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https://www.readbyqxmd.com/read/30546242/a-case-of-dental-hamartoma-associated-with-unerupted-primary-canine-in-maxillary-region
#1
Ashish Katiyar, Kirtija Gupta, Swati Solanki, Sukriti Gupta
Odontomas are usually one of the most common odontogenic tumors of the jaw and are perhaps more accurately defined as a hamartoma than a true neoplasm. It is asymptomatic, nonaggressive, slow growing, and benign nature. They are considered to be the malformations of the dental tissue and can sometimes interfere with the eruption of the associated tooth leading to its impaction or delayed eruption. Complex odontomas in primary teeth are rare and unusually diagnosed before the second decade of life. This article aims to present the case of a child with complex odontoma and its effective treatment planning...
July 2018: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/30536424/evolution-of-our-understanding-of-the-hyperparathyroid-syndromes-a-historical-perspective
#2
REVIEW
Stephen J Marx, David Goltzman
We review advancing and overlapping stages for our understanding of the expressions of six hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903 to 1967), the introduction of robust measurement of serum calcium was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects, and inheritability was reported in each syndrome...
December 10, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30526545/multicenter-phase-ii-study-on-cisplatin-pemetrexed-and-bevacizumab-followed-by-maintenance-with-pemetrexed-and-bevacizumab-for-patients-with-advanced-or-recurrent-nonsquamous-non-small-cell-lung-cancer-map-study
#3
Yasuhiro Tsutani, Yoshihiro Miyata, Takeshi Masuda, Kazunori Fujitaka, Mihoko Doi, Yoshikazu Awaya, Shoichi Kuyama, Soichi Kitaguchi, Kazuhiro Ueda, Noboru Hattori, Morihito Okada
BACKGROUND: We evaluated the safety and efficacy of induction chemotherapy with bevacizumab followed by maintenance chemotherapy with bevacizumab for advanced non-small cell lung cancer (NSCLC) in this multicenter phase II study. METHODS: Chemotherapy-naïve patient with stage IIIB-IV or recurrent nonsquamous NSCLC were eligible. We planned approximately four cycles of induction cisplatin (75 mg/m2 ), pemetrexed (500 mg/m2 ), and bevacizumab (15 mg/kg) followed by maintenance with pemetrexed (500 mg/m2 ) and bevacizumab (15 mg/kg) until disease progression...
December 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30517478/in-vivo-study-of-the-action-of-a-topical-anti-inflammatory-drug-in-rat-teeth-submitted-to-dental-bleaching
#4
Francine Benetti, André Luiz Fraga Briso, Luciana Louzada Ferreira, Marina Carminatti, Larissa Álamo, Edilson Ervolino, Eloi Dezan-Júnior, Luciano Tavares Angelo Cintra
Bleaching gel containing hydrogen peroxide (H2O2) cause damages in pulp tissue. This study investigated the action of a topical anti-inflammatory, the Otosporin®, in rats' bleached teeth with the null hypothesis of which the Otosporin® is no able to minimize the pulp inflammation that bleaching gel generates. The rat's molars were divided into groups: BLE: bleached (35% H2O2 concentration /single application of 30 min); BLE-O: bleached followed by Otosporin® (10 min); and control: placebo gel. In the second day after dental bleaching, the rats were killed, and the jaws were processed for hematoxylin-eosin and immunohistochemistry analysis for tumor necrosis factor alpha (TNF-α), interleukin (IL)-6 and IL-17...
November 2018: Brazilian Dental Journal
https://www.readbyqxmd.com/read/30510878/high-grade-burkitt-lymphoma-presenting-as-a-buttock-mass-and-foot-drop
#5
Komal Ejaz, Qalb A Khan, Muhammad A Raza, Roy Sonia Ahmed, Abdul Aleem
Burkitt lymphoma (BL), a highly aggressive B-cell non-Hodgkin lymphoma (NHL), usually presents in children and young adults with large extranodal masses involving jaw bones, gastrointestinal tract, and central nervous system. The three main subtypes of BL are endemic, sporadic, and immunodeficiency variant. Extranodal involvement is common in each variant of BL, although muscle tissue involvement is distinctly rare. Mode of spread may be hematogenous or via direct extension of the primary tumor. In this report, we present a case of a 41-year-old male who presented with a palpable mass in the buttock leading to foot drop as the initial manifestation of BL...
