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Diabetes or Hypertension and Heart Failure

Eric Shulman, Jay J Chudow, Utibe R Essien, Anusha Shanbhag, Faraj Kargoli, Jorge Romero, Luigi Di Biase, John Fisher, Andrew Krumerman, Kevin J Ferrick
BACKGROUND: Contribution of modifiable risk factors for the risk of new onset atrial fibrillation (AF) in minority populations is poorly understood. Our objective was to compare the population attributable risk (PAR) of various risk factors for incident AF between Hispanic, African American and non-Hispanic Whites. METHODS: An ECG/EMR database was interrogated for individuals free of AF for development of subsequent AF from 2000 to 2013. Cox regression analysis controlled for age > 65, male gender, body mass index > 40 kg/m2 , systolic blood pressure > 140 mm Hg, diabetes mellitus, heart failure, socioeconomic status less than the first percentile in New York State, and race/ethnicity...
October 10, 2018: International Journal of Cardiology
Gerd Hasenfuß
Prevention strategies for cardiac events depend of the risk for such an event. A very high risk is defined by a risk >10% over 10 years. For example, a patient with known coronary artery disease has such a very high risk to die. However a patient with diabetes and severe hypertension without known coronary artery disease carries the same risk. Here, secondary prevention and primary prevention overlap. Prevention guidelines include a number of general recommendations such as changes in behavior, smoking intervention strategies, nutrition, body weight, and physical activity...
October 19, 2018: Kardiologia Polska
Sophia A Traven, Russell A Reeves, Molly G Sekar, Harris S Slone, Zeke J Walton
BACKGROUND: While the 11-factor modified frailty index (mFI) has been shown to predict adverse outcomes in patients undergoing total joint arthroplasty, the 5-factor index has not been evaluated in this patient population. The goal of this study was to evaluate the utility of the mFI-5 as a predictor of morbidity and mortality in patients undergoing primary total hip and knee arthroplasty. METHODS: A retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program's database for patients undergoing total hip arthroplasty and total knee arthroplasty between the years 2005 and 2016 was conducted...
September 21, 2018: Journal of Arthroplasty
Jawad H Butt, Jonas B Olesen, Eva Havers-Borgersen, Anna Gundlund, Charlotte Andersson, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Emil L Fosbøl
BACKGROUND: The long-term risk of thromboembolism in patients developing new-onset post-operative atrial fibrillation (POAF) following noncardiac surgery is unknown, and data on stroke prophylaxis in this setting are lacking. OBJECTIVES: The purpose of this study was to assess the long-term risk of thromboembolism in patients developing new-onset POAF following noncardiac surgery relative to patients with nonsurgical, nonvalvular atrial fibrillation (NVAF). METHODS: Using Danish nationwide registries, the authors identified all patients who developed POAF following noncardiac surgery from 1996 to 2015...
October 23, 2018: Journal of the American College of Cardiology
Yung-Ho Hsu, Yu-Chun Yen, Yi-Chun Lin, Li-Chin Sung
BACKGROUND: In this study, we evaluated the effects of various medications on the patency of vascular access (VA) for hemodialysis. METHODS: We analyzed data from the Longitudinal Health Insurance Database of Taiwan. We adopted a case-control study design within a cohort of patients who had received regular hemodialysis between 2002 and 2012; 34,354 patients with first VA failure were identified, and the duration from VA creation date to the first VA failure date was calculated...
2018: PloS One
Perry V Halushka, Andrew J Goodwin, Marc K Halushka
Cardiovascular diseases exist across all developed countries societies. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis...
October 17, 2018: Annual Review of Pathology
Yu-Hsiang Chou, Wei-Lieh Huang, Chin-Hao Chang, Cheryl C H Yang, Terry B J Kuo, Shuei-Liong Lin, Wen-Chih Chiang, Tzong-Shinn Chu
AIM: Autonomic dysfunction contributes to cardiovascular morbidity/mortality and can be evaluated with heart rate variability (HRV). This study is to evaluate the prognostic significance of HRV on renal function in non-dialysis chronic kidney disease (CKD) patients. METHODS: We enrolled 326 non-dialysis CKD patients in this prospective observational study. The median follow-up period was 2.02 years. Five-minutes of electrocardiography recordings obtained at enrollment were reprocessed to assess HRV...
