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JOURNAL ARTICLE
Valentino Allocca, Luca Guidelli, Angela Galgano, Lucia Benedetti, Roberto Fabbroni, Andrea Bianco, Piero Paladini, Raffaele Scala
INTRODUCTION: Medical pleuroscopy (MP) is an invasive technique that provides access to the pleural space with a rigid or semi-rigid work instrument, allowing for visualization and the obtaining of bioptic pleural samples. Using pulmonologist-based analgosedation to perform pleuroscopy is still debated for safety reasons. The aim of this real-life study is to demonstrate the safety and diagnostic yield of MP performed under balanced analgosedation by a pulmonologist team with expertise in the management of critically ill patients in the respiratory intensive care unit (RICU) and interventional pulmonology unit as compared to video-assisted thoracic surgery (VATS) performed by a thoracic surgeon team under anesthesiologist-based analgosedation...
March 7, 2024: Diagnostics
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JOURNAL ARTICLE
C Lombardi, G Passalacqua, F Menzella, R F Mauritz Canevari, G Danesi, A M Pusateri, M Carone, C Vancheri, F Di Marco, C Micheletto, G Manzotti, M Di Gioacchino, M B Bilò, M Gelardi, G Senna, G W Canonica
Background. Chronic rhinosinusitis (CRS) is an inflammatory disease that affects the nasal mucosa and the paranasal sinuses. CRS can be associated by nasal polyposis (CRSwNP phenotype) in up to 30% of patients and it is frequently associated with bronchial asthma. CRSwNP shows predominantly an underlying activation of type 2 inflammatory pathways with the involvement of eosinophils, IgE, interleukin (IL)-4, IL-5 and IL-13. Biological drugs that target these inflammatory cytokines are currently a therapeutic option recognized by guidelines for the treatment of uncontrolled form of the disease...
March 27, 2024: European Annals of Allergy and Clinical Immunology
#3
JOURNAL ARTICLE
Rudolf Horn, Christian Görg, Helmut Prosch, Ehsan Safai Zadeh, Christian Jenssen, Christoph F Dietrich
The CME review presented here is intended to explain the significance of pleural sonography to the interested reader and to provide information on its application. At the beginning of sonography in the 80 s of the 20th centuries, with the possible resolution of the devices at that time, the pleura could only be perceived as a white line. Due to the high impedance differences, the pleura can be delineated particularly well. With the increasing high-resolution devices of more than 10 MHz, even a normal pleura with a thickness of 0...
January 18, 2024: Ultraschall in der Medizin
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JOURNAL ARTICLE
A Chapron, T Lemée, G Pau, S Jouneau, S Kerbrat, F Balusson, E Oger
In France, most spirometries are performed by pneumologists. Spirometry is difficult to access due to the distance to medical office and long delays for appointments. This lack of accessibility contributes to the underdiagnosis of chronic obstructive pulmonary disease (COPD) among patients aged between 40 and 75 years. In recent years, general practitioners (GPs) have been performing spirometry in private practice. However, the extent of this practice is unknown. A French retrospective, repetitive transversal study analysed data from the "Système National des Données de Santé" (SNDS) database...
September 30, 2023: NPJ Primary Care Respiratory Medicine
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JOURNAL ARTICLE
Giulio Rizzetto, Corrado Tagliati, Marco Fogante, Matteo Marcucci, Giulio Argalia, Giuseppe Lanni, Alberto Rebonato, Gian Marco Giuseppetti, Roberto Esposito, Elisa Molinelli, Edoardo De Simoni, Annamaria Offidani, Oriana Simonetti
Background and Objectives: Recently published articles reported an association between psoriasis and interstitial lung diseases (ILDs). The aim of this study is to evaluate the differences in ILD computed tomography (CT) patterns between smoker and never smoker plaque psoriasis (PP) patients under topical treatment without psoriatic arthritis (PA), inflammatory bowel disease (IBD) or connective tissue diseases (CTDs). Matherials and Methods : Two radiologists evaluated chest CT examinations of 65 patients (33 smokers, 32 never smokers) with PP...
