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PLA Applications

Bartolomeo Coppola, Nicola Cappetti, Luciano Di Maio, Paola Scarfato, Loredana Incarnato
In this study, the possibility of using a layered silicate-reinforced polylactic acid (PLA) in additive manufacturing applications was investigated. In particular, the aim of this work was to study the influence of printing temperature in the 3D printing process of PLA/clay nanocomposites. For this reason, two PLA grades (4032D and 2003D, D-isomer content 1.5 and 4, respectively) were melt-compounded by a twin screw extruder with a layered silicate (Cloisite 30B) at 4 wt %. Then, PLA and PLA/clay feedstock filaments (diameter 1...
October 11, 2018: Materials
Yuanyuan Xiao, Chunmei Wang, Meimei Xiong, Yuping Yang, Qianqian Zhang, Xuan Liu, Bingwen Zou, Maling Gou
Gene therapy is emerging as a promising tool for cancer treatment. Down-regulation of survivin gene can lead to the cancer inhibition. However, the lack of efficient and safe gene delivery system is still a critical obstacle to clinical gene therapy. In this study, we use a biodegradable nanoparticle to deliver human survivin-T34A ( T34A ) to dominant-negatively regulate survivin gene for ovarian cancer therapy. This nanoparticle, self-assembled from monomethoxy poly(ethylene glycol)-poly(D,L-lactide) (MPEG-PLA) copolymer and N -[1-(2,3-dioleoyloxy) propyl]- N , N , N -trimethylammonium chloride (DOTAP), has high transfection capability and negligible cytotoxicity...
December 1, 2018: Journal of Biomedical Nanotechnology
Sundus Riaz, Nosheen Fatima, Ahmed Rasheed, Mehvish Riaz, Faiza Anwar, Yamna Khatoon
Polylactic acid (PLA) is a biodegradable thermoplastic polyester. In 2010, PLA became the second highest consumed bioplastic in the world due to its wide application. Conventionally, PLA is produced by direct condensation of lactic acid monomer and ring opening polymerization of lactide, resulting in lower molecular weight and lesser strength of polymer. Furthermore, conventional methods of PLA production require a catalyst which makes it inappropriate for biomedical applications. Newer method utilizes metabolic engineering of microorganism for direct production of PLA through fermentation which produces good quality and high molecular weight and yield as compared to conventional methods...
2018: International Journal of Biomaterials
Ningjing Wu, Guoliang Fu, Yue Yang, Mingfeng Xia, Han Yun, Qingguo Wang
Flame-retarded poly(lactic acid) (PLA) biodegradable materials are viewed as promising as sustainable alternatives to petroleum-based commodity polymers. A new highly efficient flame retardant, poly(phenylphosphoryl phenylenediamine) (PPDA), was synthesized by the condensation of phenylphosphoryl dichloride with p-phenylenediamine and its structure was confirmed by 1 H nulear magnetic resonance and Fourier-transform infrared spectroscopy. When 3 wt% PPDA was incorporated into PLA, the limited oxygen index increased from 20...
September 22, 2018: Journal of Hazardous Materials
Daiana Wischral, Johanna Méndez Arias, Luiz Felipe Modesto, Douglas de França Passos, Nei Pereira
Lactic acid, traditionally obtained through fermentation process, presents numerous applications in different industrial segments, including production of biodegradable polylactic acid (PLA). Development of low cost substrate fermentations could improve economic viability of lactic acid production, through the use of agricultural residues as lignocellulosic biomass. Studies regarding the use of sugarcane bagasse hydrolysates for lactic acid production by Lactobacillus spp. are reported. First, five strains of Lactobacillus spp...
October 8, 2018: Biotechnology Progress
Xiao Du, Shaoping Yin, Yang Wang, Xiaochen Gu, Guangji Wang, Juan Li
Biocompatible, pH-sensitive and charge-conversion micelles derived from hyaluronic acid (HA), poly(lactide) (PLA) and half-generation of sectorial poly(amidoamine) dendrimers (sPA G4.5) were designed and fabricated to target delivery of docetaxel (DTX) to cancer cells. The novel micelles (HA-PALA-DTX) possessed stability against rat plasma and were capable of reversing surface zeta potential under acidic conditions in the presence of HAase. Moreover, the blank micelles demonstrated satisfactory biocompatibility and viability for biomedical applications...