October 17, 2018: Nephrology
Chien-Cheng Huang, Chung-Han Ho, Yi-Chen Chen, Chien-Chin Hsu, Yi-Fong Wang, Hung-Jung Lin, Jhi-Joung Wang, How-Ran Guo
The purpose of this study was to evaluate the effects of hyperbaric oxygen therapy (HBOT) on reducing neurological sequelae (NS) in patients with carbon monoxide poisoning (COP). Using a nationwide database of insurance claims in Taiwan, we conducted a population-based cohort study to identify 24,046 patients with COP diagnosed between 1999 and 2012, including 6793 (28.2%) patients who received HBOT and 17,253 (71.8%) patients who did not. We followed the two cohorts of patients and compared the occurrence of NS...
October 13, 2018: Journal of Clinical Medicine
Xiaoyan Wang, Chongzhe Pei, Yingnan Bai, Qiying Dai, Xin Deng, Yue Liu, Zhi Li, Jieyun You, Juan Peng, Li Lin, Yunzeng Zou
We evaluated the association of preprocedure CHA2 DS2 -VASc (congestive heart failure, hypertension, age, diabetes mellitus, stroke, vascular disease, and sex) score with ischemic events in patients undergoing percutaneous coronary intervention (PCI). The Dryad Digital Repository enrolled 2533 patients between July 2009 and August 2011. We recorded 1-year ischemic events. Univariate and multivariable logistic regression analyses were used to analyze the association between CHA2 DS2 -VASc score and ischemic events...
October 15, 2018: Angiology
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. METHODS AND RESULTS: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012...
October 12, 2018: ESC Heart Failure
Thiago Veiga Jardim, Miles D Witham, Shafika Abrahams-Gessel, F Xavier Gómez-Olivé, Stephen Tollman, Lisa Berkman, Thomas A Gaziano
OBJECTIVES: To characterize the cardiovascular disease (CVD) profile of individuals aged 80 and older in rural South Africa. DESIGN: First wave of population-based longitudinal cohort. SETTING: Agincourt subdistrict (Mpumalanga Province) in rural South Africa. PARTICIPANTS: Adults residents (N = 5,059). MEASUREMENTS: In-person interviews were conducted to obtain social, behavioral, economic, and clinical data...
October 12, 2018: Journal of the American Geriatrics Society
Kelly M Kenzik, Amitkumar Mehta, Joshua S Richman, Meredith Kilgore, Smita Bhatia
BACKGROUND: To the authors' knowledge, there is limited information regarding the long-term risk of congestive heart failure (CHF) among patients with follicular lymphoma, a prevalent non-Hodgkin lymphoma diagnosis among those aged >65 years, especially within the context of therapeutic exposures and preexisting comorbidities. METHODS: Using Surveillance, Epidemiology, and End Results-Medicare data from 1999 through 2013, the authors identified 6109 patients with follicular lymphoma who were diagnosed at age ≥66 years between January 1, 2000 and December 31, 2011, and a frequency-matched Medicare noncancer sample...
October 10, 2018: Cancer
Nicolas Lamblin, Thibaud Meurice, Olivier Tricot, Pascal de Groote, Gilles Lemesle, Christophe Bauters
BACKGROUND: We lack recent data on the incidence, correlates, and prognosis associated with heart failure (HF) development in patients with stable coronary artery disease (CAD). Here, we analyzed HF development in a contemporary population of outpatients with stable CAD. METHODS AND RESULTS: Of 4184 unselected outpatients with stable CAD (i.e., myocardial infarction [MI] and/or coronary revascularization >1 year prior) included in the multicenter CORONOR registry, we identified 3871 patients with no history of hospitalization for HF at inclusion, and followed 3785 (98%) for 5 years...
October 5, 2018: Journal of Cardiac Failure
Amr Salama, Abdullah Abdullah, Abdul Wahab, George Eigbire, Ryan Hoefen, Ruth Kouides, Nathan Ritter, Hanna Mieszczanska, Richard Alweis
BACKGROUND: Obstructive sleep apnea (OSA) is a known independent risk factor for a multiple cardiovascular morbidities and mortality. The association of OSA and ventricular arrhythmias is less well understood. The aim of this analysis to study the relationship between OSA and ventricular tachyarrhythmias. HYPOTHESIS: OSA is associated with increased ventricular arrhythmias METHODS: Data from the National Inpatient Sample (NIS) 2012 - 2014, were reviewed. Discharges associated with OSA were identified as the target population using the relevant ICD-9-CM codes...