September 12, 2023: Medicina
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JOURNAL ARTICLE
Eva Martínez Moragón, Luis Manuel Entrenas Costa, Joaquín Sánchez-Covisa Hernández, Anna de Prado Moncusí, Gema Monteagudo Ruiz
BACKGROUND AND PURPOSE OF THE STUDY: The utility measure is a method to quantify health-related quality of life according to the preference values that patients attach to their health status. This study aimed to estimate the utility measure of patients with controlled and uncontrolled severe asthma (SA) in Spain, separately. Additionally, other characteristics (sociodemographic, clinical, and healthcare resource use [HCRU]) were also assessed for both SA populations. METHODS: This cross-sectional study included 159 patients with SA in Spain...
September 1, 2023: Journal of Asthma
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JOURNAL ARTICLE
R Hindré, N Poté, P Mordant, P Le Guen
INTRODUCTION: Ectopic Cushing's syndrome (CS) is a rare condition nevertheless well-known to endocrinologists. The pneumologist may be called upon to treat CS not only because bronchial carcinoid tumors are the most frequent source of ectopic ACTH secretion, but also due to the fact that the immunosuppression induced by hypercorticism favors lower respiratory tract infections. CASE REPORT: We report the case of a female patient presenting with acute respiratory failure secondary to Enterobacter cloacae pneumonia exacerbated by SC...
August 24, 2023: Revue des Maladies Respiratoires
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REVIEW
Susan Marelli, Emanuele Micaglio, Jacopo Taurino, Paolo Salvi, Erica Rurali, Gianluca L Perrucci, Claudia Dolci, Nathasha Samali Udugampolage, Rosario Caruso, Davide Gentilini, Giuliana Trifiro', Edward Callus, Alessandro Frigiola, Carlo De Vincentiis, Carlo Pappone, Gianfranco Parati, Alessandro Pini
Marfan syndrome (MFS) is a rare inherited autosomic disorder, which encompasses a variety of systemic manifestations caused by mutations in the Fibrillin-1 encoding gene ( FBN1 ). Cardinal clinical phenotypes of MFS are highly variable in terms of severity, and commonly involve cardiovascular, ocular, and musculoskeletal systems with a wide range of manifestations, such as ascending aorta aneurysms and dissection, mitral valve prolapse, ectopia lentis and long bone overgrowth, respectively. Of note, an accurate and prompt diagnosis is pivotal in order to provide the best treatment to the patients as early as possible...
July 5, 2023: Diagnostics
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JOURNAL ARTICLE
Veronique Suttels, Sofia Guedes Da Costa, Elena Garcia, Thomas Brahier, Mary-Anne Hartley, Gildas Agodokpessi, Prudence Wachinou, Fabienne Fasseur, Noémie Boillat-Blanco
OBJECTIVES: Owing to its ease-of-use and excellent diagnostic performance for the assessment of respiratory symptoms, point-of-care lung ultrasound (POC-LUS) has emerged as an attractive skill in resource-low settings, where limited access to specialist care and inconsistent radiology services erode health equity.To narrow down the research to practice gap, this study aims to gain in-depth insights in the perceptions on POC-LUS and computer-assisted POC-LUS for the diagnosis of lower respiratory tract infections (LRTIs) in a low-income and middle-income country (LMIC) of sub-Saharan Africa...
June 26, 2023: BMJ Open
#10
JOURNAL ARTICLE
Benjamin Brunn, Alexander Hapfelmeier, Rudolf A Jörres, Konrad Schultz, Antonius Schneider
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is known as effective for ruling-in asthma. The diagnostic value might be increased in combination with clinical signs and symptoms (CSS). The aim was to develop a new model for ruling-in and ruling-out asthma. METHODS: Diagnostic multi-centre study in three practices of pneumologists in Germany. Whole-body plethysmography was combined with bronchodilation tests or bronchial provocation as diagnostic reference standard...
May 29, 2023: Respiratory Medicine
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JOURNAL ARTICLE
Emanuela Sitzia, Sara Santarsiero, Giulia Marini, Fabio Majo, Marcello De Vincentiis, Giovanni Cristalli, Maria Cristina Artesani, Alessandro Giovanni Fiocchi
Nasal polyps (NPs) are rarely reported in childhood and usually represent red flags for systemic diseases, such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and immunodeficiencies. The European Position Paper released in 2020 (EPOS 2020) provided a detailed classification and defined the correct diagnostic and therapeutic approaches. We report a one-year experience of a multidisciplinary team, made up of otorhinolaryngologists, allergists, pediatricians, pneumologists and geneticists, with the aim of ensuring a personalized diagnostic and therapeutic management of the pathology...
