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Da Young Lee, Eun-Jung Rhee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Yang-Hyun Kim, Kyungdo Han, Yong-Kyu Park, Soon Jib Yoo, Won-Young Lee
PURPOSE: This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. METHODS: We evaluated the records of 23,257,723 Koreans aged ≥20 years who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 minutes of vigorous or ≥30 minutes of moderate PA or walking were stratified into four groups: 0 days/week; 1-3 days/week; 4-5 days/week; and 6-7 days/week...
August 10, 2018: Medicine and Science in Sports and Exercise
Karina S Kanamori, Guilherme C de Oliveira, Maria Auxiliadora-Martins, Renee A Schoon, Joel M Reid, Eduardo N Chini
Current studies on the age-related development of metabolic dysfunction and frailty are each day in more evidence. It is known, as aging progresses, nicotinamide adenine dinucleotide (NAD+ ) levels decrease in an expected physiological process. Recent studies have shown that a reduction in NAD+ is a key factor for the development of age-associated metabolic decline. Increased NAD+ levels in vivo results in activation of pro-longevity and health span-related factors. Also, it improves several physiological and metabolic parameters of aging, including muscle function, exercise capacity, glucose tolerance, and cardiac function in mouse models of natural and accelerated aging...
July 20, 2018: Bio-protocol
Yusuke Koide, Masaaki Teranishi, Saiko Sugiura, Yasue Uchida, Yusuke Koide, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata, Yasuhisa Hasegawa, Tsutomu Nakashima, Michihiko Sone
OBJECTIVES: The pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk. MATERIALS AND METHODS: We compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene...
August 3, 2018: Journal of International Advanced Otology
Lila Rabinovich, Anya Samek
We conducted focus groups (n = 68) to explore how older Americans feel about their past Social Security claiming decisions. Like most older Americans, our focus group participants claimed Social Security early: about 45% claimed Social Security at age 62, and about 65% claimed before Full Retirement Age (ages 65-66). We might expect that older adults may regret early claiming, since this can result in lower financial security in later life. Respondents reported satisfaction with their decisions to claim relatively early...
September 2018: Journal of Aging Studies
Sherry A Said, Rachel Isedowo, Christilynn Guerin, Navreek N Nar, Leesa Lillie, Shawn Bukovac, Jonathan J Simone, Matthew R Green, Cheryl M McCormick, Jeffrey A Stuart
Diarylpropionitrile (DPN) is an estrogen receptor-β-specific agonist that has been linked to neuroprotection, preserving cognitive function with age, the suppression of anxiety-like behaviors, inhibition of cancer growth, and other positive properties. We hypothesized that DPN may have pro-longevity properties. DPN was administered via feed at a dose corresponding to approximately 3 mg/kg/day to ovariectomized female mice beginning at 7 months of age. Mice were followed for the duration of their lifespans while monitoring body mass, aspects of behavior, learning, memory, and frailty...
August 11, 2018: GeroScience
J M Wentz, A R Mendenhall, D M Bortz
Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. Here, we present a hypothesized mechanism that could lead to this patterned response and develop a mathematical model of this system to test our hypothesis. We propose that the patterned expression of heat shock protein is caused by a diffusion-driven instability within the pseudocoelom, or fluid-filled cavity, that borders the intestinal cells in C...
August 10, 2018: Bulletin of Mathematical Biology
Chloe A Teasdale, Nonzwakazi Sogaula, Katharine A Yuengling, Chunhui Wang, Anthony Mutiti, Stephen Arpadi, Mahlubandile Nxele, Lungile Pepeta, Mary Mogashoa, Emilia D Rivadeneira, Elaine J Abrams
INTRODUCTION: There are limited data on viral suppression (VS) in children with HIV receiving antiretroviral therapy (ART) in routine care in low-resource settings. We examined VS in a cohort of children initiating ART in routine HIV care in Eastern Cape Province, South Africa. METHODS: The Pediatric Enhanced Surveillance Study enrolled HIV-infected ART eligibility children zero to twelve years at five health facilities from 2012 to 2014. All children received routine HIV care and treatment services and attended quarterly study visits for up to 24 months...