December 15, 2018: Carbohydrate Polymers
Shuai Mao, Lei Wang, Peipei Chen, Yong Lan, Rui Guo, Minzhou Zhang
Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling...
October 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
María Dolores Samper, David Bertomeu, Marina Patricia Arrieta, José Miguel Ferri, Juan López-Martínez
Recycling polymers is common due to the need to reduce the environmental impact of these materials. Polypropylene (PP) is one of the polymers called 'commodities polymers' and it is commonly used in a wide variety of short-term applications such as food packaging and agricultural products. That is why a large amount of PP residues that can be recycled are generated every year. However, the current increasing introduction of biodegradable polymers in the food packaging industry can negatively affect the properties of recycled PP if those kinds of plastics are disposed with traditional plastics...
October 2, 2018: Materials
Ralf Wyrwa, Katja Otto, Sibylle Voigt, Astrid Enkelmann, Matthias Schnabelrauch, Thomas Neubert, Gerlind Schneider
Two major aspects need to be focused to accelerate wound healing of mucosal damages especially in the field of otorhinolaryngology. (i) The problem of application due to the small access during surgery, (ii) the fixation of the wound dressing to reveal a stable healing process. In the present work the high request to a mucosal wound dressing which additionally support hemostasis was addressed. We developed an electrospun fabric made of poly(l-lactide-co-d/l-lactide) (PLA) which can be loaded with the hemostatic agents adrenaline and tranexamic acid to cover mucosal lesions analogues to common skin patches...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Shiv Shankar, Long-Feng Wang, Jong-Whan Rhim
Zinc oxide nanoparticles (ZnO NPs) were synthesized using zinc chloride and NaOH and they were incorporated to prepare PLA/ZnO NPs composite films. The SEM images showed that the ZnO NPs were cubical in shape with size ranged from 50 to 100 nm, and the PLA/ZnO NPs composite films were smooth and compact. The composite films exhibited strong UV-light barrier property with a slight decrease in the transparency. The thickness, tensile strength, and water vapor barrier property of the films increased significantly after incorporation of ZnO NPs...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Raluca Nicoleta Darie-Niţă, Cornelia Vasile, Elena Stoleru, Daniela Pamfil, Traian Zaharescu, Liliana Tarţău, Niţă Tudorachi, Mihai Adrian Brebu, Gina Mihaela Pricope, Raluca Petronela Dumitriu, Karol Leluk
New multifunctional materials containing additives derived from natural resources as powdered rosemary ethanolic extract were obtained by melt mixing and processed in good conditions without degradation and loss of additives. Incorporation of powdered rosemary ethanolic extract (R) into poly(lactic acid) (PLA) improved elongation at break, rheological properties, antibacterial and antioxidant activities, in addition to the biocompatibility. The good accordance between results of the chemiluminescence method and radical scavenging activity determination by chemical method evidenced the increased thermoxidative stability of the PLA biocomposites with respect to neat PLA, with R acting as an antioxidant...
September 25, 2018: Materials
Fenghua Zhang, Yuliang Xia, Linlin Wang, Liwu Liu, Yanju Liu, Jinsong Leng
Conductive shape memory polymers as a class of functional materials play a significant role in sensors and actuators. A high conductivity and a high response speed are needed in practical applications. In this work, a conductive shape memory polylactic acid (PLA) microfiber membrane was synthesized by combining electrospinning with chemical vapor polymerization. The shape memory PLA was electrospun into microfibers with different diameters, and a conductive polypyrrole (PPy) coating was applied to the PLA microfiber membranes using vapor polymerization...
October 3, 2018: ACS Applied Materials & Interfaces
Weiping Zheng, Minhua Li, Yunxia Lin, Xin Zhan
PURPOSE: Ovarian cancer is usually treated with transurethral resection or systemic chemotherapy in clinic. However, the development of drug resistance in ovarian cancer is frequently observed in ovarian cancer patients, leading to failure of tumor inhibition and recurrence. In this study, we aimed to efficiently reverse the drug resistance and enhance the anticancer effects by co-delivery of chemotherapeutic agents and multi-drugs resistant proteins inhibitor in ovarian cancer treatment...
