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Mani daneshmand

David N Ranney, Judson B Williams, Hillary Mulder, Daniel Wojdyla, Morgan L Cox, C Michael Gibson, Michael J Mack, Mani A Daneshmand, John H Alexander, Renato D Lopes
Although in situ internal mammary artery (is-IMA) grafting remains the most frequent conduit in coronary artery bypass grafting (CABG), circumstances may necessitate free grafting of the IMA (f-IMA), though differences in outcomes have not been fully characterized. The purpose of this study was to compare clinical and angiographic outcomes of is-IMA versus f-IMA coronary bypass grafts in patients who underwent elective CABG surgery. In 1,829 patients in the angiographic cohort of PREVENT IV, 1,572 (85.9%) had at least 1 IMA graft; of these, 34 (2...
November 24, 2018: American Journal of Cardiology
David Ranney, Sarah Hatch, Desiree Bonadonna, Mani Daneshmand
Although life-saving, cardiopulmonary resuscitation (CPR) has been associated with traumatic injuries in adult patients surviving cardiac arrest. In addition to rib and sternal fractures, intraabdominal injuries have also been shown to occur, particularly after prolonged external cardiac massage. Early detection of these injuries remains difficult and is often masked by concomitant hemodynamic instability and the higher likelihood of other injuries such as retroperitoneal hemorrhage. Accurate diagnosis is further complicated when venoarterial (VA) extracorporeal membrane oxygenation (ECMO) is instituted...
November 28, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Yaron D Barac, Mike S Mulvihill, Morgan L Cox, Muath Bishawi, Jacob Klapper, John Haney, Mani Daneshmand, Matthew G Hartwig
BACKGROUND: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudices against the allocation of allografts to type O candidates, given that the pool of potential donors is smaller. METHODS: We performed a retrospective cohort review of the Organ Procurement and Transplantation Network/United Network of Organ Sharing registry from May 2005 to March 2017 for adult candidates on the waiting list for first-time isolated lung transplantation...
September 25, 2018: Journal of Heart and Lung Transplantation
Yaron D Barac, Dominick J Megna, Anthony W Castleberry, Jacob N Schroder, Mani A Daneshmand, Joseph G Rogers, Chetan B Patel, Mihai Podgoreanu, Carmelo A Milano
No abstract text is available yet for this article.
September 25, 2018: Journal of Thoracic and Cardiovascular Surgery
Stephen Gaeta, Jacob N Schroder, Mani A Daneshmand, Kevin L Thomas, Donald D Hegland, Jonathan P Piccini, James P Daubert, Jason I Koontz, Albert Y Sun
No abstract text is available yet for this article.
September 2018: JACC. Clinical Electrophysiology
Brandi A Bottiger, Alina Nicoara, Laurie D Snyder, Paul E Wischmeyer, Jacob N Schroder, Chetan B Patel, Mani A Daneshmand, Robert N Sladen, Kamrouz Ghadimi
The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary failure may be under consideration for heart or lung transplantation along with bridging therapies such as ventricular assist device implantation or venovenous extracorporeal membrane oxygenation, respectively. Early identification of frail patients in an attempt to modify the risk of postoperative morbidity and mortality has become an important area of study over the last decade...
August 9, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Katherine V Clark-Knowles, Danielle Dewar-Darch, Karen E Jardine, Josée Coulombe, Manijeh Daneshmand, Xiaohong He, Michael W McBurney
SIRT1 is a protein deacetylase with a broad range of biological functions, many of which are known to be important in carcinogenesis, however much of the literature regarding the role of SIRT1 in cancer remains conflicting. In this study we assessed the effect of SIRT1 on the initiation and progression of thymic T cell lymphomas. We employed mouse strains in which SIRT1 activity was absent or could be reversibly modulated in conjunction with thymic lymphoma induction using either the N-nitroso-N-methylurea (NMU) carcinogenesis or the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) transgene...
October 1, 2018: Experimental Cell Research
Muath Bishawi, Jun-Neng Roan, Jordan Richards, Zachary Brown, Laura Blue, Mani A Daneshmand, Jacob N Schroder, Dawn E Bowles, Carmelo A Milano
Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices...
May 11, 2018: Journal of Visualized Experiments: JoVE
Jamie R Privratsky, Sebastian Diaz, Alina Nicoara, Mani A Daneshmand
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly utilized life-saving measure. However, left-ventricular distention from inadequate left-ventricular off-loading can lead to unwanted pulmonary and cardiac complications. We are writing to indicate our agreement with a recent article by Brechot et al. published in the June 2017 issue where the authors demonstrated that intra-aortic balloon pump provides mechanical support to off-load the left ventricle during VA-ECMO, which prevents pulmonary edema...
May 1, 2018: European Heart Journal. Acute Cardiovascular Care
Muath Bishawi, Jeremy Joseph, Chetan Patel, Jacob Schroder, Mani Daneshmand, Dawn Bowles, Joseph Rogers, Carmelo Milano
BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-center retrospective review of all patients from 2009 to 2014 in whom a rotary flow LVAD was implanted. All patients with symptoms of a cerebrovascular event underwent a non-contrast head computed tomography scan...
