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Acute Pulmonary Hypertension

Yanjun Guo, Xin Yang, Jialin He, Jingjing Liu, Shiming Yang, Hui Dong
Ca2+ -sensing receptor (CaSR), a member of G protein-coupled receptor family, is widely expressed in the vascular system, including perivascular neurons, vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). When stimulated, CaSR can further increase the cytosolic Ca2+ concentration ([Ca2+ ]cyt ) in two ways: intracellular Ca2+ release from endo/sarcoplasmic reticulum (ER/SR) and extracellular Ca2+ entry through Ca2+ -permeable cation channels. In endothelium, increased Ca2+ subsequently activate nitric oxide synthase (NOS) and intermediate conductance Ca2+ -activated K+ channels (IKCa), resulting in vasodilation through NOS-mediated NO release or membrane hyperpolarization...
August 8, 2018: Life Sciences
Ketul R Chaudhary, Yupu Deng, Colin M Suen, Mohamad Taha, Thomas H Petersen, Shirley H J Mei, Duncan J Stewart
BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure and death. Parenteral prostaglandins, including treprostinil, a prostacyclin analogue, represent the most effective medical treatment for severe PAH. We investigated the effect of treprostinil on established severe PAH and underlying mechanisms using the rat SU5416 (SU, a vascular endothelial growth factor receptor-2 inhibitor)-chronic hypoxia (Hx) model of PAH...
August 11, 2018: British Journal of Pharmacology
Adam S Himebauch, Nadir Yehya, Yan Wang, Thomas Conlon, Todd J Kilbaugh, Francis X McGowan, Laura Mercer-Rosa
OBJECTIVES: The prevalence and importance of early right ventricular dysfunction and pulmonary hypertension in pediatric acute respiratory distress syndrome are unknown. We aimed to describe the prevalence of right ventricular dysfunction and pulmonary hypertension within 24 hours of pediatric acute respiratory distress syndrome diagnosis and their associations with outcomes. DESIGN: Retrospective, single-center cohort study. SETTING: Tertiary care, university-affiliated PICU...
August 7, 2018: Critical Care Medicine
Jui-Yuan Chung, Chung-Han Ho, Yi-Chen Chen, Jiann-Hwa Chen, Hung-Jung Lin, Jhi-Joung Wang, Chien-Chin Hsu, Chien-Cheng Huang
BACKGROUND: Methanol poisoning (MP) often causes acute mortality and morbidities; however, the association between MP and subsequent mortality has not been well studied. METHODS: We conducted a nationwide population-based cohort study by identifying 621 participants with MP from the Nationwide Poisoning Database and 6210 participants without MP from the Longitudinal Health Insurance Database 2000 by matching the index date at a 1:10 ratio between 1999 and 2012. Comparison of the mortality rate between the two cohorts was performed by following up until 2013...
August 7, 2018: BMC Public Health
Sandro Ninni, Claire Seunes, Staniel Ortmans, Stéphanie Mouton, Thomas Modine, Mohamed Koussa, Bruno Jegou, Jean-Louis Edme, Bart Staels, David Montaigne, Augustin Coisne
BACKGROUND: A relevant morning-afternoon variation in ischemia-reperfusion (IR) insult after cardiac surgery has been demonstrated. We speculated that the biorhythm might also impact systemic reactions involved in acute kidney injury (AKI) following cardiac surgery. We aimed at investigating incidence, determinants and prognostic impact of AKI in a large cohort of patients referred for surgical aortic valve replacement (SAVR) according to surgery time-of-day. METHODS: Between 2009 and 2015, we explored consecutive patients referred to our Heart Valve Center (CHU Lille) for first SAVR...
July 19, 2018: International Journal of Cardiology
Jeremy A Miles, Leonid Garber, Subha Ghosh, Daniel M Spevack
BACKGROUND: Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, pulmonary hypertension and left ventricular hypertrophy and their association with various subtypes of stroke, long-term outcomes of recurrent stroke, and all-cause mortality. METHODS AND RESULTS: Computed tomography and magnetic resonance imaging brain imaging and TTE reports were reviewed for 2464 consecutive patients referred for TTE as part of a workup for acute stroke between 1/1/01 and 9/30/07...
