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https://www.readbyqxmd.com/read/30325842/precut-dmek-using-dextran-containing-storage-medium-is-equivalent-to-conventional-dmek-a-prospective-pilot-study
#1
Annekatrin Rickmann, Silke Wahl, Nicola Hofmann, Arno Haus, Regina Michaelis, Tanja Petrich, Lutz Blomberg, Martin Börgel, Sascha Jung, Peter Szurman
PURPOSE: To compare the clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) either as precut or conventional Descemet membrane graft preparation under standard European eye bank organ culture conditions. METHODS: This was a prospective pilot study of patients receiving either precut or conventional DMEK. Graft preparation was performed using the liquid bubble technique. Precut grafts (n = 22) were prepared 1 day before surgery in the eye bank and stored in dextran-containing organ culture medium within a transport viewing chamber...
October 5, 2018: Cornea
https://www.readbyqxmd.com/read/30324748/differential-expression-profiles-of-long-noncoding-rnas-in-synchronous-multiple-and-solitary-primary-esophageal-squamous-cell-carcinomas-a-microarray-analysis
#2
Qi-Wen Li, Li Ma, Bo Qiu, Hong Yang, Yu-Jia Zhu, Meng-Yun Qiang, Song-Ran Liu, Nai-Bin Chen, Jin-Yu Guo, Ling-Zhi Cai, Jun-Ye Wang, Xu Zhang, Hui Liu
As a unique subtype of esophageal cancer, synchronous multiple primary esophageal squamous cell carcinomas (ESCCs) mostly occur in Asian patients with alcohol and/or tobacco abuse, or with a family history of cancer. Multiple ESCCs are associated with poor clinical outcomes. Growing evidence has addressed that long noncoding RNAs (lncRNAs) are involved in the carcinogenesis of various malignancies. We compared the lncRNA and messenger RNA (mRNA) profiles between solitary and multiple ESCC tissues through microarray analysis, aiming at studying their different mechanisms in tumor development...
October 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30323602/long-lasting-extrapyramidal-symptoms-after-multiple-injections-of-paliperidone-palmitate-to-treat-schizophrenia
#3
Ryohei Takada, Kazuhiko Yamamuro, Toshifumi Kishimoto
Purpose: Antipsychotic drug treatment can potentially lead to adverse events such as extrapyramidal symptoms (EPSs). If these events persist, they lower patient quality of life. The purpose of this report is to present our experience with such a case, as an example to encourage further study. Patients and methods: The patient was a 64-year-old male who had been diagnosed with schizophrenia that had been treated with oral antipsychotics for over 40 years. Due to lack of compliance, he was treated with the long-acting injectable antipsychotic, paliperidone palmitate, but developed persistent EPSs after 6 months...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30322666/pre-hospital-qsofa-as-a-predictor-of-sepsis-and-mortality
#4
Eileen Shu, Crystal Ives Tallman, William Frye, Jonathan G Boyajian, Leyla Farshidpour, Megann Young, Danielle Campagne
BACKGROUND: The quick sequential organ failure assessment score (qSOFA) has been proposed as a simple tool to identify patients with sepsis who are at risk for poor outcomes. Its utility in the pre-hospital setting has not been fully elucidated. METHODS: This is a retrospective observational study of adult patients arriving by ambulance in September 2016 to an academic emergency department in Fresno, California. The qSOFA score was calculated from pre-hospital vital signs...
September 18, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30322637/a-report-concerning-collaboration-between-a-physician-staffed-helicopter-doctor-helicopter-and-firefighting-rescue-helicopter
#5
Hiromichi Ohsaka, Youichi Yanagawa, Hiroki Nagasawa, Ikuto Takeuchi, Kei Jitsuiki, Shunsuke Madokoro, Akihiko Kondo, Kouhei Ishikawa, Kazuhiko Omori
OBJECTIVE: In Japan, the main helicopters that transport patients are physician-staffed helicopters (known as doctor helicopters [DHs]) and firefighter/rescue helicopters (F/RHs). We report the collaboration between F/RHs and DHs in eastern Shizuoka Prefecture. METHODS: We retrospectively investigated all of the patients who were transported by F/RHs in Shizuoka Prefecture between January 2015 and April 2018. RESULTS: Nine cases were defined as subjects...
