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Acute Myocardial Infarctation

Richard M Nowak, Chaun M Gandolfo, Gordon Jacobsen, Robert H Christenson, Michele Moyer, Michael Hudson, James McCord
STUDY OBJECTIVE: We determine how well a new Food and Drug Administration-approved single cardiac troponin T (cTnT) Generation 5 baseline measurement below the level of quantification (6 ng/L) and a novel study-derived baseline and 30-minute cTnT Generation 5 algorithm might adequately exclude acute myocardial infarction in patients with suspected acute coronary syndrome in a US emergency department (ED). METHODS: Patients presenting with any symptoms suspicious for acute coronary syndrome were enrolled at a single US ED...
August 14, 2018: Annals of Emergency Medicine
Getu Teressa, Mengru Zhang, Philip Lavenburg, Gregg Cantor, Pamela Noack, Jie Yang, Michael Goyfman, Eric J Feldmann, Javed Butler, Michael Poon
Although the majority of acute chest pain patients are diagnosed with noncardiac chest pain after noninvasive testing, identifying these low-risk patients before testing is challenging. The objective of this study was to validate the coronary artery disease (CAD) consortium models for predicting obstructive CAD and 30-day major adverse cardiovascular events (MACE) in acute chest pain patients considered for coronary computed tomography angiogram, as well as to determine the pretest probability threshold that identifies low-risk patients with <1% MACE...
July 17, 2018: American Journal of Cardiology
Corrie L Gallant-Behm, Joseph Piper, Brent A Dickinson, Christina M Dalby, Linda A Pestano, Aimee L Jackson
There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications. It is well established that local tissue hypoxia, vascular insufficiency and/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA-92a-3p (miR-92a) is a potent anti-angiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury and bone fracture...
August 17, 2018: Wound Repair and Regeneration
S A Afanasiev, A A Garganeeva, E A Kuzheleva, A V Andriyanova, D S Kondratieva, S V Popov
The objective of the study was to assess the impact of DM2 at baseline on long-term mortality after acute myocardial infarction (MI) among different age groups. The data were taken from: "Register of Acute Myocardial Infarction." A total of 862 patients were followed for five years after acute myocardial infarction. The primary endpoint was death from any cause. The patients were categorized into 2 groups based on their ages: group 1-comprised patients older than working age ( n = 358) and group 2-comprised employable patients ( n = 504)...
2018: Journal of Diabetes Research
Lenka Tenzera, Boris Djindjic, Olivera Mihajlovic-Elez, Bindu John Pulparampil, Seema Mahesh, George Vithoulkas
We present three cases of cardiac arrest at different stages of pathology. Acute myocardial infarction and resulting heart failure is emerging as the leading cause of mortality. In the long run, acute episodes and cardiac remodelling can cause considerable damage and result in heart failure. In these cases, individualized homeopathic therapy was instituted along with the conventional medicines and the results were encouraging. The changes in the laboratory diagnostic parameters (single-photon emission computed tomography, electrocardiograph, echocardiography and ejection fraction as the case may be) are demonstrated over time...
2018: SAGE Open Medical Case Reports
Ahmad Separham, Mohsen Abbasnezhad, Golnesa Shahnazarli, Alireza Khoshbahar
Introduction: Cancer antigen 125 (CA-125) is a tumor marker of ovarian cancer, which has shown to be increased in different cardiovascular diseases. Although the prognostic role of CA-125 in heart failure and coronary heart disease is well-established, there is little known about its role in acute myocardial infarction (AMI). In this study we aimed to evaluate the serum levels of CA-125 in patients with AMI and its prognostic role in evaluating the in-hospital outcome of AMI. Methods: We evaluated 120 male patients with AMI and 120 male normal subjects...
2018: Journal of Cardiovascular and Thoracic Research
Eliza Sharma, Suyash Dahal, Pratibha Sharma, Dipesh Kc Ghimire, Sumit Dahal
Diabetic ketoacidosis (DKA) is regularly associated with hyperkalemia that results in well-described changes on the electrocardiogram (EKG). However, ST-segment elevations on EKG mimicking acute myocardial infarction have rarely been described in the setting of DKA. Here we present a case of a 43-year-old male with DKA who had pseudoinfarction pattern of ST-segment elevation on EKG that resolved with treatment of DKA and discuss the diagnostic and therapeutic dilemma around the condition.
