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Side effect management

Ju Tian, Xiao Xuan Lei, Li Xuan, Jian Bing Tang, Biao Cheng
BACKGROUND AND OBJECTIVES: Plasma skin regeneration (PSR) and platelet-rich plasma(PRP) have gained popularity in the treatment of acne scars due to their efficacy and improved tolerability. The objective of this investigation was to evaluate the synergistic effect of PRP plus PSR (plasma-combined regeneration technology, PCRT) in managing facial acne scars. METHODS: From March 2015 to June 2017,a total of 25 cases with facial atrophic acne scars were treated with PCRT treatment for three to five times...
August 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Hae Min So, Hee Jeong Eom, Dahae Lee, Sil Kim, Ki Sung Kang, Il Kyun Lee, Kwan-Hyuck Baek, Jun Yeon Park, Ki Hyun Kim
Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B...
August 14, 2018: Archives of Pharmacal Research
Ye Guo, Pan-Pan Zhou, Sen-Yan Zhang, Xiao-Wen Fan, Yu-Wei Dou, Xuan-Ling Shi
AIDS has evolved from a fatal infectious disease to a manageable chronic disease under the treatment of anti-AIDS medications. HIV fusion inhibitors with high activity, low side effects and strong selectivity are promising drugs against HIV. Only one fusion inhibitor is currently approved, thereby highly active long-acting fusion inhibitors need to be developed for long-term AIDS treatment. Here, we synthesised MT-SC22EK (a small HIV fusion inhibitor) derivatives containing 1-2 staples to improve its stability...
July 1, 2018: MedChemComm
Shine Raju, Ranjit Joseph, Sameep Sehgal
Checkpoint immunotherapy uses highly selective humanized monoclonal antibodies against checkpoint signals such as programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1). By blocking these receptors and signals, the immune system can be reactivated to fight the tumor. Immunotherapy for advanced non-small cell lung cancer (NSCLC) has resulted in a new paradigm of treatment options resulting in improved survival and response rates and has a less severe yet unique toxicity profile when compared to chemotherapy...
2018: ImmunoTargets and Therapy
Aisha Khatoon, Iliyas Rashid, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi, Shazi Shakil, Neelam Pathak, Snober S Mir, Khurshid Ahmad, Talib Hussain, Prachi Srivastava
Diabetes is a deteriorating metabolic ailment which negatively affects different organs; however, its prime target is insulin secreting pancreatic β-cells. Although, different medications have been affirmed for diabetes management and numerous drugs are undergoing clinical trials, no significant breakthrough has yet been achieved. Available drugs either show some side effects or provide only short-term alleviation. The rationales behind the failure of current anti-diabetic treatment strategy are association of complex patho-physiologies and participation of various organs...
August 2018: 3 Biotech
Lucas Ezequiel Serrano Sponton, Ali Ayyad, Eleftherios Archavlis, Florian Alexander Ringel
Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Case Description: A 51-year-old woman undergoing immunosuppressant treatment for Crohn's disease presented due to right-sided TN...
2018: Surgical Neurology International
Gerald B Fogarty, Angela Hong, Alex Economides, Pascale Guitera
Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Other therapies, including radiotherapy (RT) and topical medicines, may then become appropriate...
2018: Dermatology Research and Practice
Parisa Aslani, Kim Hamrosi, Vivien Tong, Timothy F Chen, Jane Cook, Romano Fois, Theresa McGarry, Carter Moore, Rodney Peters, Sarah Spagnardi, Karen Whitelock
Introduction: Despite the availability of an Australian consumer adverse event (AE) reporting system for over 50 years, reporting rates remain low. A comprehensive understanding of consumer perceptions and experiences regarding AEs is needed to further ascertain factors impacting their engagement in AE reporting. Aim: The aim of this study was to explore consumer opinions about AEs potentially associated with medicines and vaccines, and their experiences and understanding of managing and reporting AEs...
2018: Patient Preference and Adherence
Osama Aa Ahmed, Waleed Y Rizq
Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness...
2018: Drug Design, Development and Therapy
Madhulika Pradhan, Amit Alexander, Manju Rawat Singh, Deependra Singh, Swarnlata Saraf, Shailendra Saraf, Ajazuddin
Psoriasis is a consistently recurring, inflammatory, autoimmune disorder of the skin, affecting about 2-5% of the world population. Abundant therapeutic agents are accessible for the treatment of psoriasis. Nevertheless, none of them are entirely secure and effective to treat the disease without compromising patient compliance. Furthermore, already existing drugs are supposed to restrain the ailment and alleviate the sign and symptoms with no complete cure. However, they focus on restraining the disease and alleviating the symptoms without providing an absolute cure...
August 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kaat De Pourcq, Paul Gemmel, Ben Devis, Jan Van Ooteghem, Tom De Caluwé, Jeroen Trybou
BACKGROUND: Healthcare managers often attempt to enhance process-oriented performance. However, this remains a challenge. New approaches aimed at increasing the implementation success of process-oriented performance measurement should be investigated. METHODS: This study investigates and discusses a step-by-step methodology to implement an automated and effective process-oriented performance measurement system in a hospital. The methodology is based on a framework for developing dashboards based on three steps: the demand side, supply side, and the fit between the two...
