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https://www.readbyqxmd.com/read/30113764/easy-discrimination-of-hematogones-from-lymphoblasts-in-b-cell-progenitor-acute-lymphoblastic-leukemia-patients-using-cd81-cd58-expression-ratio
#1
Carole Nagant, Daniele Casula, Anne Janssens, Vo Thanh Phuong Nguyen, Brigitte Cantinieaux
INTRODUCTION: The discrimination of leukemia lymphoblasts (LB) in diagnosis and follow-up of B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) by multiparameter flow cytometry (MFC) may be difficult due to the presence of hematogones (HG). The aim of this study was to compare lymphoblasts of BCP-ALL and HG for the expression of the most discriminating antigens. METHODS: A total of 82 bone marrow samples (39 BCP-ALL and 43 patients with HG) were analyzed using MFC...
August 16, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/30112704/in-vivo-imaging-of-the-immune-response-upon-systemic-rna-cancer-vaccination-by-fdg-pet
#2
Stefanie Pektor, Lina Hilscher, Kerstin C Walzer, Isabelle Miederer, Nicole Bausbacher, Carmen Loquai, Mathias Schreckenberger, Ugur Sahin, Mustafa Diken, Matthias Miederer
BACKGROUND: [18 F]Fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET) is commonly used in the clinic for diagnosis of cancer and for follow-up of therapy outcome. Additional to the well-established value in tumor imaging, it bears potential to depict immune processes in modern immunotherapies. T cells enhance their glucose consumption upon activation and are crucial effectors for the success of such novel therapies. In this study, we analyzed the T cell immunity in spleen after antigen-specific stimulation of T cells via highly innovative RNA-based vaccines using FDG-PET/MRI...
August 15, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/30111845/simultaneous-b-and-t-cell-acute-lymphoblastic-leukemias-in-zebrafish-driven-by-transgenic-myc-implications-for-oncogenesis-and-lymphopoiesis
#3
Chiara Borga, Gilseung Park, Clay Foster, Jessica Burroughs-Garcia, Matteo Marchesin, Rikin Shah, Ameera Hasan, Syed T Ahmed, Silvia Bresolin, Lance Batchelor, Teresa Scordino, Rodney R Miles, Geertruy Te Kronnie, James L Regens, J Kimble Frazer
Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T cell ALL (T-ALL)-which these fish also develop. Zebrafish pre-B ALL shares in vivo features and expression profiles with human pre-B ALL, and these profiles differ from zebrafish T-ALL or normal B and T cells. These animals also exhibit aberrant lymphocyte development...
August 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/30111403/-safety-and-efficacy-of-vdmp-re-induction-regimen-in-chinese-children-with-relapsed-acute-lymphoblastic-leukemia-a-report-from-jiangsu-childhood-hematology-group
#4
Jun-Jie Fan, Hai-Long He, Jun Lu, Pei-Fang Xiao, Yi Wan, Yi-Huan Chai, Qi An, Yong-Jun Fang, Shao-Yan Hu
OBJECTIVE: To evaluate the therapeutic safety and efficacy of VDMP re-induction regimen in Chinese children with relapsed acute lymphoblastic leukemia (ALL). METHODS: Forty-one patients with relapsed ALL were prospectively enrolled in this study. All the patients were distributed in 3 children's hospitals and treated with VDMP regimen as the first re-induction chemotherapy. Therapeutic efficacy and side-effects were analyzed. RESULTS: The ratio of male to female was 27:14...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111397/-effect-of-leukodepleted-blood-transfusions-on-the-balance-of-th1-th2-cells-in-peripheral-blood-of-patients-with-acute-lymphoblastic-leukemia
#5
Qin-Min Dong, Hai-Yun Li, Fu-Zhen Lei, Ru-Yu Yang
OBJECTIVE: To investigate the effect of leukodepleted blood transfusions on peripheral blood Th1/Th2 cell balance in patients with acute lymphoblastic leukemia (ALL). METHODS: Fifty-seven ALL patients in our hospital from March 2016 to August 2017 were selected, 31 of them received routine blood transfusion were enrolled in group A, and 26 patients received depleted-blood leukotransfusion were enrolled in group B, 36 cases in normal physical examination at the same period were enrolled in control group...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111394/-long-non-coding-rna-rp11-69i8-3-expression-in-acute-leukemia-and-its-cinical-significance