September 26, 2018: Curēus
https://www.readbyqxmd.com/read/30509964/a-trial-sequential-meta-analysis-of-tnf-%C3%AE-308g-a-rs800629-gene-polymorphism-and-susceptibility-to-colorectal-cancer
#6
Raju K Mandal, Munawwar Ali Khan, Arif Hussain, Naseem Akhter, Arshad Jawed, Sajad A Dar, Mohd Wahid, Aditya K Panda, Mohtashim Lohani, B N Mishra, Shafiul Haque
PURPOSE: Tumor necrosis factor-alpha (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of TNF -α -308 G>A (rs1800629) single nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between TNF -α -308 G>A gene polymorphism with CRC risk. METHODS: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were mined for relevant articles...
December 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30496845/evaluation-of-bone-regeneration-in-periapical-osseous-defects-with-and-without-platelet-rich-plasma-combined-calcium-sulfate-and-autologous-bone-graft-a-comparative-study
#7
Nakkeeran Komagan Prabhu, K Saravanan, P Babu, John Reena Rachel
BACKGROUND: Osseous defects of the jaw occurs naturally by pathological conditions such as infections, tumors, cysts or iatrogenic causes induced during surgical treatment of preexisting periradicular bony pathologies. Management of these bone defects poses a great challenge for surgeons who are continually exploring ways to find new modalities to improvise bone substitutes. PURPOSE: To compare and evaluate bone regeneration with and without combining Platelet rich plasma (PRP), calcium sulfate (CS) and autogenous bone graft in periapical defects of jaw...
November 26, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30484215/oropharyngeal-adenoid-cystic-carcinoma-invading-the-mandibular-bone-through-the-mandibular-foramen
#8
Yohei Takeshita, Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Hotaka Kawai, Yohei Noda, Jun Murakami, Mariko Fujita, Hitoshi Nagatsuka, Yoshinobu Yanagi, Junichi Asaumi
Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical...
November 15, 2018: Oral Radiology
https://www.readbyqxmd.com/read/30484192/a-case-of-venous-malformation-of-the-mandible
#9
Shintaro Okura, Chinami Igarashi, Satsuki Wakae-Morita, Takashi Ichiko, Hirokazu Ito, Masashi Sugisaki, Toru Sato, Kaoru Kobayashi
OBJECTIVE: Vascular malformations occur more rarely in bones than in soft tissue, with 0.5-1.0% of all intraosseous tumors occurring in the mandible. We report a diagnostically challenging case of unilocular venous malformation of the mandible. CASE REPORT: A 76-year-old man presented with a heterogeneous, unilocular, radiolucent lesion with a well-defined border. Panoramic radiography and computed tomography imaging revealed a continuous white line on the cortical bone at the inferior border of the left mandibular molar region...
May 23, 2018: Oral Radiology
https://www.readbyqxmd.com/read/30484035/a-case-of-sublingual-adenoid-cystic-carcinoma-involving-the-mandible-presenting-as-a-skip-lesion
#10
Mariko Fujita, Yoshinobu Yanagi, Arthur R G Cortes, Emiko Saito Arita, Tomoo Onoda, Hitoshi Nagatsuka, Jun-Ichi Asaumi
Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a "skip lesion" that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region...
