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https://www.readbyqxmd.com/read/30120950/meta-analysis-of-gastroesophageal-reflux-disease-and-idiopathic-pulmonary-fibrosis
#1
David Bédard Méthot, Évelyne Leblanc, Yves Lacasse
BACKGROUND: The relationship between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that clinicians use regular antacid treatment, while 2 recent meta-analyses of antacid therapy in IPF were inconclusive. Our objective was to examine the evidence regarding the association between GERD and IPF through a systematic review and a meta-analysis, with special reference to the methodological quality of the observational studies...
August 15, 2018: Chest
https://www.readbyqxmd.com/read/30094577/conversion-of-sleeve-gastrectomy-to-roux-en-y-gastric-bypass
#2
Joshua P Landreneau, Andrew T Strong, John H Rodriguez, Essa M Aleassa, Ali Aminian, Stacy Brethauer, Philip R Schauer, Matthew D Kroh
INTRODUCTION: A subset of patients undergoing laparoscopic sleeve gastrectomy (SG) require eventual conversion to Roux-en-Y gastric bypass (RYGB) due to complications from SG or to enhance weight loss. The aim of this study is to characterize the indications for conversion and perioperative outcomes in a large cohort of these patients at a single institution. METHODS: Patients who underwent revisional surgery to convert SG to RYGB at our institution from January 2008 through January 2017 were retrospectively reviewed...
August 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30088531/the-role-of-the-transdiaphragmatic-pressure-gradient-in-the-pathophysiology-of-gastroesophageal-reflux-disease
#3
Leonardo M Del Grande, Fernando A M Herbella, Rafael C Katayama, Francisco Schlottmann, Marco G Patti
Gastroesophageal reflux disease (GERD) is the most common disease of the upper gastrointestinal tract in the Western world. GERD pathophysiology is multifactorial. Different mechanisms may contribute to GERD including an increase in the transdiaphragmatic pressure gradient (TPG). The pathophysiology of GERD linked to TPG is not entirely understood. This review shows that TPG is an important contributor to GERD even when an intact esophagogastric barrier is present in the setting of obesity and pulmonary diseases...
August 6, 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29953992/diagnosis-and-management-of-systemic-endemic-mycoses-causing-pulmonary-disease
#4
Helmut J F Salzer, Gerd Burchard, Oliver A Cornely, Christoph Lange, Thierry Rolling, Stefan Schmiedel, Michael Libman, Domenico Capone, Thuy Le, Margareth P Dalcolmo, Jan Heyckendorf
Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Coccidioidomycosis and paracoccidioidomycosis are restricted to the Americas only, and while histoplasmosis and blastomycosis also occur predominantly in the Americas, these mycoses have also been reported on other continents, especially in sub-Saharan Africa...
June 28, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29773294/gastroesophageal-reflux-symptoms-and-nasal-symptoms-affect-the-severity-of-bronchitis-symptoms-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Koichi Hasegawa, Susumu Sato, Kazuya Tanimura, Yoshinori Fuseya, Kiyoshi Uemasu, Yoko Hamakawa, Atsuyasu Sato, Michiaki Mishima, Shigeo Muro, Toyohiro Hirai
BACKGROUND: Cough and sputum production (symptoms of bronchitis) are common in chronic obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as gastroesophageal reflux disease (GERD) and post-nasal drip, also cause bronchitis symptoms. The impact of extrapulmonary comorbidities on the severity of bronchitis symptoms in COPD is unknown. The aim of this study was to quantify bronchitis symptoms and assess the impact of GERD and nasal symptoms on the severity of bronchitis symptoms in COPD...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29769114/-68-ga-psma-pet-ct-for-the-evaluation-of-pulmonary-metastases-and-opacities-in-patients-with-prostate-cancer
#6
Jonathan Damjanovic, Jan-Carlo Janssen, Christian Furth, Gerd Diederichs, Thula Walter, Holger Amthauer, Marcus R Makowski
BACKGROUND: The purpose of this study was to investigate the imaging properties of pulmonary metastases and benign opacities in 68 Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC). METHODS: 68 Ga-PSMA-PET/CT scans of 739 PC patients available in our database were evaluated retrospectively for lung metastases and non-solid focal pulmonary opacities. Maximum standardized uptake values (SUVmax ) were assessed by two- and three-dimensional regions of interest (2D/3D ROI)...
