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Acute Pulmonary Hypertension

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https://www.readbyqxmd.com/read/30553991/doppler-defined-pulmonary-hypertension-in-sepsis-and-septic-shock
#1
Saraschandra Vallabhajosyula, Jeffrey B Geske, Mukesh Kumar, Rahul Kashyap, Kianoush Kashani, Jacob C Jentzer
BACKGROUND: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood. METHODS: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Patients with prior PH, pulmonary stenosis, or without measurable TRV were excluded...
December 8, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30553162/prescription-patterns-of-direct-oral-anticoagulants-in-pulmonary-embolism-a-prospective-multicenter-french-registry
#2
Romain Chopard, Jean Noel Andarelli, Sébastien Humbert, Nicolas Falvo, Mathilde Morel-Aleton, Benjamin Bonnet, Gabriel Napporn, Elsa Kalbacher, Laurent Obert, Bruno Degano, Gilles Cappelier, Yves Cottin, François Schiele, Nicolas Meneveau
BACKGROUND: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice. METHODS: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Clinical data and 6-month outcomes, including death, recurrent venous thromboembolism (VTE), bleeding, and chronic thromboembolic pulmonary hypertension (CTEPH) were recorded prospectively...
December 8, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30548748/sex-differences-in-1-year-mortality-risks-in-older-patients-experiencing-a-first-acute-heart-failure-hospitalization
#3
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Sergi Yun, Jonathan Franco, Albert Ariza-Solé, Xavier Corbella
AIM: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex. METHODS: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Mortality was assessed using multivariate Cox analysis. RESULTS: There were 648 (57...
December 12, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/30545978/paediatric-pulmonary-arterial-hypertension-updates-on-definition-classification-diagnostics-and-management
#4
Erika B Rosenzweig, Steven H Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D Dunbar Ivy, Rolf M F Berger
Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for the care of children with PAH, as presented by the Paediatric Task Force of the 6th World Symposium on Pulmonary Hypertension. We provide updates of the current definition, epidemiology, classification, diagnostics and treatment of paediatric PAH, and identify critical knowledge gaps...
December 13, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30537276/clinical-and-echocardiography-predictors-of-response-to-inhaled-nitric-oxide-in-hypoxic-preterm-neonates
#5
Mohamed Shalabi Ahmed, Regan E Giesinger, Mohamed Ibrahim, Michelle Baczynski, Deepak Louis, Karl P McNamara, Amish Jain, Dany E Weisz, Patrick J McNamara
AIM: To evaluate the clinical and echocardiography modulators of treatment response in hypoxemic preterm infants exposed to inhaled nitric oxide (iNO). METHODS: In this multicentre retrospective study, clinical parameters, including oxygenation, ventilation and haemodynamics, were collected for preterm infants <36 weeks gestation before and 2 h after initiation of iNO for acute hypoxemia. Comprehensive echocardiography, performed near the time iNO initiation, was analysed by experts blind to the clinical course...
December 8, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30536416/safeguarding-older-adults-with-dementia-depression-and-delirium-in-a-temporary-disaster-shelter
#6
Cynthia L Holle, Mary A Turnquist, James L Rudolph
Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. They provide care and comfort to those suffering from the distress, anxiety, and fear caused by disasters...
December 9, 2018: Nursing Forum
https://www.readbyqxmd.com/read/30534516/chronic-kidney-disease-in-the-emergency-centre-a-prospective-observational-study
#7
Babawale Taslim Bello, Olalekan Ezekiel Ojo, Olapeju Funke Oguntunde, Adedotun Ademola Adegboye
Introduction: Late presentation, usually to the emergency centre (EC), is frequently reported among patients with chronic kidney disease (CKD) in resource-limited settings, and is known to be associated with poor outcomes. This study aims to describe the pattern of EC presentation of adults with CKD in Southwest Nigeria. Methods: This was a prospective observational study of 158 consecutively presenting CKD patients at the EC of two tertiary hospitals in Southwest Nigeria...