April 23, 2023: Journal of Personalized Medicine
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Karina Kleinfelder, Elena Somenza, Alessia Farinazzo, Jessica Conti, Virginia Lotti, Roberta Valeria Latorre, Luca Rodella, Arianna Massella, Francesco Tomba, Marina Bertini, Claudio Sorio, Paola Melotti
An Italian, 46-year-old female patient carrying the complex allele p.[R74W;V201M;D1270N] in trans with CFTR dele22_24 was diagnosed at the Cystic Fibrosis (CF) Center of Verona as being affected by CF-pancreatic sufficient (CF-PS) in 2021. The variant V201M has unknown significance, while both of the other variants of this complex allele have variable clinical consequences, according to the CFTR2 database, with reported clinical benefits for treatment with ivacaftor + tezacaftor and ivacaftor + tezacaftor + elexacaftor in patients carrying the R74W-D1270N complex allele, which are currently approved (in USA, not yet in Italy)...
March 8, 2023: International Journal of Molecular Sciences
#13
JOURNAL ARTICLE
Emiliano Antiga, Rikke Bech, Roberto Maglie, Giovanni Genovese, Luca Borradori, Barbara Bockle, Marzia Caproni, Frédéric Caux, Nisha Suyien Chandran, Alberto Corrà, Francesco D'Amore, Maryam Daneshpazhooh, Dipankar De, Dario Didona, Marian Dmochowski, Kossara Drenovska, Jan Ehrchen, Claudio Feliciani, Matthias Goebeler, Richard Groves, Claudia Günther, Sanjeev Handa, Silke C Hofmann, Barbara Horvath, Dimitrios Ioannidis, Hana Jedlickova, Cezary Kowalewski, Khalaf Kridin, Pascal Joly, Yen Loo Lim, Branka Marinovic, Emanual Maverakis, Joost Meijer, Aikaterini Patsatsi, Carlo Pincelli, Catherine Prost, Jane Setterfield, Eli Sprecher, Dusan Skiljevic, Kaisa Tasanen, Soner Uzun, Nina Van Beek, Snejina Vassileva, Artem Vorobyev, Igor Vujic, Gang Wang, Mingyue Wang, Katarzyna Wozniak, Savas Yayli, Giovanna Zambruno, Takashi Hashimoto, Enno Schmidt, José Manuel Mascarò, Angelo Valerio Marzano
BACKGROUND: Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi-organ involvement. PNP/PAMS is typically associated with lymphoproliferative or haematological malignancies, and less frequently with solid malignancies. The mortality rate of PNP/PAMS is elevated owing to the increased risk of severe infections and disease-associated complications, such as bronchiolitis obliterans. OBJECTIVES: These guidelines summarize evidence-based and expert-based recommendations (S2k level) for the clinical characterization, diagnosis and management of PNP/PAMS...
June 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
#14
REVIEW
T Dégot, B Douvry, L Falque, N Bautin, I Frachon, J Mankikian, J Le Pavec, C Picard
BACKGROUND: Lung transplantation (LT) requires sustained care for a frequently polypathological condition. Follow-up is focused on three main issues: 1/stability of respiratory function; 2/comorbidity management; 3/preventive medicine. About 3000 LT patients in France are treated in 11 LT centers. Given the increased size of the LT recipient cohort, follow-up might be partially shared with peripheral centers. METHODS: This paper presents the suggestions of a working group of the SPLF (French-speaking respiratory medicine society) on possible modalities of shared follow-up...
March 1, 2023: Revue des Maladies Respiratoires
#15
JOURNAL ARTICLE
Ulrich Koehler, Christian Viniol, Olaf Hildebrandt, Karl Kesper, Mikail Aykut Degerli, Regina Conradt, Keywan Sohrabi
The nasal cycle refers to the anticyclic swelling and decongestion of the two nasal cavities that occur during the day and during sleep, while the overall nasal flow remains constant. The nasal cycle was first described by R. Kayser in 1895. Each cycle consists of a working phase and a subsequent resting phase, the purpose of which is the rehydration and regeneration of the mucosa. A nasal cycle occurs in about 70-90% of people. The duration of the phase is affected by age, body position, physical activity, mucociliary clearance and time of day...
