Kanako Teramoto, Wan Ting Tay, Jasper Tromp, Wouter Ouwerkerk, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Oi Wah Liew, Jenny Chong, Katrina K Poppe, Mayanna Lund, Gerry Devlin, Richard W Troughton, Robert N Doughty, Arthur Mark Richards, Carolyn S P Lam
BACKGROUND: The relationship of serial NT-proBNP (N-terminal pro-B-type natriuretic peptide) measurements with changes in cardiac features and outcomes in heart failure (HF) remains incompletely understood. We determined whether common clinical covariates impact these relationships. METHODS AND RESULTS: In 2 nationwide observational populations with HF, the relationship of serial NT-proBNP measurements with serial echocardiographic parameters and outcomes was analyzed, further stratified by HF with reduced versus preserved left ventricular ejection fraction, inpatient versus outpatient enrollment, age, obesity, chronic kidney disease, atrial fibrillation, and attainment of ≥50% guideline-recommended doses of renin-angiotensin system inhibitors and β-blockers...
April 19, 2024: Journal of the American Heart Association