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Leonardo Jönck Staub, Roberta Rodolfo Mazzali Biscaro, Erikson Kaszubowski, Rosemeri Maurici
BACKGROUND: Lung ultrasound can accelerate the diagnosis of life-threatening diseases in adults with respiratory symptoms. OBJECTIVE: Systematically review the accuracy of lung ultrasonography (LUS) for emergency diagnosis of pneumonia, acute heart failure, and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma in adults. METHODS: PubMed, Embase, Scopus, Web of Science, and LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde; until 2016) were searched for prospective diagnostic accuracy studies...
October 9, 2018: Journal of Emergency Medicine
Barbara Joschtel, Sjaan R Gomersall, Sean Tweedy, Helen Petsky, Anne B Chang, Stewart G Trost
Introduction: Chronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease. Method: Five databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease...
2018: BMJ Open Sport & Exercise Medicine
H F van der Molen, G J de Groene, C T J Hulshof, M H W Frings-Dresen
To support occupational physicians in their assessment and notification of occupational diseases, diagnostic registration guidelines are developed with information about associations between work-related risk factors and diseases. The objective of this review of systematic reviews is to examine whether work-related risk factors are associated with chronic pulmonary obstructive disease (COPD). We searched the electronic database of Medline for systematic reviews published between 1 January 2009 and 20 June 2017...
October 9, 2018: Journal of Clinical Medicine
Yu Guo, Mingmin Xu, Meiqi Ji, Jialei Zhang, Qingchuan Hu, Zeren Wei, Jian Yan, Yue Chen, Jiaxuan Lyu, Xiaoqian Shao, Ying Wang, Jiamei Guo, Yulong Wei
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide with a substantial and increasing social and economic burden. Liuzijue Qigong is a kind of traditional Chinese Qigong exercises that Traditional Chinese Medicine practitioners prescribe to individuals with COPD to strengthen the internal organs' function. Liuzijue Qigong was recommended for use in COPD rehabilitation, and some clinical trials indicate that Liuzijue Qigong would produce better functional capacity and quality of life of individuals with COPD...
October 2018: Medicine (Baltimore)
Christopher A Collura, Kristin C Mara, Amy L Weaver, Reese H Clark, William A Carey
OBJECTIVE: Meta-analysis of individual-patient clinical trial data suggests that inhaled nitric oxide (iNO) improves respiratory outcomes in premature African American neonates. We hypothesized that early iNO therapy would be associated with lower mortality and less chronic lung disease (CLD) in extremely premature African American neonates. STUDY DESIGN: We conducted a retrospective cohort study of propensity score- and race-matched neonates 22-29 weeks gestation who were mechanically ventilated for treatment of respiratory distress and associated pulmonary hypertension (RDS + PPHN)...
October 1, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Shuo Jiang, Ji Zhou, Jia Zhang, Xihao Du, Xuejiao Zeng, Kun Pan, Yuquan Xie, Haidong Kan, Qinghua Sun, Jing Cai, Jinzhuo Zhao
Lots of epidemiological and experimental studies have found that ambient fine particulate matter (PM2.5 ) exposure is associated with the development of cardiopulmonary diseases, obesity and diabetes. This study focused on the effects of cumulative PM2.5 exposure on pulmonary and systemic inflammation and insulin resistance. Thirty-two 6-week-old male Balb/c mice were randomly divided into four groups (FA, PM, WEEK and DAY groups) and were continuously or intermittently exposed to concentrated PM2.5 or filtered air (FA) for four weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS")...
September 24, 2018: Inhalation Toxicology
Lu-Lu He, Lei Zhang, Lei Jiang, Feng Xu, Dong-Sheng Fei
INTRODUCTION: Anti-interleukin-5 therapy has been proposed as a novel and promising treatment option in asthma treatment. However, the optimum monoclonal antibodies for asthma treatment remain uncertain. METHODS: We searched the PubMed, EMBASE and Cochrane databases from their inceptions to June 2018 for randomized controlled trials that reported pulmonary function, adverse events, Asthma Quality of Life Questionnaire (AQLQ) scores, and asthmatic exacerbations resulting from anti-interleukin-5 therapy in asthma patients...
September 7, 2018: International Immunopharmacology
Cong Liu, Yana Ma, Zhenlei Su, Runzhen Zhao, Xiaoli Zhao, Hong-Guang Nie, Ping Xu, Lili Zhu, Mo Zhang, Xiumin Li, Xiaoju Zhang, Michael A Matthay, Hong-Long Ji
Background: Acute lung injury (ALI) is characterized by suppressed fibrinolytic activity in bronchoalveolar lavage fluid (BALF) attributed to elevated plasminogen activator inhibitor-1 (PAI-1). Restoring pulmonary fibrinolysis by delivering tissue-type plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasmin could be a promising approach. Objectives: To systematically analyze the overall benefit of fibrinolytic therapy for ALI reported in preclinical studies...
