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Polylactic Acid

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https://www.readbyqxmd.com/read/30551013/lecithin-doped-electrospun-poly-lactic-acid-thermoplastic-polyurethane-fibers-for-hepatocyte-viability-improvement
#1
Xiang Liu, Lingtong Zhou, Peng Heng, Jingcheng Xiao, Junping Lv, Qingmiao Zhang, Michael E Hickey, Qin Tu, Jinyi Wang
The development of hepatocyte cultures in vitro holds great significance in the study of bioartificial liver support systems. Electrospun fiber cultures have received widespread attention as an effective method to culture hepatocytes in vitro. Polylactic acid (PLA) -a synthetic polymer with high biocompatibility and biodegradability- is widely used to fabricate electrospun fibers in the biomedical field. However, the use of PLA is limited in cell cultures due to its brittleness, strong hydrophobicity, and lack of biologically active functional groups...
September 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30525030/a-perfusion-culture-system-for-assessing-bone-marrow-stromal-cell-differentiation-on-plga-scaffolds-for-bone-repair
#2
Caroline Moser, Katie Bardsley, Alicia J El Haj, Mauro Alini, Martin J Stoddart, Jennifer J Bara
Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow stromal cells (BMSCs) differentiated on polylactic co-glycolic acid (PLGA). Primary human BMSCs were seeded onto porous PLGA scaffolds and cultured in static vs. perfusion culture conditions for 21 days in osteogenic vs. control media. PLGA scaffolds were osteoconductive, supporting a mature osteogenic phenotype as shown by the upregulation of Runx2 and the early osteocyte marker E11...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/30514955/thermal-degradation-and-fire-properties-of-fungal-mycelium-and-mycelium-biomass-composite-materials
#3
Mitchell Jones, Tanmay Bhat, Everson Kandare, Ananya Thomas, Paul Joseph, Chaitali Dekiwadia, Richard Yuen, Sabu John, Jun Ma, Chun-Hui Wang
Mycelium and mycelium-biomass composites are emerging as new sustainable materials with useful flame-retardant potentials. Here we report a detailed characterisation of the thermal degradation and fire properties of fungal mycelium and mycelium-biomass composites. Measurements and analyses are carried out on key parameters such as decomposition temperatures, residual char, and gases evolved during pyrolysis. Pyrolysis flow combustion calorimetry (PCFC) evaluations reveal that the corresponding combustion propensity of mycelium is significantly lower compared to poly(methyl methacrylate) (PMMA) and polylactic acid (PLA), indicating that they are noticeably less prone to ignition and flaming combustion, and therefore safer to use...
December 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30514465/how-to-manage-biocomposites-wastes-end-of-life-a-life-cycle-assessment-approach-lca-focused-on-polypropylene-pp-wood-flour-and-polylactic-acid-pla-flax-fibres-biocomposites
#4
Joana Beigbeder, Lata Soccalingame, Didier Perrin, Jean-Charles Bénézet, Anne Bergeret
Biocomposites has gained increasing attention in recent years. The environmental impacts of end-of-life (EoL) treatments of those emerging materials should be evaluated before they are produced and installed commercially, to ensure a minimal impact of these products all along their life cycle. Life cycle assessment (LCA) was carried out to evaluate environmental impacts of the EoL treatments of wood flour (WF) reinforced polypropylene (PP/WF) and flax fibers reinforced polylactic acid (PLA/Fl). The aim was to evaluate which EoL was the most environmental friendly to manage those emerging wastes in France and to help stakeholders of the waste sectors in their decisions...
January 2019: Waste Management
https://www.readbyqxmd.com/read/30497873/olfactory-ensheathing-cells-in-facial-nerve-regeneration
#5
Manyi Li, Qiubei Zhu, Jisheng Liu
INTRODUCTION: Olfactory ensheathing cell is a unique kind of glia cells, which can promote axon growth. Little is known about the differences between olfactory mucosa-olfactory ensheathing cells and olfactory bulb-olfactory ensheathing cells in the capability to promote nerve regeneration. OBJECTIVE: To study the recovery of the rat facial nerve after olfactory ensheathing cell transplantation, and to compare the differences between the facial nerve regeneration of olfactory mucosa-olfactory ensheathing cells and olfactory bulb olfactory bulb-olfactory ensheathing cells transplantation...