September 2018: Oral Radiology
https://www.readbyqxmd.com/read/30483955/evaluation-of-tumor-infiltrating-lymphocytes-in-osteosarcomas-of-the-jaws-a-multicenter-study
#11
Pollianna Muniz Alves, José Alcides Almeida de Arruda, Diego Antônio Costa Arantes, Sara Ferreira Santos Costa, Lucas Lacerda Souza, Hélder Antônio Rebelo Pontes, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Cassiano Francisco Weege Nonaka, Elismauro Francisco Mendonça, Aline Carvalho Batista
The aim of the present study was to investigate the profile of tumor-infiltrating lymphocytes (TIL) in osteosarcomas of the jaws (OSJ). A total of 21 OSJ samples were analyzed in a retrospective and cross-sectional multicenter study. Immunohistochemistry was performed to determine the recognition of TIL such as CD4+ , CD8+ , granzyme B+ (GrB), programmed cell death protein+ (PD-1), and cytotoxic T lymphocyte-associated antigen 4+ (CTLA-4) in intratumoral and peripheral (stromal) regions. Positivity was determined based on the percentage and density of TIL+ per square millimeter [1 = absent (< 25 cells/mm2 ), 2 = low (25 to 130 cells/mm2 ), and 3 = high (> 130 cells/mm2 )]...
November 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30465934/enhanced-basal-autophagy-supports-ameloblastoma-derived-cell-survival-and-reactivation
#12
Rachel C Sharp, Olajumoke A Effiom, Anuradha Dhingra, Onatolu Odukoya, Adetokunbo Olawuyi, Godwin T Arotiba, Kathleen Boesze-Battaglia, Sunday O Akintoye
OBJECTIVES: Ameloblastoma is an aggressive odontogenic jaw neoplasm. Its unlimited growth confers high potential for malignant transformation and recurrence. It is unclear why ameloblastoma is highly recurrent despite surgical resection with a wide margin of normal tissue. While canonical autophagy can be used to degrade and eliminate damaged cellular components, it is also a protective mechanism that provides energy and vital metabolites for cell survival. We used ameloblastoma-derived cells to test the hypothesis that autophagic processes play a role in survival and reactivation of ameloblastoma...
November 14, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30452964/cdc73-germline-mutation-in-a-family-with-mixed-epithelial-and-stromal-tumors
#13
Cathy D Vocke, Christopher J Ricketts, Mark W Ball, Laura S Schmidt, Adam R Metwalli, Lindsay A Middelton, J Keith Killian, Javed Khan, Paul S Meltzer, William F Simonds, Maria J Merino, W Marston Linehan
OBJECTIVE: To describe a family in which three members presented with mixed epithelial tumor of the kidney (MEST) and were found to possess a germline mutation in CDC73, a gene which is associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT). MATERIALS AND METHODS: Blood and tumor DNA from three family members who presented with a primary diagnosis of MEST was subjected to targeted gene sequencing to identify potential genetic components. RESULTS: A germline start codon mutation (p...
November 16, 2018: Urology
https://www.readbyqxmd.com/read/30449067/a-multi-institutional-retrospective-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-malignant-tumors-of-the-nasopharynx-subanalysis-of-japan-carbon-ion-radiation-oncology-study-group-study-1402-hn
#14
Takanori Abe, Tatsuya Ohno, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun-Ichi Saitoh, Katsuyuki Shirai, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
BACKGROUND: This multi-institutional retrospective study focused on the clinical outcome of carbon-ion radiotherapy (C-ion RT) for non-squamous cell malignant tumors of the nasopharynx. METHODS: The Japan Carbon-ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non-squamous cell malignant tumors of the nasopharynx treated with C-ion RT at four institutions in Japan. RESULTS: Twenty-nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies...
November 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30444778/mandibular-regeneration-with-autologous-human-bone-marrow-derived-mesenchymal-stem-cells-to-treat-unicystic-ameloblastoma-a-clinical-report
#15
Jeong Wan Son, Bong Chul Kim, Jung Hoon Yoon, Jun Lee, Hun Jun Lim
Ameloblastoma is a rare, benign tumor found in the jaw. These tumors have a tendency for locally aggressive expansion, and thus require surgical removal. For the previous 3 decades, autologous bone grafting and free flap surgeries have been most commonly used to correct bone defects after surgical removal of the lesion. In this report, the authors describe a case of unicystic ameloblastoma in a 14-year-old girl who was successfully treated with mandibular regeneration, attained by autologous human bone marrow mesenchymal stem cells without any autologous bone graft and free flap transfer...
