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https://www.readbyqxmd.com/read/30450047/effect-of-total-flavonoids-of-rhizoma-drynariae-on-tibial-dyschondroplasia-by-regulating-bmp-2-and-runx2-expression-in-chickens
#1
Wangyuan Yao, Hui Zhang, Xiong Jiang, Khalid Mehmood, Mujahid Iqbal, Aoyun Li, Jialu Zhang, Yaping Wang, Muhammad Waqas, Yaoqin Shen, Jiakui Li
Tibial dyschondroplasia (TD) is an abnormality of the growth cartilage that occurs in chickens and other rapidly growing avian species. This disease not only cause huge economic losses, but also greatly affects animal welfare. The total flavonoids of Rhizoma drynariae (TFRD) has been used to cure wide variety of diseases including bone fractures and osteoarthritis and osteoporosis. However, less information is available about the using of TFRD against the TD. The aim of this study was to determine the effect of TFRD on TD by regulating BMP-2 and Runx2 in chickens...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30446146/jellylike-flexible-nanocellulose-sers-substrate-for-rapid-in-situ-non-invasive-pesticide-detection-in-fruits-vegetables
#2
Jie Chen, Meizhen Huang, Lili Kong, Mengshi Lin
This study aimed to develop a jellylike flexible substrate based on nanocellulose decorated with Ag nanoparticles (Ag/NC substrate) and explore its applications for rapid in-situ pesticide detections in fruits and vegetables by surface-enhanced Raman spectroscopy (SERS). The performances of Ag/NC substrate were characterized by rhodamine 6G (R6G). The limit of detection recorded by a portable Raman spectrometer is 10-8 M. The substrate still exhibited satisfactory sensitivity after 60-day preservation. Jellylike and slightly sticky Ag/NC substrate demonstrated good adaptabilities in attaching to sample surfaces and is suitable for in-situ SERS detection...
February 1, 2019: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30408483/the-case-for-thyroid-disruption-in-early-life-stage-exposures-to-thiram-in-zebrafish-danio-rerio
#3
Xing Chen, Mingliang Fang, Melissa Chernick, Feng Wang, Jingfeng Yang, Yongli Yu, Na Zheng, Hiroki Teraoka, Satomi Nanba, Takeo Hiraga, David E Hinton, Wu Dong
Thiram, a pesticide in the dithiocarbamate chemical family, is widely used to prevent fungal disease in seeds and crops. Its off-site movement to surface waters occurs and may place aquatic organisms at potential harm. Zebrafish embryos were used for investigation of acute (1 h) thiram exposure (0.001-10 µM) at various developmental stages. Survival decreased at 1 µM and 10 µM and hatching was delayed at 0.1 µM and 1 µM. Notochord curvatures were seen at 0.1 and 1 μM thiram when exposure was initiated at 2 and at 10 hpf...
November 5, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/30388538/ligustrazine-recovers-thiram-induced-tibial-dyschondroplasia-in-chickens-involvement-of-new-molecules-modulating-integrin-beta-3
#4
Khalid Mehmood, Hui Zhang, Xiong Jiang, Wangyuan Yao, Xiaole Tong, Muhammad Kashif Iqbal, Mujeeb Ur Rehman, Mujahid Iqbal, Muhammad Waqas, Hammad Qamar, Jialu Zhang, Jiakui Li
Tetramethyl thiuram disulfide (thiram) is a dithiocarbamate, which is extensively used in agriculture as pesticide and fungicide for treating grains intended for seed purposes and also for storing food grains. One of the most evident and detrimental effect produced by thiram is tibial dyschondroplasia (TD) in many avian species, by feeding diets containing thiram, a growth plate cartilage disease. TD is characterized by the lack of blood vessels and impaired vascular invasion of the hypertrophic chondrocyte resulting in the massive cell death...
October 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30375227/multilayer-ag-embedded-silica-nanostructure-as-a-surface-enhanced-raman-scattering-based-chemical-sensor-with-dual-function-internal-standards
#5
Eunil Hahm, Myeong Geun Cha, Eun Ji Kang, Xuan-Hung Pham, Sang Hun Lee, Hyung-Mo Kim, Dong-Eun Kim, Yoon-Sik Lee, Dae-Hong Jeong, Bong-Hyun Jun
Surface-enhanced Raman scattering (SERS) spectroscopy is attractive in various detection analysis fields. However, the quantitative method using SERS spectroscopy remains as an area to be developed. The key issues in developing quantitative analysis methods by using SERS spectroscopy are the fabrication of reliable SERS-active materials such as nanoparticle-based structures and the acquisition of the SERS signal without any disturbance that may change the SERS signal intensity and frequency. Here, the fabrication of seamless multilayered core-shell nanoparticles with an embedded Raman label compound as an internal standard (MLRLC dots) for quantitative SERS analysis is reported...