August 2018: Journal of the International AIDS Society
Adolf Pfefferbaum, Natalie M Zahr, Stephanie A Sassoon, Dongjin Kwon, Kilian M Pohl, Edith V Sullivan
BACKGROUND: Life expectancy of successfully treated human immunodeficiency virus (HIV)-infected individuals is approaching normal longevity. The growing HIV population ≥50 years of age is now at risk of developing HIV-associated neurocognitive disorder, acquiring coinfection with the hepatitis C virus (HCV), and engaging in hazardous drinking or drug consumption that can adversely affect trajectories of the healthy aging of brain structures. METHODS: This cross-sectional/longitudinal study quantified regional brain volumes from 1101 magnetic resonance imaging scans collected over 14 years in 549 participants (25 to 75 years of age): 68 HIV-infected individuals without alcohol dependence, 60 HIV-infected individuals with alcohol dependence, 222 alcohol-dependent individuals, and 199 control subjects...
July 4, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Janusz Gajda, Witold Śmigielski, Janusz Śmigielski, Elżbieta Pakos, Wojciech Drygas
BACKGROUND: Despite the wide popularity of football, there is a paucity of scientific evidence explaining the relationship between being a competitive footballer and life expectancy AIM: The study analyses and compares cause-specific mortality between Polish elite footballers (men) and the general male population. METHODS: A retrospective method of analysis is employed to study a sample of 455 elite footballers who died between 1990 and 2015. The cause of death was established based on the official statistics of Polish Central Statistical Office...
August 9, 2018: Kardiologia Polska
Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Claudio Franceschi, Paolo Garagnani
The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were neglected in the investigation of gene-environment interactions. We propose a new "diachronic" approach that considers processes occurred at both evolutionary and lifespan timescales. We focused on a well-characterized population in terms of evolutionary history ( i...
August 8, 2018: Aging
Dan Luo, Meng Lai, Chuanfeng Xu, Haoni Shi, Xingping Liu
BACKGROUND: For capital breeding Lepidoptera, larval food quality is a key determinant of their fitness. A series of studies have suggested that the larval host species or varieties dramatically impact their development and reproductive output. However, few studies have reported the role of foliar age and adult mating success has often been ignored in these studies. In this paper, the influence of host species and needle age on larval performances, adult mating behavior and fitness consequences has been studied using a capital breeding caterpillar, Dendrolimus punctatus Walker (Lepidoptera:Lasiocampidae)...
August 8, 2018: BMC Ecology
Eva Latorre, Elizabeth L Ostler, Richard G A Faragher, Lorna W Harries
Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age-related dysregulation of expression; they are emerging as potential influences on aging and longevity. The upstream drivers of these alterations are still unclear but may involve aberrant cellular signaling. We compared the phosphorylation status of proteins in multiple signaling pathways in early and late passage human primary fibroblasts...
August 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Geralda Gillian Silva-Sena, Daniela Camporez, Lígia Ramos Dos Santos, Aline Sesana da Silva, Lúcia Helena Sagrillo Pimassoni, Alessandra Tieppo, Maria do Carmo Pimentel Batitucci, Renato Lírio Morelato, Flavia de Paula
Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender...
April 2018: Genetics and Molecular Biology
Konomi Hori, Shuichi Matsuyama, Sho Nakamura, Hisataka Iwata, Takehito Kuwayama, Akio Miyamoto, Koumei Shirasuna
Decreased fertility associated with maternal aging is a well-known critical problem, and progesterone (P4) concentration decreases during the menopause transition in women. The corpus luteum (CL) secretes P4, thereby supporting the implantation and maintenance of pregnancy. It is proposed that a bovine model is suitable for studying age-associated decline of fertility in women because the physiology of cows is similar to that of women and cows have a greater longevity compared with other animal models. Thus, we investigated the age-dependent qualitative changes and inflammatory responses in the bovine CL...