#6
Jia-Jia Si, Wei-Min Wang, Dan Yu, Si-Lin Gan, Fei-Fei Wu, Ling Sun, Ding-Ming Wan, Xin-Sheng Xie, Yan-Fang Liu, Chong Wang, Hui Sun
OBJECTIVE: To investigate the expression of long non coding RNA RP11-69I8.3 in acute leukemia and its clinical significance. METHODS: lncRNA RP11-69I8.3 expression was detected by RT-PCR in bone marrow samples from 17 healthy controls, 32 newly diagnosed AML patients and 32 newly diagnosed ALL patients, and 25 ALL patients of complete remission after chemotherapy. Meanwhile, the clinical data were collected and the relation of lncRNA RP11-6918.3 expression with the clinical characteristics was analyzed...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111389/-study-on-immunophenotypes-and-gene-of-acute-lymphoblastic-leukemia
#7
Xue-Fei Zhao, Hong-Yan Wang, Xu Zhao, Huan-Chen Cheng, Wei Li, Sheng-Wei Liu, Lin Qiu, Jun Ma
OBJECTIVE: To retrospectively analyze the immunophenotyping, fusion gene and gene mutation of 30 acute lymphoblastic leukemia (ALL) cases and to investigate the relationship between the analysis results and the clinical therapeutic effect and prognosis. METHODS: Thirty All phtients were collected from the First Hospital of Harbin, Institute of Hematology and Oncology Department of Pediatrics from August 2015 to June 2016. According to the classification of FAB standard, 27 cases were B system ALL, 3 cases were T system ALL...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111196/tisagenlecleucel-for-the-treatment-of-b-cell-acute-lymphoblastic-leukemia
#8
Allison Barz Leahy, Caitlin W Elgarten, Stephan A Grupp, Shannon L Maude, David T Teachey
Cure rates for pediatric and young adult patients with refractory or recurrently relapsed acute lymphoblastic leukemia are dismal. Survival from time of relapse is typically measured in weeks to months, and standard chemotherapy and currently approved targeted therapy achieve remission in less than a third of affected patients. To date, the only definitive curative therapy has been allogeneic hematopoietic stem cell transplant (HSCT). Advances in immunotherapy, with the introduction of chimeric antigen receptor T cell therapies and the development of tisagenlecleucel, have changed the landscape...
August 15, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/30110590/pd-1-inhibitor-therapy-in-adult-t-cell-leukemia-lymphoma
#9
(no author information available yet)
New England Journal of Medicine, Volume 379, Issue 7, Page 695-697, August 2018.
August 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30109179/the-application-of-car-t-cell-therapy-in-hematological-malignancies-advantages-and-challenges
#10
REVIEW
Zijun Zhao, Yu Chen, Ngiambudulu M Francisco, Yuanqing Zhang, Minhao Wu
Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR). The CAR-T cell is an effector T cell that recognizes and eliminates specific cancer cells, independent of major histocompatibility complex molecules. The whole procedure of CAR-T cell production is not well understood. The CAR-T cell has been used predominantly in the treatment of hematological malignancies, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma...
July 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/30108986/evaluation-of-a-ring-fused-pyridine-d-modified-androstane-derivatives-for-antiproliferative-and-aldo-keto-reductase-1c3-inhibitory-activity
#11
Marina P Savić, Jovana J Ajduković, Jovana J Plavša, Sofija S Bekić, Andjelka S Ćelić, Olivera R Klisurić, Dimitar S Jakimov, Edward T Petri, Evgenija A Djurendić
New A-ring pyridine fused androstanes in 17a-homo-17-oxa (d-homo lactone), 17α-picolyl or 17( E )-picolinylidene series were synthesized and validated by X-ray crystallography, HRMS, IR and NMR spectroscopy. Novel compounds 3 , 5 , 8 and 12 were prepared by treatment of 4-en-3-one or 4-ene-3,6-dione d-modified androstane derivatives with propargylamine catalyzed by Cu(ii), and evaluated for potential anticancer activity in vitro using human cancer cell lines and recombinant targets of steroidal anti-cancer drugs...
