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https://www.readbyqxmd.com/read/28475292/long-term-follow-up-of-endocrine-function-among-young-children-with-newly-diagnosed-malignant-central-nervous-system-tumors-treated-with-irradiation-avoiding-regimens
#1
Anne M Cochrane, Clement Cheung, Kasey Rangan, David Freyer, Leena Nahata, Girish Dhall, Jonathan L Finlay
BACKGROUND: The adverse effects of irradiation on endocrine function among patients with pediatric brain tumor are well documented. Intensive induction chemotherapy followed by marrow-ablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) without central nervous system (CNS) irradiation has demonstrated efficacy in a proportion of very young children with some malignant CNS tumors. This study assessed the long-term endocrine function of young children following chemotherapy-only treatment regimens...
May 5, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28457479/x-lag-how-did-they-grow-so-tall
#2
Albert Beckers, Liliya Rostomyan, Iulia Potorac, Pablo Beckers, Adrian F Daly
X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very advanced age-specific height Z-scores...
April 27, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28380616/does-duration-of-teat-use-in-first-parity-affect-milk-yield-and-mammary-gene-expression-in-second-parity
#3
C Farmer, M Amezcua, R Bruckmaier, O Wellnitz, R Friendship
It was recently shown that a teat that is not used in the first lactation will have a reduced development and milk yield in the second lactation. In the current study, the impact of imposing a suckling period of 2, 7, or 21 d during the first lactation on piglet performance, milk composition, endocrine status, and mammary gene expression of sows in their second lactation was studied. Pregnant Yorkshire gilts were divided into 3 groups according to lactation length: 1) 2-d lactation (2D; = 20), 2) 7-d lactation (7D; = 20), and 3) 21-d lactation (21D; = 21)...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28356085/cnv-discovery-for-milk-composition-traits-in-dairy-cattle-using-whole-genome-resequencing
#4
Yahui Gao, Jianping Jiang, Shaohua Yang, Yali Hou, George E Liu, Shengli Zhang, Qin Zhang, Dongxiao Sun
BACKGROUND: Copy number variations (CNVs) are important and widely distributed in the genome. CNV detection opens a new avenue for exploring genes associated with complex traits in humans, animals and plants. Herein, we present a genome-wide assessment of CNVs that are potentially associated with milk composition traits in dairy cattle. RESULTS: In this study, CNVs were detected based on whole genome re-sequencing data of eight Holstein bulls from four half- and/or full-sib families, with extremely high and low estimated breeding values (EBVs) of milk protein percentage and fat percentage...
March 29, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28339753/in-ovo-monochromatic-green-light-photostimulation-enhances-embryonic-somatotropic-axis-activity
#5
L Dishon, N Avital-Cohen, D Malamud, R Heiblum, S Druyan, T E Porter, M Gumulka, I Rozenboim
Previous studies demonstrated that in ovo photostimulation with monochromatic green light increases body weight and accelerates muscle development in broilers. The mechanism in which in ovo photostimulation accelerates growth and muscle development is not clearly understood. The objective of the current study was to define development of the somatotropic axis in the broiler embryo associated with in ovo green light photostimulation. Two-hundred-forty fertile broiler eggs were divided into 2 groups. The first group was incubated under intermittent monochromatic green light using light-emitting diode (LED) lamps with an intensity of 0...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28332185/mechanism-of-prolactin-inhibition-of-mir-135b-via-methylation-in-goat-mammary-epithelial-cells
#6
Zhi Chen, Jun Luo, ChangHui Zhang, Yue Ma, Shuang Sun, Tianyin Zhang, Juan J Loor
Prolactin is an important endocrine activator of lactogenesis. This study investigated the function and mechanism of miR-135b in the enhancement of lactation by prolactin in goat mammary epithelial tissue. We utilized S-Poly (T) sequencing to evaluate changes in gene regulation in the goat mammary gland after incubation with 2.5 μg/ml prolactin and 2.5 μg/ml IGF-1 by examining highly expressed miRNAs during early lactation and late-lactation. The results illustrated that miR-135b is highly expressed in the goat mammary gland during early lactation and late-lactation, and also after treatment with 2...
March 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28246273/added-value-of-serum-hormone-measurements-in-risk-prediction-models-for-breast-cancer-for-women-not-using-exogenous-hormones-results-from-the-epic-cohort
#7
Anika Husing, Renee T Fortner, Tilman Kuhn, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Gianluca Severi, Agnes Fournier, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Philippos Orfanos, Giovanna Masala, Valeria Pala, Rosario Tumino, Francesca Fasanelli, Salvatore Panico, H Bas Bueno-de-Mesquita, Petra Peeters, Carla H van Gils, J Ramon Quiros, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Ruth C Travis, Laure Dossus, Kuanrong Li, Pietro Ferrari, Melissa A Merritt, Ioanna Tzoulaki, Elio Riboli, Rudolf Kaaks
PURPOSE: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models. EXPERIMENTAL DESIGN: We evaluated improvements in discrimination gained by adding serum biomarker concentrations to risk estimates derived from risk prediction models developed by Gail et al. and Pfeiffer et al. using a nested case-control study within the EPIC cohort including 1217 breast cancer cases and 1976 matched controls...
