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https://www.readbyqxmd.com/read/30051373/relationship-of-interferon-%C3%AE-to-cognitive-function-in-midlife-women-with-schizophrenia
#1
Kathleen E Wilson, Haley Demyanovich, Leah H Rubin, Heidi J Wehring, Catherine Kilday, Deanna L Kelly
Recent literature suggests that schizophrenia is linked to an abnormal response of the immune system. Interferon-γ is a cytokine that acts as a mediator between immune stimulation and the kynurenine pathway and may be related to cognitive abilities. The objectives of the present study are to determine if serum cytokines are correlated with cognitive function differently in patients with schizophrenia compared to controls. Fourteen midlife (30-70 year-old) females with DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 13 midlife control females were analyzed...
July 26, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/30024781/longitudinal-changes-in-brain-volumetry-and-cognitive-functions-after-moderate-and-severe-diffuse-axonal-injury
#2
Fabrício Stewan Feltrin, Ana Luiza Zaninotto, Vinícius M P Guirado, Fabiola Macruz, Daniel Sakuno, Mariana Dalaqua, Luiz Gustavo Antunes Magalhães, Wellingson Silva Paiva, Almir Ferreira de Andrade, Maria C G Otaduy, Claudia C Leite
BACKGROUND AND OBJECTIVE: Diffuse axonal injury (DAI) induces a long-term process of brain atrophy and cognitive deficits. The goal of this study was to determine whether there are correlations between brain volume loss, microhaemorrhage load (MHL) and neuropsychological performance during the first year after DAI. METHODS: Twenty-four patients with moderate or severe DAI were evaluated at 2, 6 and 12 months post-injury. MHL was evaluated at 3 months, and brain volumetry was evaluated at 3, 6 and 12 months...
July 19, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29787472/a-randomised-placebo-controlled-clinical-trial-with-the-%C3%AE-2-3-5-subunit-selective-gabaa-positive-allosteric-modulator-pf-06372865-in-patients-with-chronic-low-back-pain
#3
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, David S Reynolds, Richard P Butt
The effect of PF-06372865, a subtype-selective positive allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, on chronic low back pain was investigated in a randomised, placebo- and active-controlled phase 2 clinical trial. The parallel treatment group trial consisted of a 1-week single-blind placebo run in the phase, followed by 4-week double-blind treatment. Patients were randomised to receive either PF-06372865, naproxen, or placebo twice a day for 4 weeks. The primary end point was the numerical rating score of low back pain intensity after 4 weeks of active treatment...
May 17, 2018: Pain
https://www.readbyqxmd.com/read/29730044/association-between-catechol-o-methyltransferase-genetic-variation-and-functional-connectivity-in-patients-with-first-episode-schizophrenia
#4
Hongyan Wang, Bin Zhang, Botao Zeng, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Chunbo Li, Jijun Wang, Donald C Goff
Dopamine in the prefrontal cortex (PFC) plays an important role in cognitive performance and regulates by catechol-O-methyltransferase (COMT) expression. To clarify the effect of COMT genotype on cognitive function in patients with schizophrenia, we performed DNA genotyping, cognitive evaluations, and functional magnetic resonance imaging (fMRI) in antipsychotic-naïve patients with first-episode schizophrenia (FES) and matched healthy control subjects. We found that all cognitive domains were impaired in patients with FES compared with healthy subjects...
May 3, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29617166/preoperative-verbal-memory-problems-and-their-clinical-prognostic-value-in-meningioma-patients-a-prospective-study
#5
Aistė Pranckevičienė, Vytautas Jurkuvėnas, Vytenis Pranas Deltuva, Arimantas Tamašauskas, Adomas Bunevičius
This study aimed to evaluate clinical utility of The Hopkins Verbal Learning Test-Revised (HVLT-R) for assessment of preoperative memory function in meningioma patients and to investigate prognostic value of memory assessment in predicting outcomes after meningioma excision surgery. A total of 93 meningioma patients were assessed 2-3 days preoperatively using HVLT-R, and EORTC QLQ-30 and QLQ-BN20. Functional outcome at discharge was evaluated using The Glasgow Outcome Scale. A sample of 95 healthy controls was matched to patients according to age, gender, and education...
April 4, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29571540/what-is-the-prevalence-of-cognitive-impairment-in-lupus-and-which-instruments-are-used-to-measure-it-a-systematic-review-and-meta-analysis
#6
REVIEW
Hanan Al Rayes, Chiara Tani, Andrew Kwan, Sherief Marzouk, Kenneth Colosimo, Jorge Medina-Rosas, Ahmed Mustafa, Jiandong Su, Panos Lambiris, Marta Mosca, Zahi Touma
OBJECTIVES: To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. METHODS: This review was prepared with a protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Protocols statement. Literature search in Ovid Medline, Embase, and Psyc INFO for articles on CD in adult SLE patients was conducted. Included studies were critically appraised (Newcastle-Ottawa Evaluation Scale) and the Pooled Prevalence (PP) of CD was studied for all instruments...
