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GERD and pulmonary

Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi, Pierluigi Paggiaro
Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma. Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. We collected demographic data, smoking habit, asthma history, and assessment of comorbidities...
2018: Clinical and Molecular Allergy: CMA
Houman Goudarzi, Satoshi Konno, Hirokazu Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M Ito, Masaharu Nishimura
BACKGROUND: Previous studies have shown the association of anthropometric measures with poor asthma symptoms, especially among women. However, the potential influence of visceral adiposity on asthma symptoms has not been investigated well. OBJECTIVE: In this study, we have evaluated whether visceral adiposity is related to poor adult asthma symptoms independent of anthropometric measures and sex. If this relationship presented, we investigated whether it is explained by influence on pulmonary functions and/or obesity-related comorbidities...
November 23, 2018: Journal of Allergy and Clinical Immunology in Practice
K El Chehadeh, F Becmeur, L Weiss
INTRODUCTION: Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) and digestive (gastroesophageal reflux disease [GERD])...
November 22, 2018: Revue de Pneumologie Clinique
Linda Ejlskov, Henrik Bøggild, Claus D Hansen, Jesper Wulff, Steen M Hansen, Liis Starkopf, Theis Lange, Thomas Gerds, Christian Torp-Pedersen
Background: Early-life socioeconomic position (SEP) is associated with lifestyle-related diseases in adulthood. However, evidence is lacking on the extent to which adult SEP mediates this association. Methods: Time to either chronic obstructive pulmonary disease (COPD), cardiovascular disease or diabetes were assessed in the Danish population born between 1961 and 1971 (n = 793 674) from age 30 until 2015. Early-life position was assessed in 1981 (by parental) and again at age 30 (own) by four markers; income, occupation, education-divided into high, middle, low-and a combined score for all markers...
November 14, 2018: European Journal of Public Health
Simen A Steindal, Henny Torheim, Trine Oksholm, Vivi L Christensen, Kathryn Lee, Anners Lerdal, Heidi Øksnes Markussen, Gerd Gran, Marit Leine, Christine Råheim Borge
AIM: To critically review and synthesize the findings of studies that evaluated the effectiveness of nursing interventions for improving breathlessness in adults with chronic obstructive pulmonary disease. BACKGROUND: Systematic reviews of nursing interventions for breathlessness in people with chronic obstructive pulmonary disease have not been specifically addressed. DESIGN: Systematic review with meta-analysis. DATA SOURCES: A systematic search of Medline, CINAHL, PsycINFO and Embase was performed for studies published between January 2000 - June 2017...
November 5, 2018: Journal of Advanced Nursing
Jeffrey Wessler, David Kaye, Finn Gustafsson, Mark C Petrie, Gerd Hasenfuβ, Carolyn S P Lam, Barry A Borlaug, Jan Komtebedde, Ted Feldman, Sanjiv J Shah, Daniel Burkhoff
Background Interatrial shunt device (IASD) effects have been described in patients with heart failure and ejection fractions (EFs) ≥40%. However, baseline characteristics that correlate with greatest hemodynamic effects are unknown. On the basis of fundamental principles, we hypothesized that larger pressure gradients between left and right atria would yield greater shunt flow and greater hemodynamic effects. Methods and Results REDUCE LAP-HF (Reduce Elevated Left Atrial Pressure in Patients With Heart Failure) was a multicenter study that investigated IASD safety and performance...
August 2018: Circulation. Heart Failure
Marion Delcroix, Gerd Staehler, Henning Gall, Ekkehard Grünig, Matthias Held, Michael Halank, Hans Klose, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Joanna Pepke-Zaba, Christian F Opitz, J Simon R Gibbs, Tobias J Lange, Iraklis Tsangaris, Doerte Huscher, David Pittrow, Karen M Olsson, Marius M Hoeper
Abbre via ted versions of the ESC/ERS pulmonary hypertension guidelines risk stratification have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (WHO functional class, 6-minute walking distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation)...
October 18, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Alfredo D Guerron, Camila B Ortega, Hui-Jie Lee, Gerardo Davalos, Jennifer Ingram, Dana Portenier
INTRODUCTION: Asthma is an important healthcare problem affecting millions in the United States. Additionally, a large proportion of patients with asthma suffer from obesity. These patients exhibit poor asthma control and reduced therapy response, increasing utilization of healthcare resources. Pulmonary symptoms improve after bariatric surgery (BS), and we hypothesized that asthma medication usage would decrease following BS. METHODS: A retrospective data analysis was performed in adult patients from a single institution's database...
