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(Bladder Cancer) AND Screening

SriGita K Madiraju, Tariq S Hakky, Paul E Perito, Jared J Wallen
BACKGROUND: Penile prosthesis for erectile restoration remains the only surgical option for medical refractory erectile dysfunction. Many expert prosthetic surgeons recommend special care when placing a reservoir in a patient who has undergone prior radical pelvic surgery (PRPS) due to distortion of anatomy and obliteration of the dead space in the traditionally used space of Retzius. AIM: Review all the current literature on penile prosthesis implantation in patients with prior pelvic surgery, with an emphasis on tips and tricks for reservoir placement in this unique population...
November 29, 2018: Sexual Medicine Reviews
André Tichelli, Eric Beohou, Myriam Labopin, Gérard Socié, Alicia Rovó, Manuela Badoglio, Anja van Biezen, Peter Bader, Rafael F Duarte, Grzegorz Basak, Nina Salooja
Importance: Incidence and risk factors of second solid cancers (SSCs) that occur after hematopoietic stem cell transplantation (HSCT) are well documented. However, clinical outcome data of patients who developed an SSC after HSCT are limited. Objective: To assess the outcome of patients with an SSC occurring after HSCT from the time of SSC diagnosis. Design, Setting, and Participants: This cohort study used data of 4065 patients from 26 countries registered with the European Society for Blood and Marrow Transplantation, which has maintained clinical data since 1977 of patients who received a transplant...
November 21, 2018: JAMA Oncology
Ying Zhou, Jiang Guiying, Wei Wang, Rui Wei, Xi Chen, Xueqian Wang, Juncheng Wei, Ding Ma, Fei Li, Ling Xi
Molecular imaging agents are considered to be promising tracers for tumor imaging and guided therapy. TMTP1 was screened through the FliTrx bacterial peptide display system in our laboratory previously and shown to specifically target to primary tumors and metastatic foci. In this study, Small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. It was successfully synthesized and certificated. CCK-8 assay showed it was nontoxic to normal cells and cancerous cells...
November 26, 2018: Bioconjugate Chemistry
Yanjie Xu, Ye-Hwan Kim, Pildu Jeong, Xuan-Mei Piao, Young Joon Byun, Ho Won Kang, Won Tae Kim, Jong-Young Lee, Isaac Y Kim, Sung-Kwon Moon, Yung Hyun Choi, Seok Joong Yun, Wun-Jae Kim
BACKGROUND: Urinary cell-free DNA (ucfDNA) has great potential as a "liquid biopsy" for use in diagnosis of urological cancers. In this study, we compared ucfDNA gene expression levels between patients with bladder cancer (BC) and those with hematuria, and determined whether they could be used as a noninvasive urine-based marker. METHODS: The study cohort of 355 patients included a screening group (40 BC and 41 hematuria controls) and a validation cohort (149 BC and 125 hematuria controls)...
November 13, 2018: Urologic Oncology
Liguo Liang, Yimin Wang, Siming Lu, Mengqi Kong, Yong Lin, Fabio Cuzzucoli, Ping Wang, ShuQi Wang
Bladder cancer (BC) is a common malignancy, and it accounts for one of the highest management costs among urogenital cancers. As a non-invasive method, urine cytology plays an important role in the detection of exfoliated tumor cells (ETCs) for early diagnosis of BC. However, urine cytology suffers from its low sensitivity and reliance on microscopic examination. To address this issue, an integrated filtration device was developed with a pore size of 5 μm that isolated and enriched ETCs from discarded urine samples, and then quantified ETCs using a microchip ELISA method...