September 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Zhengning Li, Ge Chen, Haichen Lyu, Frank Ko
A kind of composite was designed and additive manufacturing (AM) technology was utilized in the braiding structure fabrication. The printed polylactic acid (PLA) braiding structures were integrated with two types of resins (Epon 828 resin and urethane dimethacrylate/triethylene glycol dimethacrylate (UDMA/TEDGMA) resin) used as the matrix to make composite specimens. The compression test of the composite specimens showed that the printed PLA braiding structures had the effect of varying the compression properties of pure resins: it decreased the compression properties of Epon 828 resin, but increased those of UDMA/TEGDMA resin...
September 18, 2018: Materials
Shaobo Cai, Behnam Pourdeyhimi, Elizabeth G Loboa
In this study, we report an industrial-scale fabrication method of a multifunctional polymer composite as a scaffold material for bone tissue engineering. This study successfully demonstrated the potential of applying industrial polymer processing technologies to produce specially functionalized tissue engineering scaffolds. With the inclusion of a newly synthesized multifunctional additive, silver-doped-calcium phosphate (silver-CaP), the composite material exhibited excellent osteogenic inducibility of human adipose-derived stem cells (hASC) and satisfactory antibacterial efficacy against Escherichia coli and Staphylococcus aureus...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Rushikesh Sable, Nithya Jambunathan, Sitanshu Singh, Sandeep Pallerla, Konstantin G Kousoulas, Seetharama Jois
Protein-protein interactions (PPI) by homo-, hetero- or oligo-merization in the cellular environment regulate cellular processes. PPI can be inhibited by antibodies, small molecules or peptides, and this inhibition has therapeutic value. A recently developed method, the proximity ligation assay (PLA), provides detection of PPI in the cellular environment. However, most applications using this assay are for proteins expressed in the same cell. We employ PLA for the first time to study PPI of cell surface proteins on two different cells...
September 2018: BioTechniques
Alessandro Paolini, Luca Leoni, Ilaria Giannicchi, Zeinab Abbaszadeh, Valentina D'Oria, Francesco Mura, Antonella Dalla Cort, Andrea Masotti
Many advanced synthetic, natural, degradable or non-degradable materials have been employed to create scaffolds for cell culture for biomedical or tissue engineering applications. One of the most versatile material is poly-lactide (PLA), commonly used as 3D printing filament. Manufacturing of multifunctional scaffolds with improved cell growth proliferation and able to deliver oligonucleotides represents an innovative strategy for controlled and localized gene modulation that hold great promise and could increase the number of applications in biomedicine...
September 17, 2018: Scientific Reports
Eliška Číková, Jaroslav Kuliček, Ivica Janigová, Mária Omastová
The electrospinning of an ethylene vinyl acetate (EVA) copolymer with a vinyl acetate content of 28 wt.% is limited due to the solubility of the copolymer in standard laboratory conditions. Poly(lactic acid) (PLA) is a biodegradable polymer that can be electrospun easily. However, PLA has limited applicability because it is brittle. Blends of these polymers are of interest in order to obtain new types of materials with counterbalanced properties originating from both polymeric compounds. The fibers were electrospun on a water surface from a solution mixture containing various weight ratios of both polymers using a dichloromethane and acetone (70:30 v / v ) mixture as solvent...
September 15, 2018: Materials
Ahmed Salim, Saptarshi Ghosh, Sungjoon Lim
In this paper, a microwave cavity resonator is presented for chemical sensing applications. The proposed resonator is comprised of a three dimensional (3D) split-ring resonator (SRR) residing in an external cavity and capacitively coupled by a pair of coaxial probes. 3D-printing technology with polylactic acid (PLA) filament is used to build the 3D SRR and cavity. Then, the surfaces of the SRR and the inside walls of cavity are silver-coated. The novelty of our proposed structure is its light weight and inexpensive design, owing to the utilization of low density and low-cost PLA...
September 12, 2018: Sensors
Shiv Shankar, Jong-Whan Rhim
Antimicrobial poly(lactide) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) blend films incorporated with grapefruit seed extract (GSE) were prepared using a solvent casting method. Effect of GSE on the morphological, water vapor barrier, thermostability, color, optical, and antimicrobial properties of PLA/PBAT composite films was investigated. The composite films showed a yellowish tint after incorporation of GSE and exhibited a high UV-light barrier property. Incorporation of GSE increased the flexibility and tensile strength of the composite films...
December 2018: International Journal of Biological Macromolecules
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