February 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28229578/growth-and-pubertal-development-in-adolescent-male-wrestlers
#8
İbrahim E Pişkin, Mustafa Gümüş, Taner Bayraktaroğlu, Tevfik C Akalin, Faruk Yamaner
BACKGROUND: Adolescence is a crucial period for linear growth, and sports training during this time may have positive or negative effects on some physiological processes as growth. The purpose of this study was to evaluate the effects of intense training during somatic growth on the onset of puberty and growth development in adolescent wrestlers. METHODS: Fifty adolescent male wrestlers and twenty-one sedentary healthy male controls aged between 13-15 years were selected...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28211546/differential-effects-of-hormones-on-cellular-metabolism-in-keratoconus-in-vitro
#9
Tina B McKay, Jesper Hjortdal, Henrik Sejersen, Dimitrios Karamichos
Keratoconus (KC) is a corneal thinning disease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age. The role of hormones in regulating corneal tissue structure in homeostatic and pathological conditions is unknown. Our group recently linked altered hormone levels to KC. Our current study sought to investigate and delineate the effects of exogenous hormones, such as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics. We utilized our established 3D in vitro model to characterize the effects of DHEA, prolactin, 17β-estradiol on insulin-growth factor-1 and -2 (IGF-1, -2) signaling and metabolic function in primary corneal fibroblasts from healthy controls (HCFs) and KC patients (HKCs)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073129/alternative-treatment-strategies-in-women-poorly-tolerating-moderate-doses-of-bromocriptine
#10
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background: Metformin as well as dopaminergic agents exert a beneficial effect on glucose and lipid metabolism, often impaired in patients with hyperprolactinemia. Objective: The aim of this study was to compare metabolic- and prolactin-lowering effects of low-dose bromocriptine/metformin combination therapy and cabergoline in patients with elevated prolactin levels. Methods: The study included 27 women with hyperprolactinemia and impaired glucose tolerance who were treated with moderate doses of bromocriptine but experienced adverse effects of this treatment...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#11
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27855229/late-presentation-of-acromegaly-in-medically-controlled-prolactinoma-patients
#12
Ekaterina Manuylova, Laura M Calvi, Catherine Hastings, G Edward Vates, Mahlon D Johnson, William T Cave, Ismat Shafiq
Co-secretion of growth hormone (GH) and prolactin (PRL) from a single pituitary adenoma is common. In fact, up to 25% of patients with acromegaly may have PRL co-secretion. The prevalence of acromegaly among patients with a newly diagnosed prolactinoma is unknown. Given the possibility of mixed GH and PRL co-secretion, the current recommendation is to obtain an insulin-like growth factor-1 (IGF-1) in patients with prolactinoma at the initial diagnosis. Long-term follow-up of IGF-1 is not routinely done. Here, we report two cases of well-controlled prolactinoma on dopamine agonists with the development of acromegaly 10-20 years after the initial diagnoses...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27688483/a-long-lived-mouse-lacking-both-growth-hormone-and-growth-hormone-receptor-a-new-animal-model-for-aging-studies
#13
Adam Gesing, Denise Wiesenborn, Andrew Do, Vinal Menon, Augusto Schneider, Berta Victoria, Michael B Stout, John J Kopchick, Andrzej Bartke, Michal M Masternak
Disruption of the growth hormone (GH) signaling pathway promotes insulin sensitivity and is associated with both delayed aging and extended longevity. Two kinds of long-lived mice-Ames dwarfs (df/df) and GH receptor gene-disrupted knockouts (GHRKO) are characterized by a suppressed GH axis with a significant reduction of body size and decreased plasma insulin-like growth factor-1 (IGF-1) and insulin levels. Ames dwarf mice are deficient in GH, prolactin, and thyrotropin, whereas GHRKOs are GH resistant and are dwarf with decreased circulating IGF-1 and increased GH...
September 29, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27631333/childhood-acromegaly-due-to-x-linked-acrogigantism-long-term-follow-up
#14
Rebecca J Gordon, Jennifer Bell, Wendy K Chung, Raphael David, Sharon E Oberfield, Sharon L Wardlaw
PURPOSE: Acromegaly in infancy is extremely rare. We describe a 32 year old woman who presented at 6 months of age with isolated macrocephaly, followed by accelerated linear growth. At 21 months of age, her head circumference was 55 cm (+5.5 SD), height was 97.6 cm (+4.4 SD) and weight was 20.6 kg (+6.2 SD). She had markedly elevated levels of growth hormone (GH) (135 ng/ml), IGF-1 (1540 ng/ml) and prolactin (370 ng/ml). A pituitary macroadenoma was surgically resected. Immunohistochemical staining was positive for GH...
