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https://www.readbyqxmd.com/read/29036603/identification-of-optimal-reference-genes-for-transcriptomic-analyses-in-normal-and-diseased-human-heart
#1
Cristina E Molina, Eric Jacquet, Prishila Ponien, Christian Muñoz-Guijosa, Istvan Baczkó, Lars S Maier, Patrick Donzeau-Gouge, Dobromir Dobrev, Rodolphe Fischmeister, Anne Garnier
Aims: Quantitative real-time RT-PCR (RT-qPCR) has become the method of choice for mRNA quantification, but requires an accurate normalization based on the use of reference genes showing invariant expression across various pathological conditions. Only few data exist on appropriate reference genes for the human heart. The objective of this study was to determine a set of suitable reference genes in human atrial and ventricular tissues, from right and left cavities in control and in cardiac diseases...
September 22, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29036457/feasibility-evaluation-of-long-term-use-of-beta-blockers-and-calcium-antagonists-in-patients-with-brugada-syndrome
#2
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
Aims: Beta-blockers (BBs) and calcium antagonists (CAs) are reported to aggravate ST-segment elevation in some patients with Brugada syndrome (BrS). The feasibility of their long-term use in BrS still remains unknown. We investigated the safety of long-term use of BB and CA in BrS patients. Methods and results: Of the 360 consecutive BrS patients, 29 [5: a history of ventricular fibrillation (VF), 17: syncope, 7: asymptomatic] took BB and/or CA (BB: 22, CA: 8) for more than 1 year for the treatment of co-morbidities such as atrial tachyarrhythmia, vasospastic angina, and neurally mediated syncope...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036292/association-between-implantable-cardioverter-defibrillator-therapy-and-different-lead-positions-in-patients-with-cardiac-resynchronization-therapy
#3
Mads Brix Kronborg, Jens Brock Johansen, Jens Haarbo, Sam Riahi, Berit Thornvig Philbert, Ole Dan Jørgensen, Jens Cosedis Nielsen
Aims: To evaluate the impact of different right and left ventricular lead positions (RV-LP and LV-LP) on the risk of therapy for ventricular tachycardia/ventricular fibrillation in patients with a cardiac resynchronization therapy device (CRT-D). Methods and results: We performed a large nationwide cohort study on patients in Denmark receiving a CRT-D device from 2008 to 2012 from the Danish Pacemaker and implantable cardioverter defibrillator (ICD) registry. Lead positions were registered during the implantation and categorized as anterior/lateral/posterior and basal/mid-ventricular/apical for the LV-LP, and as apical/non-apical for the RV-LP...
September 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29035207/novel-quantitative-analytical-approaches-for-rotor-identification-and-associated-implications-for-mapping
#4
Elizabeth M Annoni, Shivaram Poigai Arunachalam, Suraj Kapa, Siva K Mulpuru, Paul A Friedman, Elena G Talkachova
OBJECTIVE: Clinical studies identifying rotors confirming these sites for ablation in treating cardiac arrhythmias have had inconsistent results with the current analysis techniques available. The aim of this study is to evaluate four new signal analysis approaches - multiscale frequency (MSF), Shannon entropy (SE), Kurtosis (Kt), and multiscale entropy (MSE) - in their ability to identify the pivot point of rotors. METHODS: Optical mapping movies of ventricular tachycardia were used to evaluate the performance and robustness of SE, Kt, MSF and MSE techniques with respect to several clinical limitations: decreased time duration, reduced spatial resolution, and the presence of meandering rotors...