2018: Frontiers in Immunology
Victoria E Jackson, Jeanne C Latourelle, Louise V Wain, Albert V Smith, Megan L Grove, Traci M Bartz, Ma'en Obeidat, Michael A Province, Wei Gao, Beenish Qaiser, David J Porteous, Patricia A Cassano, Tarunveer S Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E Harris, Ani Manichaikul, Tess D Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M Sitlani, Jennifer A Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M Justesen, Allan Linneberg, Leslie A Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E Huffman, Blair H Smith, Gail Davies, Kristin M Burkart, Josyf C Mychaleckyj, Tobias N Bonten, Stefan Enroth, Lars Lind, Guy G Brusselle, Ashish Kumar, Beate Stubbe, Mika Kähönen, Annah B Wyss, Bruce M Psaty, Susan R Heckbert, Ke Hao, Taina Rantanen, Stephen B Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M Starr, Stephen S Rich, Dennis O Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G Uitterlinden, Stefan Weiss, Olli T Raitakari, Vilmundur Gudnason, Kari E North, Sina A Gharib, Don D Sin, Kent D Taylor, George T O'Connor, Jaakko Kaprio, Tamara B Harris, Oluf Pederson, Henrik Vestergaard, James G Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J Deary, R Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P Morris, M Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P Strachan, Josée Dupuis, Alanna C Morrison, Ian P Hall, Martin D Tobin, Stephanie J London
Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1 /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals...
2018: Wellcome Open Research
Wenjing Ye, Xuejun Guo, Tianyun Yang, Fengfeng Han
Chronic obstructive pulmonary disease (COPD) is common and preventable. The long-term safety of inhaled corticosteroid (ICS) use in COPD is still unclear and requires further investigation. This systematic review aimed to determine the effect of withdrawal of ICS use in COPD by examining randomized controlled trials (RCTs) and comparing their findings with those of "real-life" studies. Two independent reviewers searched for RCTs in the PubMed, EMBASE, and Cochrane databases and in CINAHL. Searches were conducted by using controlled vocabulary and free-text aliases for corticosteroids, COPD, and RCTs in each database...
July 2018: Journal of Thoracic Disease
Bingkun Xiao, Weilan Wang, Dezhi Zhang
Aim: Bevacizumab and ramucirumab are antiangiogenic monoclonal antibodies, which target vascular endothelial growth factor-A and vascular endothelial growth factor receptor-2, respectively, used in various cancers. Bleeding events have been described with these two agents. We conducted an up-to-date meta-analysis to determine the relative risk (RR) associated with the use of antiangiogenic monoclonal antibodies, bevacizumab and ramucirumab. Methods: This meta-analysis of randomized controlled trials was performed after searching PubMed, American Society for Clinical Oncology Abstracts, European Society for Medical Oncology Abstracts, and the proceedings of major conferences for relevant clinical trials...
2018: OncoTargets and Therapy
MeiLan K Han, Riju Ray, Jason Foo, Chaienna Morel, Beth Hahn
Dual bronchodilator maintenance therapy may benefit patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) versus long-acting muscarinic antagonist (LAMA) monotherapy. The efficacy and safety of US-approved LAMA/long-acting beta-agonist (LABA) combinations versus tiotropium (TIO), a LAMA, were assessed. This systematic review and meta-analysis (GSK: 206938), conducted in MEDLINE, MEDLINE In-process, and EMBASE following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, identified randomized clinical trials (>8 weeks) in moderate-to-severe COPD (per Global Initiative for Chronic Obstructive Lung Disease guidelines), receiving LAMA/LABA or TIO...
August 27, 2018: NPJ Primary Care Respiratory Medicine
Shi-Jie Liu, Zhanbing Ren, Lin Wang, Gao-Xia Wei, Liye Zou
Baduanjin exercise is a traditional Chinese health Qigong routine created by an ancient physician for health promotion. Its mild-to-moderate exercise intensity is suitable for individuals with medical conditions. Recently, a large number of trials have been conducted to investigate the effects of Baduanjin exercise in patients with chronic obstructive pulmonary disease (COPD). It remains to be determined whether Baduanjin exercise prescription is beneficial for the management of COPD patients. Thus, we conducted a systematic review to objectively evaluate the existing literature on this topic...
August 24, 2018: International Journal of Environmental Research and Public Health
Keiichi Jingu, Haruo Matsushita, Takaya Yamamoto, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Katagiri, Kazuya Takeda, Noriyuki Kadoya
PURPOSE: The purpose of this study was to determine whether pulmonary oligometastases from colorectal cancer have greater radioresistance than that of pulmonary oligometastases from other cancers and whether good local control can be achieved by dose escalation in stereotactic body radiotherapy. MATERIALS AND METHODS: This systematic review and meta-analysis were conducted according to the preferred reporting items for systematic reviews and meta-analyses statement and methods...
January 1, 2018: Technology in Cancer Research & Treatment
Anna Beckmeyer-Borowko, Medea Imboden, Faisal I Rezwan, Matthias Wielscher, Andre F S Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C Sharp, Caroline Relton, Alexander J Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W Holloway, Nicole M Probst-Hensch
BACKGROUND: The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants. A family based study of predominantly smoking adults found methylation at two Cytosine-phosphate-Guanine sites (CpGs) in SERPINA1 gene to be associated with chronic obstructive pulmonary disease risk. The objective of this study was to confirm the association of lung function with SERPINA1 methylation in general population samples by testing a comprehensive set of CpGs in the SERPINA gene cluster...
