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Anna L McGuire, John Yee
Background: Prolonged alveolar air leak (PAL) is the most common adverse event following pulmonary resection. It carries morbidity for patients by increasing empyema risk, and for hospital administration with the cost of prolonged length of hospital stay (LOS). Intra-operative sealant technology is available to surgeons, and may decrease PAL. Our aim was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) on the effect of intraoperative polymeric sealant use on PAL, empyema, and LOS...
November 2018: Journal of Thoracic Disease
Philippe Robin, Maggie Eddy, Lindsey Sikora, Pierre-Yves Le Roux, Marc Carrier, Francis Couturaud, Benjamin Planquette, Raffaele Pesavento, Marc Rodger, Pierre-Yves Salaun, Grégoire Le Gal
BACKGROUND: In patients with a first, unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulant therapy (AT) is controversial due to tightly balanced risks and benefits of indefinite anticoagulation. The objective of this study is to assess among patients with a first acute pulmonary embolism (PE) who received ≥3 months of AT and thereafter had a planar lung scan, whether residual pulmonary vascular obstruction (RPVO) is associated with VTE recurrence after discontinuation of AT...
November 28, 2018: BMJ Open
Angela Koutsokera, Rhea A Varughese, Jenna Sykes, Ani Orchanian-Cheff, Prakesh S Shah, Cecilia Chaparro, Elizabeth Tullis, Lianne G Singer, Anne L Stephenson
BACKGROUND: Mortality risk stratification is essential in lung transplantation (LTx) to allow listing, prioritization and mitigating strategies. In cystic fibrosis (CF) patients, predictors of post-LTx mortality are not established. METHODS: For this systematic review and meta-analysis, seven databases were searched until January 3, 2018 to identify predictors of post-LTx mortality in CF. We excluded studies of multi-organ transplantation, re-transplantation and graft survival...
October 25, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Claudia Gulea, Rosita Zakeri, Jennifer K Quint
INTRODUCTION: Patients with chronic obstructive pulmonary disease (COPD) who have a clinical indication for beta-blocker therapy, are often not prescribed such medication, despite evidence suggesting that beta-blockers are not associated with adverse respiratory outcomes. The primary objective of this systematic review and meta-analysis is to examine the class effect of beta-blocker use in patients with COPD. We will focus on a broad range of endpoints including, clinical, safety, and patient-centric outcomes such as health related quality of life (HRQoL) and functional capacity...
November 13, 2018: BMJ Open
Binghu Jiang, Morgan A Mcclure, Tianming Chen, Shilin Chen
OBJECTIVE: The objective of this study was to compare the efficacy and safety of radiofrequency ablation (RFA), cryoablation, and microwave ablation (MWA) for patients with lung malignancies. METHODS: We performed a network meta-analysis to identify both direct and indirect evidence from relevant trials by searching PubMed, Embase, and the Cochrane Library to December 31, 2017, for the treatment of malignant lung tumors with the use of RFA, MWA, or cryoablation...
October 2018: Annals of Thoracic Medicine
Cheng Xu, Yu-Pei Chen, Xiao-Jing Du, Jin-Qi Liu, Cheng-Long Huang, Lei Chen, Guan-Qun Zhou, Wen-Fei Li, Yan-Ping Mao, Chiun Hsu, Qing Liu, Ai-Hua Lin, Ling-Long Tang, Ying Sun, Jun Ma
OBJECTIVE: To provide a complete toxicity profile, toxicity spectrum, and a safety ranking of immune checkpoint inhibitor (ICI) drugs for treatment of cancer. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched to include relevant studies published in English between January 2007 and February 2018. REVIEW METHODS: Only head-to-head phase II and III randomised controlled trials comparing any two or three of the following treatments or different doses of the same ICI drug were included: nivolumab, pembrolizumab, ipilimumab, tremelimumab, atezolizumab, conventional therapy (chemotherapy, targeted therapy, and their combinations), two ICI drugs, or one ICI drug with conventional therapy...
