Shawn S Jackson, Jennifer J Lee, William M Jackson, Jerri C Price, Sue R Beers, John W Berkenbosch, Katherine V Biagas, Robert H Dworkin, Constance S Houck, Guohua Li, Heidi A B Smith, Denham S Ward, Kanecia O Zimmerman, Martha A Q Curley, Christopher M Horvat, David T Huang, Neethi P Pinto, Cynthia F Salorio, Rebeccah Slater, Beth S Slomine, Leanne L West, David Wypij, Keith O Yeates, Lena S Sun
OBJECTIVES: Sedation and analgesia for infants and children requiring mechanical ventilation in the PICU is uniquely challenging due to the wide spectrum of ages, developmental stages, and pathophysiological processes encountered. Studies evaluating the safety and efficacy of sedative and analgesic management in pediatric patients have used heterogeneous methodologies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) IV hosted a series of multidisciplinary meetings to establish consensus statements for future clinical study design and implementation as a guide for investigators studying PICU sedation and analgesia...
April 1, 2024: Pediatric Critical Care Medicine