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https://www.readbyqxmd.com/read/30103064/restless-legs-syndrome-leg-motor-restlessness-and-their-variants-in-patients-with-parkinson-s-disease-and-related-disorders
#1
Takeo Matsubara, Keisuke Suzuki, Hiroaki Fujita, Yuji Watanabe, Hirotaka Sakuramoto, Masanori Matsubara, Koichi Hirata
OBJECTIVE: The objective of this study was to investigate the prevalence of restless leg syndrome (RLS), leg motor restlessness (LMR) and RLS/LMR variants and their relationship with clinical factors in patients with Parkinson's disease (PD) and related disorders. METHODS: Sixty-three PD patients, 17 multiple system atrophy (MSA) patients and 11 progressive supranuclear palsy (PSP) patients were included in this study. Through face-to-face interviews, the patients were diagnosed with RLS/LMR, or with RLS/LMR variants in which the symptoms occur predominantly in body parts other than the legs...
August 7, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30101637/sex-and-labor-trafficking-in-paraguay-risk-factors-needs-assessment-and-the-role-of-the-health-care-system
#2
Kimberly Stanford, Alyssa Cappetta, Roy Ahn, Wendy Macias-Konstantopoulos
Trafficking of adults and children for both sex and labor is a human rights violation occurring with alarming frequency throughout the world, and resulting in profound harm to close-knit communities and severe health consequences for victims. Certain areas, such as the country of Paraguay, are at a higher risk for trafficking due to unique economic, cultural, and geographic factors. Thousands of people, especially children, are trafficked within Paraguay's borders, and many eventually are transported to neighboring countries and sometimes to Europe and elsewhere...
August 11, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/30098964/antihyperglycemic-therapies-to-treat-patients-with-heart-failure-and-diabetes-mellitus
#3
REVIEW
Abhinav Sharma, Lauren B Cooper, Mona Fiuzat, Robert J Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O'Connor, Faiez Zannad
There is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF outcomes from several antihyperglycemic therapies. The absence of well-powered randomized controlled studies has resulted in significant treatment variations in the glycemic management in patients with coexisting diabetes and HF...
August 7, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30098553/the-effects-of-transport-mode-use-on-self-perceived-health-mental-health-and-social-contact-measures-a-cross-sectional-and-longitudinal-study
#4
Ione Avila-Palencia, Luc Int Panis, Evi Dons, Mailin Gaupp-Berghausen, Elisabeth Raser, Thomas Götschi, Regine Gerike, Christian Brand, Audrey de Nazelle, Juan Pablo Orjuela, Esther Anaya-Boig, Erik Stigell, Sonja Kahlmeier, Francesco Iacorossi, Mark J Nieuwenhuijsen
BACKGROUND: Transport mode choice has been associated with different health risks and benefits depending on which transport mode is used. We aimed to evaluate the association between different transport modes use and several health and social contact measures. METHODS: We based our analyses on the Physical Activity through Sustainable Transport Approaches (PASTA) longitudinal study, conducted over a period of two years in seven European cities. 8802 participants finished the baseline questionnaire, and 3567 answered the final questionnaire...
August 8, 2018: Environment International
https://www.readbyqxmd.com/read/30097772/gtpases-rac1-and-ras-signaling-from-endosomes
#5
Francesc Tebar, Carlos Enrich, Carles Rentero, Thomas Grewal
The endocytic compartment is not only the functional continuity of the plasma membrane but consists of a diverse collection of intracellular heterogeneous complex structures that transport, amplify, sustain, and/or sort signaling molecules. Over the years, it has become evident that early, late, and recycling endosomes represent an interconnected vesicular-tubular network able to form signaling platforms that dynamically and efficiently translate extracellular signals into biological outcome. Cell activation, differentiation, migration, death, and survival are some of the endpoints of endosomal signaling...