December 31, 2018: Analytica Chimica Acta
Feng Wang, Yanwen Zu, Shibin Zhu, Yu Yang, Weiping Huang, Hui Xie, Gonghui Li
Bladder cancer (BCa) belongs to a popular urological malignancy and leads to large numbers of deaths worldwide. Recently, emerging evidences indicate that long noncoding RNAs (lncRNAs) are closely related with BC occurrence and progression. However, the function of lncRNA MAGI2-AS3 remains poorly understood in BC. In this present study, we screened out a novel lncRNA MAGI2-AS3 whose expression was downregulated in BCa tissues. We showed that MAGI2-AS3 downregulation in BCa patients indicated a poor prognosis...
December 9, 2018: Biochemical and Biophysical Research Communications
Yu-Hui He, Yi-Sen Deng, Pan-Xin Peng, Ning Wang, Jian-Feng Wang, Zhen-Shan Ding, Xing Chen, Xiao-Feng Zhou
AIM: To explore the molecular mechanism of nonmuscle invasive bladder cancer (NMIBC), matched normal, and cancer tissues of 10 NMIBC were examined for RNA sequencing. METHODS: We profiled the messenger RNA (mRNA) and long noncoding RNA (lncRNA) expression of patients with NMIBC. Differentially expressed mRNAs and lncRNAs were screened between cancer and normal tissues and validated by quantitative polymerase chain reaction (qPCR), and lncRNA-mRNA-miRNA interaction network was constructed...
November 13, 2018: Journal of Cellular Biochemistry
Yousef S Khader, Ghazi F Sharkas, Kamal H Arkoub, Mahmoud A Alfaqih, Omar F Nimri, Albaraa M Khader
Objectives: This study aimed to determine the overall incidence, trend, and epidemiology of cancer among Jordanians from 2000 to 2013 using data extracted from Jordan's Cancer Registry (JCR). Methods: All cancer cases among Jordanians registered between 2000 and 2013 were analyzed using CanReg software and SPSS. The overall crude incidence rates (CIRs) and the age standardized rates (ASRs) of cancer per 100,000 were calculated. Results: A total of 58788 cancer cases were registered during the period 2000-2013...
2018: Journal of Cancer Epidemiology
Jingshu Guo, Peter W Villalta, Christopher J Weight, Radha Bonala, Francis Johnson, Thomas A Rosenquist, Robert J Turesky
Epidemiological studies have linked aromatic amines (AAs) from tobacco smoke and some occupational exposures with bladder cancer risk. Several epidemiological studies have also reported a plausible role for structurally related heterocyclic aromatic amines present in tobacco smoke or formed in cooked meats with bladder cancer risk. DNA adduct formation is an initial biochemical event in bladder carcinogenesis. We examined paired fresh-frozen (FR) and formalin-fixed paraffin-embedded (FFPE) nontumor bladder tissues from 41 bladder cancer patients for DNA adducts of 4-aminobiphenyl (4-ABP), a bladder carcinogen present in tobacco smoke, and 2-amino-9 H-pyrido[2,3- b]indole, 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine and 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline, possible human carcinogens, which occur in tobacco smoke and cooked meats...
November 19, 2018: Chemical Research in Toxicology
M Shayne Gallaway, S Jane Henley, C Brooke Steele, Behnoosh Momin, Cheryll C Thomas, Ahmed Jamal, Katrina F Trivers, Simple D Singh, Sherri L Stewart
PROBLEM/CONDITION: Tobacco use is the leading preventable cause of cancer, contributing to at least 12 types of cancer, including acute myeloid leukemia (AML) and cancers of the oral cavity and pharynx; esophagus; stomach; colon and rectum; liver; pancreas; larynx; lung, bronchus, and trachea; kidney and renal pelvis; urinary bladder; and cervix. This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U...
