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PLA Applications

Xinhai Zhou, Jie Zhou, Fengxue Xin, Jiangfeng Ma, Wenming Zhang, Hao Wu, Min Jiang, Weiliang Dong
d‑Phenyllactic acid (d‑PLA) shows great potential for biopreservative production owning to its anti-microbial activity. In this study, strain ZX1, which could inhibit the growth of other microbes was isolated and identified as Lactobacillus genus. Strain ZX1 could produce d‑PLA with 0.16 g·L-1 . Furthermore, a novel d‑lactate dehydrogenase gene was identified and expressed in Escherichia coli BL21 (DE3) with the specific activity of 71.64 U·mg-1 protein under the optimal temperature and pH of 35 °C and 6...
August 10, 2018: International Journal of Biological Macromolecules
Abubakar Hamisu Mijinyawa, Geeta Durga, Anuradha Mishra
Mucilage (represented as CEM) is abundantly present in Colocasia esculenta (L.) Schott or taro and is a water-soluble neutral polysaccharide that can act as a binder, thickening agent, and matrix agent in the pharmaceutical fields of research. Presence of hydroxyl groups on its surface structure allows chemical modification. This study describes in details the synthesis and characterization of its graft copolymer with polylactide (CEM-g-PLA). The polymerization has performed using both the microwave irradiation and conventional methods...
August 9, 2018: International Journal of Biological Macromolecules
Haotian Sun, Lingyue Yan, Kevin A Carter, Jiaqi Zhang, Julia Caserto, Jonathan F Lovell, Yun Wu, Chong Cheng
Zwitterionic crosslinked biodegradable nanocapsules (NCs) were synthesized for cancer imaging. A polylactide (PLA)-based diblock copolymer with two blocks carrying acetylenyl and allyl groups respectively was synthesized by ring-opening polymerization (ROP). Azide-alkyne "click" reaction was conducted to conjugate sulfobetaine (SB) zwitterions and fluorescent dye Cy5.5 onto the acetylenyl-functionalized first block of the diblock copolymer. The resulting copolymer with a hydrophilic SB/Cy5.5-functionalized PLA block and a hydrophobic allyl-functionalized PLA block could stabilize miniemulsions because of its amphiphilic diblock structure...
August 7, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Valentin Romanov, Raheel Samuel, Marzieh Chaharlang, Alexander R Jafek, Adam Frost, Bruce K Gale
Transparent surfaces within microfluidic devices are essential for accurate quantification of chemical, biological and mechanical interactions. Here, we report how to create lost-cost, rapid 3D-printed microfluidic devices that are optically free from artifacts and have transparent surfaces suitable for visualizing a variety of fluid phenomenon. The methodology described here can be used for creating high-pressure microfluidic systems (significantly higher than PDMS-glass bonding). We develop methods for annealing Poly-Lactic Acid (PLA) microfluidic devices demonstrating heat-resistance typically not achievable with other plastic materials...
August 3, 2018: Analytical Chemistry
Byung Kyu Park, David J Hwang, Dong Eui Kwon, Tae Jun Yoon, Youn-Woo Lee
Multiscale structured polymers have been considered as a promising category of functional materials with unique properties. We combined rapid prototyping and gas foaming technologies to fabricate multiscale functional materials of superior mechanical and thermal insulation properties. Through scanning electron microscope based morphological characterization, formation of multiscale porous structure with nanoscale cellular pores was confirmed. Improvement in mechanical strength is attributed to rearrangement of crystals within CO₂ saturated grid sample...
July 27, 2018: Nanomaterials
Tolesa Fita Chala, Chang-Mou Wu, Min Hui Chou, Zhen Lin Guo
The development of efficient photothermal materials is the most important issue in solar water evaporation. In this work, melt electrospun reduced tungsten oxide-Polylactic acid (WO2.72/PLA) fiber membranes were successfully prepared with improved near-infrared (NIR) photothermal conversion properties owing to strong NIR photoabsorption by the metal oxide. WO2.72 powder nanoparticles were incorporated into PLA matrix by melt processing, following which the composites were extruded into wires using a single screw extruder...