2018: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/30092536/pollutant-transport-analysis-and-source-apportionment-of-the-entire-non-point-source-pollution-process-in-separate-sewer-systems
#6
Yukun Ma, Shaonan Hao, Hongtao Zhao, Jinxiu Fang, Jiang Zhao, Xuyong Li
Understanding pollutant transport process and source apportionment is critical to urban stormwater pollution mitigation. Previous studies have investigated transport and sources of road deposited sediments (RDS) and sewer sediments individually, and most of these studies focused on stormwater pollution in combined sewer systems. However, studies about pollutant transport and source apportionment of the entire urban non-point source pollution process in separate sewer systems are lacking. This study analyzed particle size distribution and chemical pollutants in five media during the entire pollutant process including RDS, roof runoff, road runoff, sewer sediments, and sewer runoff...
July 31, 2018: Chemosphere
https://www.readbyqxmd.com/read/30091169/cardiovascular-protection-in-type-2-diabetes-insights-from-recent-outcome-trials
#7
REVIEW
Clifford J Bailey, Nikolaus Marx
This review examines recent randomised controlled cardiovascular (CV) outcome trials with glucose-lowering therapies in type 2 diabetes and their impact on the treatment of patients with type 2 diabetes. The trials were designed to comply with regulatory requirements to confirm that major adverse cardiac events (MACE) are not detrimrntally affected by such therapies. Trials involving dipeptidyl peptidase-4 (DPP4) inhibitors did not alter a composite MACE comprising CV deaths, nonfatal myocardial infarction (MI) and non-fatal stroke...
August 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30090842/cerebrospinal-fluid-directed-raav9-rsatp7a-plus-subcutaneous-copper-histidinate-advance-survival-and-outcomes-in-a-menkes-disease-mouse-model
#8
Marie Reine Haddad, Eun-Young Choi, Patricia M Zerfas, Ling Yi, Diego Martinelli, Patricia Sullivan, David S Goldstein, Jose A Centeno, Lauren R Brinster, Martina Ralle, Stephen G Kaler
Menkes disease is a lethal neurodegenerative disorder of copper metabolism caused by mutations in an evolutionarily conserved copper transporter, ATP7A. Based on our prior clinical and animal studies, we seek to develop a therapeutic approach suitable for application in affected human subjects, using the mottled-brindled ( mo-br ) mouse model that closely mimics the Menkes disease biochemical and clinical phenotypes. Here, we evaluate the efficacy of low-, intermediate-, and high-dose recombinant adeno-associated virus serotype 9 (rAAV9)-ATP7A delivered to the cerebrospinal fluid (CSF), in combination with subcutaneous administration of clinical-grade copper histidinate (sc CuHis, IND #34,166)...
September 21, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30090527/cytotoxicological-pathways-induced-after-nanoparticle-exposure-studies-of-oxidative-stress-at-the-nano-bio-interface
#9
REVIEW
Henry Lujan, Christie M Sayes
Nanotechnology is advancing rapidly; many industries are utilizing nanomaterials because of their remarkable properties. As of 2017, over 1800 "nano-enabled products" ( i.e. products that incorporate a nanomaterial feature and alter the product's performance) have been used to revolutionize pharmaceutical, transportation, and agriculture industries, just to name a few. As the number of nano-enabled products continues to increase, the risk of nanoparticle exposure to humans and the surrounding environment also increases...
September 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/30090003/atp-binding-cassette-transporters-in-progression-and-clinical-outcome-of-pancreatic-cancer-what-is-the-way-forward
#10
REVIEW
Aleksandra Adamska, Marco Falasca
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATP-binding cassette (ABC) transporters in this resistance, the therapeutic potential of their pharmacological inhibition has not been successfully exploited yet. In spite of the discovery of potent pharmacological modulators of ABC transporters, the results obtained in clinical trials have been so far disappointing, with high toxicity levels impairing their successful administration to the patients...