November 2, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
Wataru Usuba, Fumihiko Urabe, Yusuke Yamamoto, Juntaro Matsuzaki, Hideo Sasaki, Makiko Ichikawa, Satoko Takizawa, Yoshiaki Aoki, Shumpei Niida, Ken Kato, Shin Egawa, Tatsuya Chikaraishi, Hiroyuki Fujimoto, Takahiro Ochiya
Bladder cancer is the ninth leading cause of cancer death worldwide. The major problem in bladder cancer is primarily the high recurrence rate after drug treatment and resection. Although conventional screening methods, such as cystoscopy, urinary cytology and ultrasound sonography, have become widely used in a clinical setting, the diagnostic performance of these modalities is unsatisfactory due to low accuracy or high invasiveness. Since circulating miRNA profiles have recently been reported as an attractive tool for liquid biopsy in cancer screening, here, we performed global miRNA profiling of 392 serum samples of bladder cancer patient with 100 non-cancer samples and 480 samples of other types of cancer as controls...
November 1, 2018: Cancer Science
Margaritis Avgeris, Anastasia Tsilimantou, Panagiotis K Levis, Theodoros Tokas, Diamantis C Sideris, Konstantinos Stravodimos, Alexandros Ardavanis, Andreas Scorilas
BACKGROUND: Bladder cancer (BlCa) heterogeneity and the lack of personalised prognosis lead to patients' highly variable treatment outcomes. Here, we have analysed the utility of the GAS5 tumour-suppressor lncRNA in improving BlCa prognosis. METHODS: GAS5 was quantified in a screening cohort of 176 patients. Hedegaard et al. (2016) (n = 476) and TCGA provisional (n = 413) were used as validation cohorts. Survival analysis was performed using recurrence and progression for NMIBC, or death for MIBC...
October 30, 2018: British Journal of Cancer
Hetal Damani Shah, Dhananjaya Saranath, Soma Das, Prashant Kharkar, Anjali Karande
H-Ras oncogene plays a critical role in the transformation of normal cells to a malignant phenotype through constitutive activation of the GTP bound protein leading to uncontrolled cell proliferation in several human cancers. Thus, H-Ras oncoprotein serves as an excellent target for anticancer drug discovery. To identify novel H-Ras inhibitors, we performed structure-based virtual screening of the Maybridge HitFinder™ library using Schrodinger suite. Thirty ligands from the chemical library were identified as they showed preferential in silico binding initially to H-Ras proteins with Gly12Val, Gly13Asp, and Gly12Val-Gly13Asp mutations...
October 26, 2018: Journal of Cellular Biochemistry
Anwei Liu, Zhensheng Zhang, Weidong Xu, Shengfei Qin, Meimian Hua, Shuxiong Zeng, Chuanliang Xu
Accumulating evidence has confirmed that dysregulated long non‑coding RNAs (lncRNAs) participate in the initiation and progression of a number of solid tumors and have potential applications for early diagnosis, targeted therapy, and the prognosis of patients with bladder cancer. In the present study, via high‑throughput sequencing technology and bioinformatics analysis, a total of 169 lncRNAs with significantly differential expression between bladder cancer tissues and paired adjacent normal tissues (n=10) were initially identified by screening...
December 2018: Molecular Medicine Reports
Ming Sun, Wenyan Zhao, Zhaofu Chen, Ming Li, Shuqiang Li, Bin Wu, Renge Bu
BACKGROUND: The study was aimed to investigate the influence of circ_0058063 on tumorigenesis as well as the regulatory mechanism of circ_0058063/miR-145-5p/ CDK6 pathway in bladder cancer (BC). METHODS: Bioinformatics analysis was used to screen highly expressed circle RNA (circRNA) and search its downstream microRNA (miRNA) and protein. The expression level of circRNA, miRNA, and CDK6 in BC cell lines T24 and J82 were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot...
October 26, 2018: Journal of Cellular Physiology
Mariko Murata
Infection and inflammation account for approximately 25% of cancer-causing factors. Inflammation-related cancers are characterized by mutagenic DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. Our previous studies demonstrated the formation of 8-oxodG and 8-nitroguanine in the tissues of cancer and precancerous lesions due to infection (e.g., Opisthorchis viverrini-related cholangiocarcinoma, Schistosoma haematobium-associated bladder cancer, Helicobacter pylori-infected gastric cancer, human papillomavirus-related cervical cancer, Epstein-Barr virus-infected nasopharyngeal carcinoma) and pro-inflammatory factors (e...
