq Afzal, Khalid Ali
OBJECTIVE: To evaluate the effect of refractive error and axial length on peripapillary retinal nerve fibre layer thickness in myopic, hypermetropic and emmetropic eyes by Topcon spectral domain optical coherence tomography. METHODS: This cross-sectional study was conducted at the ophthalmology clinic of Shifa Foundation Falahee Clinic, Islamabad, Pakistan, from January to December 2016, and comprised eye patients including emmetropes, hypermetropes and myopes. All participants underwent detailed ophthalmic examination including axial lengths measurements, auto refraction andretinal nerve fibre layer thickness analysis...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Mengshan He, Pan Long, Weiming Yan, Tao Chen, Lunfeng Guo, Zouming Zhang, Siwang Wang
AIMS: Acetaldehyde dehydrogenase 2 (ALDH2) was reported for its protective properties on myocardial damage, stroke and neurodegeneration disease, but the effects and mechanisms of ALDH2 in the modulation of diabetic retinopathy remain unclear. The present study evaluated the protection effects of ALDH2 on streptozocin (STZ)-induced aged diabetic rats retinas damage. MAIN METHODS: 24 aged male diabetic Sprague-Dawley (SD) rats induced by a single intraperitoneal injection of STZ were randomly divided into Alda1-treated group and dimethylsulfoxide (DMSO) group...
October 10, 2018: Life Sciences
Ali Demircan, Ceren Yesilkaya, Cigdem Altan, Zeynep Alkin, Dilek Yasa, Ebru Demet Aygit, Damla Bektasoglu
PURPOSE: To compare the area of the superficial foveal avascular zone (SFAZ) and deep foveal avascular zone (DFAZ) between patients with nanophthalmos and age matched controls. METHODS: This prospective and comparative study included 19 eyes from 11 patients with nanophthalmos (study group) and 19 eyes from 19 healthy subjects (control group). SFAZ and DFAZ were measured with optical coherence tomography angiography (OCT-A). All participants underwent a standardised ocular examination including best corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT) anterior chamber depth (ACD), axial length (AL), and refractive error (RE) measurements...
October 12, 2018: Eye
Ding Chen, Zhangliang Li, Jinhai Huang, Liuqing Yu, Songjia Liu, Yun-E Zhao
PURPOSE: To quantitate lens nuclear opacity using long-range swept-source optical coherence tomography (SS-OCT) images and to evaluate the correlation of this method to Lens Opacities Classification System III (LOCS III) and a Scheimpflug imaging-based grading system (Pentacam Nuclear Stage function; PNS). METHODS: This study enrolled 120 participants (120 eyes) with age-related nuclear cataracts. The best-corrected visual acuity (BCVA), LOCS III nuclear opalescence (NO) and nuclear colour (NC) were obtained...
October 12, 2018: British Journal of Ophthalmology
Roman Michalik, Thorn Pauer, Nicolai Brill, Matthias Knobe, Markus Tingart, Holger Jahr, Daniel Truhn, Sven Nebelung
Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9mm, 1.1mm and 1.3mm diameter were created in the sub-surface regions of macroscopically intact human articular cartilage samples (n=60 defects of variable sizes in n=20 samples)...
October 9, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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