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https://www.readbyqxmd.com/read/30551233/impact-of-time-to-neonatal-transport-on-outcomes-of-transient-tachypnea-of-the-newborn
#1
Katsuya Hirata, Masatoshi Nozaki, Narutaka Mochizuki, Shinya Hirano, Kazuko Wada
OBJECTIVE:  To assess effects of neonatal transport on transient tachypnea of the newborn (TTN) in outborn term neonates. STUDY DESIGN:  This retrospective cohort study included 66 term neonates diagnosed with TTN and transported to the Osaka Women's and Children's Hospital neonatal intensive care unit between January 2003 and March 2018. A multivariate logistic regression analysis identified perinatal and neonatal transport factors associated with adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 hours, pulmonary hemorrhage, and requirement for inhaled nitric oxide, thoracentesis, or surfactant replacement therapy...
December 14, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30550643/internet-based-cognitive-and-behavioural-therapies-for-post-traumatic-stress-disorder-ptsd-in-adults
#2
REVIEW
Catrin Lewis, Neil P Roberts, Andrew Bethell, Lindsay Robertson, Jonathan I Bisson
BACKGROUND: Therapist-delivered trauma-focused psychological therapies are an effective treatment for post-traumatic stress disorder (PTSD). These have become the accepted first-line treatments for the disorder. Despite the established evidence-base for these therapies, they are not always widely available or accessible. Many barriers limit treatment uptake, such as the limited number of qualified therapists to deliver the interventions, cost, and compliance issues, such as time off work, childcare, and transportation, associated with the need to attend weekly appointments...
December 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30545703/gender-differences-in-the-quality-of-ems-care-nationwide-for-chest-pain-and-out-of-hospital-cardiac-arrest
#3
Jannet F Lewis, Scott L Zeger, Ximin Li, N Clay Mann, Craig D Newgard, Suzanne Haynes, Susan Wood, Mengtao Dai, Alan E Simon, Melissa L McCarthy
BACKGROUND: We sought to determine whether gender disparities exist in the prehospital management of chest pain (CP) or out-of-hospital cardiac arrest (OHCA) among patients who accessed the emergency medical services (EMS) system. METHODS: We obtained 2010-2013 data from the National Emergency Medical Services Information System and identified all EMS activations for CP or OHCA by adults 40 years of age or older. We selected American Heart Association medications and procedures to manage cardiovascular events...
November 24, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/30545480/pre-hospital-transport-times-and-outcomes-after-different-reperfusion-strategies-for-st-elevation-myocardial-infarction
#4
Hedvig B Andersson, Milan Seth, Hitinder S Gurm, Eric R Bates
This study evaluated prehospital transport times and clinical outcomes after different reperfusion strategies for ST-elevation myocardial infarction in a real-world setting. We consecutively enrolled 27,205 patients who underwent percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction in Michigan from 2010 to 2016. Primary PCI was performed in 25,927 patients (95%), whereas 1,278 (5%) were treated with a pharmacoinvasive strategy. The overall use of a pharmacoinvasive strategy decreased during the study period (p <0...
October 21, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30545346/establishing-good-samaritan-programs-in-healthcare-institutions-a-method-for-enhancing-patient-experiences-and-increasing-loyalty
#5
James K Elrod, John L Fortenberry
BACKGROUND: Healthcare institutions deliver essential services that practically everyone needs at least periodically over the course of their lives. Hospital admissions, in particular, place patients in circumstances very foreign to them, with uncertain outcomes often being the case, causing stress for care recipients and their loved ones. Health and medical establishments must be very mindful of this and work toward supplying environments that are as comforting as possible for those in their care...
December 14, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30545342/infection-free-rates-and-sequelae-predict-factors-in-bone-transportation-for-infected-tibia-a-systematic-review-and-meta-analysis
#6
Zhen Zhang, W Benton Swanson, Yan-Hong Wang, Wei Lin, Guanglin Wang
BACKGROUND: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Additionally, the prognosis factors for results of bone transportation are obscure. Therefore, this systematic review and meta-analysis was conducted to answer these questions. METHODS: A systematic review was conducted following the PRISMA-IPD guidelines...
December 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30544719/from-mrna-expression-of-drug-disposition-genes-to-in-vivo-assessment-of-cyp-mediated-biotransformation-during-zebrafish-embryonic-and-larval-development
#7
Evy Verbueken, Chloé Bars, Jonathan S Ball, Jelena Periz-Stanacev, Waleed F A Marei, Anna Tochwin, Isabelle J Gabriëls, Ellen D G Michiels, Evelyn Stinckens, Lucia Vergauwen, Dries Knapen, Chris J Van Ginneken, Steven J Van Cruchten
The zebrafish ( Danio rerio ) embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition of xenobiotics during zebrafish organogenesis is pivotal in order to correctly interpret the outcome of teratogenicity assays. Therefore, the aim of this study was to assess cytochrome P450 (CYP) activity in zebrafish embryos and larvae until 14 d post-fertilization (dpf) by using a non-specific CYP substrate, i.e., benzyloxy-methyl-resorufin (BOMR) and a CYP1-specific substrate, i...