September 2018: Air Medical Journal
https://www.readbyqxmd.com/read/30318770/an-early-warning-system-for-emerging-drugs-of-concern-in-the-emergency-department-protocol-for-the-western-australian-illicit-substance-evaluation-wise-study
#6
David McCutcheon, Mohan Raghavan, Jessamine Soderstrom, Francois Oosthuizen, Bianca Douglas, Ellen MacDonald, Daniel Fatovich
OBJECTIVE: An ever-increasing number of novel psychoactive substances are being detected worldwide. These emerging drugs have been demonstrated to cause toxicity in clusters, and deaths have been reported. We urgently need to learn more about their effects. We report the protocol for the Western Australian Illicit Substance Evaluation (WISE) study, a research project investigating illicit drug use in the ED. METHODS: Patients can be enrolled if the treating clinician strongly suspects they are currently intoxicated with a stimulant, hallucinogenic or cannabinoid drug; and an i...
October 14, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/30318281/a-gastroschisis-bundle-effects-of-a-quality-improvement-protocol-on-morbidity-and-mortality
#7
Cristian Zalles-Vidal, Alejandro Peñarrieta-Daher, Eduardo Bracho-Blanchet, Daniel Ibarra-Rios, Roberto Dávila-Perez, Raul Villegas-Silva, Jaime Nieto-Zermeño
OBJECTIVE: Gastroschisis incidence is rising. Survival in developed countries is over 95%. However, in underdeveloped countries, mortality is higher than 15% often due to sepsis. The aim of this study was to evaluate the effect on morbidity and mortality of a Quality Improvement Protocol for out-born gastroschisis patients. METHODS: The protocol consisted in facilitating transport, primary or staged reduction at the bedside and sutureless closure, without anesthesia, PICC lines and early feeding...
November 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30317146/broccoli-consumption-affects-the-human-gastrointestinal-microbiota
#8
Jennifer L Kaczmarek, Xiaoji Liu, Craig S Charron, Janet A Novotny, Elizabeth H Jeffery, Harold E Seifried, Sharon A Ross, Michael J Miller, Kelly S Swanson, Hannah D Holscher
The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and phytonutrients, including glucosinolates, which can be metabolized by gastrointestinal microbes. This study aimed to determine the impact of broccoli consumption on the gastrointestinal microbiota of healthy adults. A controlled feeding, randomized, crossover study consisting of two 18-day treatment periods separated by a 24-day washout was conducted in healthy adults (n=18)...
September 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/30316903/therapy-induced-enrichment-of-cancer-stem-like-cells-in-solid-human-tumors-where-do-we-stand
#9
REVIEW
Sara R Martins-Neves, Anne-Marie Cleton-Jansen, Célia M F Gomes
The development of local recurrence and metastatic disease most probably attributable to the intrinsic or acquired resistance of tumor cells to standard therapy, still constitute the major clinical problem preventing the cure of cancer patients. Despite progress in the research of new therapeutic targets and compounds, resistant cells displaying stem-like properties seem to play a leading role in therapeutic failures and to be the culprit cells responsible for associated tumor recurrence. A whole new plethora of research studies suggest that drug-tolerant cancer stem cells may be induced by conventional cancer chemotherapeutics such as doxorubicin, cisplatinum and ionizing radiation...
October 11, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30316245/a-partnership-model-for-improving-service-delivery-in-remote-papua-new-guinea-a-mixed-methods-evaluation
#10
Emma Field, Dominica Abo, Louis Samiak, Mafu Vila, Georgina Dove, Alex Rosewell, Sally Nathan
BACKGROUND: The Community Mine Continuation Agreement Middle (CMCA) and South Fly Health Program (the Health Program) is a partnership for improving health service delivery in remote Papua New Guinea (PNG). The Health Program is delivered by a private contractor working in partnership with existing health service providers to improve service delivery using existing government systems, where possible, and aligns with national policies, plans and strategies. A midline evaluation was conducted to determine changes in health service delivery since commencement of the Health Program...
