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https://www.readbyqxmd.com/read/30098917/comparative-study-of-neoadjuvant-chemotherapy-with-and-without-zometa-for-management-of-locally-advanced-breast-cancer-with-serum-vegf-as-primary-endpoint-the-neozol-study
#1
Loïc Lelièvre, Philippe Clézardin, Laurent Magaud, Laurent Roche, Nicole Tubiana-Mathieu, Jean-Dominique Tigaud, Delphine Topart, Nadia Raban, Marie-Ange Mouret-Reynier, Patrice Mathevet
INTRODUCTION: Neoadjuvant chemotherapy has become the treatment of choice for locally advanced breast cancer. Zoledronic acid (ZA) is a bisphosphonate initially used in the treatment of bone metastases because of its antibone resorption effect. Antitumor effects of ZA, including the inhibition of cell adhesion to mineralized bone or the antiangiogenic effect, have been demonstrated. However, the clinical significance of these effects remains to be determined. MATERIALS AND METHODS: We undertook a multicenter open-label randomized trial to analyze the value of adding ZA to neoadjuvant chemotherapy for TNM clinical stage T2/T3 breast cancer...
July 10, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30083326/the-in-vivo-tissue-effect-of-endoscopic-balloon-based-radiofrequency-ablation-in-treating-esophageal-squamous-cell-neoplasia
#2
Wen-Lun Wang, I-Wei Chang, Chien-Chuan Chen, Chi-Yang Chang, Cheng-Hao Tseng, Chi-Ming Tai, Jaw-Town Lin, Hsiu-Po Wang, Ching-Tai Lee
Background: Endoscopic radiofrequency ablation (RFA) is a rapidly evolving therapeutic modality for early flat esophageal squamous cell neoplasms (ESCNs). However, the in vivo tissue effects of RFA on the esophageal wall are uncertain. Methods: We prospectively enrolled eight patients with flat-type early ESCNs who were treated with balloon-based RFA. We evaluated the in vivo tissue effect on the esophagus using endoscopic ultrasound (EUS) and the histology of retrieved coagulum...
June 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30064005/vaginal-closure-with-endogia-to-prevent-tumor-spillage-in-laparoscopic-radical-hysterectomy-for-cervical-cancer
#3
Gokhan Boyraz, Alper Karalok, Derman Basaran, Taner Turan
STUDY OBJECTIVE: To demonstrate a method of vaginal closure with EndoGIA surgical stapler to prevent tumor spillage in laparoscopic radical hysterectomy. DESIGN: Step-by-step explanation of the procedure using video. SETTING: Women's Health Teaching and Research Hospital. PATIENT: A 40-year-old woman with clinical stage IBI cervical squamous cell carcinoma. INTERVENTION: Laparoscopic type C radical hysterectomy with pelvic lymph node dissection and ovarian transposition...
July 28, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/30057827/spontaneous-and-excellent-healing-of-bilateral-brown-tumors-in-mandible-after-endocrinal-therapy-and-subtotal-parathyroidectomy-case-report-with-4-year-follow-up
#4
Turker Yucesoy, Erdem Kilic, Fatma Dogruel, Fahri Bayram, Alper Alkan, Alper Celal Akcan, Figen Ozturk
Primary hyperparathyroidism is an endocrine disorder occurring due to increased secretion of parathormone resulting in a complex of clinical, anatomical, and biochemical alterations. On the other hand, excision of a parathyroid adenoma can normalize the metabolic status. A 24-year-old man was referred to the hospital with bilateral swelling and spontaneous gingival bleeding from posterior of the mandible also with radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions. After consultations, the patient was hospitalized in the endocrinology department where further tests were performed due to highly increased PTH level as 714 pg/ml...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/30040001/diagnosis-and-multimodal-treatment-of-metastatic-maxillofacial-juvenile-embryonal-rhabdomyosarcoma-in-a-young-golden-retriever
#5
Julie Marie Gillem, Louise Sullivan, Karin U Sorenmo
A 2 yr old male castrated golden retriever was evaluated for a rapidly progressing maxillofacial spindle cell tumor. On examination, an ill-defined left maxillary mass, a 2 cm swelling under the left eye, and an enlarged left mandibular lymph node were noted. The dog was bright and alert but appeared painful upon jaw extension. Cytology from the lymph node revealed metastatic disease. Thoracic radiographs and computed tomography scan revealed pulmonary nodules. Computed tomography of the head and neck revealed a 6...
July 24, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/30036443/ameloblastomas-of-the-mandible-and-maxilla
#6
Ivana D Petrovic, Jocelyn Migliacci, Ian Ganly, Snehal Patel, Bin Xu, Ronald Ghossein, Joseph Huryn, Jatin Shah
Ameloblastoma is a histologically benign but locally aggressive tumor of the jaws. We conducted a retrospective cohort study to review the clinical, radiologic, and pathologic features of patients with ameloblastoma of the mandible and maxilla and to report the outcomes of treatment. Our study population was made up of a series of 30 consecutively presenting patients-15 men and 15 women, aged 19 to 81 years (median: 61.5)-who had undergone their primary treatment of ameloblastoma of the mandible or maxilla at Memorial Sloan Kettering Cancer Center from January 1987 through December 2012...