March 2023: Pneumologie
#16
JOURNAL ARTICLE
Myriam Calle Rubio, José Luis López-Campos, Marc Miravitlles, Francisco Javier Michel de la Rosa, José María Hernández Pérez, Carmen Montero Martínez, José Bruno Montoro Ronsano, Francisco Casas Maldonado, Juan Luis Rodríguez Hermosa, Eva María Tabernero Huguet, José Manuel Martínez Sesmero, Carlos Martínez Rivera, Francisco Javier Callejas González, María Torres Durán
BACKGROUND: Patients with alpha-1 antitrypsin deficiency (AATD), commonly categorized as a rare disease, have been affected by the changes in healthcare management brought about by COVID-19. This study's aim was to identify the changes that have taken place in AATD patient care as a result of the COVID-19 pandemic in Spain and to propose experts' recommendations aimed at ensuring humanized and quality care for people with AATD in the post-pandemic situation. METHODS: A qualitative descriptive case study with a holistic single-case design was conducted, using focus groups with experts in AATD clinical management, including 15 health professionals with ties to the Spanish health system (12 pneumologists and 2 hospital pharmacists from 11 different hospitals in Spain) and 1 patient representative...
January 30, 2023: BMC Health Services Research
#17
JOURNAL ARTICLE
Alessandra Iacovelli, Alessandra Oliva, Guido Siccardi, Angela Tramontano, Daniela Pellegrino, Claudio Maria Mastroianni, Mario Venditti, Paolo Palange
BACKGROUND: Little is known on the burden of co-infections and superinfections in a specific setting such as the respiratory COVID-19 sub-intensive care unit. This study aims to (i) assess the prevalence of concurrent and superinfections in a respiratory sub-intensive care unit, (ii) evaluate the risk factors for superinfections development and (iii) assess the impact of superinfections on in-hospital mortality. METHODS: Single-center retrospective analysis of prospectively collected data including COVID-19 patients hospitalized in a newly established respiratory sub-intensive care unit managed by pneumologists which has been set up from September 2020 at a large (1200 beds) University Hospital in Rome...
January 20, 2023: BMC Pulmonary Medicine
#18
JOURNAL ARTICLE
Julia Salandi, Patricia Vu-Eickmann, Christian Apfelbacher, Aziz Sheikh, Adrian Loerbroks
BACKGROUND: Many patients with asthma report unmet health care needs. The Patient Needs in Asthma Treatment (NEAT) questionnaire is a validated instrument to quantify these unmet needs. We explored how health professionals evaluated the instrument's utility as well as patients' and professionals' perspectives of how NEAT could be incorporated into routine clinical practice. METHODS: Qualitative interviews were conducted by telephone between February and September 2021 with 19 patients with asthma and 21 health professionals (i...
January 17, 2023: BMC Pulmonary Medicine
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JOURNAL ARTICLE
Houda Gharsalli, Chahida Harizi, Rania Zaouche, Imen Sahnoun, Farah Saffar, Sonia Maalej, Leila Douik El Gharbi
INTRODUCTION: Organic comorbidities of obstructive sleep apnea (OSA) have been widely studied. However, psychiatric disorders, especially depression and anxiety, have not attracted so much attention. AIM: The primary aim was to determine the prevalence and the predictive factors of depression and anxiety in OSA patients. The secondary aim was to investigate the association between OSA severity and these psychiatric disorders. METHODS: A cross-sectional study including untreated OSA patients without mental illness history was conducted...
2022: La Tunisie Médicale
#20
JOURNAL ARTICLE
Jiří Votruba
Chest pain is one of the most common symptoms encountered by doctors working in acute, internal, and pulmonary clinics. In the United States in 2006, 10 percent of all visits to the emergency room were caused by diseases of the respiratory system, and chest pain was the most common symptom. The most common situations that can cause chest pain with an emphasis on their diagnosis and early treatment are chest infections, pneumothorax, pneumomediastinum and tumors affecting the pleural cavity.
2022: Casopís Lékar̆ů C̆eských
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