June 11, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/30316231/inclusion-of-health-in-environmental-impact-assessment-of-major-transport-infrastructure-projects-in-vietnam
#11
Tracy Pham, Emily Riley, Patrick Harris
BACKGROUND: Infrastructure spending, especially in the transport sector, is expected to increase rapidly in Vietnam. This boost in transportation investment impacts health. Environmental impact assessments (EIAs) are essential tools for decision-making to reduce and mitigate anticipated impacts of development projects, and integration of health assessment as an essential part of the EIA process has been regulated in many high-income countries. There is, however, limited knowledge about how health is evaluated in these environmental assessments in low- and middle-income countries (LMICs) such as Vietnam...
May 5, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/30315040/number-of-daily-peritoneal-dialysis-exchanges-and-mortality-risk-in-a-chinese-population
#12
Xue-Qing Yu, Jiang-Hua Chen, Zhaohui Ni, Nan Chen, Meng-Hua Chen, Jie Dong, Limeng Chen, Yusheng Yu, Xiao Yang, Wei Fang, Qiang Yao, James A Sloand, Mark Marshall
BACKGROUND: We report outcomes on ≥ 4 compared with < 4 exchanges/day in a Chinese cohort on continuous ambulatory peritoneal dialysis (CAPD). METHODS: Data were sourced from the Baxter (China) Investment Co. Ltd Patient Support Program database, comprising an inception cohort commencing CAPD between 1 January 2005 and 13 August 2015. We used cause-specific Cox proportional hazards and Fine-Gray competing risks (kidney transplantation, change to hemodialysis) models to estimate mortality risk on ≥ 4 compared with < 4 exchanges/day...
October 12, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/30314928/the-safety-of-bypass-to-percutaneous-coronary-intervention-facility-by-basic-life-support-providers-in-patients-with-st-elevation-myocardial-infarction-in-prehospital-setting
#13
Mark Froats, Andrew Reed, Richard Dionne, Justin Maloney, Susan Duncan, Rob Burns, Julie Sinclair, Michael Austin
BACKGROUND: Most patients transferred from a non-percutaneous coronary intervention (PCI) facility for primary PCI do not meet target reperfusion times. Direct transportation of patients with ST-elevation myocardial infarction (STEMI) from the scene by advanced life support (ALS) paramedics has been shown to improve reperfusion times and outcomes. OBJECTIVE: The aim of this study was to determine whether it is safe to bypass the closest hospital and transport by basic life support (BLS) provider to a PCI facility...
October 9, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30314451/home-hemodialysis-treatment-and-outcomes-retrospective-analysis-of-the-knowledge-to-improve-home-dialysis-network-in-europe-kihdney-cohort
#14
Shashidhar Cherukuri, Maria Bajo, Giacomo Colussi, Roberto Corciulo, Hafedh Fessi, Maxence Ficheux, Maria Slon, Eric Weinhandl, Natalie Borman
BACKGROUND: Utilization of home hemodialysis (HHD) is low in Europe. The Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) is a multi-center study of HHD patients who have used a transportable hemodialysis machine that employs a low volume of lactate-buffered, ultrapure dialysate per session. In this retrospective cohort analysis, we describe patient factors, HHD prescription factors, and biochemistry and medication use during the first 6 months of HHD and rates of clinical outcomes thereafter...