July 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Leonardo Rangel-Castilla, Adnan H Siddiqui
We present a case of a patient with pseudotumor cerebri (PC) and transverse/sigmoid junction sinus (TSJS) stenosis treated with stenting venoplasty. A 54-yr-old man with a history of hypertension, hyperlipidemia, and chronic obstructive pulmonary disease presented with subacute onset of progressive headaches, blurred vision, and papilledema. He was clinically diagnosed with PC. Left TSJS stenosis was suspected on magnetic resonance venography and confirmed with digital subtraction angiography and venography...
July 30, 2018: Operative Neurosurgery (Hagerstown, Md.)
Kamil Jonas, Wojciech Magoń, Marcin Waligóra, Michał Seweryn, Piotr Podolec, Grzegorz Kopeć
Introduction Metabolic dysregulation has been recognized as a prognostic marker in idiopathic pulmonary arterial hypertension (IPAH). Objectives We aimed to investigate the association between cardiometabolic risk factors and vascular reactivity (VR) of pulmonary arteries in IPAH patients. Patients and methods Between June 2009 and January 2015 we recruited 66 consecutive IPAH patients. We assessed main cardiometabolic risk factors, inflammatory markers, and markers of IPAH severity. Hemodynamic evaluation included pulmonary VR testing with the use of inhaled nitric oxide...
July 27, 2018: Polish Archives of Internal Medicine
Beatrice Pezzuto, Kevin Forton, Roberto Badagliacca, Yoshiki Motoji, Vitalie Faoro, Robert Naeije
NEW FINDINGS: What is the central question of this study? Right ventricular dyssynchrony in severe pulmonary hypertension is associated with a poor prognosis. However, it has recently be observed in patients with lung or connective tissue disease and pulmonary artery pressure at the upper limits of normal. The mechanisms of right ventricular dyssynchrony in pulmonary hypertension remain uncertain. What is the main finding and its importance? Acute hypoxic breathing, but not normoxic exercise, induces an increase in right ventricular dyssynchrony detected at speckle tracking echocardiography in healthy subjects...
July 28, 2018: Experimental Physiology
Emilie Clay, Aurélien Jamotte, Peter Verhamme, Alexander T Cohen, Ben A Van Hout, Pearl Gumbs
Background : Venous thromboembolism (VTE), which includes pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common acute cardiovascular disease and represents an important burden for patients and payers. Objective : The aim was to estimate the cost-effectiveness of edoxaban, a non-VKA oral anticoagulant vs. warfarin, the currently most prescribed treatment for VTE in the UK. Study design : A Markov model was built using data from the Hokusai-VTE randomised controlled trial to estimate the lifetime costs and quality-adjusted life years (QALYs) in patients with VTE treated with edoxaban or warfarin over a lifetime horizon, from the UK National Health Services perspective...
2018: Journal of Market Access & Health Policy
Vinay Bahadur Panday, Ivandito Kuntjoro, Ting Ting Low, James W L Yip, Edgar Tay Lik Wui
No abstract text is available yet for this article.
July 16, 2018: QJM: Monthly Journal of the Association of Physicians
Shuhei Miura, Yutaka Iba, Akira Yamada
No abstract text is available yet for this article.
August 1, 2018: European Journal of Cardio-thoracic Surgery
Murat Gök, Alparslan Kurtul, Murat Harman, Meryem Kara, Muhammed Süleymanoglu, Ender Ornek
In this study, the association between the right ventricular dysfunction (RVD) and CHA2DS2-VASc (C: congestive heart failure or left ventricular systolic dysfunction, H: hypertension, A: age of ≥ 75 years, D: diabetes mellitus, S: previous stroke, V: vascular disease, A: age between 65 and 74 years, Sc: female gender) scores was investigated in patients with acute pulmonary thromboembolism (PTE). The patients have been assigned to 3 subgroups as massive, submassive, and nonmassive PTE. The CHA2DS2-VASc scores were calculated for all of the patients, and the scores have been classified into 3 groups as the scores between 0 and 1, the scores of 2, and the scores of 3 and over...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
Ana Carolina B Pordeus, Leila Katz, Mariana C Soares, Sabina B Maia, Melania M R Amorim
Acute pulmonary edema (PE) affects 0.08% to 1.5% of women during pregnancy and in the postpartum. At the Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), acute PE accounts for 1.5% of admissions to the obstetric intensive care unit (ICU) and occurs in 9.3% of the patients admitted with near miss criteria. This study was conducted to describe the clinical/epidemiological profile of patients with acute PE in IMIP's obstetric ICU.A case series of 50 patients with acute PE in an obstetric ICU in northeastern Brazil between August 2012 and March 2015...
