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Aliya Sarmanova, Gwen S Fernandes, Helen Richardson, Ana M Valdes, David A Walsh, Weiya Zhang, Michael Doherty
AIM: To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms. METHODS: A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a month. Baseline prevalence, and one year incidence and progression (KP worsening) were examined. Central (e.g. Pain Catastrophizing Scale (PCS)) and peripheral (e.g. significant injury) risk factors were examined. Adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression...
August 9, 2018: Osteoarthritis and Cartilage
Richard Thomas, Naomi Sykes, Sean Doherty, David Smith
In this short communication we call attention to the discovery of a ring depression (a circumferential constriction) in the horncore of a feral bull. This discovery casts doubt on the attribution of similar lesions in archaeological deposits as conclusive evidence of 'cord impressions' resulting from yoking or reining cattle for traction. Drawing upon evidence of horncore depressions in other species, we suggest that they reflect metabolic problems following horn development; additional research is required to test this hypothesis...
August 7, 2018: International Journal of Paleopathology
N W Bray, T J Doherty, M Montero-Odasso
BACKGROUND: Vitamin D deficiency is ubiquitous in frailty but the effectiveness of vitamin D supplementation to improve outcomes in frail individuals is unclear. It has been postulated that higher than the current recommended doses (800 IU/day) may be needed to achieve a neuromuscular effect in frail individuals. OBJECTIVES: 1) determine if 4000 IU per day of vitamin D3 is safe for frail older adults; and 2) establish the efficacy of this dose to improve physical performance outcomes in this population...
2018: Journal of Frailty & Aging
Tatiana A Shnitko, Sarah C Taylor, Sierra J Stringfield, Shannon L Zandy, Roberto U Cofresí, James M Doherty, William B Lynch, Charlotte A Boettiger, Rueben A Gonzales, Donita L Robinson
After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves.
August 10, 2018: Psychopharmacology
Aislinn Macklin-Doherty
Accountability of service delivery is becoming increasingly complex and never has this been more apparent than in the field of Oncology. Cancer care has an unrivalled level of complexity not only in the heterogeneity of management of the disease itself but increasingly in the myriad of service providers, specialities, policymakers and regulatory bodies overseeing its delivery. The stepwise series of changes to NHS structures over recent decades has had an enormous impact on our ability to answer key questions which lie at the heart of accountability: who is making the key decisions about changes to cancer care delivery? What are these reforms achieving? How can they be influenced? It is only through clear and transparent decision-making that we may have any hope of implementing, monitoring and influencing the effects of evidence-based change...
2018: Ecancermedicalscience
Tracy A O'Mara, Dylan M Glubb, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Manjeet K Bolla, Hiltrud Brauch, Hermann Brenner, Louise Brinton, Daniel D Buchanan, Barbara Burwinkel, Jenny Chang-Claude, Stephen J Chanock, Chu Chen, Maxine M Chen, Timothy H T Cheng, Christine L Clarke, Mark Clendenning, Linda S Cook, Fergus J Couch, Angela Cox, Marta Crous-Bous, Kamila Czene, Felix Day, Joe Dennis, Jeroen Depreeuw, Jennifer Anne Doherty, Thilo Dörk, Sean C Dowdy, Matthias Dürst, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Christine M Friedenreich, Lin Fritschi, Jenny Fung, Montserrat García-Closas, Mia M Gaudet, Graham G Giles, Ellen L Goode, Maggie Gorman, Christopher A Haiman, Per Hall, Susan E Hankison, Catherine S Healey, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A Hoivik, Elizabeth G Holliday, John L Hopper, David J Hunter, Angela Jones, Camilla Krakstad, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M Magliocco, Lynn Martin, Mark McEvoy, Alfons Meindl, Kyriaki Michailidou, Roger L Milne, Miriam Mints, Grant W Montgomery, Rami Nassir, Håkan Olsson, Irene Orlow, Geoffrey Otton, Claire Palles, John R B Perry, Julian Peto, Loreall Pooler, Jennifer Prescott, Tony Proietto, Timothy R Rebbeck, Harvey A Risch, Peter A W Rogers, Matthias Rübner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E Sarto, Fredrick Schumacher, Rodney J Scott, V Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C Southey, Anthony J Swerdlow, Emma Tham, Jone Trovik, Constance Turman, Jonathan P Tyrer, Celine Vachon, David VanDen Berg, Adriaan Vanderstichele, Zhaoming Wang, Penelope M Webb, Nicolas Wentzensen, Henrica M J Werner, Stacey J Winham, Alicja Wolk, Lucy Xia, Yong-Bing Xiang, Hannah P Yang, Herbert Yu, Wei Zheng, Paul D P Pharoah, Alison M Dunning, Peter Kraft, Immaculata De Vivo, Ian Tomlinson, Douglas F Easton, Amanda B Spurdle, Deborah J Thompson
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer...
