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Side effect management

Badr Eldin Mostafa, Talaat Ali Elsamny, Tamer Ali Youssef, Ahmed Bahaa Elserwi, Ahmed Abdelmoneim Teaima
OBJECTIVE: To define anatomical variations associated with arterial blood supply of the nose which has clinical implications on the management of different disorders, especially intractable posterior epistaxis. STUDY DESIGN: Case series. METHODS: Selective angiography of external and internal carotid arteries of 100 patients scheduled for routine angiography was done. RESULTS: Different anatomical variations were documented...
October 18, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Matthew E Dilsizian, Eliot L Siegel
PURPOSE OF REVIEW: An understanding of the basics concepts of deep learning can be helpful in not only understanding the potential applications of this technique but also in critically reviewing literature in which neural networks are utilized for analysis and modeling. RECENT FINDINGS: The term "deep learning" has been applied to a subset of machine learning that utilizes a "neural network" and is often used interchangeably with "artificial intelligence...
October 18, 2018: Current Cardiology Reports
Janusz K Rybakowski
The use of lithium for the prevention of recurrences in mood disorders has a 55-year history. Nowadays, lithium is universally accepted as the first-choice mood-stabilizer (MS) for maintenance treatment of bipolar disorder. In addition to its mood-stabilizing properties, lithium exerts anti-suicidal, immunomodulatory and neuroprotective action which may further substantiate its clinical usefulness. Despite these facts, the use of lithium in mood disorders has been greatly underutilized. The reasons include the introduction and promoting other MS as well as a perception of lithium as a "toxic drug" due to its side effects, mainly thyroid, renal and cognitive disturbances...
2018: Frontiers in Molecular Neuroscience
Kristen M Krysko, Jennifer Graves, Mary Rensel, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu Goyal, Lauren Krupp, Timothy Lotze, Soe Mar, Moses Rodriguez, John Rose, Michael Waltz, T Charles Casper, Emmanuelle Waubant
OBJECTIVE: To characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age. METHODS: This is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of Pediatric MS Centers. DMT use, including duration, dose, and side effects, was analyzed. Newer DMTs were defined as agents receiving Food and Drug Administration approval or with increased use in adult MS after 2005...
October 17, 2018: Neurology
Satoru Kagami, Kimihiko Funahashi, Mitsunori Ushigome, Junichi Koike, Tomoaki Kaneko, Takamaru Koda, Akiharu Kurihara, Yasuo Nagashima, Yu Yoshino, Mayu Goto, Tetsuo Mikami, Kumiko Chino
BACKGROUND: Surgical management of malignant bowel obstruction carries with high morbidity and mortality. Placement of a trans-anal decompression tube (TDT) has traditionally been used for malignant bowel obstruction as a bridge to surgery. Recently, colonic metallic stent (CMS) as a bridge to surgery for malignant bowel obstruction, particularly left-sided malignant large bowel obstruction (LMLBO) caused by colorectal cancer, has been reported to be both a safe and feasible option. The aim of this retrospective study is to evaluate the clinical effects of CMS for LMLBO as a bridge to surgery compared to TDT...
October 17, 2018: World Journal of Surgical Oncology
Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones, Winette Ta van der Graaf
BACKGROUND: Sarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers. Consequently, Sarcoma UK conducted a national survey and these data were examined for age- and tumour-related differences in patients' experiences. METHODS: Patients were randomly selected from respondents to National Cancer Patient Experience Surveys (n = 900)...
October 17, 2018: BMC Cancer
Helen Senderovich, Akash Yendamuri
INTRODUCTION: Dyspnea is prominently observed in palliative care (PC). Dyspnea can be multifactorial, primarily caused by obstructive or restrictive lung diseases or secondarily induced by various comorbidities. Numerous interventions exist, with route of administration and efficacy requiring further discussion. Despite opioids being the first line of treatment, their adverse effects lead to reluctance on the side of patients to take them, creating limitations in patient management planning...