July 2018: Medicine (Baltimore)
Sanjay Pant, Chiara Corsini, Catriona Baker, Tain-Yen Hsia, Giancarlo Pennati, Irene Vignon-Clementel
GOAL: This manuscript evaluates atrioventricular valve regurgitation (AVVR) in babies born with an already very challenging heart condition, i.e. with single ventricle physiology. Although the second surgery that single ventricle patients undergo is thought to decrease AVVR, there is much controversy in the clinical literature about AVVR treatment. METHODS: The effect of atrioventricular valve regurgitation (AVVR) on Stage 1 haemodynamics and resulting acute changes from conversion to Stage 2 circulation in single ventricle patients are analysed through lumped parameter models...
January 25, 2018: IEEE Transactions on Bio-medical Engineering
Ji-Hyun Lee, Ji-Yoon Jung, Sun-Woo Park, In-Kyung Song, Eun-Hee Kim, Hee-Soo Kim, Jin-Tae Kim
BACKGROUND: The objective of this retrospective study was to determine the risk factors for acute kidney injury (AKI), including albumin, in children who underwent cardiac surgery. In addition, we evaluated the association between preoperative serum albumin level and postoperative AKI in these patients. METHODS: This retrospective study included 505 pediatric patients who underwent congenital cardiac surgery. Preoperative and perioperative risk factors for AKI, including serum albumin level, were assessed...
July 11, 2018: Acta Anaesthesiologica Scandinavica
Raneem Fallatah, Abdelfatah Elasfar, Osama Amoudi, Mohamed Ajaz, Ibraheem AlHarbi, Reda Abuelatta
To the best of our knowledge, there have not been any reports of total transcatheter approach including stenting of severe coarctation of the aorta (CoA), transcatheter aortic valve replacement (TAVR) for concomitant severe aortic valve stenosis, and percutaneous coronary intervention (PCI) to treat significant coronary artery disease in a single patient. We report a 70-year-old female, who presented with uncontrolled hypertension and acute decompensated heart failure (ADHF) and was found to have severe CoA, severe bicuspid aortic valve (BAV) stenosis, and significant proximal left anterior descending (LAD) coronary artery disease...
July 2018: Journal of the Saudi Heart Association
Liang Luo, Yangli Liu, Dubo Chen, Fengjia Chen, Hai Bing Lan, Canmao Xie
Chronic obstructive pulmonary disease (COPD) is one of the common and underdiagnosed diseases with the highest morbidity and mortality in the world. The development of COPD can lead to pulmonary vascular remodeling and pulmonary hypertension, further causing the occurrence of pulmonary heart disease. Therefore, attenuation of pulmonary vascular remodeling and pulmonary hypertension caused by COPD can significantly delay cardiovascular complications. In the study, we firstly found that the expression of CD30 and CD30L was increased in COPD...
2018: BioMed Research International
Massimo Pieraccini, Susanna Guerrini, Edoardo Laiolo, Alessio Puliti, Giandomenico Roviello, Leonardo Misuraca, Genni Spargi, Ugo Limbruno, Mauro Breggia, Morando Grechi
PURPOSE: The aim of this study is to assess the feasibility of aspiration mechanical thrombectomy in patients with massive and submassive pulmonary embolism (PE) and contraindications to thrombolysis. MATERIALS AND METHODS: Eighteen patients presenting massive (8/18) or submassive (10/18) PE were prospectively enrolled between October 2016 and November 2017. All the patients enrolled had contraindications to thrombolysis (haemorrhagic stroke n = 1, ischaemic stroke in the preceding 6 months n = 7, central nervous system damage or neoplasms n = 1, recent major trauma/surgery/head injury in the preceding 3 weeks n = 5, gastrointestinal bleeding within the last month n = 4)...
July 6, 2018: Cardiovascular and Interventional Radiology
Walter Ageno, Beverley J Hunt
Hospitalized acute medically ill patients are vulnerable to venous thromboembolism (VTE), known as hospital-acquired thrombosis (HAT). The elevated risk of HAT is usually due to a combination of factors, with immobility and a prothrombotic state due to acute illness being the most frequent. The HAT risk persists well after hospital discharge, with more than half of events occurring after patient release. These HAT events may be fatal, and patients who survive the initial event may be subject to VTE recurrence, chronic discomfort from post-thrombotic syndrome and, although rare, may develop chronic thrombo-embolic pulmonary hypertension, which is often debilitating...
May 2018: European Heart Journal Supplements: Journal of the European Society of Cardiology
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