August 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30089897/two-fold-elevation-of-endogenous-gdnf-levels-in-mice-improves-motor-coordination-without-causing-side-effects
#11
Kärt Mätlik, Vootele Võikar, Carolina Vilenius, Natalia Kulesskaya, Jaan-Olle Andressoo
Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson's disease (PD). However, how endogenous GDNF influences dopamine system function and animal behavior is not fully understood. We recently generated GDNF hypermorphic mice that express increased levels of endogenous GDNF from the native locus, resulting in augmented function of the nigrostriatal dopamine system...
August 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30087169/investigating-the-campylobacter-jejuni-transcriptional-response-to-host-intestinal-extracts-reveals-the-involvement-of-a-widely-conserved-iron-uptake-system
#12
Martha M Liu, Christine J Boinett, Anson C K Chan, Julian Parkhill, Michael E P Murphy, Erin C Gaynor
Campylobacter jejuni is a pathogenic bacterium that causes gastroenteritis in humans yet is a widespread commensal in wild and domestic animals, particularly poultry. Using RNA sequencing, we assessed C. jejuni transcriptional responses to medium supplemented with human fecal versus chicken cecal extracts and in extract-supplemented medium versus medium alone. C. jejuni exposed to extracts had altered expression of 40 genes related to iron uptake, metabolism, chemotaxis, energy production, and osmotic stress response...
August 7, 2018: MBio
https://www.readbyqxmd.com/read/30086092/role-of-18f-fdg-pet-ct-in-restrictive-allograft-syndrome-after-lung-transplantation
#13
Stijn E Verleden, Olivier Gheysens, Karolien E Goffin, Bart M Vanaudenaerde, Erik K Verbeken, Birgit Weynand, Dirk E Van Raemdonck, Geert M Verleden, Robin Vos
BACKGROUND: Differential diagnosis of phenotypes of chronic lung allograft dysfunction (CLAD) remains troublesome. We hypothesized that F-FDG PET/CT may help in differential diagnosis of CLAD phenotypes, as it showed promising results regarding diagnosis and prognosis in interstitial lung diseases. METHODS: A monocentric, retrospective study was performed including all lung transplant recipients suffering from bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) who underwent F-FDG PET/CT scan, in comparison with stable lung transplant recipients...
August 6, 2018: Transplantation
https://www.readbyqxmd.com/read/30086071/effects-of-driving-distance-and-transport-time-on-mortality-among-level-i-and-ii-traumas-occurring-in-a-metropolitan-area
#14
Theodore G Karrison, L Philip Schumm, Masha Kocherginsky, Ronald Thisted, Douglas R Dirschl, Selwyn Rogers
BACKGROUND: The purpose of this study was to evaluate the effects of ambulance driving distance and transport time on mortality among trauma incidents occurring in the City of Chicago, a large metropolitan area. METHODS: We studied individuals >16 years old who suffered a Level I or II injury and were taken to a Level I trauma center. The outcome was in-hospital mortality, including those dead on arrival but excluding those deemed dead on scene. Driving distance was calculated from the scene of injury to the trauma center where the patient was taken...
August 6, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30085106/aberrant-drp1-mediated-mitochondrial-division-presents-in-humans-with-variable-outcomes
#15
Brittany Whitley, Christina Lam, Hong Cui, Katrina Haude, Renkui Bai, Luis Escobar, Afifa Hamilton, Lauren Brady, Mark A Tarnopolsky, Lauren Dengle, Jonathan Picker, Sharyn Lincoln, Laura L Lackner, Ian A Glass, Suzanne Hoppins
Mitochondrial dynamics, including mitochondrial division, fusion and transport, are integral parts of mitochondrial and cellular function. DNM1L encodes Drp1, a member of the dynamin-related protein family that is required for mitochondrial division. Several de novo mutations in DNM1L are associated with a range of disease states. Here we report the identification of five patients with pathogenic or likely pathogenic variants of DNM1L, including two novel variants. Interestingly, all of the positions identified in these Drp1 variants are fully conserved among all members of the dynamin-related protein family that are involved in membrane division and organelle division events...