May 16, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29766521/current-and-future-perspectives-in-the-management-of-gastroesophageal-reflux-disease
#7
REVIEW
Junichi Akiyama, Shiko Kuribayashi, Myong Ki Baeg, Nicola de Bortoli, Elen Valitova, Edoardo V Savarino, Motoyasu Kusano, George Triadafilopoulos
Although the prevalence of gastroesophageal reflux disease (GERD) used to be lower in East Asia as compared to Western countries, it has recently been increasing, most likely due to the socioeconomic development in the East. The prevalence of both GERD and functional gastrointestinal disorders (FGIDs) ranges between 10% and 25% worldwide and there are distinct subgroups of patients with overlapping of GERD and FGIDs. However, the true prevalence of an overlap between GERD and FGIDs can be determined only when a formal pathophysiological evaluation has been performed...
May 16, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29716632/multi-cellular-human-bronchial-models-exposed-to-diesel-exhaust-particles-assessment-of-inflammation-oxidative-stress-and-macrophage-polarization
#8
Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde, Lena Palmberg
BACKGROUND: Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epithelial cells and their cell-cell interaction plays a crucial role. Therefore, in this study we aimed at studying the cellular crosstalk between airway epithelial cells with MQ and MQ polarization following exposure to aerosolized DEP by assessing inflammation, oxidative stress, and MQ polarization response markers...
May 2, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29642692/noncardiac-chest-pain-a-2018-update
#9
Marilena Durazzo, Giuseppe Gargiulo, Rinaldo Pellicano
Noncardiac chest pain (NCCP) is defined as recurring, angina-like, chest pain of noncardiac origin. Studies have estimated that gastroesophageal reflux disease (GERD) is the most common contributing factor for NCCP. In patients with non-GERD related NCCP, esophageal motility disorders, and functional chest pain (FCP) of presumed esophageal origin are the main underlying mechanisms for symptoms. Epidemiologic studies show a high prevalence of panic disorder, anxiety and major depression in NCCP patients. The diagnostic esophageal workup starts only after that cardiac and pulmonary diseases have been ruled out...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29617746/thoracoabdominal-pressure-gradient-and-gastroesophageal-reflux-insights-from-lung-transplant-candidates
#10
T Masuda, S K Mittal, B Kovacs, M Smith, R Walia, J Huang, R M Bremner
Advanced lung disease is associated with gastroesophageal reflux disease (GERD). The thoracoabdominal pressure gradient (TAPG) facilitates gastroesophageal reflux, but the effects of TAPG on gastroesophageal reflux in patients with pulmonary disease have not been well defined. Patients diagnosed with end-stage lung disease are expected to have the most extreme derangement in respiratory mechanics. The aim of this study is to explore the relationship between TAPG and reflux in lung transplant (LTx) candidates...
March 31, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29599188/prognostic-impact-of-copeptin-in-pulmonary-embolism-a-multicentre-validation-study
#11
Kristian Hellenkamp, Piotr Pruszczyk, David Jiménez, Anna Wyzgał, Deisy Barrios, Michał Ciurzyński, Raquel Morillo, Lukas Hobohm, Karsten Keller, Katarzyna Kurnicka, Maciej Kostrubiec, Rolf Wachter, Gerd Hasenfuß, Stavros Konstantinides, Mareike Lankeit
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 patients (2.5%, 95% CI 1.5-3.8) had an adverse outcome and 12 (1.4%, 95% CI 0.7-2.5) died due to PE. Patients with copeptin ≥24 pmol·L-1 had a 6.3-fold increased risk for an adverse outcome (95% CI 2.6-15.5, p<0.001) and a 7...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29579581/midazolam-addition-to-analgosedation-for-pulmonary-vein-isolation-may-increase-risk-of-hypercapnia-and-acidosis
#12
Bernhard M Kaess, Florian Feurich, Gerd Bürkle, Joachim R Ehrlich
BACKGROUND: Pulmonary vein isolation (PVI) is generally performed under analgosedation, but sedation protocols vary and no optimal protocol has been defined. We investigated procedural, respiratory and hemodynamic parameters in patients undergoing PVI using analgosedation either with or without midazolam. METHODS: In a prospective observational study, we compared n = 43 consecutive patients (54% male, mean age 62 years) undergoing PVI using analgosedation either with or without midazolam added to propofol and fentanyl...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29560670/current-status-of-gastroesophageal-reflux-disease-diagnosis-and-treatment
#13
REVIEW
Tang-Wei Chuang, Shou-Chien Chen, Kow-Tong Chen