August 7, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/30480159/fabrication-and-microstructure-of-quartz-ceramics-with-orderly-arranged-carbon-filler
#6
Xiangming Li, Rui Li, Guojian Yuan, Mengyao Zheng, Zhen Meng, Jia Guo, Guangyou Zhou
Ceramics with tailored pore structure are showing potential applications in some special fields. For fabricating quartz ceramics with orderly-arranged carbon filler, a combination of 3D printing, vacuum suction filtration and sintering was explored to fabricate quartz ceramics with highly-ordered and well-connected big pore channels. The spatial lattice structure in the polylactic acid (PLA) template fabricated by 3D printing together with raw material ratio and sintering temperature has great effect on the properties and pore structure of the porous quartz ceramics...
November 2018: Heliyon
https://www.readbyqxmd.com/read/30477716/determination-of-non-volatile-components-of-a-biodegradable-food-packaging-material-based-on-polyester-and-polylactic-acid-pla-and-its-migration-to-food-simulants
#7
Margarita Aznar, Sara Ubeda, Nicola Dreolin, Cristina Nerín
Bioplastic materials are increasingly used due to its benefits for the environment preservation. Among them, food packaging materials based on polylactic acid (PLA) are among the most employed. In this work, a sample treatment methodology based on dissolution/precipitation has been optimized, selecting finally dichloromethane/ethanol as solvent/antisolvent system. The extracts obtained were analysed by UPLC-MS(QTOF), that allowed the identification of the main PLA non-volatile components. The recovery results were between 100...
November 2, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30475363/the-influence-of-roughness-on-stem-cell-differentiation-using-3d-printed-polylactic-acid-scaffolds
#8
Kuan-Che Feng, Adriana Pinkas-Sarafova, Vincent Ricotta, Michael Cuiffo, Linxi Zhang, Yichen Guo, Chung-Chueh Chang, Gary P Halada, Marcia Simon, Miriam Rafailovich
With the increase in popularity of 3D printing, an important question arises as to the equivalence between devices manufactured by standard methods vs. those presenting with identical bulk specifications, but manufactured via fused deposition modeling (FDM) printing. Using thermal imaging in conjunction with electron and atomic force microscopy, we demonstrate that large thermal gradients, whose distribution is difficult to predict, are associated with FDM printing and result in incomplete fusion and sharkskin of the printing filament...
November 26, 2018: Soft Matter
https://www.readbyqxmd.com/read/30464710/bone-tunnel-enlargement-with-non-metallic-interference-screws-in-acl-reconstruction
#9
Vitor Barion Castro de Padua, Júlio Cesar Rodrigues Vilela, Wendel Aculha Espindola, Rafael Cassiolato Garcia Godoy
Objective: To compare the widening of bone tunnels between poly-etheretherketone (PEEK), absorbable polylactic acid DL (PLDL) and tricalcium phosphate (TCP) interference screws in anterior cruciate ligament (ACL) reconstruction. Methods: Three groups of patients undergoing ACL reconstruction with at least 1 year of follow-up using the out-in drilling technique and hamstring as a graft were assessed. The patients were divided according to the type of interference screw used (PEEK, PLDL and TCP)...
2018: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/30464300/tendon-fascicle-inspired-nanofibrous-scaffold-of-polylactic-acid-collagen-with-enhanced-3d-structure-and-biomechanical-properties
#10
Alberto Sensini, Chiara Gualandi, Andrea Zucchelli, Liam A Boyle, Alexander P Kao, Gwendolen C Reilly, Gianluca Tozzi, Luca Cristofolini, Maria Letizia Focarete
Surgical treatment of tendon lesions still yields unsatisfactory clinical outcomes. The use of bioresorbable scaffolds represents a way forward to improve tissue repair. Scaffolds for tendon reconstruction should have a structure mimicking that of the natural tendon, while providing adequate mechanical strength and stiffness. In this paper, electrospun nanofibers of two crosslinked PLLA/Collagen blends (PLLA/Coll-75/25, PLLA/Coll-50/50) were developed and then wrapped in bundles, where the nanofibers are predominantly aligned along the bundles...