October 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29034783/cerebral-and-limb-tissue-oxygenation-during-peripheral-venoarterial-extracorporeal-life-support
#5
Nousjka P A Vranken, Anouk A M A Lindelauf, Antoine P Simons, Marcel J H Ariës, Jos G Maessen, Patrick W Weerwind
Femoral access in extracorporeal life support (ECLS) has been associated with regional variations in arterial oxygen saturation, potentially predisposing the patient to ischemic tissue damage. Current monitoring techniques, however, are limited to intermittent bedside evaluation of capillary refill among other factors. The aim of this study was to assess whether cerebral and limb regional tissue oxygen saturation (rSO2) values reflect changes in various patient-related parameters during venoarterial ECLS (VA-ECLS)...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29034583/the-effect-of-head-up-tilt-upon-markers-of-heart-rate-variability-in-patients-with-atrial-fibrillation
#6
Hitesh C Patel, Carl Hayward, Andrew J Wardle, Lee Middleton, Alexander R Lyon, Carlo Di Mario, Tushar V Salukhe, Richard Sutton, Stuart D Rosen
BACKGROUND: Heart rate variability (HRV) analysis is uncommonly undertaken in patients with atrial fibrillation (AF) due to an assumption that ventricular response is random. We sought to determine the effects of head-up tilt (HUT), a stimulus known to elicit an autonomic response, on HRV in patients with AF; we contrasted the findings with those of patients in sinus rhythm (SR). METHODS: Consecutive, clinically indicated tilt tests were examined for 207 patients: 176 in SR, 31 in AF...
October 15, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29034311/left-atrial-deformation-useful-index-for-early-detection-of-cardiac-damage-in-chronic-mitral-regurgitation
#7
REVIEW
M Cameli, E Incampo, S Mondillo
In chronic mitral regurgitation (MR) left atrium is one of the first cardiac structures that is involved in remodeling and ultrastructural changes for a progressive volume overload. Severe left atrial (LA) dilation on echocardiography and new onset of atrial fibrillation in asymptomatic patients with preserved Left Ventricular (LV) function, appeared as a Class IIb recommendation for consideration for surgical mitral valve repair in the actual guidelines. However, before atrial dilatation and dysfunction, several ultrastructural changes appear in the atrial muscle tissue that are difficult to identify with the standard echocardiography...
December 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29033310/relation-of-elevated-serum-uric-acid-levels-to-first-degree-heart-block-and-other-cardiac-conduction-defects-in-hospitalized-patients-with-type-2-diabetes
#8
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
AIMS: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. METHODS: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014...
September 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29033048/comparison-of-outcome-after-percutaneous-mitral-valve-repair-with-the-mitraclip-in-patients-with-versus-without-atrial-fibrillation
#9
Juliëtte F Velu, Friso A Kortlandt, Tom Hendriks, Remco A J Schurer, Ad J van Boven, Karel T Koch, M Marije Vis, Jose P Henriques, Jan J Piek, Ben J L Van den Branden, Jeroen Schaap, Benno J Rensing, Martin J Swaans, Berto J Bouma, Jan A S Van der Heyden, Jan Baan
Percutaneous mitral valve repair with the MitraClip is an established treatment for patients with mitral regurgitation (MR) who are inoperable or at high risk for surgery. Atrial Fibrillation (AF) frequently coincides with MR, but only scarce data of the influence of AF on outcome after MitraClip is available. The aim of the current study was to compare the clinical outcome after MitraClip treatment in patients with versus without atrial fibrillation. Between January 2009 and January 2016, all consecutive patients treated with a MitraClip in 5 Dutch centers were included...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29032884/the-genetics-underlying-idiopathic-ventricular-fibrillation-a-special-role-for-catecholaminergic-polymorphic-ventricular-tachycardia
#10
Jaakko T Leinonen, Lia Crotti, Aurora Djupsjöbacka, Silvia Castelletti, Nella Junna, Alice Ghidoni, Annukka M Tuiskula, Carla Spazzolini, Federica Dagradi, Matti Viitasalo, Kimmo Kontula, Maria-Christina Kotta, Elisabeth Widén, Heikki Swan, Peter J Schwartz
BACKGROUND: Ventricular fibrillation (VF) is a major cause of sudden cardiac death. In some cases clinical investigations fail to identify the underlying cause and the event is classified as idiopathic (IVF). Since mutations in arrhythmia-associated genes frequently determine arrhythmia susceptibility, screening for disease-predisposing variants could improve IVF diagnostics. METHODS AND RESULTS: The study included 76 Finnish and Italian patients with a mean age of 31...