November 8, 2018: BMJ: British Medical Journal
Yayuan Zheng, Jianhong Zhu, Yuyu Liu, Weiguang Lai, Chunyu Lin, Kaifen Qiu, Junyan Wu, Weimin Yao
OBJECTIVE: To compare the rate of moderate to severe exacerbations between triple therapy and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease (COPD). DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: PubMed, Embase, Cochrane databases, and clinical trial registries searched from inception to April 2018. ELIGIBILITY CRITERIA: Randomised controlled trials comparing triple therapy with dual therapy or monotherapy in patients with COPD were eligible...
November 6, 2018: BMJ: British Medical Journal
Yun Gao, Kaifeng Deng, Xuexiang Liu, Meiyu Dai, Xiaoli Chen, Jifei Chen, Jianming Chen, Yujie Huang, Shengming Dai, Jingfan Chen
INTRODUCTION: Currently, studies have shown that microRNA-93 (miR-93) can be an oncogene or a tumor suppressor in different kinds of cancers. The role of miR-93 in human cancers is inconsistent and the underlying mechanism on the aberrant expression of miR-93 is complicated. METHODS: We first conducted gene enrichment analysis to give insight into the prospective mechanism of miR-93. Second, we performed a meta-analysis to evaluate the clinical value of miR-93. Finally, a validation test based on quantitative polymerase chain reaction (qPCR) was performed to further investigate the role of miR-93 in pan-cancer...
November 2, 2018: Journal of Cellular Biochemistry
Jing Guo, Bin Li, Wenyuan Li, Yi Pan, Zhichao Wang, Yuxiao Wu, Fei Wang
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a major public health problem worldwide. There is no curative treatment for IPF except lung transplantation. Chinese herbal medicines (CHMs) are widely used in the treatment of IPF in China. However, their effectiveness and safety are still obscure and deserve further investigation. The aim of the study was to assess the efficacy and safety of CHMs in treating IPF compared with N-acetylcysteine (NAC). METHODS: This review summarizes and meta-analyzes randomized controlled trials (RCTs) of CHMs for the treatment of IPF...
November 2018: Medicine (Baltimore)
Lystra P Hayden, Michael H Cho, Benjamin A Raby, Terri H Beaty, Edwin K Silverman, Craig P Hersh
BACKGROUND: Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood asthma in adult smokers from the COPDGene Study. We hypothesize that childhood asthma is associated with decreased lung function, increased risk for COPD, and that a genome-wide association study (GWAS) will show association with established asthma variants. METHODS: We evaluated current and former smokers ages 45-80 of non-Hispanic white (NHW) or African American (AA) race...
October 29, 2018: Respiratory Research
M J Nasiri, M Heidary, T Azimi, H Goudarzi, P Tabarsi, D D Sarokhalil, M M Feizabadi
Mycobacterium simiae is one of the most common nontuberculous mycobacteria (NTM) microorganisms causing lung disease in many countries in the world. A reliable estimate of the extent of M. simiae pulmonary disease has not been well investigated in Iran. We systematically searched multiple databases to identify relative studies. Studies were excluded if they did not use the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) diagnostic criteria for NTM diseases. Data were extracted independently and in duplicate...
November 2018: New Microbes and New Infections
Heekyung Kim, Soon Ho Yoon, Hyunsook Hong, Seokyung Hahn, Jin Mo Goo
This study aimed to determine whether a surgical lung biopsy is essential for IPF diagnosis with the possible UIP CT pattern. We performed literature searches of the MEDLINE and EMBASE databases and included studies that conducted a radiologic-pathologic evaluation of IPF according to the 2011 guideline. Outcomes were pooled using a random-effects model. Twelve studies were included. Pooled proportions of IPF for a UIP pattern were 99% (95%CI, 93% to 100%; I2  = 51.7%) and for a possible UIP pattern were 94% (scenario inclusive of probable IPF; 95%CI, 87% to 99%; I2  = 82...
October 26, 2018: Scientific Reports
Yaqing Wang, Xin Liu, Yong Jia, Jiao Xie
AIMS AND OBJECTIVES: The aim of this review was to assess the effects of breathing exercises on postoperative pulmonary complications (PPCs), pulmonary function, 6-min walk distance (6MWD) and the length of hospital stay (LOS) in lung cancer patients undergoing lung surgery. BACKGROUND: Lung cancer patients undergoing lung resection have poor pulmonary function and multiple PPCs. Breathing exercises may improve these symptoms. DESIGN: Systematic literature review and meta-analysis was conducted...