November 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30448561/surface-functionalization-of-polylactic-acid-fibers-with-alendronate-groups-does-not-improve-the-mechanical-properties-of-fiber-reinforced-calcium-phosphate-cements
#11
Daniela-Geta Petre, Nathan W Kucko, Anna Abbadessa, Tina Vermonden, Alessandro Polini, Sander C G Leeuwenburgh
Calcium phosphate cements (CPCs) are frequently used as synthetic bone substitute, but their intrinsic low fracture toughness impedes their application in highly loaded skeletal sites. However, fibers can be used to reduce the brittleness of these CPCs provided that the affinity between the fibers and cement matrix facilitates the transfer of loads from the matrix to the fibers. The aim of the present work was to improve the interface between hydrophobic polylactic acid (PLA) microfibers and hydrophilic CPC...
November 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/30429657/imaging-natural-history-museum-collections-from-the-bottom-up-3d-print-technology-facilitates-imaging-of-fluid-stored-arthropods-with-flatbed-scanners
#12
Patina K Mendez, Sangyeon Lee, Chris E Venter
Availability of 3D-printed laboratory equipment holds promise to improve arthropod digitization efforts. A 3D-printed specimen scanning box was designed to image fluid-based arthropod collections using a consumer-grade flatbed scanner. The design was customized to accommodate double-width microscope slides and printed in both Polylactic Acid (PLA) and nylon (Polyamide). The workflow with two or three technicians imaged Trichoptera lots in batches of six scanning boxes. Individual images were cropped from batch imagess using an R script...
2018: ZooKeys
https://www.readbyqxmd.com/read/30416646/scaffold-free-cartilage-cell-sheet-combined-with-bone-phase-bmscs-scaffold-regenerate-osteochondral-construct-in-mini-pig-model
#13
Feiyu Wang, Yihui Hu, Dongmei He, Guangdong Zhou, Edward Ellis
Tissue-engineered condyles provide a promising approach for end-stage osteoarthritis to reconstruct normal physiological structure and function of the temporomandibular joint (TMJ). However, lack of successful biological condyles in large animals restricts clinical translation. Scaffold-free cartilage cell sheets do not contain any polymeric material which potentially risks local nonspecific inflammatory reactions. In this study, we used cartilage cell sheets covering bone marrow mesenchymal stem cells-Polycaprolactone/Hydroxyapatite (BMSCs-PCL/HA) scaffolds (cell sheet group) transplanted subcutaneously and intramuscularly in mini-pigs...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30411116/-analysis-of-the-biocompatibility-of-a-new-plga-fish-skin-collagen-conjugated-electrostatic-spinning-film
#14
Xiao-Li Lu, Hui-Lin Miao, Feng Liu, Mei-Qin Gao
PURPOSE: To study the biocompatibility of a new polylactic acid-glycolic acid(PLGA)/fish skin collagen conjugated electrostatic spinning film. METHODS: PLGA and medical-grade fish skin-I collagen were used as raw materials to prepare nanometer fiber films by conjugated electrostatic spinning technique. Mouse fibroblast L929 was used as a model to evaluate its cell and histocompatibility, which provided experimental basis for application in guided bone regeneration (GBR)...
June 2018: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/30405165/a-versatile-method-for-the-uva-induced-cross-linking-of-acetophenone-or-benzophenone-functionalized-dna
#15
Jevgenija Jakubovska, Daiva Tauraitė, Rolandas Meškys
Bioconjugation, biosensing, bioimaging, bionanomaterials, etc., are only a few examples of application of functionalized DNA. Since base-modified nucleic acids contribute not only to a broad range of biotechnological fields but also to the understanding of various cellular processes, it is crucial to design novel modifications with unique properties. Here, we demonstrate the utilization of N4 -cytidine modified oligonucleotides, which contain reactive acetophenone (AP) or benzophenone (BP) groups, for the UV-induced cross-linking...
