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Cancer of the cervix

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https://www.readbyqxmd.com/read/29928215/an-unusual-coexistence-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-with-endometrioid-type-endometrial-cancer-in-a-58-year-old-woman-a-case-study-with-literature-review
#1
Dominik Dłuski, Dorota Lewkowicz, Bożena Leszczyńska-Gorzelak, Bogdan Obrzut, Tomasz Rechberger, Andrzej Semczuk
Introduction: The coexistence of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with different gynecologic neoplasms is a rare phenomenon. Here, we report a case of simultaneously developed CLL/SLL with endometrioid-type uterine cancer. Case Report: A 58-year-old woman was admitted to the 2nd Department of Gynecology, Lublin Medical University, Lublin, Poland, in June 2017, where the uterine cancer was diagnosed. After the surgery, pathological examination revealed a uterine moderately differentiated adenocarcinoma of endometrioid subtype (subtype I according to Bokhman) deeply infiltrating the myometrium as well as the uterine cervix...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927817/the-human-papilloma-vaccine-a-time-for-np-leadership
#2
Robin L Hardwicke, Laura J Benjamins, Richard M Grimes
The human papilloma virus (HPV) causes approximately 30,700 annual cancer cases of the cervix, vulva, vagina, penis, oral cavity, and anus. Nurse practitioners can use their unique relationships with patients to advocate for the HPV vaccine. The purpose of this article is to update NPs on current knowledge regarding the HPV vaccine while providing appropriate information necessary for counseling patients and parents.
July 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29923515/comparative-study-between-liquid-based-cytology-conventional-pap-smear-for-cytological-follow-up-of-treated-patients-of-cancer-cervix
#3
Uma Singh, Sabuhi Qureshi, Neha Negi, Nisha Singh, Madhumati Goel, Kirti Srivastava
Background & objectives: Cancer cervix is one of the most common forms of genital malignancy among Indian women. Recurrence is seen in a significant number of cases. The conventional cervical smear technique has inherent problems and screening and interpretation errors. This study was undertaken to assess the efficacy of liquid-based cytology (LBC) as a method for cytological follow up and detection of recurrence in treated cases of cancer cervix and to compare it with conventional Pap smear technique to find the best screening method for detection of recurrence in these patients...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29923470/the-impact-of-environmental-and-behavioural-cofactors-on-the-development-of-cervical-disorders-in-hr-hpv-infected-women-in-serbia
#4
D Tasic, I Lazarevic, A Knezevic, L Tasic, A Pikula, Z Perisic, T Jovanovic, M Cupic
Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progression of cervical disorder. This study aimed to evaluate the impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia. A total of 541 women have been tested by PCR for the presence of HPV on the cervix...
June 20, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29921897/jagged-1-induced-molecular-alterations-in-hpv-associated-invasive-squamous-cell-and-adenocarcinoma-of-the-human-uterine-cervix
#5
Richa Tripathi, Gayatri Rath, Showket Hussain, Poonam Jawanjal, Kapil Bandil, Vishwas Sharma, Mausumi Bharadwaj, Ravi Mehrotra
The majority of cervical cancer (CC) cases are attributable to HPV infection. Altered Notch pathway signals and HPV are believed to modify clinicopathogenesis of CC, however, the involvement of each molecular player and its mechanism is still not known. Jagged-1 (JAG1) is one of the ligands that induce Notch pathway. The involvement of JAG1 in the modulation of a disease condition is not very clear. Hence, this study aims to study the role of JAG1 in HPV-16/18 associated different histological sub-types of CC, especially ADC...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29920292/novel-tumor-necrosis-factor-%C3%AE-induced-protein-eight-tnfaip8-tipe-family-functions-and-downstream-targets-involved-in-cancer-progression
#6
Ganesan Padmavathi, Kishore Banik, Javadi Monisha, Devivasha Bordoloi, Shabnam Bano, Frank Arfuso, Gautam Sethi, Fan Lu, Ajaikumar B Kunnumakkara
The tumor necrosis factor (TNF)-α- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland...
June 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29913193/anti-proliferative-applications-of-laccase-immobilized-on-super-magnetic-chitosan-functionalized-halloysite-nanotubes
#7
Kim Min, Seung Cheol Jee, Jung-Suk Sung, Avinash A Kadam
Owing to the ubiquitous availability and simple biocatalysis, the anti-proliferative laccase holds enormous opportunities for anti-cancer applications. However, accessing efficient and specific (super-magnetically targetable) new delivery system for anti-proliferative laccase is vital step towards laccase based anti-cancer approach. Therefore, in this investigation, super-magnetized (Fe3 O4 ) and chitosan (CS) functionalized halloysite nanotubes (HNTs) (termed as Fe3 O4 -HNTs-CS) was facile synthesized. Further, laccase from Trametes versicolor was immobilized on Fe3 O4 -HNTs-CS (termed as Fe3 O4 -HNTs-CS-Lac)...