August 13, 2018: Informatics for Health & Social Care
Fernando Rizzello, Marta Mazza, Marco Salice, Carlo Calabrese, Andrea Calafiore, Massimo Campieri, Paolo Gionchetti
Beclomethasone dipropionate (BDP) is a second-generation corticosteroid that use novel drug technologies to ensure colonic targeting and potentially reducing systemic corticosteroid concentrations. It is approved for treatment of patients with mild-to-moderate ulcerative colitis (UC) who do not respond to mesalazine. The gut-selective mechanism of action has the potential to improve the safety profile of beclomethasone dipropionate compared to other conventional corticosteroids. Areas covered: We reviewed the mechanism of action, efficacy and safety of beclomethasone dipropionate in the treatment of UC...
August 11, 2018: Expert Opinion on Drug Safety
Beatriz Wills, Julie R Brahmer, Jarushka Naidoo
Immune checkpoint inhibitors have revolutionized the management of advanced NSCLC. With the intention of generating an anti-tumor immune response, ICIs can also lead to inflammatory side effects involving a wide variety of organs in the body, termed immune-related adverse events. Although no prospective clinical trial exists to guide recommendations for optimal and more specific immunosuppressive treatments rather than corticosteroids, further studies may lead to a more mechanistic-based approach towards these toxicities in the future...
August 13, 2018: Current Treatment Options in Oncology
Jin-Shan Zhang, Ge Wen, Yuan Liu, Zhao-Hong Wu, Gang-Dong Chen, Hao Wang, Tong-Chong Zhou
Extraskeletal osteosarcoma (ESOS) is a rare soft-tissue sarcoma that is treated with surgical resection, chemotherapy and radiotherapy; however, as it is now considered to be radiation resistance, it is associated with conflicting management principles and poor outcomes. A multimodality approach is currently used to treat ESOS, which entails the incorporation of multidrug chemotherapy and/or radiotherapy coupled with surgery to obtain the best outcome; however, there are many factors that influence the treatment effects and clinical outcomes of ESOS...
August 2018: Molecular and Clinical Oncology
Anna Skoracka, Brian G Rector, Gary L Hein
Wheat production and sustainability are steadily threatened by pests and pathogens in both wealthy and developing countries. This review is focused on the wheat curl mite (WCM), Aceria tosichella , and its relationship with wheat. WCM is a major pest of wheat and other cereals and a vector of at least four damaging plant viruses ( Wheat streak mosaic virus , High plains wheat mosaic virus , Brome streak mosaic virus , and Triticum mosaic virus ). The WCM-virus pathosystem causes considerable yield losses worldwide and its severity increases significantly when mixed-virus infections occur...
2018: Frontiers in Plant Science
Enrico Torre, Giacomo Matteo Bruno, Sergio Di Matteo, Chiara Martinotti, Martina Oselin, Maria Chiara Valentino, Alessio Parodi, Luigi Carlo Bottaro, Giorgio Lorenzo Colombo
Background: Diabetes represents a relevant public health problem worldwide due to its increasing prevalence and socioeconomic burden. There is no doubt that tight glycemic control reduces the development of diabetic complications such as the long-term costs related to the disease. The aim of our model was to calculate total direct costs associated with the two treatments considered in DUAL VII study, and hence evaluate the potential economic benefits for the National Health System (NHS) deriving from the use of insulin degludec plus liraglutide (IDegLira) in a once-daily fixed combination...
2018: ClinicoEconomics and Outcomes Research: CEOR
James Ds Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz, Bogdan Balas, Frederico J Calado
Purpose: The objective of this study was to describe the clinical care pathways, management and treatment patterns, and hospitalizations for patients with heart failure (HF) in China. Subjects and methods: A cross-sectional survey of cardiologists and their patients with HF was conducted. Patient record forms were completed by 150 cardiologists for 10 consecutive patients. Patients for whom a patient record form was completed were invited to complete a patient self-completion questionnaire...
2018: Drug Design, Development and Therapy
Abhijeet D Faye, Vivek C Kirpekar, Rahul Tadke, Sushil Gawande, Sudhir H Bhave
Agranulocytosis is a rare documented side effect of clozapine which can be associated with grave consequences. When it is associated with other blood dyscrasia, prognosis worsens further. In literature, there are very few cases of pancytopenia and bicytopenia caused by clozapine. We present a case of bicytopenia (reduced white and red blood cells' counts) caused by clozapine within a month of therapy and complicated by a Klebsiella pneumoniae infection. Patient improved in 3 weeks after stopping clozapine along with medical management in the Intensive Care Unit...
March 2018: Indian Journal of Pharmacology
Jonathan Penm, Régis Vaillancourt, Annie Pouliot
BACKGROUND: Medication discrepancies occur in up to 80% of hospitalized patients during transitions of care, either at admission or discharge. However, numerous organization have different definitions of medication reconciliation which may result in variations of services being implemented. OBJECTIVE: To develop a consensus definition of medication reconciliation and define the essential components of medication reconciliation based on international consensus using a modified Delphi process...
August 1, 2018: Research in Social & Administrative Pharmacy: RSAP
Michał Szczypior, Marcin Matuszewski
Idiopathic overactive bladder due to its high impact on quality of life and high prevalence is a significant problem in everyday clinical practice. Currently, we do not have medicines that allow patients to be cured completely. Therapy is focused on the elimination or reduction of symptoms. An established position in the treatment of this disease for many years has a botulinum toxin. This therapy is used in patients whose conservative methods have not improved or are not acceptable because of side effects. The therapeutic effect after the injection of bladder detrusor muscle is limited in time and does not occur in all patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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