August 9, 2018: Nature Communications
Cecilie Lindström Egholm, Henriette Knold Rossau, Per Nilsen, Gitte Bunkenborg, Morten Hulvej Rod, Patrick Doherty, Paul Bartels, Lotte Helmark, Ann-Dorthe Zwisler
A politically initiated national clinical guideline was launched in Denmark in 2013 to improve quality and equality of cardiac rehabilitation (CR) services. The guideline is to be implemented in both hospital and community (municipality) settings due to shared responsibility for provision of CR services. Little is known about implementation outcomes of a guideline in these two settings. We aimed to study this by determining the extent to which Danish CR services in hospitals and municipalities adhered to national recommendations following the launch of the guideline...
July 30, 2018: Health Policy
Sibylle Mohr, Michael Deason, Mikhail Churakov, Thomas Doherty, Rowland R Kao
The movements of livestock between premises and markets can be characterised as a dynamic network where the structure of the network itself can critically impact the transmission dynamics of many infectious diseases. As evidenced by the 2001 foot-and-mouth disease (FMD) epidemic in the UK, this can involve transmission over large geographical distances and can result in major economic loss. One consequence of the FMD epidemic was the introduction of mandatory livestock movement restrictions: a 13-day standstill in Scotland for cattle and sheep after moving livestock onto a farm (allowing many exemptions) and a 6-day standstill for cattle and sheep in England and Wales (with minor exemptions, e...
September 1, 2018: Preventive Veterinary Medicine
Jean Doherty, Sarah Cullen, Brenda Casey, Barbara Lloyd, Lucille Sheehy, Mary Brosnan, Theresa Barry, Anne McMahon, Barbara Coughlan
AIMS: To improve the confidence in student Midwives to provide bereavement careto parents following pregnancy loss and perinatal death. BACKGROUND: The one-day interactive Educational Training Workshop in Bereavement Care (ETWBC) was developed for student midwives in their final year of their B.Sc. Midwifery Degree Programme and those completing a Higher Diploma in Midwifery to help improve their confidence to provide bereavement care in clinical practice. DESIGN: A longitudinal sequential mixed-methods design was used to evaluate the outcome and processes of participation in the Workshop...
July 18, 2018: Midwifery
Sinead Holden, Cailbhe Doherty, Colin Boreham, Eamonn Delahunt
PURPOSE: Females athletes have a higher incidence of non-contact knee joint injuries compared to their male counterparts. This may be attributable to sex-specific differences in neuromuscular control, which arise during the pubertal growth spurt. The purpose of this longitudinal study was to assess the development of landing kinematics of adolescent male and female athletes during the adolescent growth-spurt. METHODS: One hundred and eighty-four adolescent athletes (55% male, 45% female; mean age = 13 ± 0...
