keyword
https://read.qxmd.com/read/38432669/-advancements-and-controversies-in-conversion-therapy-for-biliary-tract-malignant-tumors-with-insufficient-future-liver-remnant
#1
JOURNAL ARTICLE
Z Wang, D F Hong
Due to the unique location and aggressive tumor biology,hilar cholangiocarcinoma,intrahepatic cholangiocarcinoma,and gallbladder cancer often present with obstructive jaundice and require extensive liver resection,also exhibit high rates of recurrence and metastasis after radical excision. Therefore,surgeons should make treatment decisions based on the biliary anatomy of patients and the biological characteristics of tumors as it significantly affects patient's prognosis. Treatment strategy should be made to ensure the successful implementation of radical resection for biliary tract malignant tumors while maximizing the survival benefits of patients...
March 1, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/38406105/unusual-presentation-of-a-hepatic-neuroendocrine-tumor-with-elevated-cea-and-ca-19-9-a-case-report
#2
Eli Zolotov, Anat Sigal, Sara Hazaveh, Vanisha Patel, Hongfa Zhu
Neuroendocrine tumors (NETs) of the gastrointestinal tract (GIT) are rare malignancies, which may have unique presentations. The diagnostic process predominantly relies on immunohistochemical analysis. While tumor markers are extensively utilized in diagnosing and monitoring GI malignancies, their specific role in NETs has not been fully explored. This case describes an 83-year-old male presenting with jaundice and general weakness. Diagnostic imaging through MRI and CT angiography (CTA) revealed a nodular texture on the liver's surface suggesting cirrhosis...
January 2024: Curēus
https://read.qxmd.com/read/38406045/parathyroid-hormone-related-peptide-producing-gallbladder-cancer-presenting-with-humoral-hypercalcemia-of-malignancy-a-case-report
#3
Koji Takahashi, Hiroshi Ohyama, Izumi Ohno, Yuichi Takiguchi, Naoya Kato
Humoral hypercalcemia of malignancy (HHM) is often reported in cancers derived from the squamous epithelium; however, there are very few reports of HHM in patients with gallbladder cancer. We report a case of a parathyroid hormone-related protein (PTHrP)-producing gallbladder cancer presenting with HHM. A 43-year-old woman presented with appetite loss, nausea, and brown-colored urine. Blood tests revealed that she had hypercalcemia, high serum bilirubin, and high serum parathyroid hormone. Contrast-enhanced computed tomography revealed a gallbladder tumor, liver metastasis, and bile duct obstruction caused by the gallbladder tumor in the hilar region...
January 2024: Curēus
https://read.qxmd.com/read/38380564/effectiveness-of-endoscopic-ultrasound-eus-guided-choledochoduodenostomy-vs-eus-guided-gallbladder-drainage-for-jaundice-in-patients-with-malignant-distal-biliary-obstruction-after-failed-endoscopic-retrograde-cholangiopancreatography-retrospective-multicenter
#4
JOURNAL ARTICLE
Antoine Debourdeau, Jules Daniel, Ludovic Caillo, Eric Assenat, Martin Bertrand, Thomas Bardol, François-Régis Souche, Philippe Pouderoux, Romain Gerard, Diane Lorenzo, Jean-François Bourgaux
OBJECTIVES: The aim of this study was to compare endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) vs. EUS-gallbladder drainage (EUS-GBD) in cases of failed endoscopic retrograde cholangiopancreatography (ERCP) for jaundice resulting from malignant distal biliary obstruction (MDBO). METHODS: This multicenter retrospective study included patients with obstructive jaundice secondary to MDBO who underwent EUS-GBD or EUS-CDS with lumen-apposing metal stents after failed ERCP...