December 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30544314/association-of-time-to-craniectomy-with-survival-in-patients-with-severe-combat-related-brain-injury
#8
(no author information available yet)
OBJECTIVEIn combat and austere environments, evacuation to a location with neurosurgery capability is challenging. A planning target in terms of time to neurosurgery is paramount to inform prepositioning of neurosurgical and transport resources to support a population at risk. This study sought to examine the association of wait time to craniectomy with mortality in patients with severe combat-related brain injury who received decompressive craniectomy.METHODSPatients with combat-related brain injury sustained between 2005 and 2015 who underwent craniectomy at deployed surgical facilities were identified from the Department of Defense Trauma Registry and Joint Trauma System Role 2 Registry...
December 1, 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/30542615/new-hypoglycemic-agents-and-the-kidney-what-do-the-major-trials-tell-us
#9
REVIEW
Brendan Smyth, Vlado Perkovic
As the burden of diabetic kidney disease continues to expand, new therapies to preserve renal function or prevent diabetic nephropathy are urgently needed. In the past decade, a number of new hypoglycemic classes have emerged, each with a unique profile of action and benefits. Here we review the impact of glycemic control on renal outcomes and the results of the major clinical trials of glucagon-like peptide 1 (GLP-1) agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose co-transporter 2 (SGLT2) inhibitors...
2018: F1000Research
https://www.readbyqxmd.com/read/30541560/factors-influencing-referrals-for-ultrasound-diagnosed-complications-during-prenatal-care-in-five-low-and-middle-income-countries
#10
Holly L Franklin, Waseem Mirza, David L Swanson, Jamie E Newman, Robert L Goldenberg, David Muyodi, Lester Figueroa, Robert O Nathan, Jonathan O Swanson, Nicole Goldsmith, Nancy Kanaiza, Farnaz Naqvi, Irma Sayury Pineda, Walter López-Gomez, Dorothy Hamsumonde, Victor Lokomba Bolamba, Elizabeth V Fogleman, Sarah Saleem, Fabian Esamai, Edward A Liechty, Ana L Garces, Nancy F Krebs, K Michael Hambidge, Elwyn Chomba, Musaku Mwenechanya, Waldemar A Carlo, Antoinette Tshefu, Adrien Lokangaka, Carl L Bose, Marion Koso-Thomas, Menachem Miodovnik, Elizabeth M McClure
BACKGROUND: Ultrasound during antenatal care (ANC) is proposed as a strategy for increasing hospital deliveries for complicated pregnancies and improving maternal, fetal, and neonatal outcomes. The First Look study was a cluster-randomized trial conducted in the Democratic Republic of Congo, Guatemala, Kenya, Pakistan and Zambia to evaluate the impact of ANC-ultrasound on these outcomes. An additional survey was conducted to identify factors influencing women with complicated pregnancies to attend referrals for additional care...
December 12, 2018: Reproductive Health
https://www.readbyqxmd.com/read/30539765/neurobiology-of-cognitive-remediation-in-schizophrenia-effects-of-eaat2-polymorphism
#11
Marco Spangaro, Marta Bosia, Margherita Bechi, Mariachiara Buonocore, Federica Cocchi, Carmelo Guglielmino, Laura Bianchi, Antonella Mastromatteo, Cristina Lorenzi, Roberto Cavallaro
Cognitive deficits represent core features of schizophrenia, affecting quality of life and functioning. The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate reuptake and its activity is crucial for glutamatergic neurotransmission, prevention of excitotoxic damage and cerebral metabolism. Different studies reported that EAAT2 rs4354668 (-181 T/G) influences cognitive functions and brain structures in patients with schizophrenia. Specifically, the G allele, linked to lower EAAT2 expression, was associated with impaired prefrontal cognitive performance and reduced grey matter volumes...
December 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/30538605/use-and-interpretation-of-enteropathogen-multiplex-nucleic-acid-amplification-tests-in-patients-with-suspected-infectious-diarrhea
#12
Harika Yalamanchili, Dima Dandachi, Pablo C Okhuysen
Acute diarrheal illness due to gastrointestinal infection is a significant cause of morbidity and mortality in the United States and around the world. Determining the causative organism in a timely manner assists with patient care, identifying outbreaks, providing infection control, and administering antimicrobial therapy when indicated. Traditional diagnostic modalities based on culture and immunoassays are limited by their low sensitivity and long turnaround time. Nucleic acid amplification tests (NAATs) for enteric pathogens allow for the syndromic testing of stool for multiple pathogens simultaneously and have higher sensitivity with a shorter turnaround time...
November 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30536856/cardio-renal-protective-effect-of-sglt2-inhibitors-and-mitochondrial-function
#13
EDITORIAL
Hong Kyu Lee
Cardio-renal protective effect of Sodium Glucose Co-transporter-2 (SGLT2) inhibitors is well established by three large clinical trials; Empagliflozin, Cardiovascular Outcome Events Trial in Type 2 Diabetes Patients (EMPA-REG OUTCOME), Canagliflozin Cardiovascular Assessment Study (CANVAS), and most recently Dapagliflozin Effect on Cardiovascular Events Trial 58 by the Thrombolysis in Myocardial Infarction Study Group (DECLARE-TIMI 58). Three different SGLT2 inhibitors, empagliflozin, canagliflozin and dapagliflozin, were proven effective not only for their glucose lowering effect, but in reducing deterioration of renal function and prevented hospitalization due to heart failure...