November 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30288550/head-skeleton-malformations-in-zebrafish-danio-rerio-to-assess-adverse-effects-of-mixtures-of-compounds
#6
Yvonne C M Staal, Jeroen Meijer, Remco J C van der Kris, Annamaria C de Bruijn, Anke Y Boersma, Eric R Gremmer, Edwin P Zwart, Piet K Beekhof, Wout Slob, Leo T M van der Ven
The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several levels, including the target organ and specific phenotype. Here, we explore the zebrafish embryo as a test model for quantitative evaluation in one such CAG, skeletal malformations, through exposure to test compounds 0-120 hpf and alcian blue cartilage staining at 120 hpf, focusing on the head skeleton...
October 4, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30219319/molecular-heterozygosity-and-genetic-exploitations-of-trichoderma-inter-fusants-enhancing-tolerance-to-fungicides-and-mycoparasitism-against-sclerotium-rolfsii-sacc
#7
Darshna G Hirpara, H P Gajera
Protoplast fusion is an imperative tool to develop Trichoderma inter-fusants having desire traits through genetic manipulation. Study designed to develop diverse Trichoderma fusants for fungicide tolerance (Mancozeb, Thiram, Tebuconazole, and Carbendazim) and enhanced mycoparasitic activity against Sclerotium rolfsii sacc. The mycoparasitic T. virens NBAII Tvs12 and fungicide tolerant T. koningii MTCC 796 were utilized for protoplast fusion. The derived inter-fusants were subjected to diploidization using d-camphor in minimal media followed by successive three sub culturing onto potato dextrose agar to obtain 36 stable fusants...
September 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30165245/identification-of-apoptosis-related-genes-in-erythrocytes-of-broiler-chickens-and-their-response-to-thiram-induced-tibial-dyschondroplasia-and-recombinant-glutathione-s-transferase-a3-protein
#8
C X Wang, S Niu, A R Jahejo, F J Jia, Z Li, N Zhang, G B Ning, D Zhang, H Q Li, H L Ma, W F Hao, W W Gao, S M Gao, J H Li, G L Li, F Yan, R K Gao, Y J Zhao, H C Chen, W X Tian
Thiram, a carbamate pesticide, is known to induce tibial dyschondroplasia (TD) in broiler chickens. This study used a thiram-induced TD model to explore whether apoptosis-related genes were expressed in erythrocytes of broiler chickens and the impacts of thiram-induced TD and the recombinant GSTA3 protein in regulating these genes expression. In this study, mRNA and protein expression of six types of apoptosis-related genes (Bcl-2, Bax, Murine double minute MDM2, Bcl-2-associated athanogene BAG-1, BAG-3, STAT3) were identified in erythrocytes of broiler chickens by real-time PCR and immunohistochemistry, and we also found that thiram-induced TD induced the decreased expression of these antiapoptotic genes in the initial stage of TD and promoted their expression in TD recovery, which suggested that the expression of these apoptosis-related genes in erythrocytes is highly related to the development of TD...
August 23, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/30126248/direct-detection-of-toxic-contaminants-in-minimally-processed-food-products-using-dendritic-surface-enhanced-raman-scattering-substrates
#9
Hannah Dies, Maria Siampani, Carlos Escobedo, Aristides Docoslis
We present a method for the surface-enhanced Raman scattering (SERS)-based detection of toxic contaminants in minimally processed liquid food products, through the use of a dendritic silver nanostructure, produced through electrokinetic assembly of nanoparticles from solution. The dendritic nanostructure is produced on the surface of a microelectrode chip, connected to an AC field with an imposed DC bias. We apply this chip for the detection of thiram, a toxic fruit pesticide, in apple juice, to a limit of detection of 115 ppb, with no sample preprocessing...
August 19, 2018: Sensors
https://www.readbyqxmd.com/read/30098867/inhibition-of-the-lox-enzyme-family-members-with-old-and-new-ligands-selectivity-analysis-revisited
#10
István Hajdú, József Kardos, Balázs Major, Gabriella Fabó, Zsolt Lőrincz, Sándor Cseh, György Dormán
Lysyl oxidase (LOX) enzymes as potential drug targets maintain constant attention in the therapy of fibrosis, cancer and metastasis. In order to measure the inhibitory activity of small molecules on the LOX enzyme family members a fluorometric activity screening method was developed. During assay validation, previously reported non-selective small inhibitor molecules (BAPN, MCP-1, thiram, disulfiram) were investigated on all of the major LOX enzymes. We confirmed that MCP-1, thiram, disulfiram are in fact pan-inhibitors, while BAPN inhibits only LOX-like enzymes (preferably LOX-like-protein-2, LOXL2) in contrast to the previous reports...
