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Cécile Tromeur, Liselotte M van der Pol, Pierre-Yves Le Roux, Yvonne Ende-Verhaar, Pierre-Yves Salaun, Christophe Leroyer, Francis Couturaud, Lucia J M Kroft, Menno V Huisman, Frederikus A Klok
Differences of computed tomography pulmonary angiography versus ventilation-perfusion lung scan in pregnant patients with suspected acute pulmonary embolism are not well-known, leading to ongoing debate on which test to choose. We searched in PUBMED, EMBASE, Web of science and Cochrane library databases and identified all relevant articles and abstracts published up to October1st 2017. We assessed diagnostic efficiency, frequency of non-diagnostic results and radiation exposure for patient and fetus. We included 13 studies for the diagnostic efficiency analysis, 30 for non-diagnostic results analysis and 22 for radiation exposure analysis...
August 16, 2018: Haematologica
AliReza JafariNezhad, Mohammad Hossein YektaKooshali
BACKGROUND: There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. METHOD: This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients...
2018: PloS One
Huy Gia Vuong, An Thi Nhat Ho, Ahmed M A Altibi, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
MET exon 14 mutation is an uncommon genomic alteration in non-small cell lung cancer (NSCLC). This meta-analysis aimed at investigating the clinicopathological and prognostic features of NSCLCs with MET exon 14 mutation in comparison with other genetic events. We performed a search in four electronic databases including PubMed, Web of Science, Scopus, and Virtual Health Library from inception to February 2018. Relevant data were extracted and pooled into odds ratio (OR), mean differences (MD), and corresponding 95% confidence intervals (CI) using the random-effect model...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Annah B Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N Nguyen, Lies Lahousse, Jeanne C Latourelle, Albert Vernon Smith, Traci M Bartz, Mary F Feitosa, Wei Gao, Tarunveer S Ahluwalia, Wenbo Tang, Christopher Oldmeadow, Qing Duan, Kim de Jong, Mary K Wojczynski, Xin-Qun Wang, Raymond Noordam, Fernando Pires Hartwig, Victoria E Jackson, Tianyuan Wang, Ma'en Obeidat, Brian D Hobbs, Tianxiao Huan, Hongsheng Gui, Margaret M Parker, Donglei Hu, Lauren S Mogil, Gleb Kichaev, Jianping Jin, Mariaelisa Graff, Tamara B Harris, Ravi Kalhan, Susan R Heckbert, Lavinia Paternoster, Kristin M Burkart, Yongmei Liu, Elizabeth G Holliday, James G Wilson, Judith M Vonk, Jason L Sanders, R Graham Barr, Renée de Mutsert, Ana Maria Baptista Menezes, Hieab H H Adams, Maarten van den Berge, Roby Joehanes, Albert M Levin, Jennifer Liberto, Lenore J Launer, Alanna C Morrison, Colleen M Sitlani, Juan C Celedón, Stephen B Kritchevsky, Rodney J Scott, Kaare Christensen, Jerome I Rotter, Tobias N Bonten, Fernando César Wehrmeister, Yohan Bossé, Shujie Xiao, Sam Oh, Nora Franceschini, Jennifer A Brody, Robert C Kaplan, Kurt Lohman, Mark McEvoy, Michael A Province, Frits R Rosendaal, Kent D Taylor, David C Nickle, L Keoki Williams, Esteban G Burchard, Heather E Wheeler, Don D Sin, Vilmundur Gudnason, Kari E North, Myriam Fornage, Bruce M Psaty, Richard H Myers, George O'Connor, Torben Hansen, Cathy C Laurie, Patricia A Cassano, Joohon Sung, Woo Jin Kim, John R Attia, Leslie Lange, H Marike Boezen, Bharat Thyagarajan, Stephen S Rich, Dennis O Mook-Kanamori, Bernardo Lessa Horta, André G Uitterlinden, Hae Kyung Im, Michael H Cho, Guy G Brusselle, Sina A Gharib, Josée Dupuis, Ani Manichaikul, Stephanie J London
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses...
July 30, 2018: Nature Communications
X Q Li, W J Liu, J X Duan, W Q Li, X Wang, Y T Wei
Objective: To systematically evaluate the effectiveness of epidermal growth factor (EGF) in treating patients with inhalation injury by meta analysis. Methods: Databases including PubMed, Cochrance Library, and Embase were searched using key words " inhalation injury, smoke inhalation injury, epidermal growth factor, and EGF" , and Chinese Journals Full-text Database, China Biology Medicine disc, VIP Database, and Wanfang Database were searched using key words in Chinese version "," to obtain the randomized controlled trails about EGF published publicly in the treatment of patients with inhalation injury from the establishment of each database to December 2017...
