Fenna M Krienen, Kirsten M Levandowski, Heather Zaniewski, Ricardo C H Del Rosario, Margaret E Schroeder, Melissa Goldman, Martin Wienisch, Alyssa Lutservitz, Victoria F Beja-Glasser, Cindy Chen, Qiangge Zhang, Ken Y Chan, Katelyn X Li, Jitendra Sharma, Dana McCormack, Tay Won Shin, Andrew Harrahill, Eric Nyase, Gagandeep Mudhar, Abigail Mauermann, Alec Wysoker, James Nemesh, Seva Kashin, Josselyn Vergara, Gabriele Chelini, Jordane Dimidschstein, Sabina Berretta, Benjamin E Deverman, Ed Boyden, Steven A McCarroll, Guoping Feng
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million brain cells across 18 locations in the common marmoset, a New World monkey primed for genetic engineering, and examined gene expression patterns of cell types within and across brain structures. The adult transcriptomic identity of most neuronal types is shaped more by developmental origin than by neurotransmitter signaling repertoire...
October 13, 2023: Science Advances