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https://www.readbyqxmd.com/read/29928660/rho-kinase-inhibitors-do-not-expand-hematoma-volume-in-acute-experimental-intracerebral-hemorrhage
#1
Murtaza Akhter, Tom Qin, Paul Fischer, Homa Sadeghian, Hyung Hwan Kim, Michael J Whalen, Joshua N Goldstein, Cenk Ayata
Rho-associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre-hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform-nonselective inhibitor fasudil, or ROCK2-selective inhibitor KD025, or their vehicles...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928315/non-vitamin-k-antagonist-oral-anticoagulant-after-acute-coronary-syndrome-is-there-a-role
#2
REVIEW
Paul Guedeney, Birgit Vogel, Roxana Mehran
Despite dual antiplatelet therapy (DAPT) including potent P2Y12 inhibitors, recurrent ischaemic events occur in a significant number of patients after acute coronary syndrome (ACS), warranting new antithrombotic strategies. Combinations of non-vitamin K antagonist oral anticoagulant (NOAC) with antiplatelet therapy have been tested in several large phases II and III randomised trials. Overall, current evidence suggests that the use of NOACs on top of DAPT after ACS reduces the rate of recurrent ischaemic events, albeit at the price of increased risk for major bleeding...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29927858/regional-anesthesia-in-the-patient-receiving-antithrombotic-or-thrombolytic-therapy-american-society-of-regional-anesthesia-and-pain-medicine-evidence-based-guidelines-fourth-edition-erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29926562/-acute-coronary-syndrome
#4
O Gach, Husseini Z El, P Lancellotti
Acute coronary syndromes represent a major cause of mortality in our country. There is a very wide spectrum of clinical presentation since the actual classification of acute coronary syndromes is based on electrocardiographic presentation, that is to say based on absence or presence of ST segment elevation. When dealing with an acute chest pain, once the probability of acute coronary syndrome is established, the emergency care must follow the scientific guidelines. One of the critical steps is represented by the evaluation of ischaemic and hemorrhagic risk in order to tailor optimally antithrombotic and anticoagulation therapies and revascularization timing...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29925721/traumatic-basilar-artery-entrapment-without-longitudinal-clivus-fracture-a-case-report-and-review-of-the-literature
#5
Ayumu Yamaoka, Kei Miyata, Naofumi Bunya, Hirotoshi Mizuno, Hideto Irifune, Naoya Yama, Yukinori Akiyama, Takeshi Mikami, Masahiko Wanibuchi, Nobuhiro Mikuni
In blunt cerebrovascular injury, reported traumatic basilar artery occlusions have involved dissection of the basilar artery, distal embolization due to traumatic vertebral artery dissection, or entrapment of the basilar artery into the clivus fracture. To date, however, there are no reports of traumatic basilar artery entrapment without a clivus fracture. Here, we report the first case of traumatic basilar artery occlusion caused by entrapment into an originally existing bone defect. A 67-year-old man with a history of treatment for intracranial aneurysm suffered multiple traumatic injuries in a fall...
June 20, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29925473/corrigendum-to-efficacy-and-safety-of-antithrombotic-regimens-after-coronary-intervention-in-patients-on-oral-anticoagulation-traditional-and-bayesian-meta-analysis-of-clinical-trials-int-j-cardiol-205-2016-89-96
#6
Jian Liu, Meida Fan, Jingjing Zhao, Bingcheng Zhao, Chongyu Zhang, Chen Liu, Yugang Dong
No abstract text is available yet for this article.
June 18, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29925139/-multidisciplinary-collaboration-and-individualized-treatment-are-the-only-way-for-patients-with-intracranial-hemorrhage-who-are-treated-with-antithrombotic-drugs
#7
J J Wei, D Z Kang, R Z Wang
No abstract text is available yet for this article.
June 5, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29920547/efficacy-and-safety-of-triple-therapy-versus-dual-antiplatelet-therapy-in-patients-with-atrial-fibrillation-undergoing-coronary-stenting-a-meta-analysis
#8
Liyao Liu, Jietao Huang, Xiaogang Zhang, Xiaoman Tang
BACKGROUND: The optimal antithrombotic therapy for atrial fibrillation (AF) patients undergoing coronary stenting is unknown. The present meta-analysis sought to investigate the efficacy and safety of triple therapy (TT; warfarin, clopidogrel and aspirin) vs dual antiplatelet therapy (DAPT; clopidogrel plus aspirin) in those patients. METHODS: PubMed and Cochrane Library were searched for studies enrolling AF patients undergoing coronary stenting on TT and DAPT up to September 2016, and fourteen studies were included...