August 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Erika L Rangel, Heather Lyu, Adil H Haider, Manuel Castillo-Angeles, Gerard M Doherty, Douglas S Smink
Importance: Previous work shows women who have children during surgical residency face difficulty balancing childbearing with training, which negatively affects residency and career satisfaction. Little is known about the factors that drive professional discontent. Objective: To determine factors associated with professional dissatisfaction for childbearing residents. Design, Setting, and Participants: Self-administered survey questionnaire electronically distributed through the Association of Program Directors in Surgery, the Association of Women Surgeons, and targeted Twitter and Facebook platforms...
August 1, 2018: JAMA Surgery
Katie M Kinnear, Nicole M Warner, Alan M Haltiner, Michael J Doherty
Objectives: To investigate if glucose levels influence seizure patterns. Materials and methods: In a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, seizure event times and onset locations were matched to continuous tissue glucose. Results: Left focal seizure (LFS, n = 22) glucoses averaged 169 mg/dL, while right focal seizure (RFS, n = 23) glucoses averaged 131 mg/dL (p = 0.03). LFS occurred at mean time 17:02 while RFS occurred at 04:23...
2018: Epilepsy & Behavior Case Reports
Erika L Rangel, Manuel Castillo-Angeles, Marguerite Changala, Adil H Haider, Gerard M Doherty, Douglas S Smink
INTRODUCTION: Prior work shows pregnancy during surgical residency may negatively impact career satisfaction and increase risk of attrition. We sought to gain deeper insight into the experience of childbearing trainees. METHODS: An electronic survey with three open-ended questions was sent to surgeons who had ≥1 pregnancy during a US general surgery training program. Transcripts were analyzed using directed content analysis and the constant comparative approach...
July 24, 2018: American Journal of Surgery
Mahmoud B Maina, Laura J Bailey, Sherin Wagih, Luca Biasetti, Saskia J Pollack, James P Quinn, Julian R Thorpe, Aidan J Doherty, Louise C Serpell
Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer's disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus. Although its normal role in microtubule binding is well established, its nuclear role is still unclear. Here, we reveal that tau localises to the nucleolus in undifferentiated and differentiated neuroblastoma cells (SHSY5Y), where it associates with TIP5, a key player in heterochromatin stability and ribosomal DNA (rDNA) transcriptional repression...
July 31, 2018: Acta Neuropathologica Communications
Patricia Pawlow, Constance Dahlin, Caroline L Doherty, Mary Ersek
One barrier to continued growth of palliative care is the shortage of qualified hospice and palliative care clinicians. Advanced practice registered nurses are an important part of the interdisciplinary palliative care team, and strengthening this workforce can help alleviate the shortage of clinicians and improve access to quality palliative care. However, there is a dearth of information about this workforce. The purpose of this study was to describe the current hospice and palliative care advanced practice registered nurse workforce, their educational needs, and barriers to practice...
August 2018: Journal of Hospice and Palliative Nursing: JHPN
Catherine F Notarius, Philip J Millar, Connor J Doherty, Anthony V Incognito, Nobuhiko Haruki, Emma O'Donnell, John S Floras
Muscle sympathetic nerve activity (MSNA) at rest increases with age. However, the influence of age on MSNA recorded during dynamic leg exercise is unknown. We tested the hypothesis that aging attenuates the sympatho-inhibitory response observed in young subjects performing mild to moderate 1-leg cycling. After pre-determining peak oxygen uptake (VO2peak), we compared contra-lateral fibular nerve MSNA during 2 minutes each of mild (unloaded) and moderate (30-40% of the work rate at peak VO2, halved for single leg) 1-leg cycling in 18 young (23±1 years [mean±SE]) and 18 middle-aged (57±2 years) sex-matched healthy subjects...