June 1, 2018: MedChemComm
https://www.readbyqxmd.com/read/30108326/anti-thymocyte-globulin-s-activity-against-acute-myeloid-leukemia-stem-cells
#12
Rosy Dabas, Poonam Dharmani-Khan, Monica Modi, Tiffany Van Slyke, Joanne Luider, Don Morris, Joseph Brandwein, Andrew Daly, Faisal M Khan, Jan Storek
Rabbit anti-thymocyte globulin (ATG (Thymoglobulin)) kills T cells in vitro and probably also in vivo as it prevents graft-vs-host disease (GvHD) in patients. Recently we demonstrated that ATG at a clinically relevant concentration (10-50 mg/L) kills in vitro not only T cells but also leukemic blasts. In the present study, we investigated whether ATG kills not only leukemic blasts but also leukemic stem cells (LSCs). We used a flow cytometric assay of complement-mediated cytotoxicity (CDC). ATG-induced death of acute myeloid leukemia (AML) cells from patients newly diagnosed with AML was measured among blasts as well as LSCs...
August 14, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/30107177/cooperative-enhancer-activation-by-tlx1-and-stat5-drives-development-of-nup214-abl1-tlx1-positive-t-cell-acute-lymphoblastic-leukemia
#13
Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, Jolien De Bie, Simon Bornschein, Nicole Mentens, Roel Vandepoel, Ellen Geerdens, Enrico Radaelli, Beat C Bornhauser, Andreas E Kulozik, Jules P Meijerink, Jean-Pierre Bourquin, Charles E de Bock, Jan Cools
The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcription factors in T cell acute lymphoblastic leukemia (T-ALL). Here we show that NUP214-ABL1 cooperates with TLX1 in driving T-ALL development using a transgenic mouse model and human T-ALL cells. Using integrated ChIP-sequencing, ATAC-sequencing, and RNA-sequencing data, we demonstrate that TLX1 and STAT5, the downstream effector of NUP214-ABL1, co-bind poised enhancer regions, and cooperatively activate the expression of key proto-oncogenes such as MYC and BCL2...
August 13, 2018: Cancer Cell
https://www.readbyqxmd.com/read/30106137/gene-regulatory-network-construction-identified-nfya-as-a-diffuse-subtype-specific-prognostic-factor-in-gastric-cancer
#14
Bin Cao, Yu Zhao, Zheng Zhang, Hengcun Li, Jie Xing, Shuilong Guo, Xintao Qiu, Shutian Zhang, Li Min, Shengtao Zhu
Lauren classification is a pathology-based gastric cancer (GC) subtyping system, which is widely used in the clinical treatment of patients with GC. However, genome-scale molecular characteristics to distinguish between diffuse (DF) and intestinal (IT) GC remain incompletely characterized, particularly at the transcriptional regulatory level. In the present study, gene regulatory networks were constructed using the Passing Attributes between Networks for Data Assimilation (PANDA) algorithm for DF, IT and mixed GC...
August 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30104977/spinacetin-suppresses-the-mast-cell-activation-and-passive-cutaneous-anaphylaxis-in-mouse-model
#15
Ning Ji, Shunli Pan, Chen Shao, Yufen Chen, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin, Dexin Kong
We previously reported the anti-inflammatory and anti-asthmatic activities of the extract of the Inula japonica Thunb. Aiming for discovery of a novel anti-inflammatory compound, we isolated spinacetin from the extract and investigated its in vitro and in vivo anti-inflammatory effect and the related mechanism. Effect of spinacetin on the Syk signaling pathway was studied in bone marrow-derived mast cells (BMMCs), and that on the nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs) was investigated in Rat basophilic leukemia (RBL)-2H3 cells and human mast cell line (HMC-1)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30104252/cd19-alterations-emerging-after-cd19-directed-immunotherapy-cause-retention-of-the-misfolded-protein-in-the-endoplasmic-reticulum
#16
Asen Bagashev, Elena Sotillo, Chih-Hang Anthony Tang, Kathryn L Black, Jessica Perazzelli, Steven H Seeholzer, Yair Argon, David M Barrett, Stephan A Grupp, Chih-Chi Andrew Hu, Andrei Thomas-Tikhonenko
We have previously described a mechanism of acquired resistance of B-cell acute lymphoblastic leukemia to CD19-directed chimeric antigen receptor T-cell (CART) immunotherapy. It was based on in-frame insertions in or skipping of CD19 exon 2. To distinguish between epitope loss and defects in surface localization, we used retroviral transduction and genome editing to generate cell lines expressing CD19 exon 2 variants (CD19ex2vs) bearing VSV-G tags. These lines were negative by live-cell flow cytometry with an anti-VSV-G antibody and resistant to killing by VSV-G directed antibody-drug conjugates (ADC), suggestive of a defect in surface localization...