February 21, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29475220/the-correlations-among-depressive-symptoms-cognitive-performance-and-serum-bdnf-levels-in-the-patients-with-chronic-kidney-disease
#7
Jung Goo Lee, Min Kyung Park, Yeong Hoon Kim, Yang-Wook Kim, Kyubok Jin, Sung Woo Park, Mi Kyoung Seo, Young Hoon Kim
OBJECTIVE: In the current study, we investigated whether there are relations among depressive symptoms, cognitive performance and serum BDNF levels in the patients with chronic kidney disease (CKD). METHODS: Sixty patients with CKD and 65 healthy controls participated. Depressive symptoms were evaluated with Beck depression inventory (BDI) and Hamilton Depression Rating Scale (HDRS). Mini-Mental State Examination included in the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (MMSE-KC) assessment packet was used for the evaluation of overall cognitive function...
February 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29449557/differential-patterns-of-contextual-organization-of-memory-in-first-episode-psychosis
#8
Vishnu P Murty, Rachel A McKinney, Sarah DuBrow, Maria Jalbrzikowski, Gretchen L Haas, Beatriz Luna
Contextual information is used to support and organize episodic memory. Prior research has reliably shown memory deficits in psychosis; however, little research has characterized how this population uses contextual information during memory recall. We employed an approach founded in a computational framework of free recall to quantify how individuals with first episode of psychosis (FEP, N = 97) and controls (CON, N = 55) use temporal and semantic context to organize memory recall. Free recall was characterized using the Hopkins Verbal Learning Test-Revised (HVLT-R)...
February 15, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29280107/neural-response-to-working-memory-demand-predicts-neurocognitive-deficits-in-hiv
#9
Ronald A Cohen, S Siegel, J M Gullett, E Porges, A J Woods, H Huang, Y Zhu, K Tashima, M-Z Ding
Human immunodeficiency virus (HIV) continues to have adverse effects on cognition and the brain in many infected people, despite a reduced incidence of HIV-associated dementia with combined antiretroviral therapy (cART). Working memory is often affected, along with attention, executive control, and cognitive processing speed. Verbal working memory (VWM) requires the interaction of each of the cognitive component processes along with a phonological loop for verbal repetition and rehearsal. HIV-related functional brain response abnormalities during VWM are evident in functional MRI (fMRI), though the neural substrate underlying these neurocognitive deficits is not well understood...
June 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29220627/neuropsychological-functioning-in-older-adults-with-mild-cognitive-impairment-and-insomnia-randomized-to-cbt-i-or-control-group
#10
Erin Cassidy-Eagle, Allison Siebern, Lisa Unti, Jill Glassman, Ruth O'Hara
OBJECTIVES: Improving the sleep of older adults with mild cognitive impairment (MCI) represents a first step in discovering whether interventions directed at modifying this risk factor also have the potential to alter the cognitive decline trajectory. METHODS: A six-session, adapted version of a cognitive behavioral therapy for insomnia (CBT-I) was administered to older adults (N = 28; 14 per group) with MCI across two residential facilities. Participants were randomly assigned to either the sleep intervention or an active control group and completed a neuropsychological battery at three time points (e...
March 2018: Clinical Gerontologist
https://www.readbyqxmd.com/read/29161350/embedded-performance-validity-tests-in-the-hopkins-verbal-learning-test-revised-and-the-brief-visuospatial-memory-test-revised-a-replication-study
#11
K Chase Bailey, Jason R Soble, Kathleen M Bain, Chrystal Fullen
Objective: Embedded performance validity tests (PVTs) within the Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R) were recently identified. This study aimed to further validate/replicate these embedded PVTs. Method: Eighty clinically referred veterans who underwent neuropsychological evaluation were included. Validity groups were established by passing/failing 2-3 well-validated PVTs, with 75% (n = 60) classified as valid and 25% (n = 20) noncredible...
November 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29147956/endogenous-sex-hormones-and-memory-performance-in-middle-aged-greek-women-with-subjective-memory-complaints
#12
Eleni Armeni, Michail Apostolakis, Foteini Christidi, Demetrios Rizos, George Kaparos, Konstantinos Panoulis, Areti Augoulea, Andreas Alexandrou, Evangelia Karopoulou, Ioannis Zalonis, Nikolaos Triantafyllou, Irene Lambrinoudaki
The changing hormonal milieu during the menopausal transition may contribute to the development of memory disorders. We aimed to assess the association of sex hormones with memory function in a sample of Greek middle-aged women. This pilot study included 44 women with subjective memory complaints. Memory performance was evaluated using the Hopkins Verbal Learning Test (HVLT), the Brief Visuospatial Memory test (BVMT), and the verbal digits backwards test (VSPAN), to assess verbal, visuospatial, and working memory performance, respectively...
February 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29128167/a-prospective-evaluation-of-hippocampal-radiation-dose-volume-effects-and-memory-deficits-following-cranial-irradiation
#13
Ting Martin Ma, Jimm Grimm, Riley McIntyre, Heather Anderson-Keightly, Lawrence R Kleinberg, Russell K Hales, Joseph Moore, Tracy Vannorsdall, Kristin J Redmond
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone...
