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Topical vitamin a

Vítor Ferreira, Cristiana Freixo, João Gonçalves, Gabriela Teixeira, Inês Antunes, Carlos Veiga, Daniel Mendes, Joana Martins, Rui Almeida
BACKGROUND: Optimal antithrombotic therapy after lower limb infra-inguinal revascularization remains a controversial topic. The use of anticoagulants, alone or in combination with antiplatelet drugs, can potentially improve patency rate and limb salvage, particularly in patients with risk factors for early thrombosis. Bleeding is the main complication of long term anticoagulant use. New oral anticoagulants can represent an attractive alternative to the standard vitamin K-antagonists. OBJECTIVE: evaluate the effectovemess (bypass occlusion and major amputation) and safety (major bleeding and all-cause mortality) of rivaroxaban compared to acenocoumarol after infra-inguinal lower limb surgical revascularization...
August 9, 2018: Annals of Vascular Surgery
Nilay Duman, Reşat Duman, Murat Tosun, Murat Akıcı, Engin Göksel, Barış Gökçe, Oğuzhan Alagöz
PURPOSE: Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model. MATERIALS AND METHODS: A rat wound model was established, and the wound healing was evaluated by macroscopic and histological analyses among vehicle control, 2...
August 6, 2018: Advances in Medical Sciences
James McMillan
Serial observations obtained over more than eight years and 10,000 patient encounters in a general ophthalmology practice serving a population highly prone to chronic vitamin D (D3) deficiency, facilitated by the Oculus Pentacam Scheimpflug imaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany), resulted in the recognition of consistent, predictable, and highly reproducible patterns of mechanical, optical, and physiologic change in the cornea and other ocular structures correlated to adequate vs. inadequate vitamin D availability...
June 5, 2018: Curēus
Sebastian Voß, Rieke Schnakenberg, Klaus Weckbecker, Markus Bleckwenn
Because of its high prevalence acute respiratory diseases have a significant impact on the population. The focus of this review was the current state of knowledge for the prophylactic efficacy of: zinc, vitamin C, Echinacea preparations, garlic and carrying out physical measures. Furthermore, the benefits of pneumococcal and influenza vaccine were elicited. In the synopsis, the physical measures proved to be the most effective, cost-effective method to prevent infections. The intake of zinc, Echinacea preparations (for example: E...
August 2018: Laryngo- Rhino- Otologie
Ugo Bottoni, Stefania Tamburrini, Elisabetta Scali, Stefano Dastoli, Giuseppe Fabrizio Amoruso, Giovanni Paolino, Elisa Moliterni, Teresa Grieco, Guglielmo Pranteda, Stefano Calvieri
Hand eczema is a chronic disease (1), commonly considered the expression of a contact allergic or irritative dermatitis. However, when the prick/patch tests and laboratory investigations are negative, important diagnostic challenges may arise. Peripheral nerve fibers are in fact capable of releasing neuromediators. Thus, an alteration of the central and/or peripheral nervous system can cause the exacerbation as well as the onset of a cutaneous disease (2). From September 1, 2013 to August 31, 2015, we observed 5 female patients between 20 and 40 years old, with particular hand dermatitis lesions on the volar area, unilateral on the right hand in 3 patients and bilateral in 2 patients...
December 2017: Acta Dermatovenerologica Croatica: ADC
Stephen C Bondy, Arezoo Campbell
There is considerable evidence that melatonin may be of use in the prevention and treatment of cancer. This manuscript will review some of the human, animal and cellular studies that provide evidence that melatonin has oncostatic properties. Confirmation that melatonin mitigates pathogenesis of cancer will be described from both direct study of its effects on carcinogenesis, and from indirect findings implicating disruption of the circadian cycle. A distinction is made between the role of melatonin in preventing the initiation of the tumorigenic pathway and the ability of melatonin to retard the progression of cancer...
July 27, 2018: International Journal of Molecular Sciences
Solmaz Akbari, Amir Alireza Rasouli-Ghahroudi
Bone is a metabolically active tissue that renews itself throughout one's life. Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling. Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. Vitamin K exerts its anabolic effect on the bone turnover in different ways such as promoting osteoblast differentiation, upregulating transcription of specific genes in osteoblasts, and activating the bone-associated vitamin k dependent proteins which play critical roles in extracellular bone matrix mineralization...