October 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29031455/does-permanent-atrial-fibrillation-modify-response-to-cardiac-resynchronization-therapy-in-heart-failure-patients
#11
Ana Abreu, Mário Oliveira, Pedro Silva Cunha, Helena Santa Clara, Guilherme Portugal, Inês Gonçalves Rodrigues, Vanessa Santos, Luis Morais, Mafalda Selas, Rui Soares, Luísa Branco, Rui Ferreira, Miguel Mota Carmo
INTRODUCTION: The benefits of cardiac resynchronization therapy (CRT) documented in heart failure (HF) may be influenced by atrial fibrillation (AF). We aimed to compare CRT response in patients in AF and in sinus rhythm (SR). METHODS: We prospectively studied 101 HF patients treated by CRT. Rates of clinical, echocardiographic and functional response, baseline NYHA class and variation, left ventricular ejection fraction, volumes and mass, atrial volumes, cardiopulmonary exercise test (CPET) duration (CPET dur), peak oxygen consumption (VO2max) and ventilatory efficiency (VE/VCO2 slope) were compared between AF and SR patients, before and at three and six months after implantation of a CRT device...
October 12, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#12
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29030919/baseline-fragmented-qrs-increases-the-risk-of-major-arrhythmic-events-in-brugada-syndrome-systematic-review-and-meta-analysis
#13
Pattara Rattanawong, Tanawan Riangwiwat, Narut Prasitlumkum, Nath Limpruttidham, Napatt Kanjanahattakij, Pakawat Chongsathidkiet, Wasawat Vutthikraivit, Eugene H Chung
BACKGROUND: Fragmented QRS reflects disturbances in the myocardium predisposing the heart to ventricular tachyarrhythmias. Recent studies suggest that fragmented QRS (fQRS) is associated with major arrhythmic events in Brugada syndrome. However, a systematic review and meta-analysis of the literature has not been done. We assessed the association between fQRS and major arrhythmic events in Brugada syndrome by a systematic review of the literature and a meta-analysis. METHODS: We comprehensively searched the databases of MEDLINE and EMBASE from inception to May 2017...
October 14, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29030379/right-ventricular-pacing-increases-risk-of-appropriate-implantable-cardioverter-defibrillator-shocks-asymmetrically-an-analysis-of-the-altitude-database
#14
Edmond M Cronin, Paul Jones, Milan C Seth, Niraj Varma
BACKGROUND: Right ventricular pacing (RVP) increases risk of atrial fibrillation in patients with implantable cardioverter-defibrillators (ICDs), but ventricular proarrhythmia is less clear. We analyzed a large remote monitoring database to assess this question. METHODS AND RESULTS: Patients with single- or dual-chamber ICDs, engaged in remote monitoring for at least 6 months and with unchanged tachycardia programming, were included. %RVP was derived for each weekly transmission...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29029774/immediate-coronary-angiography-in-survivors-of-out-of-hospital-cardiac-arrest-without-obvious-extracardiac-cause-who-benefits
#15
Z Moutacalli, J-L Georges, B Ajlani, G Cherif, E El Beainy, G Gibault-Genty, E Blicq, C Charbonnel, R Convers-Domart, F Boutot, J-M Caussanel, B Lemaire, S Legriel, B Livarek
BACKGROUND: Immediate coronary angiography (iCA) and primary percutaneous coronary angioplasty (pPCI) in patients successfully resuscitated after out-of-hospital cardiac arrest (OHCA) of suspected cardiac cause is controversial. Our aims were to assess the results of iCA, the prognostic impact of pPCI after OHCA, and to identify subgroups most likely to benefit from this strategy. METHODS: In this single-centre retrospective study, patients aged ≥18 years with sustained return of spontaneous circulation after OHCA and no evidence of a non-cardiac cause underwent routine iCA at admission, with pPCI if indicated...