November 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30411085/lymphoid-enhancer-factor-1-contributes-to-hepatocellular-carcinoma-progression-through-transcriptional-regulation-of-epithelial-mesenchymal-transition-regulators-and-stemness-genes
#16
Chih-Li Chen, Yu-Shuen Tsai, Yen-Hua Huang, Yuh-Jin Liang, Ya-Yun Sun, Chien-Wei Su, Gar-Yang Chau, Yi-Chen Yeh, Yung-Sheng Chang, Jui-Ting Hu, Jaw-Ching Wu
Lymphoid enhancer factor 1 (LEF1) activity is associated with progression of several types of cancers. The role of LEF1 in progression of hepatocellular carcinoma (HCC) remains poorly known. We investigated LEF1 expression in HCC and its interactions with epithelial-mesenchymal transition (EMT) regulators (e.g., Snail, Slug, Twist) and stemness genes (e.g., octamer-binding transcription factor 4 [ Oct4 ], sex determining region Y-box 2 [ Sox2 ], Nanog homeobox [ Nanog ]). Microarray analysis was performed on resected tumor samples from patients with HCC with or without postoperative recurrence...
November 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30409955/rare-granular-cell-tumor-affecting-a-13-year-old-boy
#17
S M Balaji, Preetha Balaji
Granular cell tumor (GCT) is a rare soft-tissue neoplasm, first described in 1926. GCT often manifests as a single, painless nodule that shows a slow enlargement in the cutaneous, subcutaneous, or submucosal tissues. It is commonly reported in adults in the third to sixth decade of life. This case report is of an incidental finding in a young boy, who was radiologically examined for orthodontic treatment purpose and found to have a radiolucent lesion in the mandible. The lesion was later diagnosed as GCT. Central GCT is rare, and the presentation in a child is even rare...
September 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/30402324/injectable-chemotherapy-downstaged-oral-squamous-cell-carcinoma-from-nonresectable-to-resectable-in-a-rescue-dog-diagnosis-treatment-and-outcome
#18
Shuang Cai, Ti Zhang, Chad Groer, Melanie Forrest, Daniel Aires, Vern Otte, Sally Barchman, Abby Faerber, Marcus Laird Forrest
This case report documents the diagnosis, treatment, and outcome of a nonresectable oral squamous cell carcinoma in a dog with initial poor prognosis. An approximately 4-year-old female Staffordshire Bull Terrier presented with a large mass on the front of lower jaw which was diagnosed as oral papillary squamous cell carcinoma by histopathology. CT scans revealed invasion of the cancer to the frenulum of the tongue. The mass was inoperable due to location, expansiveness, and metastatic lymph nodes. The dog received 4 treatments of intralesional hyaluronan-platinum conjugates (HylaPlat™, HylaPharm LLC, Lawrence, Kansas) at 3-week intervals...
2018: Case reports in veterinary medicine
https://www.readbyqxmd.com/read/30391354/pharmacological-inhibition-of-bacterial-%C3%AE-glucuronidase-prevents-irinotecan-induced-diarrhea-without-impairing-its-antitumor-efficacy-in-vivo
#19
Kai-Wen Cheng, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yu-Lin Leu, Ta-Chun Cheng, Jaw-Yuan Wang, Jia-Ming Chang, Yun-Chi Lu, Chiu-Min Cheng, I-Ju Chen, Yi-An Cheng, Yeh-Long Chen, Tian-Lu Cheng
Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequently is exported into the intestine, where SN-38 G is hydrolyzed by bacterial β-glucuronidase (βG) to be SN-38, thus leading to intestinal toxicity. Thus, inhibition of the intestinal bacterial βG activity is expected to prevent CPT-11-induced diarrhea...
November 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30390348/melanotic-neuroectodermal-tumor-of-infancy-of-the-jaw-bones-update-on-the-factors-influencing-survival-and-recurrence
#20
REVIEW
Flavia Sirotheau Correa Pontes, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa, Andrea Maia Correa Joaquim, Liliane Silva do Nascimento, Diogo Dos Santos da Mata Rezende, Hélder Antônio Rebelo Pontes
The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty-seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow-up was 51.1 months (range 1-408 months)...
November 2, 2018: Head & Neck
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