October 7, 2018: Clinical Cardiology
Luca Faconti, Charlotte Elizabeth Mills, Virginia Govoni, Haotian Gu, Steven Morant, Benju Jiang, J Kennedy Cruickshank, Webb James Andrew
AIMS: To explore whether long-term intervention with dietary nitrate ((NO3 - ), a potential tolerance-free source of beneficial vasoactive nitric oxide) and spironolactone (to oppose aldosterone's potential deleterious cardiovascular effects) improve cardiac structure/function, independent of blood pressure (BP), in patients with/at risk of type 2 diabetes (a population at risk of heart failure). METHODS: A sub-sample of participants in our double-blind, randomised, factorial-design intervention (VaSera) trial of active beetroot juice as a nitrate source (≤11...
October 7, 2018: British Journal of Clinical Pharmacology
Michel Galinier, Eve Cariou, Olivier Lairez, Pauline Fournier, Clément Delmas, Caroline Biendel-Picquet, Jérôme Roncalli
Diagnosis of heart failure is too late. Symptoms of heart failure are non-specific. Brain natriuretic peptides allow the diagnosis of heart failure in pauci-symptomatic patients, with a threshold of 35pg/mL for BNP and 125pg/mL for NT-proBNP. Left ventricular dysfunction, either diastolic or systolic, remains asymptomatic for a long time. In diabetic and/or hypertensive patients, natriuretic peptides, can be used to diagnose asymptomatic left ventricular dysfunction, with a threshold of 125pg/mL NT-proBNP. Treatment blocking the renin-angiotensin-aldosterone system in diabetic patients with NT-proBNP levels of 125pg/mL can prevent onset of heart failure...
October 4, 2018: La Presse Médicale
Sivan Reut Shiloh, Eyal Sheiner, Tamar Wainstock, Asnat Walfisch, Idit Segal, Daniella Landau, Avi Harlev
OBJECTIVE: To determine the risk of long-term cardiovascular disease (CVD) among children born following in vitro fertilization (IVF) and compared with spontaneous pregnancies. STUDY DESIGN: A population-based cohort study including all singleton deliveries occurring between 1991and 2014 at a tertiary medical center was performed. Hospitalizations up to the age of 18 years involving CVD were evaluated in children delivered following IVF, ovulation induction, and spontaneous pregnancies...
October 2, 2018: Journal of Pediatrics
Irina Benenson, Frederick Andrew Waldron, Shelly A Jones Dillon, Shreni N Zinzuwadia, Nkehci Mbadugha, Natali Vicente, Ela Aris, Adedamola M Adeboye, Christine Makdisi
AIM: The aim of this study was to identify risk factors for hypertensive emergencies in diabetic patients presenting with severely elevated blood pressure. METHODS: Using electronic medical records, this study identified diabetic patients with hypertensive crisis who presented to the emergency department of Newark Beth Israel Medical Center, Newark, NJ from June 2013 to May 2016. Diabetic patients with hypertensive emergencies were compared with non-diabetic patients based on important demographic and clinical characteristics...
October 4, 2018: Clinical and Experimental Hypertension: CHE
Triin Habicht, Marge Reinap, Kaija Kasekamp, Riina Sikkut, Laura Aaben, Ewout van Ginneken
This analysis of the Estonian health system reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. In 2017, the Estonian government took the historic step of expanding the revenue base of the health system, which has been a longstanding challenge. However, in terms of percentage of GDP it remains a small increase and long-term financial sustainability could still pose a problem. That said, if these additional funds are invested wisely, they could play a positive role in further improving the health system...
March 2018: Health Systems in Transition
Valiollah Hassani, Gholamreza Movaseghi, Reza Safaeeyan, Sahar Masghati, Batool Ghorbani Yekta, Reza Farahmand Rad
Background: Hypotension is a common problem in general anesthesia. Maintaining the mean arterial pressure by choosing a vasopressor with minimal complications is still discussed in various surgeries. Objectives: The aim of this study is comparison of ephedrine versus norepinephrine in treating anesthesia-induced hypotension in hypertensive patients in spinal surgery in a randomized double-blinded study. Methods: This randomized, double-blinded study was approved by Iran University of Medical Sciences, operating room of medical center...
August 2018: Anesthesiology and Pain Medicine
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