October 24, 2018: Journal of Clinical Nursing
Leonardo Jönck Staub, Roberta Rodolfo Mazzali Biscaro, Erikson Kaszubowski, Rosemeri Maurici
BACKGROUND: Lung ultrasound can accelerate the diagnosis of life-threatening diseases in adults with respiratory symptoms. OBJECTIVE: Systematically review the accuracy of lung ultrasonography (LUS) for emergency diagnosis of pneumonia, acute heart failure, and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma in adults. METHODS: PubMed, Embase, Scopus, Web of Science, and LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde; until 2016) were searched for prospective diagnostic accuracy studies...
October 9, 2018: Journal of Emergency Medicine
Barbara Joschtel, Sjaan R Gomersall, Sean Tweedy, Helen Petsky, Anne B Chang, Stewart G Trost
Introduction: Chronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease. Method: Five databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease...
2018: BMJ Open Sport & Exercise Medicine
H F van der Molen, G J de Groene, C T J Hulshof, M H W Frings-Dresen
To support occupational physicians in their assessment and notification of occupational diseases, diagnostic registration guidelines are developed with information about associations between work-related risk factors and diseases. The objective of this review of systematic reviews is to examine whether work-related risk factors are associated with chronic pulmonary obstructive disease (COPD). We searched the electronic database of Medline for systematic reviews published between 1 January 2009 and 20 June 2017...
October 9, 2018: Journal of Clinical Medicine
Yu Guo, Mingmin Xu, Meiqi Ji, Jialei Zhang, Qingchuan Hu, Zeren Wei, Jian Yan, Yue Chen, Jiaxuan Lyu, Xiaoqian Shao, Ying Wang, Jiamei Guo, Yulong Wei
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide with a substantial and increasing social and economic burden. Liuzijue Qigong is a kind of traditional Chinese Qigong exercises that Traditional Chinese Medicine practitioners prescribe to individuals with COPD to strengthen the internal organs' function. Liuzijue Qigong was recommended for use in COPD rehabilitation, and some clinical trials indicate that Liuzijue Qigong would produce better functional capacity and quality of life of individuals with COPD...
October 2018: Medicine (Baltimore)
Christopher A Collura, Kristin C Mara, Amy L Weaver, Reese H Clark, William A Carey
OBJECTIVE: Meta-analysis of individual-patient clinical trial data suggests that inhaled nitric oxide (iNO) improves respiratory outcomes in premature African American neonates. We hypothesized that early iNO therapy would be associated with lower mortality and less chronic lung disease (CLD) in extremely premature African American neonates. STUDY DESIGN: We conducted a retrospective cohort study of propensity score- and race-matched neonates 22-29 weeks gestation who were mechanically ventilated for treatment of respiratory distress and associated pulmonary hypertension (RDS + PPHN)...
October 1, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Shuo Jiang, Ji Zhou, Jia Zhang, Xihao Du, Xuejiao Zeng, Kun Pan, Yuquan Xie, Haidong Kan, Qinghua Sun, Jing Cai, Jinzhuo Zhao
Lots of epidemiological and experimental studies have found that ambient fine particulate matter (PM2.5 ) exposure is associated with the development of cardiopulmonary diseases, obesity and diabetes. This study focused on the effects of cumulative PM2.5 exposure on pulmonary and systemic inflammation and insulin resistance. Thirty-two 6-week-old male Balb/c mice were randomly divided into four groups (FA, PM, WEEK and DAY groups) and were continuously or intermittently exposed to concentrated PM2.5 or filtered air (FA) for four weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS")...
September 24, 2018: Inhalation Toxicology
Lu-Lu He, Lei Zhang, Lei Jiang, Feng Xu, Dong-Sheng Fei
INTRODUCTION: Anti-interleukin-5 therapy has been proposed as a novel and promising treatment option in asthma treatment. However, the optimum monoclonal antibodies for asthma treatment remain uncertain. METHODS: We searched the PubMed, EMBASE and Cochrane databases from their inceptions to June 2018 for randomized controlled trials that reported pulmonary function, adverse events, Asthma Quality of Life Questionnaire (AQLQ) scores, and asthmatic exacerbations resulting from anti-interleukin-5 therapy in asthma patients...
September 7, 2018: International Immunopharmacology
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