July 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/30019325/t-cell-histiocyte-rich-large-b-cell-lymphoma-report-of-the-first-case-in-the-mandible
#7
Ricardo Natã Fonseca Silva, Elismauro Francisco Mendonça, Aline Carvalho Batista, Rita de Cássia Gonçalves Alencar, Ricardo Alves Mesquita, Nadia Lago Costa
T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region...
July 17, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/30009069/a-rare-case-of-large-schwannoma-of-the-parapharyngeal-space
#8
Nora Siupsinskiene, Irina Arechvo, Rimante Lapinskaite, Evaldas Padervinskis, Silvija Ryskiene, Saulius Vaitkus
Schwannoma originating from the peripheral nerves is a rare lesion of the parapharyngeal space. The special traits of the presented case included the following: the patient presented with slowly progressing dysphagia, speech difficulties, jaw numbness, and taste dysfunction. A dislocated lateral pharyngeal wall with mild inflammatory changes of the oropharyngeal mucosa was observed during pharyngoscopy. The radiological and histological characteristics of the neoplasm are consequently presented. Special emphasis is placed on the surgical treatment of the tumor...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/30003979/verapamil-potentiates-anti-glioblastoma-efficacy-of-temozolomide-by-modulating-apoptotic-signaling
#9
Farina Hanif, Kahkashan Perveen, Saima M Malhi, Huma Jawed, Shabana U Simjee
Glioblastoma Multiforme (GBM) is the most malignant and invasive tumor of the CNS. Although temozolomide (TMZ) has improved the survival, long-lasting responses have not been reported. Therefore, there is a need to develop improved treatments, one of which might be newly identified drugs which can be used in combination therapy with low doses of standard drugs. Verapamil (VP) a known antihypertensive drug has been shown to enhance the activity of bis-chloroethylnitrosourea (BCNU), a drug used to treat GBM. Since, TMZ has replaced BCNU as the standard GBM chemotherapy; therefore, we aimed to study in vitro interaction of VP and TMZ against GBM...
July 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29988278/intraosseous-mucoepidermoid-carcinoma-of-the-jaw-report-of-three-cases
#10
Bora Başaran, Can Doruk, Eren Yılmaz, Ecem Sünnetçioğlu, Bilge Bilgiç
Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands and is seen most commonly in the parotid gland. Intraosseous MECs can be rarely seen and is mostly detected in the posterior part of the mandible. This condition can be acknowledged as an entity different from salivary gland MECs. In this case series, we delineated three patients of intraosseous MEC, two mandible tumors and one maxillary tumor and discussed the diagnostic characteristics and treatment methods of this rare entity...
March 2018: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29981859/maxillary-metastasis-from-a-hepatocellular-carcinoma-report-of-an-uncommon-presentation-and-literature-review
#11
J Adnot, P Gemival, O Trost
INTRODUCTION: Oral metastases from hepatocellular carcinoma (HCC) are very rare, and predominate in the mandible. We report an exceptional case of maxillary metastasis revealing HCC. CASE REPORT: A 56-year-old man with a previous medical history of alcohol abuse presented to our department with a 3-week evolving oral mass. Physical examination showed a left maxillary tumor. The biopsy revealed a HCC and a multi-metastatic HCC with portal thrombosis and a pulmonary embolism was discovered following a CT-scan...
July 5, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29971493/oct-4-and-cd44-in-epithelial-stem-cells-like-of-benign-odontogenic-lesions
#12
Eduardo Alonso Cruz Monroy, Pedro Paulo de Andrade Santos, Maria Luiza Diniz de Sousa Lopes, Adalberto Mosqueda-Taylor, Leão Pereira Pinto, Lélia Batista de Souza
Benign epithelial odontogenic lesions are great clinical importance entities that develop in the jaws from the tissues that form teeth. It has been shown that benign and malignant tumors are present in a large number of tumor stem cells, which has great implications in the development of these lesions. Oct-4 and CD44 have been demonstrated as important markers for tumoral stem cells. The aim of this study was investigate the presence of stem cell markers Oct-4 and CD44 in benign epithelial odontogenic lesions...
July 3, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29963491/retrospective-clinical-study-of-multiple-keratocystic-odontogenic-tumors-in-non-syndromic-patients
#13
Dae-Seok Hwang, Yun-Ho Kim, Uk-Kyu Kim, Mi-Heon Ryu, Gyoo-Cheon Kim
Objectives: A keratocystic odontogenic tumor (KOT) is a type of odontogenic tumor that mainly occurs in the posterior mandible. Most KOTs appear as solitary lesions; however, they sometimes occur as multiple cysts. This study analyzed the clinical features of multiple KOTs. Materials and Methods: The participants were diagnosed with KOT by biopsy with multiple surgical sites, and were patients at the Pusan National University Hospital and the Pusan National University Dental Hospital from January 1, 2005 to March 31, 2016...