November 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28966598/verbal-memory-impairment-in-patients-with-subsyndromal-bipolar-disorder
#14
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
BACKGROUNDS: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28864643/performance-of-screening-tests-for-cognitive-impairment-in-systemic-lupus-erythematosus
#15
Stephanie G Nantes, Jiandong Su, Ashneet Dhaliwal, Kenneth Colosimo, Zahi Touma
OBJECTIVE: There is a need for a cognitive function screening test that can be administered to patients with systemic lupus erythematosus (SLE) in clinic. The objectives of this study were to determine (1) prevalence of cognitive impairment (CI) in SLE by the Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), in relation to the Hopkins Verbal Learning Test-Revised (HVLT-R), and Perceived Deficits Questionnaire 5-Item (PDQ-5); and (2) associated factors with CI...
November 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28693360/the-hopkins-verbal-learning-test-an-in-depth-analysis-of-recall-patterns
#16
Rachel Grenfell-Essam, Eef Hogervorst, Tri Budi W Rahardjo
One of the earliest signs of dementia is memory issues and verbal word lists, such as the Hopkins Verbal Learning Test (HVLT), are successfully used for screening. To gain insight in how memory is affected in dementia, and to further improve the efficacy of the HVLT, in-depth analysis of the recall patterns of dementia cases and controls was conducted. Dementia cases and controls were matched for factors that can affect performance, such as age, gender and education level. Word frequency, syllable length, and orthographic neighbourhood size did not differ in the Indonesian version of the HVLT, nor did these characteristics affect recall...
April 2018: Memory
https://www.readbyqxmd.com/read/28552027/correlates-of-recognition-memory-performance-in-amnestic-mild-cognitive-impairment
#17
Victoria Sanborn, Deepti Putcha, Geoffrey Tremont
INTRODUCTION: Determining whether the etiology of amnestic Mild Cognitive Impairment (aMCI) is Alzheimer's disease (AD) is challenging. Recognition memory (RM) performance could be helpful in identifying individuals with cognitive patterns indicative of underlying AD. In order to better identify such patterns, we examined RM discriminability in aMCI and its associations with nonmemory cognitive domains impaired in AD. METHODS: Participants were 97 individuals diagnosed with aMCI (Mage  = 74...
March 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28526295/large-scale-exploratory-genetic-analysis-of-cognitive-impairment-in-parkinson-s-disease
#18
Ignacio F Mata, Catherine O Johnson, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Vivianna M Van Deerlin, Beate Ritz, Rebecca Rausch, Stewart A Factor, Cathy Wood-Siverio, Joseph F Quinn, Kathryn A Chung, Amie L Peterson-Hiller, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Dora Yearout, Shu-Ching Hu, Brenna A Cholerton, Thomas J Montine, Karen L Edwards, Cyrus P Zabetian
Cognitive impairment is a common and disabling problem in Parkinson's disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficits in PD might provide a clearer understanding of the pathophysiology underlying this important nonmotor feature. We genotyped 1105 PD patients from the PD Cognitive Genetics Consortium for 249,336 variants using the NeuroX array. Participants underwent assessments of learning and memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), working memory/executive function (Letter-Number Sequencing and Trail Making Test [TMT] A and B), language processing (semantic and phonemic verbal fluency), visuospatial abilities (Benton Judgment of Line Orientation [JoLO]), and global cognitive function (Montreal Cognitive Assessment)...
August 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28430671/elevated-production-of-nociceptive-cc-chemokines-and-se-selectin-in-patients-with-low-back-pain-and-the-effects-of-spinal-manipulation-a-non-randomized-clinical-trial
#19
Julita A Teodorczyk-Injeyan, Marion McGregor, John J Triano, H Stephen Injeyan
BACKGROUND: The involvement of inflammatory components in the pathophysiology of low back pain is poorly understood. It has been suggested that spinal manipulative therapy (SMT) may exert anti-inflammatory effects. PURPOSE: To determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of non-specific low back pain and to evaluate the effect of SMT on that process. METHODS: Patients presenting with non-radicular, non-specific low back pain (minimum pain score 3 on 10 point visual analogue scale, VAS) were recruited according to stringent inclusion criteria...
April 19, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28329340/baseline-characteristics-of-participants-in-the-aspree-aspirin-in-reducing-events-in-the-elderly-study
#20
RANDOMIZED CONTROLLED TRIAL
John J McNeil, Robyn L Woods, Mark R Nelson, Anne M Murray, Christopher M Reid, Brenda Kirpach, Elsdon Storey, Raj C Shah, Rory S Wolfe, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Jessica E Lockery, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Ruth E Trevaks, Suzanne G Orchard, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Richard H Grimm
Background: There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin that will determine whether 5 years of daily 100-mg enteric-coated aspirin extends disability-free and dementia-free life in a healthy elderly population and whether these benefits outweigh the risks. Methods: Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability...
October 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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