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Salivary gland neoplasm

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https://www.readbyqxmd.com/read/29449729/parotid-metastasis-of-renal-cell-carcinoma-mimicking-primary-clear-cell-oncocytoma-report-of-a-case-and-brief-review-of-the-literature
#1
B J Rocca, A Gini, C Calandra, A Ginori, F Crivelli
Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. RCC has an unpredictable behavior and the unique potential to metastasize to nearly every organ in the body. Though not as frequent, metastatic RCC to the head and neck has been identified in the thyroid, salivary glands, skull base, sinuses, pharynx, tonsils, tongue, lip and skin...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29445997/human-papillomavirus-related-multiphenotypic-sinonasal-carcinoma-a-case-report-documenting-the-potential-for-very-late-tumor-recurrence
#2
Akeesha A Shah, Eric D Lamarre, Justin A Bishop
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior...
February 14, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29422843/cutaneous-metastases-from-salivary-duct-carcinoma-of-the-submandibular-gland
#3
Wahida Chakari, Luise Andersen, Jørgen Lock Andersen
Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. To the best of our knowledge, this is the first reported case of salivary duct carcinoma arising from the submandibular gland with cutaneous metastases...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29419396/expanding-primary-cells-from-mucoepidermoid-and-other-salivary-gland-neoplasms-for-genetic-and-chemosensitivity-testing
#4
Ahmad M Alamri, Xuefeng Liu, Jan K Blancato, Bassem R Haddad, Weisheng Wang, Xiaogang Zhong, Sujata Choudhary, Ewa Krawczyk, Bhaskar V Kallakury, Bruce J Davidson, Priscilla A Furth
Restricted availability of cell and animal models is a rate-limiting step for investigation of salivary gland neoplasm pathophysiology and therapeutic response. Conditionally reprogrammed cell (CRC) technology enables establishment of primary epithelial cell cultures from patient material. This study tested a translational workflow for acquisition, expansion and testing of CRC-derived primary cultures of salivary gland neoplasms from patients presenting to an academic surgical practice. Results showed that cultured cells were sufficient for epithelial cell-specific transcriptome characterization to detect candidate therapeutic pathways and fusion genes, and for screening for cancer risk-associated single nucleotide polymorphisms (SNPs) and driver gene mutations through exome sequencing...
January 29, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29417279/tumors-of-the-parapharyngeal-space-the-vu-university-medical-center-experience-over-a-20-year-period
#5
Thijs van Hees, Stijn van Weert, Birgit Witte, C René Leemans
BACKGROUND: Tumors of the parapharyngeal space (PPS) are rare, accounting for 0.5-1.5% of all head and neck tumors. The anatomy of the PPS is responsible for a wide variety of tumors arising from the PPS. This series of 99 PPS tumors provides an overview of the clinical course and management of PPS tumors. MATERIALS AND METHODS: This retrospective study included clinical data from patients treated for PPS tumors from 1991 to 2012 (warranting at least a 4-year follow-up) at the VU University Medical Center, Amsterdam, The Netherlands...
February 7, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29403173/fine-needle-aspiration-cytology-of-basal-cell-adenoma-of-parotid-simulating-adenoid-cystic-carcinoma
#6
Subrata Pal, Palash Kr Mondal, Abhishek Sharma, Mrinal Sikder
Basal cell adenoma is a rare type of monomorphic salivary adenoma most commonly involving the parotid gland. Cytology of basal cell adenoma closely mimics many other benign and malignant basaloid neoplasms. Cytological features of membranous basal cell adenoma simulate adenoid cystic carcinoma in fine needle aspiration cytology (FNAC) smears. Here, we are presenting a rare case of cytodiagnosis of membranous basal cell adenoma of parotid gland in an elderly lady, which mimicked adenoid cystic carcinoma on FNAC...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29387922/accuracy-and-effectiveness-of-ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-focal-lesions-in-the-salivary-glands
#7
Jose Luis Del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
OBJECTIVES: To review the diagnostic accuracy of ultrasound-guided core-needle biopsy (CNB) in the diagnosis of salivary gland tumours (SGT). METHODS: Retrospective, institutional review board approved, analysis of the CNB of SGT performed at our centre in 8 years. We used an automatic 18-G spring-loaded device. The final diagnosis was based on surgery in the cases that were operated on, and on clinical evolution and biopsy findings in the rest. RESULTS: Four hundred and nine biopsies were performed in 381 patients (ages, 2-97 years; mean, 55...