June 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29942110/bilocular-unicystic-ameloblastoma-of-the-mandible-in-a-9-yr-old-child-a-diagnostic-and-management-dilemma
#14
Faisal Al Sineedi, Yasin Alavi Aruveetil, Abdul Majeed Kavarodi, Shawqi Osman Harbi
Unicystic ameloblastoma is a less encountered variant of the ameloblastoma that usually presented as unicystic lesions of jaw occurring in 3rd and 4th decades of life. It shows a typical ameloblastomatous epithelium lining the cyst cavity, with or without variable tumor proliferations. The case presented here is of a 9 yr old boy who was referred to our center for the management of a large diffuse swelling on the right side of the face. Clinical and radiologic evaluation showed two interconnected cystic lesions in the right body and the symphyseal regions of the mandible associated with impacted canines bilaterally...
July 2018: Saudi Dental Journal
https://www.readbyqxmd.com/read/29941386/solitary-plasmacytoma-of-the-jaws-therapeutical-considerations-and-prognosis-based-on-a-case-reports-systematic-survey
#15
Eduardo Madruga Lombardo, Fábio Luiz Dal Moro Maito, Cláiton Heitz
INTRODUCTION: Solitary plasmacytoma is a rare malignant tumor of plasma cells with no evidence of systemic proliferation. There are two known subtypes: extramedullary solitary plasmacytoma and solitary bone plasmacytoma. The etiology is still unknown. Both lesions present a risk of progression to multiple myeloma. A number of approaches have been used for treatment of solitary plasmacytoma. OBJECTIVE: To carry out a systematic review of the case reports described in the literature, focusing on therapeutic and prognostic aspects...
June 11, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29937671/fine-needle-aspiration-cytology-as-a-useful-diagnostic-adjunct-in-the-management-of-ameloblastoma-a-report-of-four-cases
#16
Aprna Gupta, Surya Narayan Das, Sangram Patro, Subhrajit Raut
Ameloblastoma is a locally aggressive common odontogenic tumor of the jaws. Although histopathological and radiological findings have been extensively studied for the diagnosis of ameloblastoma, usefulness of fine-needle aspiration cytology (FNAC) has not been explored much. Here, we have reported four cases of ameloblastomas diagnosed by FNAC and subsequently confirmed by histopathology.
January 2018: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29937668/an-innovative-approach-to-the-prosthodontic-management-of-class-iii-mandibular-defect
#17
Saumya Pandey, Sushil Kar, Naresh Kumar Sharma, Arvind Tripathi
Class III mandibular resection due to surgical treatment of jaw tumor produces a discontinuity in the mandible which is severely incapacitating to the patient. It leads to a deviation and rotation of the mandible which depends on the amount of tissues resected the manner of surgical site closure, loss of proprioceptive sense of occlusion, the presence, and condition of teeth, and the time of initiation of prosthodontic therapy. These put together makes the task of prosthodontic rehabilitation quite arduous...
January 2018: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29930556/novel-insights-on-the-regulation-of-b-cell-functionality-by-members-of-the-tumor-necrosis-factor-superfamily-in-jawed-fish
#18
REVIEW
Carolina Tafalla, Aitor G Granja
Most ligands and receptors from the tumor necrosis factor (TNF) superfamily play very important roles in the immune system. In particular, many of these molecules are essential in the regulation of B cell biology and B cell-mediated immune responses. Hence, in mammals, it is known that many TNF family members play a key role on B cell development, maturation, homeostasis, activation, and differentiation, also influencing the ability of B cells to present antigens or act as regulators of immune responses. Evolutionarily, jawed fish (including cartilaginous and bony fish) constitute the first animal group in which an adaptive immune response based on B cells and immunoglobulins is present...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29922342/rare-case-of-bilateral-complex-odontoma-associated-with-mandibular-bicuspids
#19
Rangeeth Bollam Nammalwar, Joyson Moses, Sathya Jeeva
Among oral pathologic lesions, odontomas are the most common odontogenic tumor of the jaws and generally asymptomatic. They are mostly diagnosed as a result of routine radiographic investigation. In this report, we describe a very rare occurrence of bilateral complex odontoma in the region of the mandibular second premolar. Conservative surgical procedure was planned, and removal of the odontomas was carried out through the socket after extraction of the deciduous second molars, and the diagnosis was confirmed with a histopathological study...
May 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29896310/pre-existing-anti-polyethylene-glycol-antibody-reduces-the-therapeutic-efficacy-and-pharmacokinetics-of-pegylated-liposomes
#20
Yuan-Chin Hsieh, Hsin-Ell Wang, Wen-Wei Lin, Steve R Roffler, Ta-Chun Cheng, Yu-Cheng Su, Jia-Je Li, Chao-Cheng Chen, Chun-Han Huang, Bing-Mae Chen, Jaw-Yuan Wang, Tian-Lu Cheng, Fang-Ming Chen
Rationale: Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. Methods: We generated two pre-αPEG Ab mouse models. First, naïve mice were immunized with PEGylated protein to generate an endogenous αPEG Ab titer (endo αPEG). Second, monoclonal αPEG Abs were passively transferred (αPEG-PT) into naïve mice to establish a αPEG titer...
2018: Theranostics
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