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Brenessa M Lindeman, Matthew A Nehs, Trevor E Angell, Erik K Alexander, Atul A Gawande, Francis D Moore, Gerard M Doherty, Nancy L Cho
PURPOSE: To investigate the impact of the nomenclature change to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) on reported malignancy rates following thyroidectomy. METHODS: Retrospective cohort study of patients with thyroid nodules sampled preoperatively with fine-needle aspiration (FNA) and subsequently removed at one tertiary-care hospital from 4/2016 to 2/2017. Surgical procedure, anatomic pathology, thyroid cytopathology classification, and demographic characteristics were recorded...
October 19, 2018: Annals of Surgical Oncology
O S Kirsebom, O Tengblad, R Lica, M Munch, K Riisager, H O U Fynbo, M J G Borge, M Madurga, I Marroquin, A N Andreyev, T A Berry, E R Christensen, P Díaz Fernández, D T Doherty, P Van Duppen, L M Fraile, M C Gallardo, P T Greenlees, L J Harkness-Brennan, N Hubbard, M Huyse, J H Jensen, H Johansson, B Jonson, D S Judson, J Konki, I Lazarus, M V Lund, N Marginean, R Marginean, A Perea, C Mihai, A Negret, R D Page, V Pucknell, P Rahkila, O Sorlin, C Sotty, J A Swartz, H B Sørensen, H Törnqvist, V Vedia, N Warr, H De Witte
The ^{12}C(α,γ)^{16}O reaction plays a central role in astrophysics, but its cross section at energies relevant for astrophysical applications is only poorly constrained by laboratory data. The reduced α width, γ_{11}, of the bound 1^{-} level in ^{16}O is particularly important to determine the cross section. The magnitude of γ_{11} is determined via sub-Coulomb α-transfer reactions or the β-delayed α decay of ^{16}N, but the latter approach is presently hampered by the lack of sufficiently precise data on the β-decay branching ratios...
October 5, 2018: Physical Review Letters
Colin P Doherty, Eoin O'Keeffe, James Keaney, Brian Lawlor, Robert F Coen, Michael Farrell, Matthew Campbell
A history of brain trauma has long been acknowledged as increasing an individual's risk of developing dementia in later life. The underlying mechanisms that belie this pre-disposition are, however, very poorly understood. Here, we report a clinical-neuropathological correlation of a man who presented at the age of 66 with a progressive complex atypical dementia with early and prominent neurobehavioral symptoms. His neurological condition continued to decline up to his death at the age of 74. During the compilation of his clinical history, it was established that the subject had experienced a single severe traumatic brain injury (TBI) aged 12 years in 1954 resulting in loss of consciousness, hospitalization, and coma for a number of days after which he was deemed to have recovered...
October 19, 2018: Clinical Neuropathology
Mackenzie Graham, Colin P Doherty, Lorina Naci
Robust prognostic indicators of neurological recovery are urgently needed for acutely comatose patients. Functional neuroimaging is a highly sensitive tool for uncovering covert cognition and awareness in behaviorally nonresponsive patients with prolonged disorders of consciousness, and may be applicable to acutely comatose patients. Establishing a link between early detection of covert awareness in acutely comatose patients and eventual recovery of function could have significant implications for patient prognosis, treatment, and end-of-life decisions...
October 2018: Seminars in Neurology
Jonathan Dodd, Samantha Murphy, Meghan Doherty
The present study introduces the Verbal Associated Pairs Screen (VAPS) as a new measure for assessing performance validity in pediatric populations. This study presents initial data on psychometric properties and establishes construct validity for the VAPS in a sample of 30 adolescent healthy controls and 206 youths with traumatic brain injury (TBI: moderate/severe, N = 30; mild, N = 176). The control group's age (M = 14.93, SD = 1.8) was significantly higher than the moderate/severe TBI (M = 13.9, SD = 2...
October 15, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Jordan Doherty, David E Dawe, Gregory R Pond, Peter M Ellis
OBJECTIVES: Small cell lung cancer (SCLC) represents a significant health burden. There is a lack of information about patterns of referral and treatment for older patients over 70 years of age, in comparison to younger patients with SCLC. MATERIALS AND METHODS: A population-based retrospective cohort study was undertaken for patients identified from the Ontario Cancer Registry, Canada. All cases of SCLC diagnosed between January 2000 and December 2010 were eligible...