December 2016: Pituitary
https://www.readbyqxmd.com/read/27416038/how-is-the-relation-between-endocrine-changes-and-bone-markers-in-pediatric-thalassemic-patients-after-hematopoietic-stem-cell-transplantation
#15
Amir A Hamidieh, Zohreh Hamidi, Maryam Behfar, Zeinab Pajouhi, Kamran Alimoghaddam, Fariba Mohseni, Ardeshir Ghavamzadeh, Maryam Sobhani, Bagher Larijani, Mohammad R Mohajeri Tehrani
BACKGROUNDS: Beta Thalassemia Major, and its treatment by hematopoietic stem cell transplantation can have deleterious effect on bone integrity and a main part of such effects is due to their deleterious effects on endocrine systems. So, we assessed the effects of endocrine changes during HSCT (Hematopoietic Stem Cell Transplantation) on growing bones of pediatric thalassemic patients. METHODS: Bone-specific alkaline phosphatase and osteocalcin (bone formation markers), NTX (bone resorption marker), Ca, P, Alk ph, PTH, Vitamin D (vit D), prolactin, LH, FSH, T4, T3, TSH, IGF-1, testosterone (in males) or estradiol (in females), measured in 20 major thalassemic patients with mean age of 10...
July 14, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27348437/growth-hormone-insulin-like-growth-factor-axis-thyroid-axis-prolactin-and-exercise
#16
Anthony C Hackney, Hope C Davis, Amy R Lane
This chapter addresses what is known about the endocrine system components growth hormone (GH)-insulin-like growth factor (IGF) axis, thyroid axis, and prolactin relative to exercise and exercise training. Each one of these hormone axes contributes to the maintenance of homeostasis in the body through impact on a multitude of physiological systems. The homeostatic disruption of exercise causes differing responses in each hormone axis. GH levels increase with sufficient stimulation, and IGFs are released in response to GH from the anterior pituitary providing multiple roles including anabolic properties...
2016: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/27267848/role-of-mtor-inhibitors-in-growth-hormone-producing-pituitary-adenomas-harboring-different-fgfr4-genotypes
#17
Shahrzad Jalali, Eric Monsalves, Toru Tateno, Gelareh Zadeh
Pituitary adenomas (PAs) are common intracranial lesions. Available medical therapies are limited in PAs, and therefore, it is essential to identify treatments that control PA growth when surgery is not an option. Fibroblast growth factor 4 is implicated in PA pathogenesis; therefore, in this study, we used an isogenic mammosomatotroph cell line (GH4C1) harboring different fibroblast growth factor receptor (FGFR)-4 genotypes to establish and characterize intracranial xenograft mouse models that can be used for preclinical drug testing...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27184708/blood-biomarkers-of-endocrine-immune-inflammatory-and-metabolic-systems-in-obstructive-sleep-apnea
#18
MULTICENTER STUDY
Wesley Elon Fleming, Aliya Ferouz-Colborn, Michael K Samoszuk, Armaghan Azad, Jiuliu Lu, John S Riley, Amabelle B Cruz, Susann Podolak, Doni J Clark, Kurtis R Bray, Paula C Southwick
OBJECTIVE/BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder, affecting over 100 million adults. Untreated OSA leads to serious health consequences and perturbations in endocrine, immune, inflammatory, and metabolic systems. Study objectives are to evaluate the association between OSA and biomarkers, and to test the hypothesis that a combination of markers may be useful in screening for OSA. PATIENTS/METHODS: A multicenter trial was conducted enrolling symptomatic male patients with suspected OSA...
August 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27163168/effects-of-liver-transplantation-on-endocrine-function-a-systematic-review
#19
REVIEW
Karim Gariani, Christian Toso, Jacques Philippe, Lorenzo A Orci
Patients with chronic liver disease (CLD) often experience secondary endocrine dysfunction. Therefore, because the liver plays a major role in endocrine function, liver transplantation (LT) may also be beneficial for the restoration of hormonal regulation. This systematic review collects and interprets the available literature on the effect of LT on endocrine and sexual function in adult patients. A systematic review was conducted by searching Pubmed (including Medline) and EMBASE for studies published from database inception until November 2015...
October 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27083162/igf-i-levels-reflect-hypopituitarism-severity-in-adults-with-pituitary-dysfunction
#20
Amit Tirosh, Yoel Toledano, Hiba Masri-Iraqi, Yoav Eizenberg, Gloria Tzvetov, Dania Hirsch, Carlos Benbassat, Eyal Robenshtok, Ilan Shimon
PURPOSE: To evaluate the utility of Insulin-like growth factor I (IGF-I) standard deviation score (SDS) as a surrogate marker of severity of hypopituitarism in adults with pituitary pathology. METHODS: We performed a retrospective data analysis, including 269 consecutive patients with pituitary disease attending a tertiary endocrine clinic in 1990-2015. The medical files were reviewed for the complete pituitary hormone profile, including IGF-I, and clinical data...
August 2016: Pituitary
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