January 31, 2018: European Radiology
https://www.readbyqxmd.com/read/29383488/-diagnostic-and-predictive-molecular-pathology-of-head-and-neck-neoplasms
#8
REVIEW
A Agaimy, W Weichert, F Haller, A Hartmann
As a result of some seminal observations as well as a consequence of increasing use of modern and innovative molecular diagnostic technologies, a variety of new genetic aberrations have been discovered in head and neck neoplasms of different anatomic locations and histogenetic origins. These advances resulted in the establishment of new molecularly defined disease entities. On the other hand, some of these new genetic biomarkers paved the way to potentially promising novel therapeutic opportunities. Diverse old (well known in other entities) and newly discovered translocations and gene fusions represent the leading subgroup of these genetic aberrations...
January 30, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29352614/who-is-in-and-who-is-out-of-the-mouth-salivary-glands-and-jaws-sections-of-the-4th-edition-of-the-who-classification-of-head-and-neck-tumours
#9
REVIEW
R A Kennedy
This review of changes to the 4th edition of the WHO classification of head and neck tumours focuses on their impact on the surgical care of diseases that affect the salivary glands, jaws, and oral cavity. Updates to the chapter on the salivary glands include the addition of secretory carcinoma and sclerosing polycystic adenosis. The odontogenic cysts are back, and the odontogenic keratocyst is listed among them, as it has now lost its brief and confusing designation as a neoplasm. The newly-defined sclerosing odontogenic carcinoma and primordial odontogenic tumour have been added...
January 15, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29338644/pulmonary-mucoepidermoid-carcinoma-diagnosis-and-treatment
#10
Neda Kalhor, Cesar A Moran
Primary mucoepidermoid carcinomas (MEC) of the lung are rare and represent a diagnostic challenge. MEC in the lung is under the umbrella of primary salivary gland type tumors of the lung. Areas Covered: In general, salivary gland type tumors are represented by malignant neoplasms that may range from low to intermediate to high-grade type of malignancy sharing similar histopathological features as those in salivary glands. The focus in this review will be on one tumor in particular - mucoepidermoid carcinoma...
January 17, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29284907/pleomorphic-adenoma-of-minor-salivary-glands-in-child
#11
Jehona Reçica Ahmedi, Enis Ahmedi, Ferjall Perjuci, Resmije Ademi, Ali Gashi, Zana Agani, Fisnik Kurshumliu, Bylbyl Reçica
Introduction: Tumors of salivary glands are very rare in children overall, and rarely in minor salivary glands. Among them pleoomorphic adenoma (PA) is the most common benign tumor of salivary glands in children and it acounts 60% of all salivary neoplasms, frequently found in major salivary glands (85 %) and rarely in minor salivary glands (10-15%). PA appears as painless oval mass, elastic consistency and smooth surface. It characterized by slow evolution of growing. The diagnosis can be confirmed only by histopathological features, after total excision of the lesion...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29274041/intraoral-pigmented-low-grade-adenocarcinoma-not-otherwise-specified-case-report-and-immunohistochemical-study
#12
Jessica Luana Dos Santos, Albina Messias de Almeida Milani Altemani, Alexandre Elias Trivellato, Cássio Edvard Sverzut, Luciana Yamamoto Almeida, Lucas Ribeiro Teixeira, Alfredo Ribeiro-Silva, Jorge Esquiche León
Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29251639/mammary-analog-secretory-carcinoma-with-etv6-rearrangement-arising-in-the-conjunctiva-and-eyelid
#13
Yongyang Bao, Jiang Li, Yanbo Zhu
Mammary analog secretory carcinoma (MASC) of salivary gland is a recently described neoplasm that morphologically and immunohistochemically resembles secretory carcinoma of the breast. Genetically, both of them harbor ETV-6-NTRK-3 fusion rearrangement. One case of primary MASCs arising from the eyelid is reported. The patient was a 52-year-old man. Microscopically, the tumor exhibited nodular aggregation of solid, tubular, and microcystic/macrocystic structures. Characteristic "colloid-like" eosinophilic secretory material was present within intraluminal spaces...