July 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Dandi Qiao, Asher Ameli, Dmitry Prokopenko, Han Chen, Alvin T Kho, Margaret M Parker, Jarrett Morrow, Brian D Hobbs, Yanhong Liu, Terri H Beaty, James D Crapo, Kathleen C Barnes, Deborah A Nickerson, Michael Bamshad, Craig P Hersh, David A Lomas, Alvar Agusti, Barry J Make, Peter M A Calverley, Claudio F Donner, Emiel F Wouters, Jørgen Vestbo, Peter D Paré, Robert D Levy, Stephen I Rennard, Ruth Tal-Singer, Margaret R Spitz, Amitabh Sharma, Ingo Ruczinski, Christoph Lange, Edwin K Silverman, Michael H Cho
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is substantially influenced by genetic factors. Alpha-1 antitrypsin deficiency demonstrates that rare coding variants of large effect can influence COPD susceptibility. To identify additional rare coding variants in patients with severe COPD, we conducted whole exome sequencing analysis in 2,543 subjects from two family-based studies (Boston Early-Onset COPD Study and International COPD Genetics Network) and one case-control study (COPDGene)...
July 27, 2018: Human Molecular Genetics
Sanne C van Kampen, Amanda Wanner, Miles Edwards, Anthony D Harries, Bruce J Kirenga, Jeremiah Chakaya, Rupert Jones
Introduction: Pulmonary tuberculosis (TB) is an important risk factor for chronic respiratory disease due to residual lung damage. Yet, the WHO End TB strategy does not mention post-TB chronic lung disorders (PTBLDs) and programmatic interventions to address PTBLD are lacking. This study assessed the scope of current guidelines and evidence on PTBLD to inform policy and research action. Methods: A systematic literature search was conducted following Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines...
2018: BMJ Global Health
Natalie Terzikhan, Fangui Sun, Fien M Verhamme, Hieab H H Adams, Daan Loth, Ken R Bracke, Bruno H C Stricker, Lies Lahousse, Josée Dupuis, Guy G Brusselle, George T O'Connor
Background: Although several genome wide association studies (GWAS) have investigated the genetics of pulmonary ventilatory function, little is known about the genetic factors that influence gas exchange. Aim: To investigate the heritability of, and genetic variants associated with the diffusing capacity of the lung. Methods: GWAS was performed on diffusing capacity, measured by carbon monoxide uptake (DLCO) and per alveolar volume (DLCO/VA) using the single-breath technique, in 8,372 individuals from two population-based cohort studies, the Rotterdam Study and the Framingham Heart Study...
July 26, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Joanne Guay, Edward A Ochroch, Sandra Kopp
BACKGROUND: Since the 2000s, there has been a trend towards decreasing tidal volumes for positive pressure ventilation during surgery. This an update of a review first published in 2015, trying to determine if lower tidal volumes are beneficial or harmful for patients. OBJECTIVES: To assess the benefit of intraoperative use of low tidal volume ventilation (less than 10 mL/kg of predicted body weight) compared with high tidal volumes (10 mL/kg or greater) to decrease postoperative complications in adults without acute lung injury...
July 9, 2018: Cochrane Database of Systematic Reviews
Mehrnaz Ghasemiesfe, Divya Ravi, Marzieh Vali, Deborah Korenstein, Mehrdad Arjomandi, James Frank, Peter C Austin, Salomeh Keyhani
Background: The health effects of smoking marijuana are not well-understood. Purpose: To examine the association between marijuana use and respiratory symptoms, pulmonary function, and obstructive lung disease among adolescents and adults. Data Sources: PubMed, Embase, PsycINFO, MEDLINE, and the Cochrane Library from 1 January 1973 to 30 April 2018. Study Selection: Observational and interventional studies published in English that reported pulmonary outcomes of adolescents and adults who used marijuana...
July 17, 2018: Annals of Internal Medicine
Jia-Jia Wang, Yang Xie, Hu-Lei Zhao, Wei-Hong Han, Xiao-Chun Wang
BACKGROUND: There is a limited evidence concerning the efficacy of transcutaneous electric nerve stimulation over acupoints (Acu-TENS) for chronic obstructive pulmonary disease (COPD). Thus, this review aims to systematically determine the effect of Acu-TENS on COPD. METHODS: PubMed, Embase, The Cochrane Library, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data will be searched from their inception to May 10, 2018...
June 2018: Medicine (Baltimore)
Juan Gea-Banacloche
PURPOSE OF REVIEW: The current review highlights the most relevant articles on lung infections following hematopoietic stem cell transplantation (HCT) published over the last year. Between 30 and 50% of HCT recipients will develop pulmonary infiltrates. These pulmonary complications may be infectious (caused by virus, bacteria, fungi, or protozoa) or noninfectious (e.g., fluid overload, heart failure, transfusion reactions like transfusion associated lung injury and transfusion-associated circulatory overload, drug reactions, engraftment syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, cryptogenic organizing pneumonia, and bronchiolitis obliterans syndrome)...