October 16, 2018: Rambam Maimonides Medical Journal
Hanno M Witte, Armin Riecke, Thomas Mayer, Tobias Bartscht, Dirk Rades, Hendrik Lehnert, Hartmut Merz, Sebastian Fetscher, Harald Biersack, Niklas Gebauer
PURPOSE: The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivative, has been utilized as alternative treatment option for patients with lymphoproliferative diseases unsuitable for conventional chemotherapy agents and protocols because of age, comorbidity, or poor performance score. While data on the activity and safety of single-agent trofosfamide have been published, the potential value of this agent in immunochemotherapy in combination with anti-CD20 antibodies such as rituximab has not been investigated to our knowledge...
October 16, 2018: Journal of Cancer Research and Clinical Oncology
Selim Özdoğan, Özcan Gökçek, Yavuz Katırcı, Şeref Kerem Çorbacıoğlu, Emine Emektar, Yunsur Çevik
OBJECTIVE: In this study, it was aimed to evaluate whether spinal immobilization at 20°, instead of the traditional 0°, affects intracranial pressure (ICP) via the ultrasonographic (USG) measurement of optic nerve sheath diameter (ONSD). METHODS: 140 healthy, adult, non-smoking volunteers who had no acute or chronic diseases were included this study. Volunteers were randomly divided into two groups; performed spinal immobilization at 0° (Group 1) and at 20° (Group 2)...
October 11, 2018: American Journal of Emergency Medicine
Pan Liu, Chun Ying Ren, Zong Ming Wang, Bai Zhang, Lin Chen
Scientific and rapid assessment of the ecological environment quality based on remote sensing can provide basis for regional protection, management and planning. In this study, using Landsat TM/OLI/TIRS in 1990, 2000 and 2015 as data sources, four indices including the wetness component of the tasseled cap transformation (WET), normalized difference vegetation index (NDVI), normalized difference built-up and soil index (NDSI), and land surface temperature (LST) were derived, with the weights being determined by principal components analysis (PCA)...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Jing Zheng, Hao Yu
Eco-product is scarce product with consequences on human health, economy and society all over the world. In order to understand the effective supply of eco-product and figure out its law of scale efficiency, panel data from 2004 to 2015 with labor force, capital, resource, and energy source was carefully selected as the input variables and GDP, sustainable product, and undesirable output as the output variables, the scale efficiency and its differences of effective supply of eco-product in China were measured in this study...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Deniz Özçeker, Utkucan Uçkun, Dürdane İslamova, Zeynep Tamay, Nermin Güler
Özçeker D, Uçkun U, İslamova D, Tamay Z, Güler N. Corticosteroid phobia among parents of asthmatic children. Turk J Pediatr 2018; 60: 142-146. Asthma is one of the most prevalent chronic diseases among children. Its prevalence and morbidity have been rising in recent decades. Pediatric asthma causes a significant burden on families; allergen-avoidance measures, uncontrolled disease, and disease severity which are the major cost predictors of childhood asthma in Turkey. Inhaled corticosteroids (ICS) are considered as cornerstone medications in asthma management which reduce asthma morbidity and mortality...
2018: Turkish Journal of Pediatrics
Gustavo Wandresen, Fernanda Sgarbi, Renato Nisihara
Enhanced health care for patients with Down syndrome (DS) results in improved overall quality of life and longer life expectancy. The main gynecologic complaints of patients with DS and their caregivers relate to menstrual cycles, hygiene and reproductive issues. Certain aspects, such as age of menarche, menstrual cycles, internal genitalia, and hormone profile are similar to those observed in the general population. However, individuals with DS may have a higher incidence of other disorders related to menstruation, such as hypothyroidism, epilepsy and use of anticonvulsants...
October 16, 2018: Gynecological Endocrinology
David A Woodrum, Akira Kawashima, Krzysztof R Gorny, Lance A Mynderse
In 2018, the American Cancer Society (ACS) estimates that 164,690 new cases of prostate cancer will be diagnosed and 29,430 will die due to the prostate cancer in the United States (Siegel et al., CA Cancer J Clin 67:7-30, 2018). Many men with prostate cancer are often managed with aggressive therapy including radiotherapy or surgery. No matter how expertly done, these therapies carry significant risk and morbidity to the patient's health related quality of life with impact on sexual, urinary and bowel function (Potosky et al...