October 11, 2018: Journal of Geriatric Oncology
Lene Joensen, Lawrence Fisher, Timothy Skinner, Yvonne Doherty, Ingrid Willaing
AIMS: To identify challenges and solutions to integrating psychosocial support into routine diabetes care from the perspective of stakeholders with an expertise in diabetes self-management education and support. METHODS: Ninety-four people attended the annual international Diabetes Self-management Alliance meeting in 2016, including plenary sessions and workshops around self-management education, support and prevention. One workshop focused on how to integrate psychosocial support into routine diabetes care, which was run four times consecutively allowing all conference participants to attend the workshops in groups of 20-25 people...
October 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Hasnain M Dalal, Rod S Taylor, Kate Jolly, Russell C Davis, Patrick Doherty, Jackie Miles, Robin van Lingen, Fiona C Warren, Colin Green, Jennifer Wingham, Colin Greaves, Susannah Sadler, Melvyn Hillsdon, Charles Abraham, Nicky Britten, Julia Frost, Sally Singh, Christopher Hayward, Victoria Eyre, Kevin Paul, Chim C Lang, Karen Smith
Background Cardiac rehabilitation improves health-related quality of life (HRQoL) and reduces hospitalizations in patients with heart failure, but international uptake of cardiac rehabilitation for heart failure remains low. Design and methods The aim of this multicentre randomized trial was to compare the REACH-HF (Rehabilitation EnAblement in CHronicHeart Failure) intervention, a facilitated self-care and home-based cardiac rehabilitation programme to usual care for adults with heart failure with reduced ejection fraction (HFrEF)...
October 10, 2018: European Journal of Preventive Cardiology
Erin E Doherty, Erica K Schallert, Alexandra M Stevens, Jyotinder N Punia, Jennifer H Foster
We report the case of a 3-year-old girl diagnosed with acute megakaryoblastic leukemia, who presented after >1 year of bilateral leg pain. At times the pain was severe enough to prevent ambulation, prompting visits to her primary care provider. However, it was not until acute respiratory failure occurred with subsequent hospitalization in the pediatric intensive care unit that severe anemia and thrombocytopenia were discovered and the diagnosis of acute myeloid leukemia was made. Bilateral lower extremity swelling was noted on admission and radiographs showed diffusely abnormal appearance of the long bones of her lower extremities with periosteal reaction and echogenic debris in the subperiosteal space, thought to represent leukemic cells...
October 9, 2018: Journal of Pediatric Hematology/oncology
Katherine L Roberts, Nicola J Doherty, Elizabeth A Maylor, Derrick G Watson
In vision, humans have the ability to mentally "tag" approximately 4 objects, allowing us to monitor, attend, and interact with them. As a consequence, we can rapidly and accurately enumerate up to 4 objects-a process known as subitizing. Here, we investigate whether a similar ability exists for tagging auditory stimuli and find that only 2 or 3 auditory stimuli can be enumerated with high accuracy. We assess whether this high accuracy indicates the existence of an auditory subitizing mechanism, and if it is influenced by factors known to influence visual subitizing...
October 8, 2018: Journal of Experimental Psychology. Human Perception and Performance
Laura L Allen, Katie L Morrison, Wesley A E Scott, Steve Shinn, Alan M Haltiner, Michael J Doherty
BACKGROUND: Skateboarders, snowboarders, and surfers all show stance preferences for which foot is forward while moving. We are unaware of other animals than humans with a stance preference, perhaps excepting Osprey, who fly their caught fish beneath them in a foot-forward stance. We hypothesize there should be no difference between left foot forward, right foot back (conventional) versus right foot forward left foot back (goofy) stances or for fish holding with unilateral left or right foot...
October 9, 2018: Brain and Behavior
Daniel T Doherty, Iestyn M Shapey, Zia Moinuddin, Linda Birtles, Angela Summers, Ashique Ahamed, David van Dellen, Titus Augustine
Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis. It is characterized by peritoneal neovascularization, fibrosis, and calcification ultimately leading to intestinal obstruction and eventual failure. Surgery for EPS has a mortality approaching 50% and most patients require some form of postoperative life-sustaining therapy (LST) during their admission. A 43-year-old gentleman with progressive EPS and significant comorbidities was assessed for enterolysis after a failed first attempt at another center...
October 4, 2018: Journal of Palliative Medicine
S Sahami, M E Wildenberg, L Koens, G Doherty, S Martin, G R A M D'Haens, G Cullen, W A Bemelman, D Winter, C J Buskens
Background and Aims: The objective of this study was to examine the modulating effect of an appendectomy on the disease course of therapy-refractory ulcerative colitis [UC] patients, and to analyse appendiceal pathological characteristics predictive of pathological response. Methods: Patients with therapy-refractory UC, and referred for proctocolectomy, were invited to undergo laparoscopic appendectomy first. The primary end points were clinical response after 3 and 12 months...