June 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29901630/three-primary-synchronous-malignancies-of-the-uterus-cervix-and-fallopian-tube-a-case-report
#8
Liang Song, Qingli Li, Kaixuan Yang, Rutie Yin, Danqing Wang
RATIONALE: Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The vast majority of patients have multiple metachronous malignant tumors; multiple synchronous tumors are rare. PATIENT CONCERNS: A 63-year-old woman presented with the chief complaint of vaginal fluid discharge for 3 months and abdominal pain for 1 month...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899606/cross-sectional-study-on-visual-inspection-with-acetic-acid-and-pap-smear-positivity-rates-according-to-sociodemographic-factors-among-rural-married-women-of-bareilly-uttar-pradesh
#9
Ruchi Arun, Jai Prakash Singh, Shyam Bihari Gupta
Background: It is possible to prevent deaths due to cervical cancer through screening and treatment. Cervical cytology which is a standard screening tool in developed countries fails as a screening method in low-resource countries due to financial and technical constraints. Objective: To determine the prevalence of pre-malignant lesions of the cervix by VIA and Pap smear test among rural married women and to find out association of socio demographic factors with positive screening test results...
April 2018: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29898440/results-of-cervical-cancer-screening-in-the-rural-population-of-lucknow-west-india-through-a-camp-approach
#10
Jata S Misra, Anand N Srivastava, Hem P Gupta
OBJECTIVE: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis. STUDY DESIGN: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India)...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896404/primary-breast-cancer-relapse-as-metastasis-to-the-cervix-uteri-a-case-report
#11
Aude Thouvenot, Yasmine Bizet, Laurent S Baccar, Michele Lamuraglia
Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass with irregular contours and abnormal vascularization with associated increase of the blood level of cancer antigen 15-3 to 34 kU/l...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29896305/ultrahigh-resolution-optical-coherence-microscopy-accurately-classifies-precancerous-and-cancerous-human-cervix-free-of-labeling
#12
Xianxu Zeng, Xiaoan Zhang, Canyu Li, Xiaofang Wang, Jason Jerwick, Tao Xu, Yuan Ning, Yihong Wang, Linlin Zhang, Zhan Zhang, Yutao Ma, Chao Zhou
Cervical cancer remains the fourth most common cause of cancer worldwide and the third leading cause of cancer deaths for women in developing countries. Traditional screening tools, such as human papillomavirus and Pap tests, cannot provide results in real-time and cannot localize suspicious regions. Colposcopy-directed biopsies are invasive in nature and only a few sites of the cervix may be chosen for investigation. A non-invasive, label-free and real-time imaging method with a resolution approaching that of histopathology is desirable for early detection of the disease...
2018: Theranostics
https://www.readbyqxmd.com/read/29895125/clinical-efficacy-of-p16-ki-67-dual-stained-cervical-cytology-in-secondary-prevention-of-cervical-cancer
#13
Aleksander Celewicz, Marta Celewicz, Małgorzata Wężowska, Anita Chudecka-Głaz, Janusz Menkiszak, Elzbieta Urasińska
Cervical cancer is the third most common malignant neoplasm in women worldwide. HPV infection is the necessary factor for the cancer to develop. HPV DNA can be integrated into the genome of squamous epithelium and cause transcription of the viral oncoproteins and development of invasive cancer within 15-20 years. We assessed ICC co-expression of p16/Ki-67 proteins in smears collected from the uterine cervix and the association between p16/Ki-67 co-expression and cytologic and histologic results. Samples were collected from 93 women using liquid based cytology (LBC)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29893472/portable-pocket-colposcopy-performs-comparably-to-standard-of-care-clinical-colposcopy-using-acetic-acid-and-lugol-s-iodine-as-contrast-mediators-an-investigational-study-in-per%C3%A3%C2%BA
#14
Jenna L Mueller, Christopher T Lam, Denali Dahl, Mercy Nyamewaa Asiedu, Marlee S Krieger, Yenny Bellido-Fuentes, Mark Kellish, Jenna Peters, Alaattin Erkanli, Ernesto J Ortiz, Lisa C Muasher, Peyton T Taylor, John W Schmitt, Gino Venegas, Nirmala Ramanujam
OBJECTIVE: Our goal is to develop a tele-colposcopy platform for primary care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare center in Perú. DESIGN AND SETTING: Images of the cervix were captured with a standard-of-care and Pocket colposcope at la Liga Contra el Cáncer in Lima, Perú. POPULATION: 200 Peruvian women with abnormal cytology and/or HPV positivity were enrolled...