October 17, 2018: Surgical Endoscopy
Othmar Moser, Gerhard Tschakert, Alexander Mueller, Werner Groeschl, Max L Eckstein, Gerd Koehler, Richard M Bracken, Thomas R Pieber, Peter Hofmann
To investigate the heart rate during cardio-pulmonary exercise (CPX) testing in individuals with type 1 diabetes (T1D) compared to healthy (CON) individuals. Fourteen people (seven individuals with T1D and seven CON individuals) performed a CPX test until volitional exhaustion to determine the first and second lactate turn points (LTP1 and LTP2 ), ventilatory thresholds (VT1 and VT2 ), and the heart rate turn point. For these thresholds cardio-respiratory variables and percentages of maximum heart rate, heart rate reserve, maximum oxygen uptake and oxygen uptake reserve, and maximum power output were compared between groups...
2018: Frontiers in Endocrinology
David M Kaye, Mark C Petrie, Scott McKenzie, Gerd Hasenfuβ, Filip Malek, Martijn Post, Robert N Doughty, Jean-Noël Trochu, Finn Gustafsson, Irene Lang, Adam Kolodziej, Ralf Westenfeld, Martin Penicka, Mark Rosenberg, Jörg Hausleiter, Philip Raake, Guillaume Jondeau, Martin W Bergmann, Tim Spelman, Huseyin Aytug, Piotr Ponikowski, Chris Hayward
AIMS: Impaired left ventricular diastolic function leading to elevated left atrial pressures, particularly during exertion, is a key driver of symptoms and outcomes in heart failure with preserved ejection fraction (HFpEF). Insertion of an interatrial shunt device (IASD) to reduce left atrial pressure in HFpEF has been shown to be associated with short-term haemodynamic and symptomatic benefit. We aimed to investigate the potential effects of IASD placement on HFpEF survival and heart failure hospitalization (HFH)...
October 11, 2018: ESC Heart Failure
Zheng Wang, Francesco Bonella, Wenting Li, Eda B Boerner, Qiongya Guo, Xianglong Kong, Xiaoju Zhang, Ulrich Costabel, Michael Kreuter
The mechanisms of idiopathic pulmonary fibrosis (IPF), a rare, devastating disease with a median survival of 3-5 years, are not fully understood. Gastroesophageal reflux disease (GERD) is a frequent comorbidity encountered in IPF. Hypothetically, GERD-associated microaspiration may lead to persistent inflammation impairing lung infrastructure, thereby possibly accelerating the progression of IPF. IPF may increase intrathoracic pressure, which can aggravate GERD and vice versa. On the basis of the possible beneficial effects of antireflux or antacid therapy on lung function, acute exacerbation, and survival, the recent international IPF guideline recommends antacid therapies for patients with IPF, regardless of symptomatic GERD...
2018: Respiration; International Review of Thoracic Diseases
Valentina Biasin, Malgorzata Wygrecka, Thomas Bärnthaler, Katharina Jandl, Pritesh P Jain, Zoltán Bálint, Gabor Kovacs, Gerd Leitinger, Dagmar Kolb-Lenz, Karin Kornmueller, Florian Peters, Katharina Sinn, Walter Klepetko, Akos Heinemann, Andrea Olschewski, Christoph Becker-Pauly, Grazyna Kwapiszewska
Pulmonary arterial hypertension (PAH) is a rare disease characterized by increased pulmonary pressure and vascular remodelling as a consequence of smooth muscle cell proliferation, endothelial cell dysfunction and inflammatory infiltrates. Meprin α is a metalloproteinase whose substrates include adhesion and cell-cell contact molecules involved in the process of immune cell extravasation. In this study, we aimed to unravel the role of meprin α in PAH-induced vascular remodelling. Our results showed that meprin α was present in the apical membrane of endothelial cells in the lungs and pulmonary arteries of donors and idiopathic PAH (IPAH) patients...
October 2018: Thrombosis and Haemostasis
Gabor Kovacs, Daniel Dumitrescu, Andreas Barner, Sebastian Greiner, Ekkehard Grünig, Alfred Hager, Thomas Köhler, Rainer Kozlik-Feldmann, Irmtraut Kruck, Astrid E Lammers, Derliz Mereles, Andreas Meyer, Joachim Meyer, Stefan Pabst, Hans-Jürgen Seyfarth, Christoph Sinning, Stephan Sorichter, Gerd Stähler, Heinrike Wilkens, Matthias Held
In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the 2015 European Pulmonary Hypertension guidelines, aiming at their practical implementation, considering country-specific issues, and including new evidence, where available...