2018: PloS One
https://www.readbyqxmd.com/read/29916838/simvastatin-reverses-multiple-myeloma-serum-induced-prothrombotic-phenotype-in-endothelial-cells-via-erk-1-2-signalling-pathway
#9
Rujiao Dong, Guibo Ma, Shunji Zhang, Yujuan Gao, Shuchuan Liu, Yanhua Su
: The introduction of new agents in multiple myeloma therapy has increased the overall response rate and improved clinical outcomes, but the increased risk of thrombotic complications impairs the quality of life of patient and the optimal thromboprophylaxis remains unknown. Increasing evidence has shown that statins can prevent venous thrombosis. Hence, we investigated the effects of simvastatin on multiple myeloma serum-related haemostatic imbalance in endothelial cells in vitro. The effects of simvastatin on procoagulant and anticoagulant protein expression were assessed on mixed multiple myeloma serum-treated human umbilical vein endothelial cells (HUVECs)...
June 18, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29915905/antithromboembolic-strategies-for-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention
#10
REVIEW
Ayesha Ather, Benjamin Laliberte, Brent N Reed, Ashley Schenk, Kristin Watson, Sandeep Devabhakthuni, Vincent Y See
We set out to synthesize available data on antithrombotic strategies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), with a focus on triple antithrombotic therapy (triple therapy [TT]; dual antiplatelet therapy plus an anticoagulant) versus dual therapy (DT; one antiplatelet agent and an anticoagulant). We searched OVID MEDLINE and PubMed from January 2005 to September 2017 using the search terms oral anticoagulant, triple therapy, dual therapy, acute coronary syndrome, percutaneous coronary intervention, and atrial fibrillation (limited to randomized controlled trials, observational studies, English language, minimum 6-12 months of follow-up, minimum 100 human patients)...
June 19, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29915616/clinical-characteristics-and-type-of-antithrombotic-treatment-in-a-spanish-cohort-of-elderly-patients-with-atrial-fibrillation-according-to-dependency-frailty-and-cognitive-impairment
#11
Jose María Mostaza, Manuel Jesús Romero Jiménez, Fernando José Ruiz Laiglesia, José Antonio Díaz Peromingo, Manuel Beltrán Robles, Ernesto Guevara Sierra, Ana Santander Bilbao, Carmen Suárez
Background: Available data regarding clinical profile and management of elderly patients with atrial fibrillation (AF) according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods: Cross-sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain...
April 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29914560/predictive-factors-of-intracranial-bleeding-in-head-trauma-patients-receiving-antiplatelet-therapy-admitted-to-an-emergency-department
#12
Farès Moustafa, Jean Roubin, Bruno Pereira, Alain Barres, Jennifer Saint-Denis, Christophe Perrier, Marine Mondet, Frederic Dutheil, Jeannot Schmidt
BACKGROUND: In head trauma cases involving antiplatelet agent treatment, the French Society of Emergency Medicine recommends performing computed tomography (CT) scans to detect brain lesions, 90% of which are normal. The value of CT is still debatable given the scarce number of studies and controversial results. METHODS: We used the RATED registry (Registry of patient with Antithrombotic agents admitted to an Emergency Department, NCT02706080) to assess factors of cerebral bleeding related to antiplatelet agents following head trauma...
June 19, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29910193/closure-anticoagulation-or-antiplatelet-therapy-for-cryptogenic-stroke-with-patent-foramen-ovale-systematic-review-of-randomized-trials-sequential-meta-analysis-and-new-insights-from-the-close-study
#13
REVIEW
Guillaume Turc, David Calvet, Patrice Guérin, Marjorie Sroussi, Gilles Chatellier, Jean-Louis Mas
BACKGROUND: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing patent foramen ovale (PFO) closure, anticoagulation, and antiplatelet therapy to prevent stroke recurrence in patients with PFO-associated cryptogenic stroke. METHODS AND RESULTS: We searched Medline, Cochrane Library, and EMBASE through March 2018. The primary outcome was stroke recurrence. Pooled incidences, hazard ratios, and risk ratios (RRs) were calculated in random-effects meta-analyses...
June 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29908761/health-related-quality-of-life-after-bleeding-adverse-events-associated-with-antithrombotic-drug-therapy-a-systematic-review
#14
REVIEW
Lodewijk C S Res, Bart Lubberts, Shivesh H Shah, Christopher W DiGiovanni
BACKGROUND: Little is known about the health-related quality of life (HRQOL) following adverse bleeding events associated with antithrombotic drug therapy. This systematic review assesses the HRQOL of patients who suffered a bleeding event related to antithrombotic drug use. METHODS: Literature search was performed using PubMed, EMBASE, and the Cochrane Library from inception through June 16, 2017. Studies measuring HRQOL after a bleeding event related to antithrombotic drug therapy for primary or secondary prevention of a thromboembolic event were included...