February 21, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/38226074/effects-of-cystic-duct-margin-involvement-on-the-survival-rates-of-patients-with-gallbladder-cancer-a-propensity-score-matched-case-control-study
#5
JOURNAL ARTICLE
Vasistha Jajal, Phani K Nekarakanti, Sugumaran K, Hirdaya Nag
Background In gallbladder cancer (GBC), extrahepatic bile duct (EHBD) resection is selectively performed if gross direct extension or microscopic involvement of the cystic duct margin (CDM) is detected. Although CDM is usually sent for frozen biopsy intraoperatively in most centers, there are no studies regarding the routine use of CDM frozen biopsy irrespective of the tumor location and paucity of literature regarding the impact of CDM status on recurrence-free and overall survival in GBC. The presence of obstructive jaundice in GBC usually indicates the involvement of EHBD or cystic duct-bile duct junction...
December 2023: Curēus
https://read.qxmd.com/read/38086134/challenges-in-diagnosing-and-managing-cystic-duct-carcinoma-a-case-report-from-syria
#6
Mohammed Jomaa, Jamal Ataya, Rand Hamed, Ali Alshiekh, Muhammad Fadi Alkurdi, Hamoud Hamed
INTRODUCTION AND IMPORTANCE: Primary cystic duct carcinoma, an uncommon and aggressive biliary cancer variant, poses a significant challenge in clinical practice. This study examines recent clinical cases, focusing on diagnostics, interventions, and implications in managing this disease, with a prevalence ranging from 0.03 % to 0.05 %, contributing to 2.6-12.6 % of extrahepatic biliary neoplasms. CASE PRESENTATION: A 57-year-old male, a smoker with hypertension and hyperuricemia, presented symptoms of severe upper right abdominal pain, jaundice, and altered stool color...
December 8, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38047044/pattern-of-care-and-outcomes-of-gallbladder-cancer-patients-retrospective-study-from-a-high-incidence-region-in-india
#7
JOURNAL ARTICLE
Lakhan Kashyap, Arpita Singh, Subham Tomar, Anuj Gupta, Bipinesh Sansar, Amit Kumar Chaudhary, Bal Krishna Mishra, Kuraparthy Sambasivaiah, Akhil Kapoor
Lakhan Kasyap Introduction  Gallbladder cancer (GBC) is the 20th most common cancer in India with a crude incidence rate of 2.3 per 100,000 persons. Of note, it is relatively common in states which fall in the Gangetic plains. Patients often present in the advanced stage and have an unfavorable prognosis. Materials and Methods  From January to June 2021, 170 treatment-naive GBC (adenocarcinoma) patients who were registered at a tertiary care cancer center in North India, were included. Data were extracted from electronic medical records and was analyzed with SPSS...
July 2023: South Asian Journal of Cancer
https://read.qxmd.com/read/37900613/ruptured-cystic-artery-pseudoaneurysm-after-self-expandable-metal-stent-placement-for-malignant-biliary-obstruction
#8
Takafumi Mie, Takashi Sasaki, Kiyoshi Matsueda, Takeshi Okamoto, Tatsuki Hirai, Takahiro Ishitsuka, Manabu Yamada, Hiroki Nakagawa, Takaaki Furukawa, Tsuyoshi Takeda, Akiyoshi Kasuga, Masato Ozaka, Naoki Sasahira
We report a case of ruptured cystic artery pseudoaneurysm after self-expandable metal stent placement for malignant biliary obstruction. A 78-year-old woman on palliative care after chemotherapy for unresectable pancreatic head cancer presented with obstructive jaundice. Imaging revealed a dilated common bile duct and an enlarged gallbladder with cystic wall thickening. Endoscopic retrograde cholangiopancreatography was performed and a fully-covered self-expandable metal stent was placed in the bile duct, leading to resolution of jaundice...
