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Curcuma breast cancer

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https://www.readbyqxmd.com/read/30181769/anti-cancer-effects-of-rhizoma-curcumae-against-doxorubicin-resistant-breast-cancer-cells
#1
Zhangfeng Zhong, Haibing Yu, Shengpeng Wang, Yitao Wang, Liao Cui
Background: Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese medicine may shed light on design of new therapeutic modes to overcome chemo-resistance. Although Rhizoma Curcumae possesses anti-cancer activities in various types of cancers, the effects and underlying mechanisms of its bioactive components against chemo-resistance are not clear...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/30066930/curcumin-and-paclitaxel-induce-cell-death-in-breast-cancer-cell-lines
#2
Gloria M Calaf, Richard Ponce-Cusi, Flavio Carrión
Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), a polyphenol derived from turmeric (Curcuma longa), possesses several properties that could enable it to exert an anticancer effect. Previous reports have demonstrated the synergistic effects of several chemotherapeutic drugs in combination with curcumin...
October 2018: Oncology Reports
https://www.readbyqxmd.com/read/30038010/orthogonal-self-assembly-of-an-organoplatinum-ii-metallacycle-and-cucurbit-8-uril-that-delivers-curcumin-to-cancer-cells
#3
Sougata Datta, Santosh K Misra, Manik Lal Saha, Nabajit Lahiri, Janis Louie, Dipanjan Pan, Peter J Stang
Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It is known to exhibit anticancer properties via inhibiting the STAT3 phosphorylation process. However, its poor water solubility and low bioavailability impede its clinical application. Herein, we used organoplatinum(II) ← pyridyl coordination-driven self-assembly and a cucurbit[8]uril (CB[8])-mediated heteroternary host-guest complex formation in concert to produce an effective delivery system that transports Cur into the cancer cells...
August 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29987021/ancient-drug-curcumin-impedes-26s-proteasome-activity-by-direct-inhibition-of-dual-specificity-tyrosine-regulated-kinase-2
#4
Sourav Banerjee, Chenggong Ji, Joshua E Mayfield, Apollina Goel, Junyu Xiao, Jack E Dixon, Xing Guo
Curcumin, the active ingredient in Curcuma longa , has been in medicinal use since ancient times. However, the therapeutic targets and signaling cascades modulated by curcumin have been enigmatic despite extensive research. Here we identify dual-specificity tyrosine-regulated kinase 2 (DYRK2), a positive regulator of the 26S proteasome, as a direct target of curcumin. Curcumin occupies the ATP-binding pocket of DYRK2 in the cocrystal structure, and it potently and specifically inhibits DYRK2 over 139 other kinases tested in vitro...
August 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29709646/cytotoxicity-of-18-cameroonian-medicinal-plants-against-drug-sensitive-and-multi-factorial-drug-resistant-cancer-cells
#5
Armelle T Mbaveng, Hermione T Manekeng, Gaelle S Nguenang, Joachim K Dzotam, Victor Kuete, Thomas Efferth
ETHNOPHARMACOLOGICAL RELEVANCE: Recommendations have been made stating that ethnopharmacological usages such as immune and skin disorders, inflammatory, infectious, parasitic and viral diseases should be taken into account if selecting plants for anticancer screening, since these reflect disease states bearing relevance to cancer or cancer-like symptoms. Cameroonian medicinal plants investigated in this work are traditionally used to treat cancer or ailments with relevance to cancer or cancer-like symptoms...
