Lisa Hobuß, Ariana Foinquinos, Mira Jung, Franziska Kenneweg, Ke Xiao, Yong Wang, Karina Zimmer, Janet Remke, Annette Just, Juliette Nowak, Arne Schmidt, Andreas Pich, Stephane Mazlan, Stella M Reamon-Buettner, Gustavo Campos Ramos, Stefan Frantz, Janika Viereck, Xavier Loyer, Chantal Boulanger, Kai C Wollert, Jan Fiedler, Thomas Thum
Myocardial ischemia induces a multifaceted remodeling process in the heart. Novel therapeutic entry points to counteract maladaptive signalling include the modulation of non-coding RNA molecules such as long non-coding RNA (lncRNA). We here questioned if the lncRNA candidate H19 exhibits regulatory potential in the setting of myocardial infarction. Initial profiling of H19 expression revealed a dynamic expression profile of H19 with upregulation in the acute phase after murine cardiac ischemia. In vitro, we found that oxygen deficiency leads to H19 upregulation in several cardiac cell types...
July 7, 2020: Journal of Molecular and Cellular Cardiology