April 2024: DEN Open
https://read.qxmd.com/read/37882194/eus-guided-gallbladder-drainage-as-second-option-of-biliary-decompression-after-failed-ercp-for-the-management-of-malignant-distal-biliary-obstruction
#9
JOURNAL ARTICLE
Carlos Miguel Chavarría Herbozo, Lorena Sancho-Del Val, Cristina Cuadrado-Tiemblo, Cristina Vicente Martín, Luis Wong Becerra, Daniel Riado Mínguez
Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is recommended as a rescue treatment of malignant distal biliary obstruction (MBDO) after failed ERCP and endoscopic ultrasound-guided biliary drainage (EUS-BD). A 64-year-old male was admitted for painless obstructive jaundice and anemia. For religious reasons, he refused any blood transfusions. Abdominal computed tomography scan showed a pancreatic tumor with dilation biliary tree and liver metastasis. ERCP failed and advanced biliary cannulation technique such as precut were avoided due to a high risk of bleeding...
October 26, 2023: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/37622087/efficacy-and-complications-of-inoperable-malignant-distal-biliary-obstruction-treatment-by-metallic-stents-fully-covered-or-uncovered
#10
REVIEW
Jiangning Gu, Xiaoyi Guo, Yong Sun, Bin Fan, Haoran Li, Ting Luo, Haifeng Luo, Jiao Liu, Feng Gao, Yuan Gao, Guang Tan, Xiaoming Liu, Zhuo Yang
Obstructive jaundice caused by malignant distal biliary obstruction is a common clinical symptom in patients with inoperable biliary-pancreatic cancer. Endoscopic retrograde cholangiopancreatography (ERCP)-guided stent implantation is an effective treatment for obstructive jaundice. Internal stent drainage is more physiologic and associated with a better quality of life than external stent drainage methods such as percutaneous transhepatic gallbladder drainage or percutaneous transhepatic cholangiodrainage...
2023: Gastroenterology Report
https://read.qxmd.com/read/37396494/extensively-invasive-gallbladder-cancer-from-intracholecystic-papillary-neoplasm-treated-with-pylorus-preserving-pancreaticoduodenectomy-and-extended-cholecystectomy-a-case-report-and-literature-review
#11
Hideki Kumagai, Akira Umemura, Hiroyuki Nitta, Hirokatsu Katagiri, Masao Nishiya, Noriyuki Uesugi, Tamotsu Sugai, Akira Sasaki
BACKGROUND: Intracholecystic papillary neoplasm (ICPN) is a rare tumor first classified by the World Health Organization in 2010. ICPN is a counterpart of the intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct. Previous reports on ICPN are limited; thus, the diagnosis, surgical intervention, and prognosis are controversial. Here, we report an extensively invasive gallbladder cancer arising in ICPN treated with pylorus-preserving pancreaticoduodenectomy (PPPD) and extended cholecystectomy...
2023: Case Reports in Surgery
https://read.qxmd.com/read/37392954/eus-guided-gallbladder-drainage-using-a-lumen-apposing-metal-stent-as-rescue-treatment-for-malignant-distal-biliary-obstruction-a-large-multicenter-experience
#12
JOURNAL ARTICLE
Cecilia Binda, Andrea Anderloni, Alessandro Fugazza, Arnaldo Amato, Germana de Nucci, Alessandro Redaelli, Roberto Di Mitri, Luigi Cugia, Valeria Pollino, Raffaele Macchiarelli, Benedetto Mangiavillano, Edoardo Forti, Mario Luciano Brancaccio, Roberta Badas, Marcello Maida, Emanuele Sinagra, Alessandro Repici, Carlo Fabbri, Ilaria Tarantino
BACKGROUND AND AIMS: EUS-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMSs) has been reported as a rescue treatment with encouraging results for the relief of jaundice in patients with distal malignant biliary obstruction (DMBO) and after failure of both endoscopic retrograde cholangiopancreatography (ERCP) and EUS-guided choledochoduodenostomy. METHODS: This was a multicenter retrospective analysis of all cases of consecutive EUS-GBD with LAMSs used as a rescue treatment for patients with DMBO in 14 Italian centers from June 2015 to June 2020...