October 3, 2018: Journal of Crohn's & Colitis
Margaret Johnson, Heather McPheron, Rachel Dolin, Julia Doherty, Lisa Green
Purpose: The creation of the Centers for Medicare & Medicaid Services Office of Minority Health placed increased emphasis on federal efforts to address health disparities. Although the literature establishes a social justice case for addressing health disparities, there is limited evidence of this case being sufficient for businesses to invest in such initiatives. The purpose of this study was to better understand the "business case" behind an organization's investment in health disparity reduction work...
2018: Health Equity
Muhammad Fahmi Ismail, Kieran Doherty, Paula Bradshaw, Iomhar O'Sullivan, Eugene M Cassidy
INTRODUCTION: We previously reported that benzodiazepine detoxification for alcohol withdrawal using symptom-triggered therapy (STT) with oral diazepam reduced length of stay (LOS) and cumulative benzodiazepine dose by comparison with standard fixed-dose regimen. In this study, we aim to describe the feasibility of STT in an emergency department (ED) short-stay clinical decision unit (CDU) setting. METHODS: In this retrospective cohort study, we describe our experience with STT over a full calendar year (2014) in the CDU...
October 3, 2018: Emergency Medicine Journal: EMJ
Sam Salman, Julie Hibbert, Madhu Page-Sharp, Laurens Manning, Karen Simmer, Dorota A Doherty, Sanjay Patole, Kevin T Batty, Tobias Strunk
AIMS: Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotising enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterise the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. METHOD: An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation <32 weeks) with suspected LOS or NEC was undertaken...
October 3, 2018: British Journal of Clinical Pharmacology
Wallace Grimmett, Julie Lee, James Doherty, Benjamin Cheung, Meher Chinthamuneedi
Preeclampsia presenting as severe hyponatremia is an enigma of modern obstetric practice. The hyponatremia can cause severe maternal neurological morbidity, including cerebral edema and seizures. Neonates, with serum sodium reflecting maternal levels, are also at risk. Despite this, the literature remains ambiguous about its incidence, the pathophysiology is poorly understood, and guidelines on preeclampsia (including those of the American College of Obstetricians and Gynecologists) do not discuss the issue...
September 28, 2018: A&A practice
Laura E Crowell, Amos E Lu, Kerry R Love, Alan Stockdale, Steven M Timmick, Di Wu, Yu Annie Wang, William Doherty, Alexandra Bonnyman, Nicholas Vecchiarello, Chaz Goodwine, Lisa Bradbury, Joseph R Brady, John J Clark, Noelle A Colant, Aleksandar Cvetkovic, Neil C Dalvie, Diana Liu, Yanjun Liu, Craig A Mascarenhas, Catherine B Matthews, Nicholas J Mozdzierz, Kartik A Shah, Shiaw-Lin Wu, William S Hancock, Richard D Braatz, Steven M Cramer, J Christopher Love
Conventional manufacturing of protein biopharmaceuticals in centralized, large-scale, single-product facilities is not well-suited to the agile production of drugs for small patient populations or individuals. Previous solutions for small-scale manufacturing are limited in both process reproducibility and product quality, owing to their complicated means of protein expression and purification. We describe an automated, benchtop, multiproduct manufacturing system, called Integrated Scalable Cyto-Technology (InSCyT), for the end-to-end production of hundreds to thousands of doses of clinical-quality protein biologics in about 3 d...
October 1, 2018: Nature Biotechnology
Abhishek Abhishek, Annamaria Iagnocco, J W J Bijlsma, Michael Doherty, Frédéric Lioté
Objectives: To survey the undergraduate rheumatic and musculoskeletal diseases (RMDs) curriculum content in a sample of medical schools across Europe. Methods: The undergraduate musculoskeletal diseases and disability curriculum of University of Nottingham, UK, was used as a template to develop a questionnaire on curriculum content. The questionnaire elicited binary (yes/no) responses and included the option to provide additional information as free text. The survey was mailed to members of the European League Against Rheumatism (EULAR) School of Rheumatology (Undergraduate Classroom) and to EULAR Standing Committee on Education and Training members in January 2017, with a reminder in February 2017...
2018: RMD Open
Sergios Kimon Karatzos, Leslie Alan Edye, William Orlando Sinclair Doherty
No abstract text is available yet for this article.
September 27, 2018: Bioresource Technology
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