August 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29686295/curcumin-interacts-directly-with-the-cysteine-259-residue-of-stat3-and-induces-apoptosis-in-h-ras-transformed-human-mammary-epithelial-cells
#6
Young-Il Hahn, Su-Jung Kim, Bu-Young Choi, Kyung-Cho Cho, Raju Bandu, Kwang Pyo Kim, Do-Hee Kim, Wonki Kim, Joon Sung Park, Byung Woo Han, Jeewoo Lee, Hye-Kyung Na, Young-Nam Cha, Young-Joon Surh
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is latent but constitutively activated in many types of cancers. It is well known that STAT3 plays a key role in inflammation-associated tumorigenesis. Curcumin is an anti-inflammatory natural compound isolated from the turmeric (Curcuma longa L., Zingiberaceae) that has been extensively used in a traditional medicine over the centuries. In the present study, we have found that curcumin inhibits STAT3 signaling that is persistently overactivated in H-Ras transformed breast epithelial cells (H-Ras MCF10A)...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29556774/design-synthesis-and-cytotoxic-effects-of-curcuminoids-on-hela-k562-mcf-7-and-mda-mb-231-cancer-cell-lines
#7
Siti Noor Hajar Zamrus, Muhammad Nadeem Akhtar, Swee Keong Yeap, Ching Kheng Quah, Wan-Sin Loh, Noorjahan Banu Alitheen, Seema Zareen, Saiful Nizam Tajuddin, Yazmin Hussin, Syed Adnan Ali Shah
BACKGROUND: Curcumin is one of the leading compound extracted from the dry powder of Curcuma longa (Zingiberaceae family), which possess several pharmacological properties. However, in vivo administration exhibited limited applications in cancer therapies. RESULTS: Twenty-four curcumin derivatives have synthesized, which comprises cyclohexanone 1-10, acetone 11-17 and cyclopentanone 18-24 series. All the curcuminoids were synthesized by the acid or base catalyzed Claisen Schmidt condenstion reactions, in which β-diketone moiety of curcumin was modified with mono-ketone...
March 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29358127/the-role-of-curcumae-rhizoma-sparganii-rhizoma-medicated-serum-in-epithelial-mesenchymal-transition-in-the-triple-negative-breast-cancer-pharmacological-role-of-cr-sr-in-the-tbnc
#8
Yukun Yin, Li Feng, Lei Wang, Lixiang Ding
The aim of this study was to investigate the effect of Curcumae Rhizoma-Sparganii Rhizoma (CR-SR) medicated serum on the changes of epithelial-mesenchymal transition (EMT) in the triple-negative breast cancer (TNBC). The EMT model was developed by using the TNBC MDA-MB-468 cells, which were treated with TGF-β1. The migration and invasion abilities of TGF-β1-treated MDA-MB-468 cells were detected by wound healing assay and transwell assay. Protein expression levels of E-cadherin and vimentin were determined by western blot...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29039582/curcumol-inhibits-the-proliferation-of-gastric-adenocarcinoma-mgc-803-cells-via-downregulation-of-idh1
#9
Shilei Zang, Qiling Tang, Fangrui Dong, Huan Liu, Lili Li, Fang Guo, Xuediao Pan, Haorong Lin, Weibin Zeng, Zhaoxu Cai, Qibin Zhong, Ning Zang, Linquan Zang
Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its anticancer activity in GC are still unclear. In this study, the antitumor efficacy of curcumol was ascertained in human gastric adenocarcinoma MGC-803 cells. An MTT assay was used to assess the viability of the MGC-803 cells treated by curcumol. The results of the Annexin V/propidium iodide (PI) staining followed by fluorescence activated cell sorting (FACS) analysis demonstrated that the cell cycle was arrested in the G2/M phase by curcumol...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/28959205/furanodiene-induces-extrinsic-and-intrinsic-apoptosis-in-doxorubicin-resistant-mcf-7-breast-cancer-cells-via-nf-%C3%AE%C2%BAb-independent-mechanism
#10
Zhang-Feng Zhong, Hai-Bing Yu, Chun-Ming Wang, Wen-An Qiang, Sheng-Peng Wang, Jin-Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De-Qiang Li, Yi-Tao Wang
Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae . Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28959140/curcumin-reduces-mitomycin-c-resistance-in-breast-cancer-stem-cells-by-regulating-bcl-2-family-mediated-apoptosis
#11
Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Shi-Bing Su
BACKGROUND: Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemotherapy drugs through regulation of Bcl-2-mediated apoptosis in breast cancer stem-like cells (BCSCs). METHODS: Cell survival was measured using MTT assay. Apoptosis-related proteins were observed using western blot analysis. Apoptosis was detected with flow cytometric analysis and by Hoechst 33258 staining...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28827004/labdane-diterpenoids-from-curcuma-amada-rhizomes-collected-in-myanmar-and-their-antiproliferative-activities
#12
Nwet Nwet Win, Takuya Ito, Hla Ngwe, Yi Yi Win, Prema, Yasuko Okamoto, Masami Tanaka, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita
Four new labdane diterpenoids, 12β-hydroxy-15-norlabda-8(17),13(14)-dien-16-oic acid (1), (E)-15-ethoxy-15-methoxylabda-8(17),12-dien-16-al (2), (E)-15α-ethoxy-14α-hydroxylabda-8(17),12-dien-16-olide (3), and 15-ethoxy-12β-hydroxylabda-8(17),13(14)-dien-16,15-olide (4) were isolated from the methanol extract of Curcuma amada rhizomes collected in Myanmar, together with 13 known analogs. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were evaluated for their antiproliferative activities against a small panel of five different human cancer cell lines (A549, human lung cancer; HeLa, human cervical cancer; MCF7, human breast cancer; PANC-1 and PSN-1, human pancreatic cancer)...
