Liubov Kyrpychova, Tomas Vanecek, Petr Grossmann, Petr Martinek, Petr Steiner, Ladislav Hadravsky, Irena E Belousova, Ksenya V Shelekhova, Marian Svajdler, Pavol Dubinsky, Michal Michal, Dmitry V Kazakov
Adenoid cystic carcinoma (ACC) of the skin is a rare malignant neoplasm histologically identical to homonymous tumors in other organs. Cutaneous ACC has been found to harbor MYB gene activations, either through MYB chromosomal abnormalities or by generation of the MYB-NFIB fusion. In salivary gland ACC, in addition to the MYB gene, alterations in MYBL1, the gene closely related to MYB, have been reported. We studied 10 cases of cutaneous ACC (6 women, 4 men; and age range 51-83 years) for alterations in the MYB, NFIB, and MYBL1 genes, using FISH and PCR...
March 21, 2018: American Journal of Dermatopathology