July 27, 2018: ACS Applied Materials & Interfaces
Junxiu Zhao, Xiaobo Peng, Chunyan Wang, Lili Bai, Jianguang Dong, Xiaoxia Lu, Yanqing Liu, Shufang Feng, Jianhai Long, Zewu Qiu
OBJECTIVE: To investigate the efficacy of prussian blue (PB) or its combination with hemoperfusion (HP) in the treatment of acute thallium poisoning. METHODS: Forty-seven patients with acute thallium poisoning with complete data hospitalized in the 307th Hospital of PLA from September 2002 to December 2017 were enrolled, and they were divided into mild poisoning group (blood thallium < 150 μg/L, urinary thallium < 1 000 μg/L) and moderate-severe poisoning group (blood thallium ≥ 150 μg/L, urinary thallium ≥ 1 000 μg/L) according to the toxic degrees...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Shuhong Wu, Zhili Xiao, Jinlin Song, Min Li, Wenhua Li
BACKGROUND: The aim of this study is to evaluate the effects of recombinant human bone morphogenetic protein 2 (rhBMP-2), human amnion mesenchymal stem cells (hAMSCs), and nanohydroxyapatite/collagen/poly(l-lactide) (nHAC/PLA) in tissue engineering to provide potential approaches for periodontal bone regeneration. METHODS: hAMSCs were isolated from discarded amniotic membrane samples and cultured in vitro. Alkaline phosphatase (ALP) staining and alizarin red staining were performed to evaluate the osteoblast (OB) differentiation ability of hAMSCs...
July 25, 2018: International Journal of Molecular Sciences
Razieh Khalifehzadeh, Winston Ciridon, Buddy D Ratner
Surface-induced thrombosis is still a significant clinical concern for many types of blood-contacting medical devices. In particular, protein adsorption and platelet adhesion are important events due to their ability to trigger the coagulation cascade and initiate thrombosis. Poly(lactic acid) (PLA) has been the predominant polymer used for making bioresorbable stent. Despite long-term advantages, these stents are associated with higher rates of early thrombosis compared with permanent metallic stents. To address this issue, we modified the surface of PLA with a perfluoro compound facilitated by surface activation using radio frequency (RF) plasma...
July 20, 2018: Acta Biomaterialia
Jiannan Li, Xiangru Feng, Jian Shi, Tongjun Liu, Jianxun Ding
Peritoneal adhesion is a common postoperative complication that causes many kinds of organ dysfunctions. It can be minimized by the integration of physical isolation and pharmaceutical treatment. However, the gas permeability of traditional medical devices for adhesion prevention is not satisfactory, which increases the risk of infection and inflammation, thus facilitating the formation of peritoneal adhesion. In this study, a device of porous polylactide (PLA) film plus atorvastatin (ATV)-loaded thermogel was developed for peritoneal adhesion prevention...
March 31, 2018: ACS Omega
Zhengbo Zhang, Wanguo Xue, Desen Cao, Tanshi Li
A detailed, high-scale clinical data can be generated in the process of diagnosis and treatment of emergency critically ill patients. The integration and analysis and utilization of these data are of great value for improving the treatment level and efficiency and developing the data-driven clinical assistant decision support. China has large volume of health information resources, however, the construction of healthcare databases and subsequent secondary analysis has just started. With the effort of the Chinese PLA General Hospital in building an emergency database and promoting data sharing, the first emergency database was published in China and a health Datathon was organized utilizing this database, providing experience for clinical data integration, database construction, cross-disciplinary collaboration and data sharing...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Roberto Scaffaro, Francesco Lopresti, Andreana Marino, Antonia Nostro
Poly(lactic acid)-based antimicrobial materials received considerable attention as promising systems to control microbial growth. The remarkable physicochemical properties of PLA such as renewability, biodegradability, and US Food and Drug Administration (FDA) approval for clinical use open up interesting perspectives for application in food packaging and biomedical materials. Nowadays, there is an increasing consumer demands for fresh, high-quality, and natural foods packaged with environmentally friendly materials that prolong the shelf life...
July 16, 2018: Applied Microbiology and Biotechnology
Juliana Botelho Moreira, Ana Luiza Machado Terra, Jorge Alberto Vieira Costa, Michele Greque de Morais
Phycocyanin is a pigment of intense blue color, constituting the biomass of microalga such as Spirulina. This pigment is sensitive to pH and this instability results in color change. Thus, phycocyanin fading may become interesting for application in intelligent packaging. The objective of the study was to develop PLA/PEO ultrafine fibers containing phycocyanin to be used as pH indicators membranes for food packaging. The ultrafine fibers were formed by electrospinning process. The average diameter of 1318 nm was obtained for PLA/PEO ultrafine fibers with 2% (w·v-1 ) of phycocyanin and 921 nm for those developed with 3% (w·v-1 ) of the dye...
