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https://www.readbyqxmd.com/read/30317121/jaw-tumor-in-recurrent-primary-hyperparathyroidism-a-case-report
#1
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
October 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30309829/benign-and-malignant-odontogenic-neoplasms-of-the-jaws-show-a-concordant-nondiscriminatory-p63-p40-positive-immunophenotype
#2
Prokopios P Argyris, Chris Malz, Reda Taleb, Ioannis G Koutlas
OBJECTIVES: Antibody p40, which recognizes exclusively ΔNp63 but not TAp63, has shown diagnostic utility in salivary gland and sinonasal tract malignancies. Although p63 immunophenotypic characterization of odontogenic lesions has been reported, p40 expression has not been previously studied. We aimed to study p40 immunoreactivity in odontogenic tumors (OTs) and odontogenic cysts (OCs) and to investigate possible discriminatory properties of the combined p63/p40 immunoprofile in OTs and OCs...
September 5, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30300686/genetic-hypercalcemia
#3
Catherine Cormier
A genetic disorder should be suspected in patients with hypercalcemia, notably those who are young; have family members with hypercalcemia; or have had a tumor of the endocrine pancreas, thyroid, pituitary, adrenal gland, or jaw bone. All forms of hypercalcemia should be interpreted according to the serum level of parathyroid hormone (PTH). Genetic forms are thus classified as related or unrelated to a parathyroid gland disorder. When the PTH level is elevated or is not depressed despite the hypercalcemia, findings that suggest hyperparathyroidism due to a genetic cause include syndromic manifestations in the patient or family members, parathyroid cancer (either suspected before surgery or confirmed during parathyroidectomy), multiple or recurrent parathyroid tumors, a family history of primary hyperparathyroidism, and the onset of primary hyperthyroidism before 50 years of age...
October 6, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/30297386/indirect-evaluation-of-bone-saturation-with-zoledronic-acid-after-long-term-dosing
#4
Gabriel N Hortobagyi, Ming Zheng, Ramon Mohanlal
BACKGROUND: Zoledronic acid (ZA), a potent bisphosphonate used for treatment of bone metastasis, has high bone affinity. This post hoc analysis evaluated the effects of long-term treatment and reduction in dosing frequency of ZA on bone saturation. MATERIALS AND METHODS: Pharmacokinetic data from three independent studies, OPTIMIZE-2 (patients receiving ≥9 doses of bisphosphonates) and two phase I studies, CZOL4460503 and CZOL4460506 (patients who were bisphosphonate naïve/bisphosphonate free for ≥1 year after previous dosing), were pooled...
October 8, 2018: Oncologist
https://www.readbyqxmd.com/read/30291007/a-clinicopathologic-study-on-central-odontogenic-fibroma-with-special-reference-to-amyloid-variant
#5
Chuan-Xiang Zhou, Tie-Jun Li
OBJECTIVE: The aim of this study was to clarify the clinicopathologic features of central odontogenic fibroma (OF), especially the amyloid variant, and to discuss its association with the Langerhans cell variant of calcifying epithelial odontogenic tumor (CEOT). STUDY DESIGN: The clinicopathologic features and immunophenotypes of 17 OFs, including 6 amyloid variants, were analyzed. The Langerhans cell variant of CEOT is reviewed, and its relationship with OF is discussed...
September 6, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30279115/denosumab-toxicity-when-combined-with-anti-angiogenic-therapies-on-patients-with-metastatic-renal-cell-carcinoma-a-getug-study
#6
Aline Guillot, Charlotte Joly, Philippe Barthélémy, Emeline Meriaux, Sylvie Negrier, Damien Pouessel, Christine Chevreau, Hakim Mahammedi, Nadine Houede, Guilhem Roubaud, Gwenaelle Gravis, Sophie Tartas, Laurence Albiges, Cécile Vassal, Mathieu Oriol, Fabien Tinquaut, Sophie Espenel, Wafa Bouleftour, Stéphane Culine, Karim Fizazi
BACKGROUND: About one-third of patients with renal cell carcinoma (RCC) have detectable metastases at diagnosis. Among them, bone is the second most frequent metastatic site. Treatment of metastatic RCC mostly relies on anti-angiogenic (AA) therapies and, more recently, immunotherapy. Skeletal-related events (SREs) can be prevented with bone-targeted therapies such as denosumab (Dmab), which has demonstrated superiority when compared with zoledronic acid in solid tumors. However, there is limited available data on Dmab toxicity in combination with AA therapies in patients with kidney cancer...
September 6, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/30256456/adenomatoid-odontogenic-tumor-an-updated-analysis-of-the-cases-reported-in-the-literature
#7
REVIEW
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. METHODS: An electronic search was undertaken in July/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs...