August 2018: Current Opinion in Organ Transplantation
Yu Shi, Hong Yu, Lili Huang, Siyang Wang, Dongmei Chi, Chan Chen, Bin Liu
BACKGROUND: Since postoperative pulmonary complications are one of the main causes of morbidity and mortality in patients undergoing lung resection surgery, we performed a meta-analysis to compare the incidence of postoperative pulmonary complications and hospital death, and the length of hospital stay in patients who received nonintubated or intubated anesthesia during thoracoscopic surgery for lung resection and further explore the tricks in nonintubated anesthesia. METHODS: PubMed, Embase, and Cochrane Library were searched from inception to September 2017...
May 2018: Medicine (Baltimore)
Stein Ove Danielsen, Philip Moons, Irene Sandven, Marit Leegaard, Svein Solheim, Theis Tønnessen, Irene Lie
BACKGROUND: The 30-day all-cause readmission rate after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) vary substantially. We conducted a systematic review and meta-analysis to examine the overall incidence, causes, and risk factors of 30-day all-cause readmission rate after SAVR and TAVR. METHODS: Eight medical research databases were searched; Cochrane, Medline, Embase, UpToDate, PROSPERO, National Guideline Clearinghouse, SweMed and Oria...
October 1, 2018: International Journal of Cardiology
Fang He, Aiting Zhou, Shuo Feng
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) urgently requires effective treatment. Bleomycin-induced lung injury models are characterized by initial inflammation and secondary fibrosis, consistent with the pathological features of IPF. Human amniotic epithelial cells (hAECs) exhibit good differentiation potential and paracrine activity and are thus ideal for cell-based clinical therapies. The therapeutic effects of hAECs on lung fibrosis are attributed to many factors. We performed a systematic review of preclinical studies investigating the treatment of pulmonary fibrosis with hAECs to provide suggestions for their clinical use...
2018: PloS One
Nitin Kapur, Helen L Petsky, Scott Bell, John Kolbe, Anne B Chang
BACKGROUND: Bronchiectasis is being increasingly diagnosed and recognised as an important contributor to chronic lung disease in both adults and children in high- and low-income countries. It is characterised by irreversible dilatation of airways and is generally associated with airway inflammation and chronic bacterial infection. Medical management largely aims to reduce morbidity by controlling the symptoms, reduce exacerbation frequency, improve quality of life and prevent the progression of bronchiectasis...
May 16, 2018: Cochrane Database of Systematic Reviews
Qian-Yun Pang, Ran An, Hong-Liang Liu
INTRODUCTION: There is a high incidence of postoperative cardiopulmonary complications after thoracic surgery with one lung ventilation (OLV), the effect of general anaesthetics on intraoperative cardiopulmonary function and postoperative complications is still unclear. EVIDENCE ACQUISITION: We searched the Embase, Pubmed, Cochrane Library, Springer, Wiley, CNKI, VIP and Wanfang databases for randomized controlled trials (RCTs) in which inhalation anaesthesia and intravenous anaesthesia were compared; intraoperative cardiopulmonary function and postoperative complications were assessed in patients undergoing thoracic surgery with intraoperative one-lung ventilation (OLV)...
May 11, 2018: Minerva Anestesiologica
Mario Cazzola, Luigino Calzetta, Peter J Barnes, Gerard J Criner, Fernando J Martinez, Alberto Papi, Maria Gabriella Matera
Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and displays a better safety profile than theophylline. Therefore, we performed a quantitative synthesis to compare the efficacy and safety profile of different xanthines in COPD.The primary end-point of this meta-analysis was the impact of xanthines on lung function...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
Z Ding, K Wang, J Li, Q Tan, W Tan, G Guo
Chronic obstructive pulmonary disease (COPD) is a severe lung disease characterized by long-term breathing problems. A series of studies have indicated that the glutathione S-transferase genes M1 and T1 are associated with COPD susceptibility; however, the result still remains inconclusive. This meta-analysis was performed to estimate the effect of GSTM1 and GSTT1 polymorphisms in COPD risk. Eligible case-control studies published between January 2000 and December 2017 was searched and retrieved. A total of 37 articles were screened out, including 4674 COPD patients and 5006 controls...
April 28, 2018: Clinical Genetics
Pablo A Salcedo, Jacob B Lindheimer, Jacquelyn C Klein-Adams, Anays M Sotolongo, Michael J Falvo
OBJECTIVE: To quantify the effect of exercise training on indices of pulmonary function in adults with chronic lung disease using meta-analytic techniques. DATA SOURCES: Eligible trials were identified using a systematic search of MEDLINE, Web of Science, Physiotherapy Evidence Database, and GoogleScholar databases. STUDY SELECTION: Randomized controlled trials that evaluated pulmonary function before and after whole-body exercise training among adult patients (aged ≥19y) with chronic lung disease were included...
April 17, 2018: Archives of Physical Medicine and Rehabilitation
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