August 2018: Cardiology Research
Libo Li, Jing Hao, Shi Qu, Yancheng Fang
Computed tomography angiography (CTA) is an efficient method for the diagnosis of heart disease. However, few contemporary studies have evaluated the prognostic value of three-dimensional (3D)-CTA for patients with acute coronary artery disease. The aim of the present study was to investigate the diagnostic value of 3D-CTA for patients with acute coronary artery disease. A total of 136 patients with suspected acute coronary artery disease were recruited and received conventional coronary angiography (CCA) and 3D-CTA...
August 2018: Experimental and Therapeutic Medicine
Fengli Zhang, Fengyan Guo
In the present study, we aimed to investigate the effect of transplantation of cardiac stem cells (CSCs) overexpressing integrin-linked kinase (ILK) on cardiac function of rats with acute myocardial infarction (MI). A total of 60 rats were randomly divided into normal saline (NS) group (n=20), green fluorescent protein (GFP)-CSC group (n=20) and ILK-CSC group (n=20). In the ILK-CSC group, CSCs in rats were transfected with GFP adenovirus vector overexpressing ILK. The rat model of MI was established. The cardiac function 4 weeks after transplantation was detected via echocardiography, and the exhaustive swimming experiment was performed to observe the exercise load capacity...
August 2018: Experimental and Therapeutic Medicine
Hassan Ghobadi, Zahra Amirajam, Afshin Habibzadeh
Massive pulmonary thromboembolism (PTE) has an increased risk of mortality. Thrombolytic therapy is the accepted treatment. Reteplase, a variant of tissue plasminogen activator, has been used in acute myocardial infarction with acceptable safety and efficacy, but studies in massive PTE are rare. In this study we report five cases of successful treatment of massive PTE with reteplase.
January 2018: Tanaffos
T Jadczyk, K Baranski, M Syzdol, E Nabialek, W Wanha, R Kurzelowski, M Z Ratajczak, M Kucia, B Dolegowska, M Niewczas, J Zejda, W Wojakowski
Background: Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process. Aim: The aim of this study was to evaluate plasma levels of CC cleavage fragments (C3a, C5a, and C5b9), sphingosine (SP), sphingosine-1-phosphate (S1P), and free hemoglobin (fHb) in AMI patients treated with primary percutaneous coronary intervention (pPCI) and stable coronary artery disease (SCAD) undergoing CABG...
2018: Mediators of Inflammation
Hans C Beck, Lisette O Jensen, Charlotte Gils, Albertine M M Ilondo, Martin Frydland, Christian Hassager, Ole K Møller-Helgestad, Jacob E Møller, Lars M Rasmussen
BACKGROUND: Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. This may relate to interference of medication on plasma protein concentrations. We used proteomics to identify plasma proteins that changed in concentration with heparin administration and therefore potentially may confound their evaluation as biomarkers in situations in which heparin is used. METHODS: We used a proteomic approach based on isobaric tagging and nano-LC-MS/MS analysis to quantify several hundred proteins in a discovery study in which individual plasma samples from 9 patients at intravascular ultrasound follow-up 12 months after an acute myocardial infarction before heparin administration and 2, 15, and 60 min after heparin administration; we validated our findings in 500 individual plasma samples obtained at admission from patients with suspected ST segment elevation myocardial infarction (STEMI), of whom 363 were treated with heparin before admission...
August 16, 2018: Clinical Chemistry
Golnaz Sadjadieh, Thomas Engstrøm, Dan Eik Høfsten, Steffen Helqvist, Lars Køber, Frants Pedersen, Peter Nørkjær Laursen, Hedvig Bille Andersson, Lars Nepper-Christensen, Peter Clemmensen, Rikke Sørensen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Henning Kelbæk, Lene Holmvang
Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third DANish Study of Optimal Acute Treatment of Patients with STEMI (DANAMI-3)). Hospital charts were read and bleedings classified according to thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium (BARC) criteria in 2,490 consecutive STEMI patients who underwent primary percutaneous coronary intervention in a single, large, and tertiary heart center...