December 2018: African Journal of Emergency Medicine Revue Africaine de la Médecine D'urgence
https://www.readbyqxmd.com/read/30529287/efficacy-and-safety-of-a-novel-nitric-oxide-generator-for-the-treatment-of-neonatal-pulmonary-hypertension-experimental-and-clinical-studies
#8
Fernanda Blasina, Lucía Vaamonde, Fernando Silvera, Gonzalo Solla, Juan Andrés Abin-Carriquiry, Carmen Gutiérrez, Pilar Beltramo, Irene García, Miguel Martell
Persistent pulmonary hypertension of the newborn (PPHN) is a complex pathology resulting from a failure of the post-natal reduction in pulmonary vascular resistance leading to hypoxemia. The standard therapy is inhaled Nitric Oxide (NO) improving oxygenation but its availability is limited, especially in hospitals with restricted financial resources. We evaluated the efficacy and safety of a new device generating NO (TAS + PLUS), in an experimental piglet models of pulmonary hypertension (PH), and we later tested its application in a pilot study of newborn patients suffering from PPHN...
December 7, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30526491/cardiovascular-risk-factors-differently-affect-the-survival-of-patients-undergoing-manual-or-mechanical-resuscitation
#9
Dóra Ujvárosy, Veronika Sebestyén, Tamás Pataki, Tamás Ötvös, István Lőrincz, György Paragh, Zoltán Szabó
BACKGROUND: Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device-assisted resuscitation as well as the effects of cardiovascular risk factors on the outcome of resuscitation. METHODS: In our retrospective, randomised 3-year study the data of adult patients suffering non-traumatic, out-of-hospital, sudden cardiac death (SCD) were analysed (n = 287)...
December 7, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/30526117/statin-use-is-associated-with-less-postoperative-cardiac-arrhythmia-after-total-hip-arthroplasty
#10
Michael J Chen, Abiram Bala, James I Huddleston, Stuart B Goodman, William J Maloney, Alistair J Aaronson, Derek F Amanatullah
INTRODUCTION: While statins have been found to reduce postoperative atrial fibrillation after cardiac surgery, little is known about their use in total hip arthroplasty (THA). This study investigated if statins would similarly reduce postoperative arrhythmias in patients undergoing THA. METHODS: We queried a large Medicare and private-payer database from 2005 to 2012 and identified 12,075 patients who were on a statin prior to THA. We then age and sex matched 34,446 non-statin users who underwent THA...
December 10, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/30524200/galectin-1-as-an-emerging-mediator-of-cardiovascular-inflammation-mechanisms-and-therapeutic-opportunities
#11
REVIEW
Ignacio M Seropian, Germán E González, Sebastián M Maller, Daniel H Berrocal, Antonio Abbate, Gabriel A Rabinovich
Galectin-1 (Gal-1), an evolutionarily conserved β -galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presenting cells. In addition, this lectin promotes angiogenesis by co-opting the vascular endothelial growth factor receptor (VEGFR) 2 signaling pathway. Since a coordinated network of immunomodulatory and proangiogenic mediators controls cardiac homeostasis, this lectin has been proposed to play a key hierarchical role in cardiac pathophysiology via glycan-dependent regulation of inflammatory responses...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/30523661/standardization-of-nitric-oxide-inhalation-in-extremely-preterm-infants-in-japan
#12
Jun Shiraishi, Satoshi Kusuda, Kazutoshi Cho, Atsushi Nakao, Takehiko Hiroma, Hiroshi Sugiura, Satoshi Suzuki, Makoto Oshiro, Seiji Yoshimoto, Shinichi Watabe
BACKGROUND: In perinatal medicine, inhaled nitric oxide (iNO) has been an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn (PPHN) and hypoxemic respiratory failure (HRF). However, its use in more premature infants is controversial. To evaluate the current clinical practices regarding use of acute inhaled nitric oxide (iNO) therapy in extremely preterm infants, a nationwide survey was conducted in Japan. METHODS: A questionnaire survey was conducted from May to September, 2015...