2018: BioMed Research International
Xin Liu, Xia Liao, Qiannan Ren, Meng Luo, Lei Yang, Jing Lin, Jie Chang
BACKGROUND: Complementary feeding (CF) is an important determinant of infant growth and development. However, CF practices are influenced by caregivers' perceptions and knowledge. This study aimed to describe perceptions and factors that potentially influence CF practices among Chinese mothers living in Xi'an, a rapidly developing city in China. METHODS: This focus group study included three discussion groups. Topics related to practices and concerns regarding CF were discussed among women with at least one child aged 4-36 months...
July 24, 2018: Journal of Health, Population, and Nutrition
Soheila Arefi, Gholamreza Khalili, Homa Iranmanesh, Fattaneh Farifteh, Ahmad Hosseini, Human M Fatemi, Barbara Lawrenz
BACKGROUND: In the recent years, vitamin D has become a topical subject and a focus of research not only in reproductive medicine but across many medical disciplines. In reproductive medicine, studies have identified an association between vitamin D status in women and ovarian reserve. In humans, exposure of the skin to sunlight is the main important source of vitamin D. A dress code of wearing concealing clothing is a risk factor for vitamin D deficiency. The objective of this prospective observational study was to evaluate the correlation between vitamin D deficiency and ovarian reserve in a population of infertile women in Iran...
July 24, 2018: Journal of Ovarian Research
Christina Bothou, Alexis Alexopoulos, Eleni Dermitzaki, Kleanthis Kleanthous, Anastasios Papadimitriou, George Mastorakos, Dimitrios T Papadimitriou
Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol...
2018: Case Reports in Pediatrics
Nhu T Nguyen, David E Fisher
Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning, vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing damaged DNA secrete both α-melanocyte-stimulating hormone (α-MSH), which stimulates pigment production by melanocytes, and the opioid β-endorphin, which can trigger addiction-like responses to UVR. The pigmentation (tanning) response is an adaptation that provides some delayed protection against further DNA damage and carcinogenesis, while the opioid response may be an evolutionary adaptation for promoting sun-seeking behavior to prevent vitamin D deficiency...
July 17, 2018: Pigment Cell & Melanoma Research
M Maarouf, A R Vaughn, V Y Shi
The role of dietary factors is an important and controversial topic in the pathogenesis of atopic dermatitis (AD). Despite the preponderance of consumer products utilizing oral micronutrients supplementation for relief AD symptoms, less attention has been paid on the utility of topical micronutrients, specifically for individuals with AD. We review evidence on topical formulations of vitamins (A, B, C, D, and E) and trace minerals (magnesium, manganese, zinc, and iodine) for treatment of AD. While topical B, C, and E formulations appear to provide some benefit to AD individuals, topical vitamin A has no utility, and topical vitamin D may exacerbate symptoms...
July 17, 2018: Dermatologic Therapy
R L Nelson, A Kravets, R Khateeb, M Raza, M Siddiqui, I Taha, A Tummala, R Epple, S Huang, M Wen
BACKGROUND: Among the techniques investigated to reduce the risk of surgical wound infection or surgical space infection (SSI) in patients having colorectal surgery are topical application of antimicrobials (antibiotics and antiseptics) to the open wound or immediately after closure. The aim of the present study was to perform a systematic review of the literature on those treatments, with the exception of antibiotic ointments applied to closed skin, which are adequately assessed elsewhere, and a meta-analysis...
July 17, 2018: Techniques in Coloproctology
Claudio Augusto Marroni, Alfeu Medeiros Fleck, Sabrina Alves Fernandes, Lucas Homercher Galant, Marcos Mucenic, Mario Henrique de Mattos Meine, Guilherme Mariante-Neto, Ajacio Bandeira de Mello Brandão
Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease (ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation (LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a "self-inflicted disease". One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide...