June 29, 2023: Gastrointestinal Endoscopy
https://read.qxmd.com/read/37288584/textbook-outcomes-in-liver-surgery-for-gallbladder-cancer-patients-treated-with-curative-intent-resection-a-multicenter-observational-study
#13
JOURNAL ARTICLE
Zhi-Peng Liu, Wei Guo, Da-Long Yin, Wei-Yue Chen, Jiao-Yang Wang, Xue-Lei Li, Ping Yue, Chao Yu, Zhao-Ping Wu, Rui Ding, Yi Zhu, Fan Huang, Jin-Xue Zhou, Dong Zhang, Wei Chen, Yan Jiang, Jie Bai, Jing-Jing Wang, Yan-Qi Zhang, Hai-Su Dai, Wan Yee Lau, Zhi-Yu Chen
BACKGROUND: Cholecystectomy, hepatectomy, and lymphadenectomy are recommended as the curative treatment for resectable gallbladder cancer (GBC). Textbook outcomes in liver surgery (TOLS) is a novel composite measure that has been defined by expert consensus to represent the optimal postoperative course after hepatectomy. This study aimed to determine the incidence of TOLS and the independent predictors associated with TOLS after curative-intent resection in GBC patients. METHODS: All consecutive GBC patients who underwent curative-intent resection between 2014 and 2020 were enrolled from a multicenter database from 11 hospitals as the training and the internal testing cohorts, and Southwest Hospital as the external testing cohort...
June 6, 2023: International Journal of Surgery
https://read.qxmd.com/read/36875276/long-term-results-and-prognostic-factors-after-surgical-treatment-for-gallbladder-cancer
#14
JOURNAL ARTICLE
Mehmet Ali Uzun, Metin Tilki, Sevcan Alkan Kayaoğlu, Gülten Çiçek Okuyan, Zeynep Gamze Kılıçoğlu, Aylin Gönültaş
OBJECTIVES: Gallbladder cancer is relatively rare and traditionally regarded as having poor prognosis. There is controversy about the effects of clinicopathological features and different surgical techniques on prognosis. The aim of this study was to investigate the effects of clinicopathological characteristics of the patients with surgically treated gallbladder cancer on long-term survival. MATERIAL AND METHODS: We retrospectively analyzed the database of gallbladder cancer patients treated at our clinic between January 2003 and March 2021...
December 2022: Turkish Journal of Surgery
https://read.qxmd.com/read/36733093/-a-rapid-clinical-course-of-pulmonary-embolism-associated-with-gallbladder-mucinous-carcinoma
#15
JOURNAL ARTICLE
Kensuke Hattori, Takayoshi Nakajima, Masataka Fujikawa, Yusuke Tomoo, Goshi Matsuki, Noriko Ichise, Meidai Kasai, Ryo Okamoto, Shinichi Ikuta, Yoshihiko Nakamoto, Tsukasa Aihara, Noriko Kajimoto, Ayako Kakuno, Hidenori Yanagi, Naoki Yamanaka
A 51-year-old woman with edema of the lower extremities and exertional dyspnea was admitted to our hospital. Enhanced CT revealed thrombi of the pulmonary artery and a gallbladder tumor. After anticoagulation therapy was started on her, anemia and jaundice progressed; thus, endoscopic retrograde cholangiopancreatography(ERCP)was performed on suspicion of bleeding from a gallbladder tumor. We performed cholecystectomy in emergency to control the anemia due to hemorrhage. Oxygenation suddenly worsened intraoperatively, maintaining her blood pressure became difficult, and the patient decompensated...
December 2022: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/36732993/-a-case-of-gallbladder-cancer-with-long-survival-treated-with-resection-after-downstaging-with-gc-therapy
#16
JOURNAL ARTICLE
Sota Watanabe, Gaku Mizojiri, Akitada Sada, Hiroki Kai, Koki Takeda, Yasunori Masuike, Yoshinobu Nagasawa, Kentaro Maruyama, Kyowon Lee, Hiroshi Oka, Mai Ohata, Atsushi Takeshita
A 68-year-old woman with a chief complaint of obstructive jaundice was referred to our hospital. She was diagnosed with gallbladder cancer with invasion to the liver, extrahepatic bile duct, right hepatic artery and portal vein. After endoscopic retrograde biliary drainage, she received chemotherapy with gemcitabine and cisplatin. After 9 courses, the size of the tumor and the lymph nodes decreased, and we planned surgery. There were no unresectable factors, and the right hepatic artery and portal vein were detached from the tumor...