July 19, 2018: American Journal of Cardiology
Mingjie Yang, Lei Song, Lai Wang, Ada Yukht, Haley Ruther, Fuqiang Li, Minghui Qin, Homayon Ghiasi, Behrooz G Sharifi, Prediman K Shah
BACKGROUND: Macrophages are highly plastic cells that play an important role in the pathogenesis of cardiovascular disease. OBJECTIVES: This study investigated the role of GATA3-positive macrophages in modulating cardiac function after myocardial infarction (MI) or in response to pressure overload hypertrophy. METHODS: Myeloid-specific GATA3-deficient (mGATA3KO) mice were generated, MI or pressure overload was induced, and cardiac function was determined by echocardiography...
August 21, 2018: Journal of the American College of Cardiology
Vladica M Veličković, Ursula Rochau, Annette Conrads-Frank, Frank Kee, Stefan Blankenberg, Uwe Siebert
Introduction Despite the emphasis on the clinical importance of cardiac troponin assays (cTn), there are insufficient cost-effectiveness comparisons of various troponin test protocols for the diagnosis of myocardial infarction (MI). Therefore, the purpose of review was to identify and systematically assess published economic evaluations using decision-analytic models for diagnostic testing strategies based on cTn, and to make recommendations for the development of future models. Areas covered MEDLINE, Science Direct, Cochrane Database, CRD Database and grey literature were screened for full economic evaluation studies with relevant clinical outcomes over a defined time horizon addressing a population with suspected myocardial infarction (MI) and comparison of different diagnostic test strategies...
August 17, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
J Huart, C Visée, A Colassin, P Maréchal, K Hafraoui, L Davin
We report the clinical case of a patient presenting with an acute myocardial infarction with ST- segment elevation. The patient is affected by polycythemia vera for many years and doesn't have any other cardiovascular risk factors. The frequency of thrombotic events in polycythemia vera (and more particularly myocardial infarction), their predictive factors, pathophysiology and treatment will be discussed.
July 2018: Revue Médicale de Liège
Dhruvkumar M Patel, Mukundkumar V Patel, Kamal H Sharma, Greshaben Rajeshkumar Patel, Manish B Patel, Vipul B Shah
BACKGROUND: Atherosclerosis and coronary plaque destabilization are linked to each other. Infections due to various microbes may trigger acute coronary syndrome (ACS) by systemic inflammation cascade. METHODS: We have evaluated the prevalence of Post chikungunya chronic arthritis (PCCA) among 400 consecutive ACS patients (Case group) and compared with control group subjected to elective surgery by the prospective case-control observational study. Cases were excluded if standard criteria of ACS were not satisfied and in control group if the patient suffered a myocardial infarction (MI) within 28 days of elective surgery...
August 15, 2018: Current Rheumatology Reviews
Elena Teringova, Martin Kozel, Jiri Knot, Viktor Kocka, Klara Benesova, Petr Tousek
Background: Apoptosis plays an important role in the myocardial injury after acute myocardial infarction and in the subsequent development of heart failure. Aim: To clarify serum kinetics of apoptotic markers TRAIL and sFas and their relation to left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods: In 101 patients with STEMI treated with pPCI, levels of TRAIL and sFas were measured in series of serum samples obtained during hospitalization and one month after STEMI...
2018: BioMed Research International
Georgi Kotov, Iva N Dimitrova, Alexandar Iliev, Violeta Groudeva
The azygos lobe is a rare anatomical variant, most often encountered in the right lung. Its etiology is related to a defect of the migration of the azygos vein during the embryonic development. Here, we describe a rare case of an azygos lobe of the right lung, diagnosed incidentally on a computed tomography (CT) scan in a 40-year-old male patient who presented with chest pain, shortness of breath, and fever. The initial differential diagnosis included acute myocardial infarction, aortic dissection, and myocarditis...
June 11, 2018: Curēus
Yun-Xia Qian, Ke-Sheng Dai, Li-Li Zhao, Xiang-Jun Yang
The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post-conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis...
August 2018: Experimental and Therapeutic Medicine
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