November 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29238382/a-case-of-central-mucoepidermoid-carcinoma-associated-with-dentigerous-cyst
#14
Sayed Mohammad Razavi, Roya Yahyaabadi, Saeedeh Khalesi
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland neoplasm. Central MEC (CMEC) is a rare primary intraosseous bony lesion with an incidence of 2%-4.3% of all MECs reported. In this article, we present a rare case of a CMEC in the anterior region of maxilla at a 43-year-old female patient that was arising from a dentigerous cyst. CMECs are extremely rare tumor. They are usually low-grade lesions with favorable prognosis. Odontogenic cysts are one of the origins of this lesion. Treatment of impacted tooth is necessary in the early stage for prevention of this neoplasm...
November 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29237344/epithelial-myoepithelial-carcinoma-of-the-nasal-cavity-clinical-histopathological-and-immunohistochemical-distinction-of-a-case-report
#15
Sally Nguyen, Marjorie Perron, Sylvie Nadeau, Alexandre Nakao Odashiro, Marie-Noëlle Corriveau
BACKGROUND: Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma. METHODS: Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29224720/ctnnb1-mutations-in-basal-cell-adenoma-of-the-salivary-gland
#16
Yi-Hsuan Lee, Wen-Chih Huang, Min-Shu Hsieh
BACKGROUND/PURPOSE: Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are uncommon salivary gland tumors comprising proliferation of basaloid cells. Nuclear β-catenin expression and mutations in its encoding gene (CTNNB1) are reported to be specific to BCA. PIK3CA mutations are only found in BCAC not in BCA. However, in previous studies the number of cases was relatively small. The present study analyzed 44 cases of basal cell neoplasms to identify the CTNNB1 and PIK3CA mutation profiles in this rare salivary gland tumor...
December 7, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29217083/hyalinizing-clear-cell-carcinoma-of-salivary-gland-origin-in-the-head-and-neck-clinical-and-histopathological-analysis
#17
X-H Yang, L Liu, Y-Y Shi, Y-J Hu, Q-G Hu, P Zhang
Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm of salivary gland origin with a low-grade indolent nature. It is difficult to distinguish from other malignant salivary gland tumours. Clinical outcomes following surgery are generally reported as good. The aim of this study was to further determine the features of HCCC. This study was approved by Medical ethics review of affiliated hospital of jiangsu university. Fourteen new cases of HCCC are reported. The clinical and histopathological data of these 14 cases were analysed alongside those of 141 cases identified in a systematic review of the literature (up to 2016)...
December 4, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29200960/solitary-fibrous-tumor-occurring-in-the-parotid-gland-a-case-report
#18
Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas, Nadia Cherradi
Background: Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the parotid gland are exceptional; their clinical and radiologic features are non specific, often mimicking more common salivary gland tumors. Pathologic examination and immunohistochemistry are required to make the correct diagnosis. The prognosis is favorable, with most tumors being benign, and complete surgical resection is the treatment of choice...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29193882/giant-cell-tumor-of-temporomandibular-joint-presenting-as-a-parotid-tumor-challenges-in-the-accurate-subclassification-of-giant-cell-tumors-in-an-unusual-location
#19
Rongqin Ren, Sandra Mueller, Adele O Kraft, Celeste N Powers
Fine needle aspiration is frequently used as the initial diagnostic procedure in the work-up of head and neck lesions, including soft tissue masses and salivary gland neoplasms. Giant cell tumors (GCTs), both osseous and extraosseous, are benign tumors that occur, albeit rarely, in the head and neck region. Extraosseous GCTs may be further classified based on their tissue of origin and specific anatomic location. Regardless of location, giant cell tumors are morphologically similar and share cytologic and histologic diagnostic criteria...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29178364/fine-needle-aspiration-cytology-for-parotid-lesions-can-we-avoid-surgery
#20
Yotam Shkedy, Uri Alkan, Aviram Mizrahi, Tzippy Shochat, Orr Dimitstein, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar
OBJECTIVE: Salivary gland neoplasms are rare tumors, with most arising in the parotid gland. Fine-needle aspiration cytology (FNAC) is a common method for pre-operative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of FNAC in a large cohort of patients, with emphasis on diagnosis of benign tumors and especially Warthin tumor which can be managed conservatively. STUDY DESIGN: Retrospective case series with chart review...
November 27, 2017: Clinical Otolaryngology
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