July 14, 2018: World Journal of Gastroenterology: WJG
Concepción Parrado, Neena Philips, Yolanda Gilaberte, Angeles Juarranz, Salvador González
Electromagnetic radiation in the ultraviolet, visible, and infrared ranges produces biologic effects in humans. Where some of these effects are beneficial, others are harmful to the skin, particularly those stemming from ultraviolet radiation (UVR). Pharmacological photoprotection can be topical or systemic. Systemic photoprotection is often administered orally, complementing topical protection. New and classic oral agents (e.g., essential micronutrients as vitamins, minerals, polyphenols, carotenoids) are endowed with photoprotective and anti-photocarcinogenic properties...
2018: Frontiers in Medicine
Krystal Iacopetta, Lyndsey E Collins-Praino, Femke T A Buisman-Pijlman, Jiajun Liu, Amanda D Hutchinson, Mark R Hutchinson
BACKGROUND: The clinical and preclinical exploration of the therapeutic properties of vitamin D have significantly increased in the past decade, owing to the growing associative evidence suggesting vitamin D is neuroprotective. However, whether depletion of vitamin D contributes to the onset of neurological disorders or is a symptom of neurological disease has yet to be defined. Much remains unclear about the causal role of vitamin D and the method of use and forms of vitamin D. OBJECTIVES: We sought to quantitatively assess if neuroprotective benefits from vitamin D in neurodegenerative diseases are dependent on route of administration: comparing the effect of endogenously sourced vitamin D from UV exposure to exogenously derived vitamin D through synthetic supplementation...
July 9, 2018: Nutritional Neuroscience
Guy Shalom, Devy Zisman, Meir Babaev, Amir Horev, Shmuel Tiosano, Yochai Schonmann, Doron Comaneshter, Arnon D Cohen
BACKGROUND: Updated data regarding the epidemiology of psoriasis and related healthcare utilization are lacking. OBJECTIVE: To investigate the epidemiology, comorbidities, healthcare services utilization, and drug use in a large group of patients with psoriasis from Clalit Health Services (CHS) database. METHODS: A controlled cross-sectional study was performed. Case patients were defined when there was at least one documented diagnosis of psoriasis registered by a CHS dermatologist between the years 1998-2016...
July 6, 2018: International Journal of Dermatology
Noreen Chikotas, Rebecca Toothaker
This article, the second in a two-part series, reviews and examines the components of clinical nutrition. In Part 2, the authors discuss nutritional components of fats, proteins, vitamins, minerals, and water. A resource guide is provided for the occupational health nurse to assist in the implementation of employee education in the area of healthy nutrition. The intent of the articles is to acquaint and inform the occupational health nurse on the current guidelines for healthy eating so she or he can better appraise their employee population, thus creating a healthier workforce...
July 1, 2018: Workplace Health & Safety
Katrien Corbeels, Lieve Verlinden, Matthias Lannoo, Caroline Simoens, Christophe Matthys, Annemieke Verstuyf, Ann Meulemans, Geert Carmeliet, Bart Van der Schueren
Bariatric surgery has proven to be a valuable treatment option for morbid obesity. However, these procedures can lead to impaired intestinal absorption of calcium and vitamin D, thereby challenging calcium homeostasis and possibly contributing to bone loss leading to an increased fracture risk. Besides calcium and vitamin D malabsorption, hormonal changes occurring after surgery can also be the source of observed bone loss. In this review, first, a case report will be discussed, highlighting the relevance of this topic...
June 2018: Bone Reports
Preethi B Nayak, Banavasi Shanmukha Girisha, Tonita Mariola Noronha, Handattu Sripathi
Context: Psoriasis is a chronic, systemic disease with the beneficial effect of topical vitamin D3 analogs, known for a long time. Low levels of vitamin D are increasingly found to be associated with the initial development of some autoimmune diseases. There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis. Aims: (1) To determine the serum levels of vitamin D, calcium and C-reactive protein (CRP) in patients with psoriasis vulgaris, (2) To compare these levels with the serum levels of controls, and (3) To correlate them with the severity of the disease...
May 2018: Indian Journal of Dermatology
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