September 26, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/30221984/effects-of-unilateral-nasal-obstruction-on-the-characteristics-of-jaw-closing-muscles-in-growing-rats
#8
Huan Tang, Ikuo Yonemitsu, Yuhei Ikeda, Kenzo Watakabe, Shunichi Shibata, Jun Hosomichi, Ono Takashi
OBJECTIVES: Mouth breathing caused by nasal obstruction (owing to abnormal pressure of masticatory muscles) affects craniofacial growth and development. The influence of unilateral nasal obstruction on jaw-closing muscles was investigated in rats to reveal one of the etiologic mechanisms. MATERIALS AND METHODS: Forty 8-day-old male Wistar rats were used in this study. Experimental rats were subjected to left-sided nasal obstruction by burning the external nostril tissue at the age of 8 days...
September 17, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/30216090/image-segmentation-based-volume-approximation-volume-as-a-factor-in-the-clinical-management-of-osteolytic-jaw-lesions
#9
Martin Kauke, Ali-Farid Safi, Andrea Grandoch, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
OBJECTIVE: Size characterization of osteolytic jaw lesions (OJL), in particular of neoplastic nature, is heterogeneously performed and lacks standardization in the medical literature and clinical practice. An OJL's volume holds promise as a surrogate for treatment response and prognosis. We comparatively evaluate various methods for size characterization of odontogenic OJLs. METHODS: We retrospectively performed semiautomatic image segmentation of CBCT data sets for volume approximation of neoplastic (51) and non-neoplastic odontogenic OJLs (100)...
September 21, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/30182577/-gardner-syndrome-with-chronic-osteomyelitis-of-the-jaw-a-case-report
#10
Pei-Wen Chen, Le-Shi Wang, Yue-Hong Wang, Xiao-Dan Fang
Gardner syndrome is a rare autosomal dominant disease. Its symptoms include multiple intestinal polyps, soft tissue tumors, dental disorders, osteoma, and congenital hypertrophy of the retinal pigment epithelium. Here, we present a patient with Gardner syndrome and chronic osteomyelitis of the jaw to highlight the serious damage that can be caused by Gardner syndrome.
August 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/30175083/association-between-tooth-impaction-and-odontogenic-lesions-a-matched-case-control-study
#11
Shervan Shoaee, Pegah Khazaei, Fatemeh Mashhadiabbas, Masoud Varshosaz, Farshad Sharifi, Hossein HessarI
Background: Impacted tooth is common in dental practice. Dentists usually remove them if they are associated with any pathologic sign or symptom. The challenge is whether to extract the asymptomatic tooth or not. This study was conducted to determine the association between developmental odontogenic cysts and tumors and impacted and unerupted teeth, if left untreated. Methods: In this matched case-control study, 262 participants were recruited in case and control groups to evaluate the association between the presence of odontogenic cyst and tumors and unerupted and impacted teeth in patient records in the School of Dentistry, Shahid Beheshti University of Medical Sciences during 2000-2002...
2018: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/30168218/implant-associated-gene-expression-in-the-jaw-bone-of-smokers-and-nonsmokers-a-human-study-using-quantitative-qpcr
#12
Shariel Sayardoust, Omar Omar, Ola Norderyd, Peter Thomsen
OBJECTIVES: This study aimed to compare the molecular events in implant-adherent cells and in peri-implant bone during the osseointegration of machined and oxidized titanium implants in smokers and nonsmokers. MATERIALS AND METHODS: Twenty-four smokers and 24 nonsmokers each received machined and anodically oxidized mini-implants. The mini-implants and the surrounding bone were retrieved after 1, 7, and 28 days, for gene expression analysis of selected factors using quantitative polymerase chain reaction (qPCR)...
September 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30158768/clinicopathological-profile-of-central-giant-cell-granulomas-an-institutional-experience-and-study-of-immunohistochemistry-expression-of-p63-in-central-giant-cell-granuloma
#13
Mahadevi B Hosur, Rudrayya S Puranik, Shreenivas S Vanaki, Surekha R Puranik, Pramod S Ingaleshwar
Background: The central giant cell granuloma(CGCG) of bone constitutes about 10% of benign jawbone lesions. It affects females more often than males, mandible than maxilla. Biological behavior of CGCG ranges from a slow growing asymptomatic swelling to an aggressive process. True giant cell tumor (GCT) should be distinguished from CGCG. The histological distinction between these lesions depends on quite subtle differences. Expression of p63 has been demonstrated in GCT of bone conversely, has not been detected in CGCG...
May 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/30140199/cardiac-fibroma-with-ventricular-tachycardia-an-unusual-clinical-presentation-of-nevoid-basal-cell-carcinoma-syndrome
#14
Alyssa L Ritter, Eric J Granquist, V Ramesh Iyer, Kosuke Izumi
Pediatric cardiac tumors are rare and often benign with an incidence of approximately 0.03-0.32% and can be associated with genetic conditions. For example, approximately 3% of individuals with nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, have a cardiac fibroma. NBCCS is also characterized by lamellar or early calcification of the falx, jaw keratocysts, palmar and/or plantar pits, and a predisposition for basal cell carcinomas. Given the management implications of NBCCS, including appropriate cancer screenings and precautions, prompt identification of affected individuals is critical...
