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Long-term potentiation

Andreas Burgdorf, Inga Güthe, Marko Jovanović, Ekaterina Kutafina, Christian Kohlschein, Jó Ágila Bitsch, Stephan M Jonas
BACKGROUND: Sleep disorders have a prevalence of up to 50% and are commonly diagnosed using polysomnography. However, polysomnography requires trained staff and specific equipment in a laboratory setting, which are expensive and limited resources are available. Mobile and wearable devices such as fitness wristbands can perform limited sleep monitoring but are not evaluated well. Here, the development and evaluation of a mobile application to record and synchronize data from consumer-grade sensors suitable for sleep monitoring is presented and evaluated for data collection capability in a clinical trial...
October 6, 2018: Computers in Biology and Medicine
Zhaoqiang Qian, Xiaojie Wu, Yanning Qiao, Meimei Shi, Zhiqiang Liu, Wei Ren, Jing Han, Qiaohua Zheng
Drugs of abuse modify synaptic long-term potentiation and long-term depression (LTD) in the nucleus accumbens, and the impairment of synaptic plasticity in this brain region may be a universal feature of drug addiction. It is unknown whether metabotropic glutamate receptors (mGluRs) play a role in synaptic plasticity induced by drugs such as morphine. The neurochemical, electrophysiological, and Western blotting experiments reported here reveal a novel form of LTD in synapses of the shell region of the nucleus accumbens induced in vivo by low-frequency stimulation of the medial prefrontal cortex...
October 10, 2018: Neuroscience Letters
Anthony M Villano, Alexander Lofthus, Thomas J Watson, Nadim G Haddad, M Blair Marshall
BACKGROUND: A minimally invasive intragastric approach to the gastroesophageal junction (GEJ) allows resection of intramural pathology while avoiding disruption of the lower esophageal sphincter (LES) and vagi. Few surgeons use this approach, thus little is known regarding its indications, feasibility, technical aspects, complication profile, and long-term outcomes. We reviewed our experience with this technique. METHODS: We performed a retrospective review of a prospectively maintained IRB-approved database covering the time period 01/01/2005-8/01/2017...
October 10, 2018: Annals of Thoracic Surgery
K Kurzinski, C K Zigler, K S Torok
BACKGROUND: Localized scleroderma (LS) is an autoimmune condition of the skin and underlying tissue. Active or recurring disease can lead to cumulative tissue damage, especially in paediatric-onset disease. OBJECTIVES: To highlight the rate of relapse of LS activity in a cohort of paediatric patients and to evaluate for potential clinical and laboratory predictors of disease relapse. METHODS: Clinical and laboratory data were gathered prospectively...
October 13, 2018: British Journal of Dermatology
Martin Kozel, Viktor Kočka, Libor Lisa, Tomáš Buděšínský, Petr Toušek
A higher rate of bioresorbable vascular scaffold (BVS) thrombosis has been observed after device implantation compared to implantation of permanent metallic stents in recently published studies. The mechanism of BVS thrombosis is currently under debate. To assess whether the immune-inflammatory response after BVS implantation is a potential trigger of BVS thrombosis. The PRAGUE-19 study was an academic study that enrolled consecutive patients with ST-segment elevation myocardial infarction (STEMI) with the intention to implant a BVS...
October 12, 2018: Heart and Vessels
Ivana Rajkovic, Raymond Wong, Eloise Lemarchand, Jack Rivers-Auty, Olivera Rajkovic, Cecilia Garlanda, Stuart M Allan, Emmanuel Pinteaux
Restoration of cerebral blood flow (CBF) and upregulation of angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia. Pentraxin 3 (PTX3) is a key regulator of angiogenesis and is emerging as a promising target for cerebrovascular repair after stroke. Here, we investigated for the first time the role of PTX3 in long-term CBF, angiogenesis, and neuronal viability after ischaemic stroke induced by transient middle cerebral artery occlusion (MCAo). Lack of PTX3 had no effect on early brain damage, but significantly impaired restoration of CBF, 14 and 28 days after MCAo, compared to wild-type (WT) mice...