August 7, 2018: Reproduction in Domestic Animals, Zuchthygiene
Jia-Zhuang Xu, Orhun K Muratoglu, Ebru Oral
Radiation crosslinking decreases the wear of ultrahigh molecular weight polyethylene (UHMWPE) used in total joint implants and creates residual free radicals, which are the precursors of oxidative degradation. It is desirable to obtain a simultaneously wear- and oxidation-resistant UHMWPE in order to prolong the longevity of implants. In this study, we hypothesized that the oxidative stability of a vitamin E-containing, wear resistant UHMWPE can be improved by limiting the exposure of the antioxidant to radiation to maximize its activity...
August 6, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Andrea Bednářová, Aleš Tomčala, Michaela Mochanová, Dalibor Kodrík, Natraj Krishnan
The impact of disruption of adipokinetic hormone (AKH) signaling was studied during aging in Drosophila in a sexually dimorphic manner. A mutant ( Akh 1 ) producing a non-functional AKH peptide was compared with isogenized wild-type controls ( w 1118 ), and Akh -rescue line where AKH was ectopically expressed in the mutant background ( EE-Akh ). Longevity, fecundity, and locomotor activity rhythms remained unaffected by lack of AKH signaling. While the strength of rhythms declined in general with age across all fly lines tested this was more so in case of Akh 1 flies...
2018: Frontiers in Physiology
Elizabeth T Hurren
Victorian and Edwardian cottage hospitals, compared to infirmaries and workhouse institutions, have been neglected by social historians. Yet, they provided an infrastructure dedicated to localism and healthcare for the aged under the new National Health Service (NHS) after World War Two. This article focuses on two renowned Midlands cottage hospitals built in mid-Northamptonshire at Pitsford. In their patient case-histories we can engage with: dignity standards, medical regime, ward designs, staffing levels, budget provisions, and patient voices...
October 5, 2018: Family & Community History: Journal of the Family and Community Historical Research Society
Maxwell C Park, Yasuo Itami, Charles C Lin, Adam Kantor, Michelle H McGarry, Chong J Park, Thay Q Lee
PURPOSE: To assess an anterior cable reconstruction (ACR) using autologous proximal biceps tendon for large to massive rotator cuff tears. METHODS: Nine cadaveric shoulders (mean age, 58 years) were tested with a custom testing system. Range of motion, superior translation of the humeral head, and subacromial contact pressure were measured at 0°, 30°, 60°, and 90° of external rotation (ER) with 0°, 20°, and 40° of glenohumeral abduction. Five conditions were tested: intact, stage II tear (supraspinatus), stage II tear + ACR, stage III tear (supraspinatus + anterior half of infraspinatus), and stage III tear + ACR...
August 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Xiuling Chen, Guangkun Yin, Andreas Börner, Xia Xin, Juanjuan He, Manuela Nagel, Xu Liu, Xinxiong Lu
The longevity of seeds stored in Genebank is based on their storability. However, the mechanism of seed storability is largely unknown. In previous studies, accelerated ageing treatments were always applied for rapidly acquiring different seed viabilities, which could not reflect the actual situation during seed storage, especially for the seed stored in Genebank. In this study, two wheat genotypes (accession TRI_23248 and TRI_10230) were supplied by IPK-Gatersleben Genebank, Germany, where they were stored for 10 years in the long-term storage (-18 °C) and at ambient conditions (20 °C) The comparison of viability of those seed after this storage period, identified TRI_23248 as storage tolerant (ST) and TRI_10230 as storage sensitive (SS)...
July 20, 2018: Plant Physiology and Biochemistry: PPB
David A Ellis, Ville Mustonen, María Rodríguez-López, Charalampos Rallis, Michał Malecki, Daniel C Jeffares, Jürg Bähler
Quantitative traits often show large variation caused by multiple genetic factors. One such trait is the chronological lifespan of non-dividing yeast cells, serving as a model for cellular aging. Screens for genetic factors involved in ageing typically assay mutants of protein-coding genes. To identify natural genetic variants contributing to cellular aging, we exploited two strains of the fission yeast, Schizosaccharomyces pombe, that differ in chronological lifespan. We generated segregant pools from these strains and subjected them to advanced intercrossing over multiple generations to break up linkage groups...
August 2, 2018: Genetics
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