July 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/30135292/-a-case-of-bone-marrow-metastasis-of-oligodendroglioma-with-idh-mutation-and-1p-19q-codeletion
#15
Katsunari Kiko, Kenichiro Suyama, Kuniatsu Yamamoto, Hidetoshi Mochida, Shigeru Oya, Hideharu Karasawa, Saburo Watanabe, Yoshio Suzuki
A 71-year-old woman was transferred to our hospital, complaining of a seizure for the first time. A tumor was detected in the right frontal lobe, and a craniotomy was performed with a partial tumor resection. The pathological diagnosis was oligodendroglioma with IDH mutation and 1p/19q codeletion, and irradiation therapy was performed. Six months later, the patient's lactate dehydrogenase(LDH)level elevated remarkably, and the fluoro-deoxyglucose-positron emission tomography/computed tomography showed abnormal uptake in multiple bone marrow locations...
August 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/30126803/biological-profile-of-ameloblastoma-and-its-location-in-the-jaw-in-1246-nigerians
#16
Jimoh Olubanwo Agbaje, Akinyele Olumuyiwa Adisa, Mariya Ivanova Petrova, Adeola Adenike Olusanya, Tolulope Osayomi, Olajumoke Ajibola Effiom, Olujide Oladele Soyele, Olufemi Gbenga Omitola, Adetokunbo Babajide Olawuyi, Robinson Obos Okiti, Thelma Eziafa Saiki, Benjamin Fomete, Adebayo Aremu Ibikunle, Chuckwubuzor Okwuosa, Mofoluwaso Abimbola Olajide, Adeola Mofoluwake Ladeji, Kehinde Emmanuel Adebiyi, Mubarak Mobola Emmanuel, Hammed Sikiru Lawal, Emeke Uwadia, Babatunde Oludare Fakuade, Yusuf Mohammed Abdullahi, Constantinus Politis
OBJECTIVES: Ameloblastoma is a benign, slow-growing, locally invasive epithelial tumor of odontogenic origin, with unlimited growth capacity and a strong tendency to recur. This multicentric study analyzed ameloblastoma diagnosed in Nigeria among different ethnic groups. STUDY DESIGN: This retrospective study included ameloblastoma cases diagnosed from 1964 to 2017 at 10 hospitals or medical centers in Nigeria. Age, sex, tribe, and location of the ameloblastoma in the jaw were analyzed...
July 24, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30125736/adenoid-cystic-carcinoma-with-myoepithelial-predominance-affecting-maxilla-and-maxillary-sinus
#17
S Nascimento de Aquino, F Silvestre Verner, R Álvares Cabral, C H Najar Rios, O Paes de Almeida, C Sánchez-Romero
Adenoid cystic carcinoma (ACC) represents less than 10% of all salivary gland tumors, rarely occurring centrally in the jaws. Herein we describe the case of a 36-year-old female patient presenting a painless swelling in the right maxilla, resulting in marked facial asymmetry. Intra-orally it was observed a swelling covered by an erythematous and irregular-surfaced mucosa, affecting the gingiva and crossing the midline of the hard palate. Imaging studies showed a mixed radiolucent-radiopaque lesion with ill-defined borders, involving the right side of the maxilla and the maxillary sinus...
August 17, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30115896/interaction-between-tumor-associated-dendritic-cells-and-colon-cancer-cells-contributes-to-tumor-progression-via-cxcl1
#18
Ya-Ling Hsu, Yi-Jen Chen, Wei-An Chang, Shu-Fang Jian, Hsiao-Li Fan, Jaw-Yuan Wang, Po-Lin Kuo
Crosstalk of a tumor with its microenvironment is a critical factor contributing to cancer development. This study investigates the soluble factors released by tumor-associated dendritic cells (TADCs) responsible for increasing cancer stem cell (CSC) properties, cell mobility, and epithelial-to-mesenchymal transition (EMT). Dendritic cells (DCs) of colon cancer patients were collected for phenotype and CXCL1 expression by flow cytometry and Luminex assays. The transcriptome of CXCL1-treated cancer cells was established by next generation sequencing...
August 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30109555/non-calcifying-langerhans-cell-rich-variant-of-calcifying-epithelial-odontogenic-tumor-a-distinct-entity-with-predilection-for-anterior-maxilla
#19
Neetha Santosh, Kristin K McNamara, John R Kalmar, O Hans Iwenofu
Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT...
August 14, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/30109156/application-of-convolutional-neural-network-in-the-diagnosis-of-jaw-tumors
#20
Wiwiek Poedjiastoeti, Siriwan Suebnukarn
Objectives: Ameloblastomas and keratocystic odontogenic tumors (KCOTs) are important odontogenic tumors of the jaw. While their radiological findings are similar, the behaviors of these two types of tumors are different. Precise preoperative diagnosis of these tumors can help oral and maxillofacial surgeons plan appropriate treatment. In this study, we created a convolutional neural network (CNN) for the detection of ameloblastomas and KCOTs. Methods: Five hundred digital panoramic images of ameloblastomas and KCOTs were retrospectively collected from a hospital information system, whose patient information could not be identified, and preprocessed by inverse logarithm and histogram equalization...
July 2018: Healthcare Informatics Research
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