August 27, 2018: International Journal of Cardiology
Srikanth Karnati, Vannuruswamy Garikapati, Gerhard Liebisch, Paul P Van Veldhoven, Bernhard Spengler, Gerd Schmitz, Eveline Baumgart-Vogt
Lipids play very important roles in lung biology, mainly reducing the alveolar surface tension at the air-liquid interface thereby preventing end-expiratory collapse of the alveoli. In the present study we performed an extensive quantitative lipidomic analysis of mouse lung to provide the i) total lipid quantity, ii) distribution pattern of the major lipid classes, iii) composition of individual lipid species and iv) glycerophospholipid distribution pattern according to carbon chain length (total number of carbon atoms) and degree of unsaturation (total number of double bonds)...
2018: PloS One
David Bédard Méthot, Évelyne Leblanc, Yves Lacasse
BACKGROUND: The relationship between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that clinicians use regular antacid treatment, while two recent meta-analyses of antacid therapy in IPF were inconclusive. The objective of this study was to examine the evidence regarding the association between GERD and IPF through a systematic review and a meta-analysis, with special reference to the methodologic quality of the observational studies...
August 16, 2018: Chest
Joshua P Landreneau, Andrew T Strong, John H Rodriguez, Essa M Aleassa, Ali Aminian, Stacy Brethauer, Philip R Schauer, Matthew D Kroh
INTRODUCTION: A subset of patients undergoing laparoscopic sleeve gastrectomy (SG) require eventual conversion to Roux-en-Y gastric bypass (RYGB) due to complications from SG or to enhance weight loss. The aim of this study is to characterize the indications for conversion and perioperative outcomes in a large cohort of these patients at a single institution. METHODS: Patients who underwent revisional surgery to convert SG to RYGB at our institution from January 2008 through January 2017 were retrospectively reviewed...
December 2018: Obesity Surgery
Leonardo M Del Grande, Fernando A M Herbella, Rafael C Katayama, Francisco Schlottmann, Marco G Patti
Gastroesophageal reflux disease (GERD) is the most common disease of the upper gastrointestinal tract in the Western world. GERD pathophysiology is multifactorial. Different mechanisms may contribute to GERD including an increase in the transdiaphragmatic pressure gradient (TPG). The pathophysiology of GERD linked to TPG is not entirely understood. This review shows that TPG is an important contributor to GERD even when an intact esophagogastric barrier is present in the setting of obesity and pulmonary diseases...
August 6, 2018: Arquivos de Gastroenterologia
Helmut J F Salzer, Gerd Burchard, Oliver A Cornely, Christoph Lange, Thierry Rolling, Stefan Schmiedel, Michael Libman, Domenico Capone, Thuy Le, Margareth P Dalcolmo, Jan Heyckendorf
Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Coccidioidomycosis and paracoccidioidomycosis are restricted to the Americas only, and while histoplasmosis and blastomycosis also occur predominantly in the Americas, these mycoses have also been reported on other continents, especially in sub-Saharan Africa...
2018: Respiration; International Review of Thoracic Diseases
Koichi Hasegawa, Susumu Sato, Kazuya Tanimura, Yoshinori Fuseya, Kiyoshi Uemasu, Yoko Hamakawa, Atsuyasu Sato, Michiaki Mishima, Shigeo Muro, Toyohiro Hirai
BACKGROUND: Cough and sputum production (symptoms of bronchitis) are common in chronic obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as gastroesophageal reflux disease (GERD) and post-nasal drip, also cause bronchitis symptoms. The impact of extrapulmonary comorbidities on the severity of bronchitis symptoms in COPD is unknown. The aim of this study was to quantify bronchitis symptoms and assess the impact of GERD and nasal symptoms on the severity of bronchitis symptoms in COPD...
May 2018: Respiratory Investigation
Jonathan Damjanovic, Jan-Carlo Janssen, Christian Furth, Gerd Diederichs, Thula Walter, Holger Amthauer, Marcus R Makowski
BACKGROUND: The purpose of this study was to investigate the imaging properties of pulmonary metastases and benign opacities in 68 Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC). METHODS: 68 Ga-PSMA-PET/CT scans of 739 PC patients available in our database were evaluated retrospectively for lung metastases and non-solid focal pulmonary opacities. Maximum standardized uptake values (SUVmax ) were assessed by two- and three-dimensional regions of interest (2D/3D ROI)...
May 16, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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