August 13, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30104242/activation-of-th1-immunity-within-the-tumor-microenvironment-is-associated-with-clinical-response-to-lenalidomide-in-chronic-lymphocytic-leukemia
#17
Georg Aue, Clare Sun, Delong Liu, Jae-Hyun Park, Stefania Pittaluga, Xin Tian, Elinor Lee, Susan Soto, Janet Valdez, Irina Maric, Maryalice Stetler-Stevenson, Constance Yuan, Yusuke Nakamura, Pawel Muranski, Adrian Wiestner
Immune stimulation contributes to lenalidomide's antitumor activity. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature, autoreactive B cells in secondary lymphoid tissues, blood, and bone marrow and progressive immune dysfunction. Previous studies in CLL indicated that lenalidomide can repair defective T cell function in vitro. Whether T cell activation is required for clinical response to lenalidomide remains unclear. In this study, we report changes in the immune microenvironment in patients with CLL treated with single-agent lenalidomide and associate the immunologic effects of lenalidomide with antitumor response...
August 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30104217/north-american-atll-has-a-distinct-mutational-and-transcriptional-profile-and-responds-to-epigenetic-therapies
#18
Urvi A Shah, Elaine Y Chung, Orsolya Giricz, Kith Pradhan, Keisuke Kataoka, Shanisha Gordon-Mitchell, Tushar D Bhagat, Yun Mai, Yongqiang Wei, Elise Ishida, Gaurav S Choudhary, Ancy Joseph, Ronald Rice, Nadege Gitego, Crystall Parrish, Matthias Bartenstein, Swati Goel, Ioannis Mantzaris, Aditi Shastri, Olga Derman, Adam Binder, Kira Gritsman, Noah Kornblum, Ira Braunschweig, Chirag Bhagat, Jeff Hall, Armin Graber, Lee Ratner, Yanhua Wang, Seishi Ogawa, Amit Verma, B Hilda Ye, Murali Janakiram
Adult T cell leukemia lymphoma (ATLL) is a rare T cell neoplasm, endemic in the Japanese, Caribbean and Latin American populations. Most North American ATLL patients are of Caribbean descent and are characterized by high rates of chemo-refractory disease and worse prognosis compared to the Japanese ATLL. To determine genomic differences between these two cohorts, we performed targeted exon sequencing on 30 North American ATLL patients and compared the results to the Japanese ATLL cases. Although the frequency of TP53 mutations was comparable, the mutation frequency in epigenetic and histone modifying genes (57%) was significantly higher whereas the mutation frequency in JAK/STAT and TCR/NF-κB pathway genes was significantly lower in our cohort...
August 13, 2018: Blood
https://www.readbyqxmd.com/read/30104084/a-case-of-subacute-combined-degeneration-of-the-spinal-cord-due-to-folic-acid-and-copper-deficiency
#19
Takuji Nakamura, Masanori Nishi, Mihoko Rikitake, Daisuke Koga, Junya Eto, Daisuke Tajima, Shuji Toda, Muneaki Matsuo
Subacute combined degeneration of the spinal cord (SACD) is a rare neurologic disorder manifesting progressive symptoms of paresthesia and spastic paralysis. Herein we present an autopsy case of SACD caused by folic acid and copper deficiency. A 16-year-old male presented with gradually worsening unsteady gait, and bladder and rectal dysfunction. He had a medical history of T-cell acute lymphoblastic leukemia (T-ALL), diagnosed 1.5 years previously. The patient had undergone chemotherapy, including methotrexate, as well as allogeneic bone mallow transplantation...
August 10, 2018: Brain & Development
https://www.readbyqxmd.com/read/30103821/foxp3-knockdown-inhibits-the-proliferation-and-reduces-notch1-expression-of-t-cell-acute-lymphoblastic-leukemia-cells
#20
Satoru Yonekura, Mai Itoh, Erika Shiratori, Mika Ohtaka, Shuji Tohda
OBJECTIVE: Forkhead box P3 (FOXP3) is a master transcriptional factor of regulatory T-cells (Tregs). Recent studies have shown that FOXP3 is associated with growth inhibition of cancer cells. However, the role of FOXP3 in acute T-lymphoblastic leukemia (T-ALL) cells is not known. It was also reported that NOTCH signaling promoted the expression of FOXP3 in Tregs. However, the effect of FOXP3 on NOTCH expression in T-ALL cells is little known. Therefore, we examined the effect of FOXP3 knockdown on the proliferation of T-ALL cells and NOTCH1 signaling...
August 13, 2018: BMC Research Notes
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