October 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Kwan-Yeung Lee, Kwong-Sak Leung, Nelson L S Tang, Man-Hon Wong
In this paper, we aim at discovering genetic factors of psoriasis through searching for statistically significant SNP-SNP interactions exhaustively from two real psoriasis genome-wide association study datasets (phs000019.v1.p1 and phs000982.v1.p1) downloaded from the database of Genotypes and Phenotypes. To deal with the enormous search space, our search algorithm is accelerated with eight biological plausible interaction patterns and a pre-computed look-up table. After our search, we have discovered several SNPs having a stronger association to psoriasis when they are in combination with another SNP and these combinations may be non-linear interactions...
October 12, 2018: Scientific Reports
Maria Camila Montealegre, Subarna Roy, Franziska Böni, Muhammed Iqbal Hossain, Tala Navab-Daneshmand, Lea Caduff, A S G Faruque, Mohammad Aminul Islam, Timothy R Julian
Soils in household environments in low- and middle-income countries may play an important role in the persistence, proliferation, and transmission of Escherichia coli Our goal was to investigate the risk factors for detection, survival, and growth of E. coli in soils collected from household plots. E. coli was enumerated in soil and fecal samples from human, chicken, and cattle from 52 households in rural Bangladesh. Associations between E. coli concentrations in soil, household-level factors, and soil physicochemical characteristics were investigated...
October 12, 2018: Applied and Environmental Microbiology
Abigail Quintos, Mario Naranjo, Colleen Kelly, Stuart F Quan, Sunil Sharma
PURPOSE: The HoSMed Database recently demonstrated a high prevalence of obstructive sleep apnea (OSA) in hospitalized obese patients. Based on a long-term follow-up, this study showed an improved survival among patients who were adherent with the therapy. In this post-hoc analysis we explore the characteristics, associations, and mortality outcome of OSA in the African American (AA) population. METHODS: These subset analyses included obese AA patients screened in the hospital as high-risk for OSA...
October 9, 2018: Journal of the National Medical Association
Sandra Leal, Lídia Rocha, Ana Silva, Juliana Faria, Ricardo Jorge Dinis-Oliveira, Susana I Sá
Tamoxifen (TAM) therapy is the better treatment for breast cancer and the drug use the prophylaxis of this disease in young premenopausal women. Yet, the effects associated with this therapy are unknown. To better understand the extension of this problem, we developed an animal model to mimic this therapy, aiming to evaluate its potential biochemical and histopathological changes in the liver. Young cycling female rats were treated with TAM for one, two and three months and toxicological biomarkers and liver histomorphometry were evaluated...
October 3, 2018: Pathology, Research and Practice
Jung Wook Huh, Hee Cheol Kim, Seok Hyung Kim, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Hee Chul Park, Doo Ho Choi, Joon Oh Park, Young Suk Park, Ho-Kyung Chun
BACKGROUND: The prognostic role of tumor regression grade is not clear. This study evaluated the prognostic significance of tumor regression grade in patients with rectal cancer after preoperative chemoradiotherapy. METHODS: A total of 639 patients with confirmed rectal cancer who had undergone preoperative chemoradiotherapy and radical resection during the period October 2002 through December 2011 were included in this study. The tumor regression grade was graded: TRG0 (complete response), TRG1 (moderate), TRG2 (minimal), and TRG3 (poor)...
October 9, 2018: Surgery
Boštjan Luzar, Blanca Martin, Cyril Fisher, Eduardo Calonje
Glomus tumours (GTs) have traditionally been classified into benign GTs, GTs with uncertain malignant potential and malignant GTs, based on a combination of criteria such as size of the tumour, degree of nuclear atypia and the level of mitotic activity. Several of the proposed grading criteria are difficult, or even impossible to apply for GTs occurring in the skin. The aim of the study was to analyse the applicability of the currently established GT malignancy criteria for tumours occurring in the skin and to establish their prognostic significance...
October 9, 2018: Pathology
Christine Ghadery, Mikaeel Valli, Alexander Mihaescu, Rebecca Strafella, Irene Navalpotro, Jinhee Kim, Antonio P Strafella
Parkinson's disease (PD) is commonly associated with motor symptoms, however cognitive and neurobehavioral complications are increasingly recognized and contribute to long-term disability. Dopamine replacement therapy is effective for motor symptoms, but can also lead to motor side-effects and addictive behavior such as impulse control disorders. Molecular imaging is advancing our knowledge of the mechanisms involved in the development of behavioral addictions. This chapter will discuss potential risk factors and associations with the development of addictive behavior in PD including the role of dopaminergic medication and genetic predisposition...