October 2017: Fitoterapia
https://www.readbyqxmd.com/read/28693277/curcumol-triggers-apoptosis-of-p53-mutant-triple-negative-human-breast-cancer-mda-mb-231-cells-via-activation-of-p73-and-puma
#13
Lanzhen Huang, Ang Li, Guanzhen Liao, Feicheng Yang, Jing Yang, Xu Chen, Xiaoshan Jiang
Triple-negative breast cancer (TNBC; estrogen receptor-negative, progesterone receptor-negative and Her-2-negative) is often accompanied by a higher frequency of p53 gene mutations. Therefore, TNBC is challenging to treat due to a lack of biological targets and a poor sensitivity to conventional therapies. Curcumol is a monomer composition isolated from the ethanol extracts of Curcuma wenyujin, a Chinese medicinal herb traditionally used as a cancer remedy. Previous studies have revealed that curcumol is able to block proliferation in various human tumor cell lines...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28560389/elemene-inhibits-the-migration-and-invasion-of-4t1-murine-breast-cancer-cells-via-heparanase
#14
Yi Zhang, Xu Sun, Nan Nan, Ke-Xin Cao, Cong Ma, Guo-Wang Yang, Ming-Wei Yu, Lin Yang, Jin-Ping Li, Xiao-Min Wang, Gan-Lin Zhang
Elemene (ELE), a natural plant drug extracted from Curcumae Rhizoma, has been widely used for cancer treatment in China for more than 20 years. Although it is reported to be a broad‑spectrum anticancer drug, the mechanism underlying the action of ELE in the treatment of breast cancer remains to be fully elucidated. Heparanase, a mammalian endo‑D‑glucuronidase, is involved in degradation of the extracellular matrix (ECM), and thus promotes tumor progression and metastasis. The downregulation of heparanase can effectively reduce tumor malignant behaviors...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28542135/furanodienone-induces-g0-g1-arrest-and-causes-apoptosis-via-the-ros-mapks-mediated-caspase-dependent-pathway-in-human-colorectal-cancer-cells-a-study-in-vitro-and-in-vivo
#15
Ying Jiang, Xiaoqin Wang, Daode Hu
Furanodienone, a major bioactive constituents of sesquiterpene derived from Rhizoma Curcumae, has been proven to possess the potent anticancer efficacy on human breast cancer cells. Here, we investigated the cytotoxicity of furanodienone on human colorectal carcinoma cell lines in vitro and in vivo, as well as its underlying molecular mechanisms in the induction of apoptosis. In this study, we found that furanodienone significantly inhibited proliferation of RKO and HT-29 cells, induced mitochondrial dysfunction characterized by collapse of mitochondrial transmembrane potential and reduction of ATP level, and promoted the production of reactive oxygen species (ROS) that functions upstream of caspase-dependent apoptosis...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28412809/selective-estrogen-receptor-modulator-serm-like-activities-of-diarylheptanoid-a-phytoestrogen-from-curcuma-comosa-in-breast-cancer-cells-pre-osteoblast-cells-and-rat-uterine-tissues
#16
Natthakan Thongon, Nittaya Boonmuen, Kanoknetr Suksen, Patsorn Wichit, Arthit Chairoungdua, Patoomratana Tuchinda, Apichart Suksamrarn, Wipawee Winuthayanon, Pawinee Piyachaturawat
Diarylheptanoids from Curcuma comosa, of the Zingiberaceae family, exhibit diverse estrogenic activities. In this study we investigated the estrogenic activity of a major hydroxyl diarylheptanoid, 7-(3,4 -dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 092) isolated from C. comosa. The compound elicited different transcriptional activities of estrogen agonist at low concentrations (0.1-1 μM) and antagonist at high concentrations (10-50 μM) using luciferase reporter gene assay in HEK-293T cells...
