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Prolactin igf

Adam Gesing, Denise Wiesenborn, Andrew Do, Vinal Menon, Augusto Schneider, Berta Victoria, Michael B Stout, John J Kopchick, Andrzej Bartke, Michal M Masternak
Disruption of the growth hormone (GH) signaling pathway promotes insulin sensitivity and is associated with both delayed aging and extended longevity. Two kinds of long-lived mice-Ames dwarfs (df/df) and GH receptor gene-disrupted knockouts (GHRKO) are characterized by a suppressed GH axis with a significant reduction of body size and decreased plasma insulin-like growth factor-1 (IGF-1) and insulin levels. Ames dwarf mice are deficient in GH, prolactin, and thyrotropin, whereas GHRKOs are GH resistant and are dwarf with decreased circulating IGF-1 and increased GH...
September 29, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Rebecca J Gordon, Jennifer Bell, Wendy K Chung, Raphael David, Sharon E Oberfield, Sharon L Wardlaw
PURPOSE: Acromegaly in infancy is extremely rare. We describe a 32 year old woman who presented at 6 months of age with isolated macrocephaly, followed by accelerated linear growth. At 21 months of age, her head circumference was 55 cm (+5.5 SD), height was 97.6 cm (+4.4 SD) and weight was 20.6 kg (+6.2 SD). She had markedly elevated levels of growth hormone (GH) (135 ng/ml), IGF-1 (1540 ng/ml) and prolactin (370 ng/ml). A pituitary macroadenoma was surgically resected. Immunohistochemical staining was positive for GH...
September 8, 2016: Pituitary
Amir A Hamidieh, Zohreh Hamidi, Maryam Behfar, Zeinab Pajouhi, Kamran Alimoghaddam, Fariba Mohseni, Ardeshir Ghavamzadeh, Maryam Sobhani, Bagher Larijani, Mohammad R Mohajeri Tehrani
BACKGROUNDS: Beta Thalassemia Major, and its treatment by hematopoietic stem cell transplantation can have deleterious effect on bone integrity and a main part of such effects is due to their deleterious effects on endocrine systems. So, we assessed the effects of endocrine changes during HSCT (Hematopoietic Stem Cell Transplantation) on growing bones of pediatric thalassemic patients. METHODS: Bone-specific alkaline phosphatase and osteocalcin (bone formation markers), NTX (bone resorption marker), Ca, P, Alk ph, PTH, Vitamin D (vit D), prolactin, LH, FSH, T4, T3, TSH, IGF-1, testosterone (in males) or estradiol (in females), measured in 20 major thalassemic patients with mean age of 10...
July 14, 2016: Minerva Pediatrica
Anthony C Hackney, Hope C Davis, Amy R Lane
This chapter addresses what is known about the endocrine system components growth hormone (GH)-insulin-like growth factor (IGF) axis, thyroid axis, and prolactin relative to exercise and exercise training. Each one of these hormone axes contributes to the maintenance of homeostasis in the body through impact on a multitude of physiological systems. The homeostatic disruption of exercise causes differing responses in each hormone axis. GH levels increase with sufficient stimulation, and IGFs are released in response to GH from the anterior pituitary providing multiple roles including anabolic properties...
2016: Frontiers of Hormone Research
Shahrzad Jalali, Eric Monsalves, Toru Tateno, Gelareh Zadeh
Pituitary adenomas (PAs) are common intracranial lesions. Available medical therapies are limited in PAs, and therefore, it is essential to identify treatments that control PA growth when surgery is not an option. Fibroblast growth factor 4 is implicated in PA pathogenesis; therefore, in this study, we used an isogenic mammosomatotroph cell line (GH4C1) harboring different fibroblast growth factor receptor (FGFR)-4 genotypes to establish and characterize intracranial xenograft mouse models that can be used for preclinical drug testing...
September 2016: Endocrinology
Wesley Elon Fleming, Aliya Ferouz-Colborn, Michael K Samoszuk, Armaghan Azad, Jiuliu Lu, John S Riley, Amabelle B Cruz, Susann Podolak, Doni J Clark, Kurtis R Bray, Paula C Southwick
OBJECTIVE/BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder, affecting over 100 million adults. Untreated OSA leads to serious health consequences and perturbations in endocrine, immune, inflammatory, and metabolic systems. Study objectives are to evaluate the association between OSA and biomarkers, and to test the hypothesis that a combination of markers may be useful in screening for OSA. PATIENTS/METHODS: A multicenter trial was conducted enrolling symptomatic male patients with suspected OSA...