June 2018: Journal of Cardiac Surgery
Haider J Warraich, Di Lu, Stacy Cobb, Lauren B Cooper, Adam DeVore, Chetan B Patel, Paul B Rosenberg, Jacob N Schroder, Mani A Daneshmand, Carmelo A Milano, Adrian F Hernandez, Joseph G Rogers, Robert J Mentz
BACKGROUND: Deaths from drug intoxication have increased in the United States but outcomes of recipients of orthotopic heart transplantation (OHT) from these donors are not well characterized. METHODS: We performed a retrospective analysis of the United Network for Organ Sharing's STAR database between January 2000 and March 2014 and assessed mortality and retransplantation using adjusted Cox models by mechanism of donor death. RESULTS: Of the 31,660 OHTs from 2000 to 2014, 1233 (3...
May 2018: American Heart Journal
Morgan L Cox, Brian C Gulack, Dylan P Thibault, Xia He, Matthew L Williams, Vinod H Thourani, Jeffery P Jacobs, J Matthew Brennan, Mani A Daneshmand, Deepak Acharya
OBJECTIVES: Previous studies have demonstrated a 20% mortality rate among patients undergoing isolated coronary artery bypass grafting (CABG) for cardiogenic shock. However, outcomes following CABG for cardiogenic shock in patients who are neurologically unresponsive preoperatively are unknown. METHODS: Utilizing the Society of Thoracic Surgeons Adult Cardiac Surgery Database between July 2011 and December 2013, patients undergoing urgent or emergent CABG within 7 days of an acute myocardial infarction complicated by cardiogenic shock were identified...
October 1, 2018: European Journal of Cardio-thoracic Surgery
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
Jessica L Seidelman, Sarah S Lewis, Kirk Huslage, Nancy Strittholt, Sheila Vereen, Chris Sova, Bonnie Taylor, Desiree Bonadonna, David Ranney, Utlara Nag, Mani Daneshmand, Deverick J Anderson, Daniel J Sexton, Becky A Smith
No abstract text is available yet for this article.
March 2018: Infection Control and Hospital Epidemiology
Yaron D Barac, Hazim Alwair, David F Kong, Chetan B Patel, Mani A Daneshmand, Carmelo A Milano, Jacob N Schroder
Axillary artery intraaortic balloon pump (IABP) placement enables those awaiting transplant to ambulate and get stronger, but motion increases risk of IABP migration. The management of a migrated pump in a 44-year-old man with heart failure is described.
January 2018: Journal of Invasive Cardiology
Yaron D Barac, Brittany Zwischenberger, Jacob N Schroder, Mani A Daneshmand, John C Haney, Jeffrey G Gaca, Andrew Wang, Carmelo A Milano, Donald D Glower
BACKGROUND: Outcome of mitral valve replacement in extreme scenarios of small mitral annulus with the use of the Regent mechanical aortic valve is not well documented. METHODS: Records were examined in 31 consecutive patients who underwent mitral valve replacement with the use of the aortic Regent valve because of a small mitral annulus. RESULTS: Mean age was 60 ± 14 years. Mitral stenosis or mitral annulus calcification was present in 30 of 31 patients (97%)...
April 2018: Annals of Thoracic Surgery
Nnamdi Nwaejike, Andre Y Son, Chetan B Patel, Jacob N Schroder, Carmelo A Milano, Mani A Daneshmand
We evaluated the feasibility, tolerability, and efficacy of a strategy for transaxillary artery intra-aortic balloon pump placement for extended mechanical circulatory support of patients with postcardiotomy shock as a bridge to recovery. Patients requiring prolonged intra-aortic balloon pump support for postcardiotomy heart failure were identified. Intra-aortic balloon pump was tunneled through a 6-mm Dacron graft anastomosed to the right axillary artery. The intra-aortic balloon pump catheter is advanced under fluoroscopic guidance into the descending thoracic aorta...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Michael S Mulvihill, Matthew G Hartwig, Mani A Daneshmand
Lung transplantation is the gold standard therapy for patients with end-stage lung disease. The use of the lung allocation score (LAS) has permitted improved allocation of scarce pulmonary allografts. Recently, Crawford et al. examined the experience in the United States in lung transplantation in candidates with the highest LAS, demonstrating that outcomes for candidates with the highest LAS scores have improved significantly. This editorial places these data in the broader context of thoracic transplantation, and highlights the critical need for ongoing examination of this critically-ill patient population...
September 2017: Journal of Thoracic Disease
Visakha Suresh, Muath Bishawi, Michael W Manning, Chetan Patel, Joseph Rogers, Carmelo Milano, Jacob Schroder, Mani Daneshmand, David Powers
PURPOSE: An increasing number of patients with end-stage heart failure are supported with left ventricular assist device (LVAD) implantation and must be maintained on a consistent anticoagulation regimen. Pre-emptive extraction of carious teeth in these patients is necessary to prevent seeding of the implanted device and endocarditis. Thus, the objective of this study was to evaluate bleeding complications after minor oral surgery, specifically teeth extractions, in this unique patient population requiring long-term anticoagulation...
September 2018: Journal of Oral and Maxillofacial Surgery
Alina Nicoara, David Ruffin, Mary Cooter, Chetan B Patel, Annemarie Thompson, Jacob N Schroder, Mani A Daneshmand, Adrian F Hernandez, Joseph G Rogers, Mihai V Podgoreanu, Madhav Swaminathan, Adam Kretzer, Mark Stafford-Smith, Carmelo A Milano, Raquel R Bartz
Changes in heart transplantation (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 and December 2014 at our institution. Patients were categorized as having PGD using the International Society for Heart & Lung Transplantation (ISHLT)-defined criteria. Variables, including clinical and demographic characteristics of donors and recipients, were selected to assess their independent association with PGD...
June 2018: American Journal of Transplantation
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