October 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30313033/a-case-report-of-a-polytrauma-patient-with-penetrating-iron-rods-in-thorax-and-head
#15
Xinpu Tang, Hongxu Chen, Chaoyue Chen, Jianguo Xu
INTRODUCTION: Impalement injury is an uncommon presentation, and penetrating chest injuries account for 1% to 13% of thoracic trauma hospital admissions. The vast majority of patients with penetrating thoracic trauma who survive to reach the hospital alive can be managed nonoperatively. Nevertheless, in 10% to 15% of cases, emergency operation is necessary due to the associated hemorrhagic shock and visceral injury. CASE PRESENTATION: Here, we report on a 39-year-old male, a construction worker, who fell down from a height of a construction site, landing ventrally on a clump of iron rods with 4 projecting heavy metallic rods penetrating into his thorax and head (scalp pierced only)...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312459/chronic-pain-self-management-program-for-low-income-patients-themes-from-a-qualitative-inquiry
#16
Barbara J Turner, Natalia Rodriguez, Raudel Bobadilla, Arthur E Hernandez, Zenong Yin
Objective: To examine factors influencing initial engagement, ongoing participation, learned behaviors, and subjective functional outcomes after a trial of the Living Better Beyond Pain (LBBP) chronic pain self-management program. Design: Qualitative study using the Grounded Theory approach. Setting: Two 60-minute focus groups and phone interviews in May 2017. Subjects: Focus groups with 18 participants who completed LBBP and six-month measures; telephone interviews with 17 participants who stopped attending...
October 11, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/30311228/how-do-we-fund-flourishing-maybe-not-through-health-care
#17
Lauren A Taylor
The health policy community has a growing interest in the impact of nonmedical determinants of health, such as housing, nutrition, and social supports, on both health outcomes and costs. This interest has been spurred by the Affordable Care Act's emphasis on prevention, Robert Wood Johnson's grant-making focus on a Culture of Health, and an uptick of research demonstrating the potential returns to health care from investments in social services. Much of this policy-making, grant making, and research has focused on older Americans...
September 2018: Hastings Center Report
https://www.readbyqxmd.com/read/30310332/mechanisms-and-the-clinical-relevance-of-complex-drug-drug-interactions
#18
REVIEW
Arthur G Roberts, Morgan E Gibbs
As a result of an increasing aging population, the number of individuals taking multiple medications simultaneously has grown considerably. For these individuals, taking multiple medications has increased the risk of undesirable drug-drug interactions (DDIs), which can cause serious and debilitating adverse drug reactions (ADRs). A comprehensive understanding of DDIs is needed to combat these deleterious outcomes. This review provides a synopsis of the pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms that underlie DDIs...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/30307905/differences-in-characteristics-and-clinical-outcomes-among-hispanic-latino-men-and-women-receiving-hiv-medical-care-united-states-2013-2014
#19
Ruth E Luna-Gierke, R Luke Shouse, Qingwei Luo, Emma Frazier, Guangnan Chen, Linda Beer
The prevalence of diagnosed human immunodeficiency virus (HIV) infection among Hispanics/Latinos in the United States is approximately twice that of non-Hispanic whites (1). Barriers to, and experiences with, medical care have been found to vary by sex (2). Describing characteristics of Hispanics/Latinos in care by sex can help identify disparities and inform delivery of tailored services to this underserved population. Data from the 2013 and 2014 cycles of the Medical Monitoring Project (MMP) were analyzed to describe demographic, behavioral, and clinical characteristics among Hispanics/Latinos by sex...
October 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30305050/breech-birth-at-home-outcomes-of-60-breech-and-109-cephalic-planned-home-and-birth-center-births
#20
Stuart James Fischbein, Rixa Freeze
BACKGROUND: Research on outcomes of out-of-hospital breech birth is scarce. This study evaluates the outcomes of singleton term breech and cephalic births in a home or birth center setting. METHODS: This is a retrospective observational cohort study of 60 breech and 109 cephalic planned out-of-hospital term singleton births during a 6 year period with a single obstetrician. Outcomes measured included mode of delivery; birth weights; 1 & 5-min Apgar scores; ante-, intra-, and post-partum transports; perineal integrity; and other maternal and neonatal morbidity...
October 11, 2018: BMC Pregnancy and Childbirth
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