May 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28345336/proteomic-identification-of-eef1a1-as-a-molecular-target-of-curcumol-for-suppressing-metastasis-of-mda-mb-231-cells
#17
Hongyi Qi, Ling Ning, Zanyang Yu, Guojun Dou, Li Li
Curcumol, a major volatile component in Rhizoma Curcumae, exhibits a potent antimetastatic effect on breast cancer cells. However, its molecular mechanism remains poorly understood. In this study, we employed two-dimensional gel electrophoresis-based proteomics to investigate the cellular targets of curcumol in MDA-MB-231 cells and identified 10 differentially expressed proteins. Moreover, Gene Ontology analysis revealed that these proteins are mainly involved in nine types of cellular components, seven different biological processes, and nine kinds of molecular functions, and 35 pathways (p < 0...
March 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28239299/synthetic-curcumin-derivative-dk1-possessed-g2-m-arrest-and-induced-apoptosis-through-accumulation-of-intracellular-ros-in-mcf-7-breast-cancer-cells
#18
Norlaily Mohd Ali, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Huynh Ky, Ahmad Zaim Mat Pauzi, Wan Yong Ho, Sheau Wei Tan, Han Kiat Alan-Ong, Seema Zareen, Noorjahan Banu Alitheen, M Nadeem Akhtar
AIMS: Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. Despite of its strong biological properties, curcumin has yet been recommended as a therapeutic agent because of its poor bioavailability. MAIN METHODS: A curcumin derivative (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1) was synthesized and its cytotoxicity was tested on breast cancer cell MCF-7 and normal cell MCF-10A using MTT assay...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28184941/combined-effects-of-furanodiene-and-doxorubicin-on-the-migration-and-invasion-of-mda-mb-231-breast-cancer-cells-in-vitro
#19
Zhang-Feng Zhong, Wen Tan, Ke Tian, Hua Yu, Wen-An Qiang, Yi-Tao Wang
Furanodiene is one of the major bioactive components isolated from the natural product of the plant, Curcuma wenyujin Y.H. Chen et C. Ling. Furanodiene has been found to exert anticancer effects in various types of cancer cell lines, as well as exhibit antimetastatic activities. However, the antimetastatic capacity of furanodiene in combination with the common chemotherapy drug doxorubicin has not been investigated. We found that doxorubicin at a non-toxic concentration induced cell migration and cell invasion in highly metastatic breast cancer cells...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/27779649/effect-of-curcumin-and-paclitaxel-on-breast-carcinogenesis
#20
Edgar Teddy Quispe-Soto, Gloria M Calaf
Global cancer burden increased to 14.1 million new cases in 2012; and breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. Curcumin is the major bioactive ingredient extracted from the rhizome of the plant Curcuma longa (turmeric). Paclitaxel is a microtubule-stabilizing agent originally isolated from the bark of Taxus brevifolia. Curcumin and paclitaxel were evaluated with two human breast cancer cell lines as the luminal MCF-7 and the basal-like MDA-MB-231 that are either positive or negative for hormonal receptors estrogen receptor, progesterone receptor and HER2, respectively...
December 2016: International Journal of Oncology
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