November 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30402630/electrospun-nanofibers-facilitate-better-alignment-differentiation-and-long-term-culture-in-an-in-vitro-model-of-the-neuromuscular-junction-nmj
#16
Baiwen Luo, Lingling Tian, Nuan Chen, Seeram Ramakrishna, Nitish Thakor, In Hong Yang
The neuromuscular junction (NMJ) is a specialized synapse between motor neurons and the muscle fibers they innervate. Due to the complexity of various signalling molecules and pathways, in vivo NMJs are difficult to study. Therefore, in vitro motor neuron-muscle co-culture plays a pivotal role in studying the mechanisms of NMJ formation associated with neurodegenerative diseases. There is a growing need to develop novel methodologies that can be used to develop long-term cultures of NMJs. To date, there have been few studies on NMJ development and long-term maintenance of the system, which is also the main challenge for the current in vitro models of NMJs...
November 20, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30387142/therapeutic-potential-of-human-mesenchymal-stem-cells-derived-beta-cell-precursors-on-a-nanofibrous-scaffold-an-approach-to-treat-diabetes-mellitus
#17
Elham Hoveizi, Shima Tavakol
Diabetes mellitus is an autoimmune and chronic disorder that is rapidly expanding worldwide due to increasing obesity. In the current study, we were able to design a reliable 3-dimensional differentiation process of human Wharton's jelly mesenchymal stem cells into pancreatic beta cell precursors (PBCPs) and detected that transplanted PBCPs could improve hyperglycemia in a diabetes-induced model in mice. Polylactic acid/chitosan nanofibrous scaffold was prepared using an electrospinning method. Quantitative real-time reverse transcription-polymerase chain reaction and immunocytochemistry analysis were carried out to assess pancreatic marker expression in the differentiated cells...
November 1, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30370869/preparation-characterization-and-drug-release-of-salicylic-acid-loaded-porous-electrospun-nanofibers
#18
Wang Yaru, Xu Lan, Sui Jianhua, Fan Chenxu
BACKGROUND: Salicylic acid (SA), used as an important component in a lot of skin care products, has been reported widely. And because of large specific surface area, high porosity and good surfactivity, electrospun drug-loaded nanofibers have been widely used in various applications including wound dressing, tissue engineering and drug release. Particularly, the electrospun SA loaded porous nanofibers could be fabricated by regulating electrospinning (ES) parameters, and the release property of SA from nanofibers could be improved by the porous structure...
October 29, 2018: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/30367954/restoring-electrical-connection-using-a-conductive-biomaterial-provides-a-new-therapeutic-strategy-for-rats-with-spinal-cord-injury
#19
Bing Shu, Xiaodan Sun, Raynald Liu, Fenjun Jiang, Hao Yu, Nan Xu, Yihua An
Spinal cord injury (SCI) involves damage to the central nervous system, and there is no effective treatment available currently. The injured spinal cord is unable to transmit physiological electrical signals caudal to the location of the injury after a complete transection. In this study, we attempted to use a conductive biomaterial as a novel scaffold to aid SCI repair. A composite biomaterial was fabricated by embedding conductive polypyrrole (PPy) in an electrospun polylactic acid (PLA) nanofibrous scaffold (PLA/PPy scaffold), and an electrospun PLA nanofibrous scaffold without the PPy component was used as a control...
October 24, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30364755/polymeric-materials-and-films-in-dentistry-an-overview
#20
REVIEW
Dinesh Rokaya, Viritpon Srimaneepong, Janak Sapkota, Jiaqian Qin, Krisana Siraleartmukul, Vilailuck Siriwongrungson
The use of polymeric materials (PMs) and polymeric films (PMFs) has increased in medicine and dentistry. This increasing interest is attributed to not only the excellent surfaces of PMs and PMFs but also their desired mechanical and biological properties, low production cost, and ease in processing, allowing them to be tailored for a wide range of applications. Specifically, PMs and PMFs are used in dentistry for their antimicrobial, drug delivery properties; in preventive, restorative and regenerative therapies; and for corrosion and friction reduction...
November 2018: Journal of Advanced Research
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