June 12, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29892149/a-preliminary-study-on-the-estimation-of-the-number-of-cancer-patients-eligible-for-hadron-therapy-in-iran-and-fars-province
#15
Mohammad Amin Hosseini, Mohammad Mohamadianpanah, Mohammad Zare-Bandeamiri, Mohammad Amin Mosleh-Shirazi
Hadron therapy (HT) with protons and carbon ions is an advanced radiotherapy technique. As the first report addressing this topic, the present study aimed to estimate the number of patients eligible for HT in Fars province and the whole of Iran. The data were collected through direct inspection of medical records of the patients treated at the Radiotherapy Department, Namazi Hospital, Shiraz, Iran in 2014. The patients who were treated with external-beam radiotherapy and declared to be a resident of Fars province were extracted from the medical records...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29887698/outcomes-of-computed-tomography-guided-image-based-interstitial-brachytherapy-for-cancer-of-the-cervix-using-gec-estro-guidelines
#16
Karthik S Rishi, Ram Charith Alva, Amrit Raghav Kadam, Sanjiv Sharma
Locally advanced cancer of the cervix is treated by concurrent chemoradiation followed by brachytherapy. Interstitial brachytherapy is used to treat large tumors with involvement of parametrium, post-hysterectomy, and narrow, conical vagina. The GYN GEC-ESTRO working group described target volume delineation and also 3D image-based planning using MRI and 3D dose-volume parameters for brachytherapy of carcinoma cervix. CT-based as compared to MR-based image-guided brachytherapy (IGBT) is much more feasible and practical because MR access is still difficult for most departments...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29886786/apatinib-a-novel-tyrosine-kinase-inhibitor-suppresses-tumor-growth-in-cervical-cancer-and-synergizes-with-paclitaxel
#17
Haifeng Qiu, Jing Li, Qiuli Liu, Mei Tang, Yuan Wang
Apatinib is a novel tyrosine kinase inhibitor that targets VEGFR2 signal and exhibits potent anti-tumor effects in human cancers. In this study, we aim to investigate the efficacy of Apatinib in cervical cancer. The protein expression of VEGFR2 and its relationships with clinical parameters were investigated in a panel of cervical cancer patients. In vitro, a series of experiments were performed to detect the effects of Apatinib on the proliferation, apoptosis and cell cycle in cervical cancer cells. Both the immortalized cell lines and primary cultured tissues were used to investigate the synergy between Apatinib and chemotherapeutic drugs...
June 9, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29873205/optical-spectroscopic-sensing-of-tumor-hypoxia
#18
Sina Dadgar, Joel Rodríguez Troncoso, Narasimhan Rajaram
Tumor hypoxia is a critical indicator of poor clinical outcome in patients with cancers of the breast, cervix, and oral cavity. The ability to noninvasively and reliably monitor tumor oxygenation both prior to and during therapy can aid in identifying poor treatment response earlier than is currently possible and lead to effective changes in treatment regimen. Diffuse reflectance spectroscopy (DRS) has been used in several studies to measure tissue scattering, total hemoglobin content (THb), and vascular oxygenation (sO2) in tissue...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29869485/18f-fdg-pet-ct-guided-external-beam-radiotherapy-volumes-in-inoperable-uterine-cervical-cancer
#19
Judit A Adam, Hester Arkies, Karel Hinnen, Lukas J Stalpers, Jan H van Waesberghe, Jaap Stoker, Rob van Os, Janna J Laan, Constantijne H Mom, Berthe L van Eck-Smit
BACKGROUND: In patients with advanced stage cancer of the uterine cervix who undergo irradiation with curative intent, there is the necessity to treat all suspicious nodes on imaging. Our hypothesis was that adding PET/CT to the imaging workup would alter the EBRT treatment plan, either resulting in an extended EBRT field to the para-aortal region or an additional boost to suspicious nodes. Since extended field radiotherapy or additional boost can cause toxicity, our secondary aim was to assess the incidence of severe late bowel toxicity in patients treated with extended para-aortal EBRT-field compared to elective pelvic EBRT...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29864112/hand-grip-strength-and-cognitive-function-among-elderly-cancer-survivors
#20
Lin Yang, Ai Koyanagi, Lee Smith, Liang Hu, Graham A Colditz, Adetunji T Toriola, Guillermo Felipe López Sánchez, Davy Vancampfort, Mark Hamer, Brendon Stubbs, Thomas Waldhör
BACKGROUND: We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: Data in two waves of NHANES (2011-2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value achieved using either hand. Two cognitive function tests were conducted among adults 60 years and older. The Animal Fluency Test (AFT) examines categorical verbal fluency (a component of executive function), and the Digital Symbol Substitution test (DSST) assesses processing speed, sustained attention, and working memory...
2018: PloS One
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