August 2016: Clinical Biochemistry
Karim Gariani, Christian Toso, Jacques Philippe, Lorenzo A Orci
Patients with chronic liver disease (CLD) often experience secondary endocrine dysfunction. Therefore, because the liver plays a major role in endocrine function, liver transplantation (LT) may also be beneficial for the restoration of hormonal regulation. This systematic review collects and interprets the available literature on the effect of LT on endocrine and sexual function in adult patients. A systematic review was conducted by searching Pubmed (including Medline) and EMBASE for studies published from database inception until November 2015...
October 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Amit Tirosh, Yoel Toledano, Hiba Masri-Iraqi, Yoav Eizenberg, Gloria Tzvetov, Dania Hirsch, Carlos Benbassat, Eyal Robenshtok, Ilan Shimon
PURPOSE: To evaluate the utility of Insulin-like growth factor I (IGF-I) standard deviation score (SDS) as a surrogate marker of severity of hypopituitarism in adults with pituitary pathology. METHODS: We performed a retrospective data analysis, including 269 consecutive patients with pituitary disease attending a tertiary endocrine clinic in 1990-2015. The medical files were reviewed for the complete pituitary hormone profile, including IGF-I, and clinical data...
August 2016: Pituitary
M Szczuko, M Zapałowska-Chwyć, A Drozd, D Maciejewska, A Starczewski, E Stachowska
OBJECTIVE: The aim of this study was to determine the correlations between the concentration of tumor necrosis factor (TNF-α) and insulin-like growth factor I (IGF-I) in each woman with polycystic ovary syndrome (PCOS) phenotypes based on the levels of androgen. METHODS: Two groups of women with PCOS differing in their levels of androgens. The test group composed of 39 women with PCOS according to the Rotterdam criteria in their reproductive age. The hormonal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin (PRL), androstenedione, testosterone (T), estradiol (E2) and sex hormone binding globulin (SHBG) were measured...
March 16, 2016: Gynecological Endocrinology
Vatroslav Cerina, Ivan Kruljac, Jelena Marinkovic Radosevic, Lora Stanka Kirigin, Darko Stipic, Hrvoje Ivan Pecina, Milan Vrkljan
The insulin tolerance test (ITT) is the gold standard for diagnosing adrenal insufficiency (AI) after pituitary surgery. The ITT is unpleasant for patients, requires close medical supervision and is contraindicated in several comorbidities. The aim of this study was to analyze whether tumor size, remission rate, preoperative, and early postoperative baseline hormone concentrations could serve as predictors of AI in order to increase the diagnostic accuracy of morning serum cortisol. This prospective study enrolled 70 consecutive patients with newly diagnosed pituitary adenomas...
March 2016: Medicine (Baltimore)
Y M Xi, F Wu, D Q Zhao, Z Yang, L Li, Z Y Han, G L Wang
Residual feed intake (RFI), defined as the difference between an animal's actual feed intake and expected feed intake over a specific period, is an inheritable character of feed conversion efficiency in dairy cows. Research has shown that a lower RFI could improve the profitability of milk production. This study explored variation in RFI by comparing the differences in body size, milk performance, feeding behavior, and serum metabolites in 29 Holstein cows in mid lactation. The cows were selected from a total of 84 animals based on their RFI following feedlot tests...
August 2016: Animal: An International Journal of Animal Bioscience
Robert Krysiak, Małgorzata Gilowska, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Chronic metformin treatment was found to reduce elevated thyrotropin levels. Amiodarone treatment is associated with a range of effects in thyroid function from mild derangements to overt thyroid dysfunction. No previous study has investigated the effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with amiodarone-induced hypothyroidism. METHODS: The study included three age-, sex- and weight-matched groups of amiodarone-treated patients with type 2 diabetes: patients with treated overt hypothyroidism (group I, n=15), patients with untreated subclinical hypothyroidism (group II, n=15), and subjects without thyroid disorders (group III, n=18)...
April 2016: Pharmacological Reports: PR
R Krysiak, W Szkrobka, B Okopien
BACKGROUND: One of the most frequent adverse effects of interferon-α therapy is thyroiditis. Metformin was found to improve insulin sensitivity in hepatitis C patients, as well as to reduce elevated thyrotropin levels in patients with hypothyroidism. The aim of this study was to investigate the effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with interferon-induced thyroiditis. METHODS: The study included 2 matched groups of women with type 2 diabetes and untreated subclinical hypothyroidism: patients with interferon-induced thyroiditis (n=8) and patients with Hashimoto's thyroiditis (n=12)...
February 2016: Experimental and Clinical Endocrinology & Diabetes
Božidar Perić, Ivan Kruljac, Sara Šundalić, Hrvoje Ivan Pećina, Andrijana Jović, Mario Štefanović, Dražan Butorac, Milan Vrkljan
PURPOSE: Increasing evidence exists that hyperprolactinemia alters metabolic profile. The mechanism of this effect is unknown. We aimed to investigate the differences between the metabolic profile of patients with prolactinomas and nonfunctional pituitary adenomas and to evaluate the impact of other pituitary hormones on their metabolic profile. METHODS: Our retrospective study included 86 consecutive patients with prolactinomas and nonfunctional adenomas (29 prolactinomas and 57 adenomas)...