2018: International Review of Neurobiology
M J Connolly, J B Broad, T Bish, X Zhang, D Bramley, N Kerse, K Bloomfield, M Boyd
INTRODUCTION: The complexity of care required by many older people living in long-term care (LTC) facilities poses challenges that can lead to potentially avoidable referrals to a hospital emergency department (ED). The Aged Residential Care Intervention Project (ARCHIP) ran an implementation study to evaluate a multidisciplinary team (MDT) intervention supporting LTC facility staff to decrease potentially avoidable ED presentations by residents. METHODS: ARCHIP (conducted in 21 facilities [1,296 beds] with previously noted high ED referral rates) comprised clinical coaching for LTC facility staff by a gerontology nurse specialist (GNS) and an MDT (facility senior nurse, resident's general practitioner, GNS, geriatrician, pharmacist) review of selected high-risk residents' care-plans...
November 2018: Maturitas
Yanchao Cheng, Nils Benjamin Tjaden, Anja Jaeschke, Renke Lühken, Ute Ziegler, Stephanie Margarete Thomas, Carl Beierkuhnlein
BACKGROUND: Usutu virus (USUV) is a mosquito-borne flavivirus, reported in many countries of Africa and Europe, with an increasing spatial distribution and host range. Recent outbreaks leading to regional declines of European common blackbird (Turdus merula) populations and a rising number of human cases emphasize the need for increased awareness and spatial risk assessment. METHODS: Modelling approaches in ecology and epidemiology differ substantially in their algorithms, potentially resulting in diverging model outputs...
October 12, 2018: International Journal of Health Geographics
Sebastian Kvist, Christer ErsÉus
Two new species of Tubificoides (subfamily Tubificinae), T. charlotteae n. sp. and T. mackiei n. sp., are described based on morphological analyses. Both species were flagged as potentially cryptic in a previous investigation, based on both mitochondrial and nuclear sequence data. Tubificoides charlotteae n. sp., known only from an intertidal site in southern Spain, is characterized by the lack of cuticular papillation, the possession of several needle-like hair chaetae in dorsal bundles, a cone-shaped penis sheath, and a rather large, muscular penial sac...
June 13, 2018: Zootaxa
Hsiao-Yue Wee, Chung-Han Ho, Ching-Hung Chang, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang, Jinn-Rung Kuo
BACKGROUND: Traumatic brain injury (TBI) has been reported as a risk factor for brain tumor, but whether TBI affects systemic cancer remains to be determined. We aimed to investigate the incidence and factors associated with cancer development in TBI patients. MATERIALS AND METHODS: A propensity score (age, gender, and comorbidity)-matched longitudinal cohort study of 34,556 pre-existing TBI patients and 69,112 patients without TBI between January 2000 and December 2015 was presented using Taiwan's National Health Insurance Research Database...
October 9, 2018: World Neurosurgery
Coy R St Clair, Claire A Fuller
Agricultural runoff containing herbicide is known to have adverse effects on freshwater organisms. Aquatic insects are particularly susceptible, and herbicide runoff has the potential to affect immunity in this group. Here we examined the effect of ecologically relevant levels of atrazine, an herbicide commonly used in the United States, on immune function in larvae of the blue dasher dragonfly (Odonata: Libelluludae, Pachydiplax longipennis Burmeister 1839) during a long-term exposure at ecologically relevant concentrations...
September 1, 2018: Journal of Insect Science
Vicente E Torres
No treatment until now has directly targeted the mechanisms responsible for the development and growth of cysts in autosomal dominant polycystic kidney disease (ADPKD). Strong rationale and preclinical studies using in vitro and in vivo models justified the launching of two large phase 3 clinical trials of tolvaptan in early and later stages of ADPKD. Their design was based on preliminary studies informing on the pharmacokinetics, pharmacodynamics, short-term safety and self-reported tolerability in patients with ADPKD...
October 12, 2018: Nephrology, Dialysis, Transplantation
Aida Dias, Trudy Mooren, Rolf J Kleber
Background: Child maltreatment (CM) is associated with long-lasting poor health outcomes, as well as increased levels of disability and health-services consumption across the life-span. However, less is known about how CM consequences can be reduced during adulthood. We investigated professional opinions on how to mitigate long-term consequences of CM in a public health (PH) perspective. Methods: Using the Delphi method in three rounds, we inquired 91 professionals, mostly European researchers and clinicians about potential PH actions to mitigate CM consequences during adulthood...
October 11, 2018: European Journal of Public Health
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