October 20, 2018: Environmental Health and Preventive Medicine
Zhaoju Tian, Shuang Cao, Cheng Li, Mingfang Xu, Huaiqing Wei, Han Yang, Qiyu Sun, Qikui Ren, Le Zhang
PURPOSE: The aim of our study was to validate the sway of long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on the metabolism and growth of bladder cancer cells by microRNA-31 (miR-31)/cyclin-dependent kinase 1 ( CDK1). METHODS: The Gene Expression Omnibus database was used for analyzing the differentially expressed lncRNA and messenger RNA (mRNA) in bladder cancer tissues, with the highly expressed lncRNA PVT1 and mRNA CDK1 screened out. The expression level of PVT1 was detected by quantitative reverse-transcription polymerase chain reaction, cell viability by Cell Counting Kit-8 assay, cell proliferation and scratch by 5-bromo-2'-deoxyuridine assay, cell migration and invasion by transwell assays, the expression level of CDK1 by immunohistochemistry and western blot analysis, transcription factor targeting by dual-luciferase assay, and the effect of PVT1 on bladder cancer growth by nude mice tumor formation experiment...
October 14, 2018: Journal of Cellular Physiology
Xin Chen, Rixin Chen, Wen-Su Wei, Yonghong Li, Zi-Hao Feng, Lei Tan, Jie-Wei Chen, Gangjun Yuan, Siliang Chen, Shen-Jie Guo, Kanghua Xiao, Zhuo-Wei Liu, Jun Hang Luo, Fang-Jian Zhou, Dan Xie
PURPOSE: Circular RNAs (circRNAs), a novel class of non-coding RNAs, have recently been drawn lots of attention in the pathogenesis of human cancers. However, the role of circRNAs in cancer cells epithelial-mesenchymal transition (EMT) remains unclear. In this study, we aimed to identify novel circRNAs that regulates urothelial carcinoma of the bladder (UCB) cells EMT and explored their regulatory mechanisms and clinical significance in UCBs. EXPERIMENTAL DESIGN: We first screened circRNA expression profiles using a circRNA microarray in paired UCB and normal tissues, and then studied the clinical significance of an up-regulated circRNA, circPRMT5, in a large cohort of UCB patients...
October 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Su Zhang, Yong-Yan Chang, Yu-Wen Gong, Yan-Jun Gao, Qi Guo, Yu-Han Wang, You-Li Zhao, Zhi-Ping Wang
Chemotherapy is still a standard treatment of unresectable bladder cancer or distant metastases. The chemotherapy resistance always occurs after a period of treatment indicating poor prognosis. The current study aimed to explore the molecular mechanism of chemoresistance in bladder cancer cells. The gene expression profiles of GSE77883, including three untreated T24 cells samples and three gemcitabine-resistant T24 cells samples, was downloaded from Gene Expression Omnibus database. The screening of differentially expressed genes (DEGs), gene function analysis, and interaction prediction between microRNAs (miRNAs) and DEGs were performed by R software...
October 10, 2018: Journal of Cellular Biochemistry
Yin Wang, Mark L Day, Diane M Simeone, Phillip L Palmbos
Bladder cancer is a significant health problem. It is estimated that more than 16,000 people will die this year in the United States from bladder cancer. While 75% of bladder cancers are non-invasive and unlikely to metastasize, about 25% progress to an invasive growth pattern. Up to half of the patients with invasive cancers will develop lethal metastatic relapse. Thus, understanding the mechanism of invasive progression in bladder cancer is crucial to predict patient outcomes and prevent lethal metastases...
September 13, 2018: Journal of Visualized Experiments: JoVE
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