October 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30076550/effect-of-tetramethyl-thiuram-disulfide-thiram-in-relation-to-tibial-dyschondroplasia-in-chickens
#11
Hui Zhang, Khalid Mehmood, Xiong Jiang, Wangyuan Yao, Mujahid Iqbal, Muhammad Waqas, Mujeeb Ur Rehman, Aoyun Li, Yaoqin Shen, Jiakui Li
Tetramethyl thiuram disulfide (thiram) is one of the important pesticides, which is extensively used in agriculture, but if it is combined with the cell membrane, then it causes membrane damage, bone morphogenic inactivation, and inhibited angiogenesis. Thiram has been considered a common cause of tibial dyschondrolplasia (TD) in various avian species, because it becomes the part of feed due to environmental contamination and its overuse in agriculture as pesticides or fungicide. However, there is no systematic study on the changes of the correlation indexes with toxic effect of the thiram in chickens...
October 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30004119/clinical-efficiency-and-safety-of-hsp90-inhibitor-novobiocin-in-avian-tibial-dyschondroplasia
#12
Fazul Nabi, Muhammad K Iqbal, Hui Zhang, Mujeeb Ur Rehman, Muhammad Shahzad, Shucheng Huang, Zhaoqing Han, Khalid Mehmood, Nisar Ahmed, Bahram Chachar, Muhammad A Arain, Jiakui Li
Tibial dyschondroplasia (TD) is a bone defect of broilers and other poultry birds that disturbs growth plate and it causes lameness. Previously we evaluated differential expression of multiple genes involved in growth plate angiogenesis and reported the safety and efficacious of medicinal plant root extracted for controlling TD. In this study, clinical and protective effect of an antibiotic Novobiocin (Hsp90 inhibitor) and expression of Hsp90 and proteoglycan aggrecan was examined. The chicks were divided into three groups; Control, thiram-induced TD, and Novobiocin injected TD...
December 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30002295/large-scale-fabrication-of-ultrasensitive-and-uniform-surface-enhanced-raman-scattering-substrates-for-the-trace-detection-of-pesticides
#13
Jia Zhu, Guanzhou Lin, Meizhang Wu, Zhuojie Chen, Peimin Lu, Wengang Wu
Technology transfer from laboratory into practical application needs to meet the demands of economic viability and operational simplicity. This paper reports a simple and convenient strategy to fabricate large-scale and ultrasensitive surface-enhanced Raman scattering (SERS) substrates. In this strategy, no toxic chemicals or sophisticated instruments are required to fabricate the SERS substrates. On one hand, Ag nanoparticles (NPs) with relatively uniform size were synthesized using the modified Tollens method, which employs an ultra-low concentration of Ag⁺ and excessive amounts of glucose as a reducing agent...
July 12, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30001109/polydopamine-gold-nanowaxberry-enabling-improved-sers-sensing-of-pesticides-pollutants-and-explosives-in-complex-samples
#14
Dongzhen Chen, Xiaodong Zhu, Jian Huang, Gen Wang, Yue Zhao, Feng Chen, Jing Wei, Zhongxiao Song, Yongxi Zhao
Surface-enhanced Raman scattering (SERS) is a promising analysis technique for detecting various analytes in complex samples due to its unique vibrational fingerprints and high signal enhancement. However, impurity interference and substrate unreliability are direct suppression factors for practical application. Herein, we synthesize polydopamine@gold (PDA@Au) nanowaxberry, where Au nanoparticles are deposited on the surface of PDA sphere with high density and uniformity. Seed-mediated synthesis is used for fabrication of nanowaxberry...