December 2022: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/36646424/role-of-radiofrequency-ablation-in-advanced-malignant-hilar-biliary-obstruction
#17
REVIEW
Mamoru Takenaka, Tae Hoon Lee
Malignant hilar biliary obstruction (MHO), an aggressive perihilar biliary obstruction caused by cholangiocarcinoma, gallbladder cancer, or other metastatic malignancies, has a poor prognosis. Surgical resection is the only curative treatment for biliary malignancies. However, the majority of patients with MHO cannot undergo surgery on presentation because of an advanced inoperable state or a poor performance state due to old age or comorbid diseases. Therefore, palliative biliary drainage is mandatory to improve symptomatic jaundice and the quality of life...
January 16, 2023: Clinical Endoscopy
https://read.qxmd.com/read/36575822/survival-after-extended-resections-for-gallbladder-cancer
#18
JOURNAL ARTICLE
Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Shahzad Riyaz, Nusrat Yar Khan, Najla Rahman Qureshi, Nasir Ayub Khan
BACKGROUNDS/AIMS: Locally advanced gallbladder cancer (GBC) is associated with survival limited to a few months. Extended resections (ER) are occasionally performed in this group and outcomes remain inconclusive. This study assessed outcomes after ER for locally advanced GBC. METHODS: Patients who underwent ER for GBC between 2011 and 2020 were reviewed. ER was defined as a major hepatectomy alone (n = 9), a pancreaticoduodenectomy (PD) with or without minor hepatectomy (n = 3), a major hepatectomy with PD (HPD) (n = 3) or vascular resection and reconstruction (n = 4)...
December 28, 2022: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/36539838/survival-analysis-and-prognostic-factors-of-the-carcinoma-of-gallbladder
#19
JOURNAL ARTICLE
Zainab Feroz, Priyanka Gautam, Sonia Tiwari, Girish C Shukla, Munish Kumar
BACKGROUND: The present study aims to evaluate the survival status of patients with gallbladder cancer (GBC) and explore the prognostic factors for the improvement and preventions. METHODS: The study consists of 176 patients with clinically diagnosed gallbladder cancer; the study was conducted between 2019 and 2021 registered at Kamala Nehru Memorial Cancer Hospital, Prayagraj, India. The survival rates were analyzed by the Kaplan-Meier method; survival rate difference was analyzed by log-rank test, prognosis factors; and hazard ratio for mortality outcomes was estimated using Cox regression method...
December 20, 2022: World Journal of Surgical Oncology
https://read.qxmd.com/read/36510998/a-clinicoepidemiological-and-management-profile-of-metastatic-carcinoma-gallbladder-in-the-northeast-part-of-indian-patients-in-a-tertiary-care-center
#20
JOURNAL ARTICLE
Anvesh Rathore, Abhishek Pathak, Subhash Ranjan, Rahul Sud, M S Shivshankara, Tejas Pandaya, Prince Arvind, V P Singh, P Nikhil, Bhupesh Guleria
INTRODUCTION: Metastatic gallbladder cancer (GBC) is a highly fatal malignancy and it is difficult to treat the advanced stage of GBC. In India, northern and northeastern states are the worst affected by this disease. We, hereby, report the clinicoepidemiological and management profile of 242 patients of metastatic carcinoma of GB. MATERIALS AND METHODS: In this study, a total of 242 cases of metastatic GBC (detected either on the first presentation or during follow-up) were managed at the Department of Medical Oncology tertiary care oncology center in the northeast part of India from May 2018 to September 2019...
December 2022: Journal of Cancer Research and Therapeutics
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