August 22, 2018: Respiratory Research
G He, Q Li, W Li, Y Ruan, X Xiong, X Song, F Zeng
BACKGROUND: Our aim was to evaluate the effect of urinary trypsin inhibitors (UTI) on interleukin, tumor necrosis factor-α (TNF-α), and polymorphonuclear neutrophil elastase (PMNE) levels as well as on pulmonary function in patients undergoing cardiopulmonary bypass. MATERIALS AND METHODS: We searched the following databases for relevant studies: PubMed, Medline (Ovid SP), Cochrane Library, Wanfang Data, China Biology Medicine Database, Chinese Periodical Database, China Knowledge Resource Integrated Database, and Chinese Clinical Trial Registry...
August 20, 2018: Herz
Cécile Tromeur, Liselotte M van der Pol, Pierre-Yves Le Roux, Yvonne Ende-Verhaar, Pierre-Yves Salaun, Christophe Leroyer, Francis Couturaud, Lucia J M Kroft, Menno V Huisman, Frederikus A Klok
Differences of computed tomography pulmonary angiography versus ventilation-perfusion lung scan in pregnant patients with suspected acute pulmonary embolism are not well-known, leading to ongoing debate on which test to choose. We searched in PUBMED, EMBASE, Web of science and Cochrane library databases and identified all relevant articles and abstracts published up to October1st 2017. We assessed diagnostic efficiency, frequency of non-diagnostic results and radiation exposure for patient and fetus. We included 13 studies for the diagnostic efficiency analysis, 30 for non-diagnostic results analysis and 22 for radiation exposure analysis...
August 16, 2018: Haematologica
AliReza JafariNezhad, Mohammad Hossein YektaKooshali
BACKGROUND: There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. METHOD: This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients...
2018: PloS One
Huy Gia Vuong, An Thi Nhat Ho, Ahmed M A Altibi, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
MET exon 14 mutation is an uncommon genomic alteration in non-small cell lung cancer (NSCLC). This meta-analysis aimed at investigating the clinicopathological and prognostic features of NSCLCs with MET exon 14 mutation in comparison with other genetic events. We performed a search in four electronic databases including PubMed, Web of Science, Scopus, and Virtual Health Library from inception to February 2018. Relevant data were extracted and pooled into odds ratio (OR), mean differences (MD), and corresponding 95% confidence intervals (CI) using the random-effect model...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Annah B Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N Nguyen, Lies Lahousse, Jeanne C Latourelle, Albert Vernon Smith, Traci M Bartz, Mary F Feitosa, Wei Gao, Tarunveer S Ahluwalia, Wenbo Tang, Christopher Oldmeadow, Qing Duan, Kim de Jong, Mary K Wojczynski, Xin-Qun Wang, Raymond Noordam, Fernando Pires Hartwig, Victoria E Jackson, Tianyuan Wang, Ma'en Obeidat, Brian D Hobbs, Tianxiao Huan, Hongsheng Gui, Margaret M Parker, Donglei Hu, Lauren S Mogil, Gleb Kichaev, Jianping Jin, Mariaelisa Graff, Tamara B Harris, Ravi Kalhan, Susan R Heckbert, Lavinia Paternoster, Kristin M Burkart, Yongmei Liu, Elizabeth G Holliday, James G Wilson, Judith M Vonk, Jason L Sanders, R Graham Barr, Renée de Mutsert, Ana Maria Baptista Menezes, Hieab H H Adams, Maarten van den Berge, Roby Joehanes, Albert M Levin, Jennifer Liberto, Lenore J Launer, Alanna C Morrison, Colleen M Sitlani, Juan C Celedón, Stephen B Kritchevsky, Rodney J Scott, Kaare Christensen, Jerome I Rotter, Tobias N Bonten, Fernando César Wehrmeister, Yohan Bossé, Shujie Xiao, Sam Oh, Nora Franceschini, Jennifer A Brody, Robert C Kaplan, Kurt Lohman, Mark McEvoy, Michael A Province, Frits R Rosendaal, Kent D Taylor, David C Nickle, L Keoki Williams, Esteban G Burchard, Heather E Wheeler, Don D Sin, Vilmundur Gudnason, Kari E North, Myriam Fornage, Bruce M Psaty, Richard H Myers, George O'Connor, Torben Hansen, Cathy C Laurie, Patricia A Cassano, Joohon Sung, Woo Jin Kim, John R Attia, Leslie Lange, H Marike Boezen, Bharat Thyagarajan, Stephen S Rich, Dennis O Mook-Kanamori, Bernardo Lessa Horta, André G Uitterlinden, Hae Kyung Im, Michael H Cho, Guy G Brusselle, Sina A Gharib, Josée Dupuis, Ani Manichaikul, Stephanie J London
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses...
July 30, 2018: Nature Communications
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