2018: Advances in Experimental Medicine and Biology
Carole Farrell, Catherine Heaven
PURPOSE: Chemotherapy poses challenges for older patients, with potential comorbidities, mobility and functional problems that may adversely affect their dignity. Patients may struggle with side-effects but fail to inform health professionals, impacting on clinical management and unresolved needs/concerns. This study aims to explore the impact of dignity during chemotherapy for older people and partners. METHODS: A qualitative study using semi-structured interviews of patients/partners following chemotherapy for non-metastatic cancer...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Sunwoo Park, Whasun Lim, Gwonhwa Song
Endometriosis is a benign gynecological disease of women of reproductive ages, wherein endometrial cells grow ectopically, decreasing their quality of life due to chronic pelvic pain and severe dysmenorrhea. Although surgery and hormone therapies are gold standards for treating endometriosis, side effects are common and the recurrence rate is nearly 50%. Recent studies are exploring phytochemicals as pharmacological adjuvants for treating endometriosis. Delphinidin is an anthocyanin with anti-inflammatory, antioxidative, and anticancerous properties...
October 15, 2018: Journal of Cellular Biochemistry
David Pépin, Mary E Sabatini, Patricia K Donahoe
PURPOSE OF REVIEW: The nascent field of oncofertility is quickly gaining traction as novel experimental treatments are being developed, driving a renewed interest in Müllerian inhibiting substance (MIS) as an ovarian fertoprotectant. RECENT FINDINGS: MIS is unique in its mechanisms of ovarian protection by virtue of acting directly on granulosa cells of primordial follicles and for being a benign reproductive hormone, with few side effects. We will explore in this review how it may be utilized to protect the ovary from chemotherapy, or to enhance ovarian tissue cryopreservation therapy...
October 12, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Jonathan E Silverman, Amitabh Gulati
Pain is a ubiquitous part of the cancer experience. Often the presenting symptom of malignancy, pain becomes more prevalent in advanced or metastatic disease and often persists despite curative treatment. Although management of cancer pain improved following publication of the WHO's analgesic ladder, when used in isolation, conservative approaches often fail to control pain and are limited by intolerable side effects. Interventional strategies provide an option for managing cancer pain that remains refractory to pharmacologic therapy...
September 2018: Pain Management
Yong-Guo Zhang, Yinglin Xia, Rong Lu, Jun Sun
Fish oil is a natural product that has shown efficacy for managing inflammatory conditions with few side effects. There is emerging evidence that crosstalks between gut epithelial cells and immune cells contribute to chronic infectious diseases. HIV-infected (HIV+) older adults show age-related co-morbidities at a younger age than their uninfected counterparts. Persistent inflammation related to the chronic viral infection and its sequelae is thought to contribute to this disparity. However, little is known about whether fish oil reduces intestinal inflammation in HIV + patients...
September 2018: Genes & Diseases
Nikolaos Spathas, Panagiota Economopoulou, Myrto Cheila, Ioannis Kotsantis, Antonis Fanouriakis, Dimitra Kassara, Amanda Psyrri
Introduction: T cell checkpoint inhibitors targeting Programmed cell Death protein-1 (PD-1) have emerged as novel immunotherapy agents showing remarkable efficacy in head and neck squamous cell carcinoma (HNSCC). Despite important clinical benefits, they are associated with side effects that occur as a consequence of general immunological stimulation due to loss of T cell inhibition. Herein, we report the unusual case of inflammatory arthritis induced by anti-PD-1 agent pembrolizumab. Case report: A 55-years old male was treated with pembrolizumab at a dose of 200 mg every 3 weeks for a metastatic hypopharyngeal carcinoma...
2018: Frontiers in Oncology
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