August 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30083276/-18-f-fluoroethyltyrosine-induced-cerenkov-luminescence-improves-image-guided-surgical-resection-of-glioma
#16
David Y Lewis, Richard Mair, Alan Wright, Kieren Allinson, Scott K Lyons, Tom Booth, Julia Jones, Robert Bielik, Dmitry Soloviev, Kevin M Brindle
The extent of surgical resection is significantly correlated with outcome in glioma; however, current intraoperative navigational tools are useful only in a subset of patients. We show here that a new optical intraoperative technique, Cerenkov luminescence imaging (CLI) following intravenous injection of O‑(2-[18 F]fluoroethyl)-L-tyrosine (FET), can be used to accurately delineate glioma margins, performing better than the current standard of fluorescence imaging with 5-aminolevulinic acid (5-ALA). Methods: Rats implanted orthotopically with U87, F98 and C6 glioblastoma cells were injected with FET and 5-aminolevulinic acid (5-ALA)...
2018: Theranostics
https://www.readbyqxmd.com/read/30081968/polygenic-differential-susceptibility-to-prenatal-adversity
#17
Jay Belsky, Irina Pokhvisneva, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Michael Pluess, Kieran J O'Donnell, Michael J Meaney, Patrícia P Silveira
A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes...
August 7, 2018: Development and Psychopathology
https://www.readbyqxmd.com/read/30081225/the-effects-of-subacute-inhaled-multi-walled-carbon-nanotube-exposure-on-signaling-pathways-associated-with-cholesterol-transport-and-inflammatory-markers-in-the-vasculature-of-wild-type-mice
#18
Griffith Davis, JoAnn Lucero, Caitlin Fellers, Jacob D McDonald, Amie K Lund
Exposure to multi-walled carbon nanotubes (MWCNTs) has been associated with detrimental cardiovascular outcomes; however, underlying mechanisms have not yet been fully elucidated. Thus, we investigated alterations in proatherogenic and proinflammatory signaling pathways in C57Bl6/ mice exposed to MWCNTs (1 mg/m3 ) or filtered air (FA-Controls), via inhalation, for 6 hr/day, 14d. Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-α and interleukin (IL)-1β/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-κB), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/-21/-1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature...
August 3, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30080474/social-determinants-as-public-goods-a-new-approach-to-financing-key-investments-in-healthy-communities
#19
Len M Nichols, Lauren A Taylor
Good research evidence exists to suggest that social determinants of health, including access to housing, nutrition, and transportation, can influence health outcomes and health care use for vulnerable populations. Yet adequate, sustainable financing for interventions that improve social determinants of health has eluded most if not all US communities. This article argues that underinvestment in social determinants of health stems from the fact that such investments are in effect public goods, and thus benefits cannot be efficiently limited to those who pay for them-which makes it more difficult to capture return on investment...
August 2018: Health Affairs
https://www.readbyqxmd.com/read/30079960/inherited-variation-in-the-xenobiotic-transporter-pathway-and-survival-of-multiple-myeloma-patients
#20
Angelica Macauda, Eleonora Castelli, Gabriele Buda, Matteo Pelosini, Aleksandra Butrym, Marzena Watek, Marcin Kruszewski, Annette Juul Vangsted, Marcin Rymko, Krzysztof Jamroziak, Niels Abildgaard, Eva Kannik Haastrup, Grzegorz Mazur, Rafael Ríos, Artur Jurczyszyn, Daria Zawirska, Marek Dudziński, Małgorzata Raźny, Magdalena Dutka, Waldemar Tomczak, Anna Suska, Agnieszka Druzd-Sitek, Herlander Marques, Mario Petrini, Miroslaw Markiewicz, Joaquin Martinez-Lopez, Lene Hyldahl Ebbesen, Elżbieta Iskierka-Jażdżewska, Juan Sainz, Federico Canzian, Daniele Campa
Over the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathways. We performed an association study of 71 germline variants within the major genes in those pathways (ABCB1, ABCC2, ABCG2, and their regulators NR1I2/PXR and NR1I3/CAR) in the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 1365 MM cases with survival information recruited in 5 European countries...
August 6, 2018: British Journal of Haematology
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