AIMS: The aim of this study was to explore the recent advances in diagnosis and treatment of gastroesophageal reflux disease (GERD). METHODS: Previous studies were searched using the terms "gastroesophageal reflux disease" and "diagnosis" or "treatment" in Medline and Pubmed. Articles that were not published in the English language, manuscripts without an abstract, reviews, meta-analysis, and opinion articles were excluded from the review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29513175/current-status-of-gastroesophageal-reflux-disease-diagnosis-and-treatment
#14
REVIEW
T-W Chuang, S-C Chen, K-T Chen
AIMS: The aim of this study was to explore the recent advances in diagnosis and treatment of gastroesophageal reflux disease (GERD). METHODS: Previous studies were searched using the terms "gastroesophageal reflux disease" and "diagnosis" or "treatment" in Medline and Pubmed. Articles that were not published in the English language, manuscripts without an abstract, reviews, meta-analysis, and opinion articles were excluded from the review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29504332/gastro-oesophageal-reflux-diseases-in-chronic-obstructive-pulmonary-disease-patients
#15
Hamid Nisar Khan, Amir Suleman, Raza Ullah, Azmat Abdullah, Shahida Naz
BACKGROUND: There is an association of Gastroesophageal reflux disease (GERD) with chronic obstructive pulmonary disease (COPD). This study was designed to determine the frequency of GERD in COPD patients. METHODS: This descriptive, cross-sectional study was conducted in the Pulmonology Unit Ayub Teaching Hospital Abbottabad. Patients more than 40 years of age of both genders presenting with features of COPD such as cough and breathlessness for more than 6 months and confirmed by spirometry were included in the study...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#16
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29435748/surgery-for-benign-esophageal-disorders-in-the-us-risk-factors-for-complications-and-trends-of-morbidity
#17
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Gastroesophageal reflux disease (GERD), paraesophageal hernia (PEH), and achalasia are the most frequent benign esophageal disorders that may need surgical treatment. We aimed to identify risk factors for postoperative complications and to characterize trends of morbidity for surgery for benign esophageal disorders in a national cohort. METHODS: A retrospective population-based analysis was performed using the National Inpatient Sample for the period 2000-2013...
August 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29429996/application-of-light-sheet-microscopy-for-qualitative-and-quantitative-analysis-of-bronchus-associated-lymphoid-tissue-in-mice
#18
David Twapokera Mzinza, Henrike Fleige, Kristin Laarmann, Stefanie Willenzon, Jasmin Ristenpart, Julia Spanier, Gerd Sutter, Ulrich Kalinke, Peter Valentin-Weigand, Reinhold Förster
Bronchus-associated lymphoid tissue (BALT) develops at unpredictable locations around lung bronchi following pulmonary inflammation. The formation and composition of BALT have primarily been investigated by immunohistology that, due to the size of the invested organ, is usually restricted to a limited number of histological sections. To assess the entire BALT of the lung, other approaches are urgently needed. Here, we introduce a novel light sheet microscopy-based approach for assessing lymphoid tissue in the lung...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29428028/chronic-obstructive-pulmonary-disease-exacerbations-are-influenced-by-gastroesophageal-reflux-disease
#19
Amilcar M Bigatao, Fernando A M Herbella, Leonardo M Del Grande, Oliver A Nascimento, Jose R Jardim, Marco G Patti
Gastroesophageal reflux disease (GERD) is associated with different pulmonary diseases, including chronic obstructive pulmonary disease (COPD). Whether GERD is contributory to COPD severity remains unclear. This study aims to evaluate the contribution of GERD to the clinical manifestation of COPD based on ventilatory parameters and yearly clinical exacerbations. We studied 48 patients (56% females, age 66 years) with COPD. All patients underwent high-resolution manometry and esophageal pH monitoring. The patients were separated into two groups according to the presence of GERD...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29427733/extraesophageal-symptoms-and-diseases-attributed-to-gerd-where-is-the-pendulum-swinging-now
#20
Michael F Vaezi, David Katzka, Frank Zerbib
The purpose of this review is to outline the recent developments in the field of extraesophageal reflux disease and provide clinically relevant recommendations. The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed and EMbase. The Clinical Practice Updates Committee of the American Gastroenterological Association proposes the following recommendations: Best Practice Advice 1: The role of a gastroenterologist in patients referred for evaluation of suspected extra esophageal symptom is to assess for gastroesophageal etiologies that could contribute to the presenting symptoms...
July 2018: Clinical Gastroenterology and Hepatology
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