December 6, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/30518007/-multicenter-investigation-of-extracorporeal-membrane-oxygenation-application-in-pediatric-intensive-care-unit-in-china
#13
G F Yan, X D Cai, C B Zhou, X Y Hong, Y Wang, C M Zhang, Z H Yang, Y C Zhang, Y Cui, Y Q Cui, Y B Cheng, S Y Qian, P F Zhang, Y P Jin, X D Zhu, H Gao, Z P Li, X L Lu, H J Miao, Q Y Zhang, Y M Li, W G Yang, C Y Liu, B Li, Y Li, Z J Bo, J P Chu, X Wang, G P Lu
Objective: To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. Methods: In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. Results: By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30506974/in-hospital-outcomes-of-transcatheter-mitral-valve-repair-with-mitraclip-in-patients-with-pulmonary-hypertension-insights-from-the-national-inpatient-sample
#14
Abdelrahman Ahmed, Emmanuel Akintoye, Oluwole Adegbala, Ahmed Yassin, Ahmed Subahi, Lamin Bangura, Hossam Abubakar, Mahir Elder, Mohamed Shokr, Luis Afonso
BACKGROUND: Periprocedural outcomes of transcatheter mitral valve repair (TMVR) with Mitraclip in patients with pulmonary hypertension (PH) are not well studied. METHODS: Patients who underwent TMVR with Mitraclip between 2011 and 2015 were identified using the National Inpatient Sample (NIS). All missing variables were excluded from the analysis and therefore, complete case analysis was performed. RESULTS: A total of 1,037 patients underwent TMVR with Mitraclip between 2011 and 2015...
December 2, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30504113/-pulmonary-hypertension-as-presentation-in-multiple-myeloma
#15
Fernando Di Tullio, Glenda Ernst, Félix Vigovich, Claudia Shanley, Felipe Chertcoff, Martín Bosio
Multiple myeloma is a hematologic disease, which accounts for 15% of hematologic malignancies. The average age of onset is between 65-70 years and is very rare in young patients, as 2% are under 40 years old. We present a case of 36-year-old women with history of 20 pack years (p/y) smoking, who complaints of dyspnea associated with signs of right cardiac overload, anemia, proteinuria, elevated acute phase reactants and spirometry pattern suggestive of moderately-severe restriction and severe drop in diffusing capacity for carbon monoxide (DLCO)...
2018: Medicina
https://www.readbyqxmd.com/read/30501615/extracorporeal-membrane-oxygenation-with-prone-position-ventilation-successfully-rescues-infantile-pertussis-a-case-report-and-literature-review
#16
Jingyi Shi, Chunxia Wang, Yun Cui, Yucai Zhang
BACKGROUND: Bordetella pertussis can cause fatal illness with severe acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PHT). CASE PRESENTATION: A 6-month-old non-vaccinated boy with B. pertussis infection who developed ARDS was treated by extracorporeal membrane oxygenation (ECMO). During his ECMO support stage, sudden occurred decreasing of ECMO flow implied increasing intrathoracic pressure. The airway spasm followed caused sudden drop of ventilator tidal volume as well as poor lung compliance...
November 30, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30499214/clinical-features-of-canine-pulmonary-veno-occlusive-disease-and-pulmonary-capillary-hemangiomatosis
#17
Carol R Reinero, L Ari Jutkowitz, Nathan Nelson, Isabelle Masseau, Samuel Jennings, Kurt Williams
BACKGROUND: Histologic features of pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description. OBJECTIVES: To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH. ANIMALS: Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small-sized to medium-sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both...
November 29, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30496427/magnetic-resonance-direct-thrombus-imaging-for-pre-operative-assessment-of-acute-thrombosis-in-chronic-thromboembolic-pulmonary-hypertension
#18
Frederikus A Klok, Diethard Pruefer, Andreas Rolf, Stavros V Konstantinides
No abstract text is available yet for this article.
November 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30485885/acute-respiratory-failure-and-pulmonary-complications-in-end-stage-liver-disease
#19
Nida Qadir, Tisha Wang, Igor Barjaktarevic, Steven Y Chang
Acute respiratory failure has a high mortality in patients with end-stage liver disease (ESLD). These patients may develop acute respiratory failure for reasons specific to advanced liver disease, including hepatopulmonary syndrome, portopulmonary hypertension, and hepatic hydrothorax. They may also develop respiratory complications due to conditions seen in the general intensive care unit population to which ESLD patients are at higher risk, including infection, volume overload, and the acute respiratory distress syndrome...
October 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30485762/cell-death-in-the-lung-the-apoptosis-necroptosis-axis
#20
Maor Sauler, Isabel S Bazan, Patty J Lee
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. As an understanding of the cellular mechanisms that mediate regulated cell death continues to grow, there is increasing evidence that these pathways are implicated in the pathogenesis of many pulmonary disorders...
November 28, 2018: Annual Review of Physiology
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