August 7, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29988477/icariin-a-potential-compound-for-the-recovery-of-tibial-dyschondroplasia-affected-chicken-via-up-regulating-bmp-2-expression
#15
Mujahid Iqbal, Hui Zhang, Khalid Mehmood, Aoyun Li, Xiong Jiang, Yaping Wang, Jialu Zhang, Muhammad Kashif Iqbal, Mujeeb Ur Rehman, Wangyuan Yao, Shijin Yang, Jiakui Li
Background: Tibial dyschondroplasia (TD) is a skeletal disease of fast growing chicken and other avian species. It is characterized by an avascular and non-mineralized growth plate, which leads to a deformed tibial bone and lameness. Unfortunately, this disease is not only responsible for causing huge economic losses but also raises animal welfare concerns. Icariin is a flavonoid, which is isolated from Epimedium pubescens herb, and it has been used to cure different diseases including bone fractures and osteoporosis...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/29960240/synthesis-and-sers-activity-of-super-multibranched-auag-nanostructure-via-silver-coating-induced-aggregation-of-nanostars
#16
Jian-Jun Li, Chen Wu, Jing Zhao, Guo-Jun Weng, Jian Zhu, Jun-Wu Zhao
The super-multibranched AuAg bimetallic nanostructures are synthesized due to the aggregation of Au nanostars in the process of silver coating. The super-multibranched bimetallic nanostructures with different silver coating thickness are obtained by changing the concentration of silver nitrate and ascorbic acid. It has been found that the formation of these nanostructures is due to the stacking of several nanostars during the process of silver coating. By comparing the silver coating process of gold nanostars with different branch lengths, we found that the nanostars with longish branches are easy to aggregate and form the super-multibranched nanostructures in the process of silver coating...
November 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29938920/influence-of-agro-environmental-pollutants-on-a-biocontrol-strain-of-bacillus-velezensis
#17
Mónika Vörös, László Manczinger, László Kredics, András Szekeres, Kadaikunnan Shine, Naiyf S Alharbi, Jamal M Khaled, Csaba Vágvölgyi
Metal- and pesticide-tolerant biocontrol agents are preferred in integrated pest management, as such strains can be applied in combination with different pesticides. The Bacillus velezensis strain SZMC 6161J proved to be sensitive to copper, nickel, zinc, and cadmium, while manganese elevated its growth. At concentrations higher than 1 mmol L-1 , zinc and iron inhibited the chymotrypsin-like activity of this strain. In addition, trypsin-like protease and palmitoyl esterase activities were insensitive to all tested heavy metals in the applied concentration range...
June 25, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29882674/fabrication-of-a-flexible-gold-nanorod-polymer-metafilm-via-a-phase-transfer-method-as-a-sers-substrate-for-detecting-food-contaminants
#18
Nan Yang, Ting-Ting You, Yu-Kun Gao, Chen-Meng Zhang, Peng-Gang Yin
Surface enhanced Raman scattering (SERS) has been widely used in detection of food safety due to the nondestructive examination property. Here, we reported a flexible SERS film based on a polymer-immobilized gold nanorod polymer metafilm. Polystyrene-polyisoprene-polystyrene (SIS), a transparent and flexible, along with having excellent elasticity, polymer, was chosen as the main support of gold nanorods. A simple phase transfer progress was adopted to mix the gold nanorods with the polymer, which can further be used in most water-insoluble polymers...
July 5, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29862005/composition-adjustable-ag-au-substitutional-alloy-microcages-enabling-tunable-plasmon-resonance-for-ultrasensitive-sers
#19
Xiaotian Wang, Guanshui Ma, Anran Li, Jian Yu, Zhao Yang, Jie Lin, Ang Li, Xiaodong Han, Lin Guo
Engineering the surface plasmon resonance (SPR) properties is a critical issue for improving device performance in the fields of plasmonics, nanophotonics, optoelectronics, and electrochemistry. Here, we demonstrated a programmable manipulation of the surface plasmon resonance (SPR) effect using composition-adjustable Ag-Au substitutional alloy microcages (SAMCs) through a facile NaBH4 -cooperative galvanic replacement reaction. The SPR frequency of the Ag-Au SAMCs can be continuously and exquisitely manipulated without resonance damping or broadening via accurate adjustment of the elemental composition distribution at the perfect homogeneity on the atomic-level...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29845168/flexible-transparent-and-highly-sensitive-sers-substrates-with-cross-nanoporous-structures-for-fast-on-site-detection
#20
Yingcheng Wang, Yuanhao Jin, Xiaoyang Xiao, Tianfu Zhang, Haitao Yang, Yudan Zhao, Jiaping Wang, Kaili Jiang, Shoushan Fan, Qunqing Li
A flexible and transparent film assembled from the cross-nanoporous structures of Au on PET (CNS of Au@PET) is developed as a versatile and effective SERS substrate for rapid, on-site trace analysis with high sensitivity. The fabrication of the CNS of Au can be achieved on a large scale at low cost by employing an etching process with super-aligned carbon nanotubes as a mask, followed by metal deposition. A strongly enhanced Raman signal with good uniformity can be obtained, which is attributed to the excitation of "hot spots" around the metal nanogaps and sharp edges...
August 16, 2018: Nanoscale
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