July 31, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Peter F Rambau, Robert A Vierkant, Maria P Intermaggio, Linda E Kelemen, Marc T Goodman, Esther Herpel, Paul D Pharoah, Stefan Kommoss, Mercedes Jimenez-Linan, Beth Y Karlan, Aleksandra Gentry-Maharaj, Usha Menon, Susanna Hernando Polo, Francisco J Candido Dos Reis, Jennifer Anne Doherty, Simon A Gayther, Raghwa Sharma, Melissa C Larson, Paul R Harnett, Emma Hatfield, Jurandyr M de Andrade, Gregg S Nelson, Helen Steed, Joellen M Schildkraut, Micheal E Carney, Estrid Høgdall, Alice S Whittemore, Martin Widschwendter, Catherine J Kennedy, Frances Wang, Qin Wang, Chen Wang, Sebastian M Armasu, Frances Daley, Penny Coulson, Micheal E Jones, Micheal S Anglesio, Christine Chow, Anna deFazio, Montserrat García-Closas, Sara Y Brucker, Cezary Cybulski, Holly R Harris, Andreas D Hartkopf, Tomasz Huzarski, Allan Jensen, Jan Lubiński, Oleg Oszurek, Javier Benitez, Mina Fady, Annette Staebler, Florin Andrei Taran, Jana Pasternak, Aline Talhouk, Mary Anne Rossing, Joy Hendley, Robert P Edwards, Sian Fereday, Francesmary Modugno, Roberta B Ness, Weiva Sieh, Mona A El-Bahrawy, Stacey J Winham, Jenny Lester, Susanne K Kjaer, Jacek Gronwald, Peter Sinn, Peter A Fasching, Jenny Chang-Claude, Kirsten B Moysich, David D Bowtell, Brenda Y Hernandez, Hugh Luk, Sabine Behrens, Mitul Shah, Audrey Jung, Prafull Ghatage, Jennifer Alsop, Kathryn Alsop, Jesús García-Donas, Pamela J Thompson, Anthony J Swerdlow, Chloe Karpinskyj, Alicia Cazorla-Jiménez, María J García, Susha Deen, Lynne R Wilkens, José Palacios, Andrew Berchuck, Jennifer M Koziak, James D Brenton, Linda S Cook, Ellen L Goode, David G Huntsman, Susan J Ramus, Martin Köbel
We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6,525 ovarian carcinomas including 4,334 HGSC using tissue microarrays from 24 studies participating in the Ovarian Tumor Tissue Analysis (OTTA) consortium. p16 expression patterns were interpreted as abnormal (either overexpression referred to as block expression or absence) or normal (heterogeneous)...
July 30, 2018: Journal of Pathology. Clinical Research
Audrey Prost, David Sanders, Anthony Costello, Joanna Vogel, Abdullah H Baqui, Nirmala Nair, Magali Romedenne, Ketan Chitnis, Geoffrey Bisoborwa, Tanya Doherty
No abstract text is available yet for this article.
July 30, 2018: BMJ: British Medical Journal
Tanya Doherty, Nhan Tran, David Sanders, Sarah L Dalglish, David Hipgrave, Kumanan Rasanathan, Thiagarajan Sundararaman, Rajani Ved, Elizabeth Mason
No abstract text is available yet for this article.
July 30, 2018: BMJ: British Medical Journal
Chang-Fu Kuo, I-Jun Chou, Lai-Chu See, Jung-Sheng Chen, Kuang-Hui Yu, Shue-Fen Luo, Ao-Ho Hsieh, Weiya Zhang, Michael Doherty
Objectives: To examine whether gout is an independent risk factor for total joint replacement (TJR) and whether urate-lowering treatment (ULT) reduces this risk. Methods: Using the Taiwan National Health Insurance database and the UK Clinical Practice Research Datalink, 74 560 Taiwan patients and 34 505 UK patients with incident gout were identified and age and sex matched to people without gout. Cox proportional hazards models and condition logistic regression were used to examine the risk of TJR in gout patients and the association between cumulative defined daily dose (cDDD) of ULT and TJR...
July 27, 2018: Rheumatology
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