December 9, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30536571/hypoxia-inducible-factor-2%C3%AE-directly-promotes-bcrp-expression-and-mediates-the-resistance-of-ovarian-cancer-stem-cells-to-adriamycin
#14
Miao He, Huizhe Wu, Qian Jiang, Yinuo Liu, Li Han, Yuanyuan Yan, Binbin Wei, Fangxiao Liu, Xiaolan Deng, Huiying Chen, Lin Zhao, Min Wang, Xin Wu, Weifan Yao, Haishan Zhao, Jianjun Chen, Minjie Wei
Ovarian cancer stem cells (OCSCs) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the chemoresistance of cancer stem cells (CSCs), but the underlying mechanism is not fully understood yet. Here, we show that increased HIF-2α expression is associated with enhanced stemness of OCSCs and poor outcomes in ovarian cancer patients. OVCAR-3 and CAOV-3 sphere-forming (OVCAR-3 S and CAOV-3 S) cells with OCSC-like properties showed strong resistance to adriamycin (ADR)...
December 10, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/30536140/acute-ischaemic-stroke-a-systematic-review-of-the-cost-effectiveness-of-emergency-endovascular-therapy-using-mechanical-thrombectomy
#15
Conor Teljeur, Patricia Harrington, Ronan W Glynn, Máirín Ryan
PURPOSE: Although good evidence exists regarding the clinical effectiveness of mechanical thrombectomy for people with acute ischaemic stroke, cost-effectiveness should also be considered. The aim of this study was to systematically review the evidence of cost-effectiveness of emergency endovascular therapy using mechanical thrombectomy in the management of acute ischaemic stroke. METHODS: The search was carried out in PubMed, EMBASE, Cochrane Library, and a grey literature search...
December 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/30535838/mitochondrial-membrane-transporters-and-metabolic-switch-in-heart-failure
#16
REVIEW
Vikas Kumar, T R Santhosh Kumar, C C Kartha
Mitochondrial dysfunction is widely recognized as a major factor for the progression of cardiac failure. Mitochondrial uptake of metabolic substrates and their utilization for ATP synthesis, electron transport chain activity, reactive oxygen species levels, ion homeostasis, mitochondrial biogenesis, and dynamics as well as levels of reactive oxygen species in the mitochondria are key factors which regulate mitochondrial function in the normal heart. Alterations in these functions contribute to adverse outcomes in heart failure...
December 10, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/30534411/reinforcing-kangaroo-mother-care-uptake-in-resource-limited-settings
#17
Subhashchandra Daga
Background: The national and global coverage of kangaroo mother care (KMC) remains low. Hence, adjuncts to KMC may be necessary, especially on day1 of life when neonatal mortality is high. It is important to provide warmth and reduce mortality in preterm low birth weight (LBW) infants in the community/hospital setting. In this manuscript, the outcome of using a Styrofoam box (SB) for LBW infants in various situations in India, such as in a home-setting in tribal/extra-remote areas, at a primary health center in tribal/extra-remote areas and at a referral hospital, is presented...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/30531054/community-based-learning-enhances-doctor-retention
#18
Pairoj Boonluksiri, Hathaitip Tumviriyakul, Rajin Arora, Win Techakehakij, Parinya Chamnan, Nawapat Umthong
Background: Rural doctor shortage is a problem in many countries. Factors associated with doctor retention were reported such as colleagues, workload, accommodations, transportation, proximity of family and friends, incentives and career path. Rural background recruitment, increasing the quantity of doctor production to supply in rural and remote areas, and regulation are claimed to alleviate doctor scarcity in rural communities. Many programs have been developed, but an imbalance in physician distribution persists...
May 2018: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/30530909/therapeutic-hypothermia-during-neonatal-transport-at-regional-perinatal-centers-active-vs-passive-cooling
#19
Rishi Lumba, Pradeep Mally, Michael Espiritu, Elena V Wachtel
Background Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature. Methods We undertook a prospective cohort quality improvement study with historic controls of therapeutic hypothermia during transport. Primary outcome measures were analyzed: time to cool after initiation of transport, time to achieve target temperature from birth and temperature on arrival to cooling centers...
December 7, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/30527483/can-planned-traffic-patterns-improve-survival-among-the-injured-during-mass-casualty-motorcycle-rallies
#20
Cecily DuPree, Aaron Pinnola, Stefanie Gibson, Keely Muertos, John M Davis, Jason D Sciarretta
BACKGROUND: Mass casualty events are infrequent and create an abrupt surge of patients requiring emergency medical services within a brief period. We hypothesize that implementation of a controlled "traffic loop" pattern during a planned high-volume motorcycle rally could improve overall mortality and impact patient outcomes. MATERIALS AND METHODS: We performed a retrospective analysis of all motorcycle-related injuries during the city's annual motorcycle rally over a 4-y period...
February 2019: Journal of Surgical Research
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