June 14, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29904963/experience-of-a-single-center-in-the-conservative-approach-of-20-consecutive-cases-of-asymptomatic-extracranial-carotid-artery-aneurysms
#15
V E C Pourier, J C Welleweerd, L J Kappelle, G J E Rinkel, Y M Ruigrok, H B van der Worp, T H Lo, M L Bots, F L Moll, Gert J de Borst
BACKGROUND: The clinical course and optimal treatment strategy for asymptomatic aneurysms of the extracranial carotid artery (ECAA) are unknown. We report our single-center experience with conservative management of patients with an asymptomatic ECAA. METHODS: A search in our hospital records from 1998 to 2013 revealed 20 patients (mean age 52 years, SD 12.5) with 23 ECAA, defined as a 150% or more fusiform dilation or any saccular dilatation compared to the healthy internal carotid artery...
June 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29903520/a-meta-analysis-of-randomized-controlled-trials-of-uninterrupted-periprocedural-anticoagulation-strategy-in-patients-undergoing-atrial-fibrillation-catheter-ablation
#16
Yating Zhao, Yao Lu, Yue Qin
BACKGROUND: In patients undergoing atrial fibrillation (AF) ablation, despite uninterrupted oral anticoagulants (OACs) have been recommended, no consensus has emerged regarding to whether uninterrupted novel oral anticoagulants (NOACs) are superior to uninterrupted vitamin K antagonists (VKAs) for the periprocedural antithrombotic management. This meta-analysis aimed to compare the efficacy and safety of uninterrupted NOACs and uninterrupted VKAs in patients undergoing AF ablation. METHODS: Databases were searched for articles published up to March 20, 2018...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29902903/-mechanisms-of-hirudo-in-promoting-blood-circulation-and-removing-stasis-based-on-network-pharmacology
#17
Luo-Dan Ouyang, Xiao-Song Hu, Ming Niu, Wen Gao, Yu Cheng, Jia-Bo Wang, Li Ma
The study aims to analyze the mechanisms of Hirudo in promoting blood circulation and removing blood stasis based on network pharmacology. A database of chemical components of Hirudo was established through literature retrieval. The targets were predicted by using the reverse pharmacophore matching method and screened according to the antithrombotic and anticoagulant drug targets approved by FDA in the DrugBank database. Then, the targets were analyzed by KEGG pathway analysis, the protein interactions were analyzed by using BioGrid database, and the active constituents-target-pathway network model of Hirudo was established to study the mechanisms of Hirudo in promoting blood circulation and removing blood stasis...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29901638/multiple-penetrating-aortic-ulcers-and-rupture-of-superior-mesenteric-artery-branch-presenting-with-symptoms-similar-to-unstable-angina-a-case-report
#18
Suqiao Zhang, Rui Lian, Guoqiang Zhang
RATINALE: Penetrating aortic ulcer (PAU) and rupture of a superior mesenteric artery branch is a rare but potentially life-threatening condition. PATIENT CONCERNS: We describe a case of 73-year-old man was brought to our Emergency Department for intermittent back pain. DIAGNOSES: The final diagnoses are PAU (Stanford B) and rupture of a branch of the superior mesenteric artery. INTERVENTIONS: Two covered stents were placed in the thoracic aorta and the right external iliac artery, and the superior mesenteric artery branch was embolized...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901447/long-term-effectiveness-and-safety-of-transcatheter-closure-of-patent-foramen-ovale-compared-with-antithrombotic-therapy-a-meta-analysis-of-6-randomised-clinical-trials-and-3560-patients-with-reconstructed-time-to-event-data
#19
Daniele Giacoppo, Nicola Caronna, Antonio H Frangieh, Jonathan Michel, Giuseppe Andò, Giuseppe Tarantini, Albert M Kasel, Davide Capodanno, Robert A Byrne
AIMS: Although three recent trials showed a significant stroke risk reduction after tPFOc, the impact on pooled evidence deserves attention and individual statistical power is limited. We aimed to pool available randomised clinical trials (RCT) to assess whether tPFOc is more effective and safe than antithrombotic therapy alone (ATA). METHODS AND RESULTS: Major electronic databases and tangential sources were searched and 6 trials (3560 patients) identified. At a median follow-up of 3...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29898848/oral-anti-xa-anticoagulation-after-trans-aortic-valve-implantation-for-aortic-stenosis-the-randomized-atlantis-trial
#20
Jean-Philippe Collet, Sergio Berti, Angel Cequier, Eric Van Belle, Thierry Lefevre, Pascal Leprince, Franz-Josef Neumann, Eric Vicaut, Gilles Montalescot
BACKGROUND: Antithrombotic treatment regimen following transcatheter aortic valve replacement (TAVR) is not evidence-based. Apixaban, a non-vitamin K direct anticoagulant (NOAC) was shown to be superior to VKA and superior to aspirin to prevent cardioembolic stroke in non-valvular atrial fibrillation. It may have the potential to reduce TAVR-related thrombotic complications including subclinical valve thrombosis along with a better safety than the standard of care. DESIGN: ATLANTIS is a multicenter, randomized, phase IIIb, prospective, open-label, superiority study comparing standard of care (SOC Group) versus an apixaban-based strategy (Anti-Xa Group) after successful TAVR (ClinicalTrials...
June 2018: American Heart Journal
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