July 11, 2018: International Journal of Biological Macromolecules
R M Luo, X M Zhang, Z L Du, Y Wang, W Chen, W J Gu, Y J Si, G S Xing, Y Wang, B Hu, W M Da
Objective: To investigate the safety and efficacy of haploidentical hematopoietic stem cell transplantation with different intensity conditioning regimen in the treatment of childhood aplastic anemia (AA) . Methods: Thirty-seven AA patients who underwent haploidentical transplantation in BaYi Children's Hospital Affiliated to PLA Army General Hospital from January 2013 to January 2017 were enrolled. According to the dosage of conditioning regimen, 34 patients excluding 3 other conditioning regimens were divided into high-dosage group (regimen 2, 22 cases) and low-dosage group (regimen 3, 12 cases)...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Maria Persson, Petri P Lehenkari, Lena Berglin, Sanna Turunen, Mikko A J Finnilä, Juha Risteli, Mikael Skrifvars, Juha Tuukkanen
Fiber-based scaffolds produced by textile manufacturing technology offer versatile materials for tissue engineering applications since a wide range of crucial scaffold parameters, including porosity, pore size and interconnectivity, can be accurately controlled using 3D weaving. In this study, we developed a weavable, bioactive biodegradable composite fiber from poly (lactic acid) (PLA) and hydroxyapatite powder by melt spinning. Subsequently, scaffolds of these fibers were fabricated by 3D weaving. The differentiation of human mesenchymal stem cells (hMSCs) in vitro was studied on the 3D scaffolds and compared with differentiation on 2D substrates having the same material composition...
July 11, 2018: Scientific Reports
Jingjunjiao Long, Ashveen V Nand, Sudip Ray, Sam Mayhew, David White, Craig R Bunt, Ali Seyfoddin
Customisation of sustained and controlled release of contraceptives plays a key role in veterinary applications. A biodegradable projectile containing different doses of contraceptive progesterone was prepared using fused deposition modelling 3D printing. Three concentrations of progesterone (2, 5 and 10% w/w) with polylactic acid was prepared as a 1.75 mm filament by hot melt extrusion. Solvent dissolution tests confirmed the successful incorporation of progesterone in the polymer while microscopic (SEM) studies indicated the drug was melted and thoroughly mixed with the polymer matrix and pore-formation after dissolution...
September 5, 2018: International Journal of Pharmaceutics
Yujie Zhang, Qiang Zeng, Xiaoying Li, Pengli Zhu, Feng Huang
The aim of the study was to evaluate the usefulness of conicity index (CI) adjusted total body fat (TBF), which was defined as TBF/CI, in various metabolic diseases in young adults. A cross-sectional study was carried out in Chinese PLA General Hospital and a total of 1365 young adults (age 20-40 years) who underwent a health check-up examination were finally included in the analysis from February 2016 to 2017. Linear Regression and logistic regression were used to further examine relationship between the index and metabolic diseases...
July 4, 2018: Scientific Reports
Mostafa Shahrezaee, Majid Salehi, Sara Keshtkari, Ahmad Oryan, Amir Kamali, Babak Shekarchi
Large bone defects constitute a major challenge in bone tissue engineering and usually fail to heal due to the incomplete differentiation of recruited mesenchymal stem cells (MSCs) into osteogenic precursor cells. As previously proposed, metformin (MET) induces differentiation of MSCs into osteoblastic lineages in vitro. We fabricated a Poly (lactic acid) and Polycaprolactone (PLA/PCL) scaffold to deliver metformin loaded gelatin nanocarriers (MET/GNs) to critical-sized calvarial bone defects in a rat model...
June 28, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Chen Chen, Iris Pla-Palacín, Pedro M Baptista, Peng Shang, Loes A Oosterhoff, Monique E van Wolferen, Louis C Penning, Niels Geijsen, Bart Spee
Direct reprogramming represents an easy technique to generate hepatocyte-like cells (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here, we established a polycistronic expression system to induce the direct reprogramming of mouse embryonic fibroblasts towards hepatocytes. The resulting iHeps are homogenous and display key properties of primary hepatocytes, such as expression of hepatocyte markers, albumin secretion, and presence of liver transaminases...
June 30, 2018: Biotechnology and Bioengineering
Weidong Han, Linlin Shi, Lulu Ren, Liqian Zhou, Tongyu Li, Yiting Qiao, Hangxiang Wang
Drug resistance, accounting for therapeutic failure in the clinic, remains a major challenge to effectively manage cancer. Cyclosporin A (CsA) can reverse multidrug resistance (MDR), especially resistance to epidermal growth factor receptor tyrosine kinase inhibitors. However, the application of both drugs in cancer therapies is hampered by their poor aqueous solubility and low bioavailability due to oral administration. CsA augments the potency of gefitinib (Gef) in both Gef-sensitive and Gef-resistant cell lines...
2018: Signal Transduction and Targeted Therapy
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