August 2016: Endocrine Research
Miika Mehine, Eevi Kaasinen, Hanna-Riikka Heinonen, Netta Mäkinen, Kati Kämpjärvi, Nanna Sarvilinna, Mervi Aavikko, Anna Vähärautio, Annukka Pasanen, Ralf Bützow, Oskari Heikinheimo, Jari Sjöberg, Esa Pitkänen, Pia Vahteristo, Lauri A Aaltonen
Uterine leiomyomas are common benign smooth muscle tumors that impose a major burden on women's health. Recent sequencing studies have revealed recurrent and mutually exclusive mutations in leiomyomas, suggesting the involvement of molecularly distinct pathways. In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic inactivation of fumarate hydratase (FH), and collagen, type IV, alpha 5 and collagen, type IV, alpha 6 (COL4A5-COL4A6) deletions...
February 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
Vincenzo De Sanctis, Heba Elsedfy, Ashraf T Soliman, Ihab Zaki Elhakim, Alessia Pepe, Christos Kattamis, Nada A Soliman, Rania Elalaily, Mohamed El Kholy, Mohamed Yassin
INTRODUCTION: In males, acquired hypogonadotropic hypogonadism (AHH) includes all disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and/or pituitary gonadotroph cells. The clinical characteristics of AHH are androgen deficiency and lack, delay or halt of pubertal sexual maturation. AHH lead to decreased libido, impaired erectile function, and strength, a worsened sense of well-being and degraded quality of life (QOL). PATIENTS AND METHODS: We studied 11 adult men with thalassemia major (TM) aged between 26 to 54 years (mean ± SD: 34...
2016: Mediterranean Journal of Hematology and Infectious Diseases
Amit Tirosh, Dania Hirsch, Eyal Robenshtok, Hiba Masri-Iraqi, Uri Yoel, Yoel Toledano, Orit Twito, Gloria Tsvetov, Ilan Shimon
OBJECTIVE: To describe the various patterns of presentation, including assisting analyses, associated with the timing of diagnosis of females with hypopituitarism and suspected clinical diagnosis of lymphocytic hypophysitis. METHODS: A retrospective study of 9 consecutive females with pituitary dysfunction developed during or after pregnancy. All subjects were treated in our clinics between 2008 and 2014. Data were collected on clinical characteristics, pituitary hormone levels, and imaging findings...
April 2016: Endocrine Practice
Y Yang, K Landin-Wilhelmsen, H Zetterberg, G Oleröd, J Isgaard, C Wikkelsö
BACKGROUND: Hypopituitarism has been reported in patients with idiopathic normal pressure hydrocephalus (iNPH), which could enhance characteristic symptoms like impaired wakefulness, gait, body balance, and subcortical cognitive deterioration. PURPOSE: To compare basal serum levels of pituitary and sex hormones and serum insulin-like growth factor-1 (S-IGF-1) in patients with iNPH and an age-matched control population, and to correlate the preoperative hormone levels with symptoms and signs pre-operatively and three months after surgery...
December 2015: Growth Hormone & IGF Research
Juergen Kratzsch
An overview of the detection, mechanism of formation and clinical function of hormone binding proteins shedded from the membrane receptor and detected in the last twenty years is presented. The representatives of such binding proteins are restricted only to human soluble receptors that have been already detected in blood or other intravasal fluids such as soluble receptors for LH/hCG, prolactin, TSH, erythropoietin, insulin and IGF-I. The clinical or diagnostic significance of these putative-detectable or indeed circulating proteins often remains largely unclear...
October 2015: Best Practice & Research. Clinical Endocrinology & Metabolism
Khaled Mohammed-Geba, J A Martos-Sitcha, A Galal-Khallaf, J M Mancera, G Martínez-Rodríguez
The role of insulin-like growth factor 1 (IGF-1) on regulation of growth hormone (GH) and prolactin (PRL) as well as the possible involvement of IGF-1 receptor subtype a (IGF-1Ra) mRNA was assessed in juvenile specimens of Sparus aurata. IGF-1Ra was successfully cloned, and active receptor domains were localized in its mRNA precursor. Also, phylogenetic analysis of the protein sequence indicated a closer proximity to IGF-1Ra isoform found in zebrafish and other teleosts, than to the isoform IGF-1Rb. The most abundant presence of IGF-1Ra mRNA was detected in white muscle, whereas head kidney showed the lowest gene expression among 24 different studied tissues...
February 2016: Fish Physiology and Biochemistry
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