October 10, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29027295/progression-of-late-post-operative-atrial-fibrillation-in-patients-with-tetralogy-of-fallot
#16
Tanwier T T K Ramdjan, Elisabeth M J P Mouws, Christophe P Teuwen, Gustaf D S Sitorus, Charlotte A Houck, Ad J J C Bogers, Natasja M S de Groot
INTRODUCTION: ToF patients are at risk for ventricular deterioration at a relatively young age, which can be aggravated by AF development. Therefore, knowledge on AF development and its timespan of progression is essential to guide treatment strategies for AF. OBJECTIVE: We examined late post-operative AF onset and progression in ToF patients during long-term follow-up after ToF correction. In addition, co-existence of regular supraventricular tachyarrhythmias (SVT) and ventricular tachyarrhythmias (VTA) was analyzed...
October 13, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29025686/-usefulness-of-spectral-tissue-doppler-e-e-ratio-in-the-management-of-patients-with-atrial-fibrillation
#17
S Arques, E Roux
Atrial fibrillation is the most common cardiac rhythm disorder encountered in daily clinical practice. It carries high morbidity and mortality rates, mainly related to sudden death, heart failure and stroke. Validation of noninvasive markers in the diagnosis of heart failure with preserved ejection fraction and risk stratification is therefore attractive in this clinical setting. The spectral tissue Doppler-derived E/e' ratio is a simple and user-friendly index which has been validated in the assessment of left ventricular diastolic pressures, regardless of rhythm...
October 9, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29025372/drugs-in-cardiac-arrest-the-rise-and-fall-of-antiarrhythmics
#18
George Karlis, Sevasti Afantenou
Since the publication of 2000 guidelines for resuscitation, amiodarone is considered the antiarrhythmic drug of choice for refractory ventricular fibrillation/pulseless ventricular tachycardia. However, to date there is no proven benefit in terms of neurologically intact survival to hospital discharge. A comprehensive search of the recent literature on amiodarone, nifekalant and lidocaine in cardiac arrest was performed. Amiodarone and nifekalant are superior to lidocaine with regards to the return of spontaneous circulation and survival to hospital admission...
October 12, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29024533/global-longitudinal-strain-corrected-by-rr-interval-is-a-superior-predictor-of-all-cause-mortality-in-patients-with-systolic-heart-failure-and-atrial-fibrillation
#19
Daniel Modin, Morten Sengeløv, Peter Godsk Jørgensen, Niels Eske Bruun, Flemming Javier Olsen, Maria Dons, Thomas Fritz Hansen, Jan Skov Jensen, Tor Biering-Sørensen
AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination...
October 11, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29024227/impact-of-atrial-fibrillation-on-rest-and-exercise-haemodynamics-in-heart-failure-with-mid-range-and-preserved-ejection-fraction
#20
David M Kaye, Frank E Silvestry, Finn Gustafsson, John G Cleland, Dirk J van Veldhuisen, Piotr Ponikowski, Jan Komtebedde, Shane Nanayakkara, Dan Burkhoff, Sanjiv J Shah
AIMS: Heart failure with preserved (HFpEF) and mid-range ejection fraction (HFmrEF) are becoming the most prevalent forms of heart failure. Patients with HFpEF/HFmrEF in atrial fibrillation (AF) have poorer survival and quality of life, but the mechanism underpinning this is unknown. We sought to investigate the influence of AF on the haemodynamic profile of HFpEF/HFmrEF patients at rest and during exercise. METHODS AND RESULTS: We invasively measured central haemodynamics at rest and during symptom-limited supine bicycle exercise in HFpEF/HFmrEF patients, 35 in sinus rhythm and 20 in AF with matched left ventricular ejection fraction...
October 11, 2017: European Journal of Heart Failure
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