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Vulvar pathology

David A Siegel, Reda Wilson, Edward J Wilkinson, Julia W Gargano, Meg Watson, Brenda Y Hernandez, Marc T Goodman, Charles F Lynch, Elizabeth R Unger, Mona Saraiya
CONTEXT: -Knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus-related cancer etiology. Surveillance of human papillomavirus-related vulvar cancers informs public health decisions related to vaccination against human papillomavirus. OBJECTIVE: -To assess the accuracy of registry classifications of vulvar cancer and determine the histologic classification of cases reported as not otherwise specified. DESIGN: -Pathology specimens were collected from Florida, Iowa, and Hawaii cancer registries...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Anastasia M Konstantinova, Liubov Kyrpychova, Irena E Belousova, Dominic V Spagnolo, Denisa Kacerovska, Michal Michal, Katrin Kerl, Dmitry V Kazakov
The normal histology of anogenital mammary-like glands (AGMLG) has been studied previously, but some aspects, including glandular depth, presence of columnar epithelium resembling columnar cell change/hyperplasia as defined in mammary pathology, and distribution of elastic fibers, have not been previously investigated. To address these issues, we studied 148 AGMLG identified in 133 paraffin blocks sampled from 64 vulvar wide excision or vulvectomy specimens (64 patients, various indications for surgery). The depth of AGMLG ranged from 0...
October 18, 2016: American Journal of Dermatopathology
Gozde Kulhan, Mehmet Kulhan, Umit Nayki, Cenk Nayki, Pasa Ulug, Emrah Akkaya, Onur S Aldemir, Yusuf Yildirim, Mehmet Sipahi
OBJECTIVES: Our study aimed to determine the epidemiological characteristics and diagnostic and treatment protocols of primary vaginal carcinoma. Also, we compared the clinical and pathological features of primary vaginal carcinoma which intersect with cervical and vulvar carcinomas. MATERIAL AND METHODS: Sixteen patients with primary vaginal carcinoma, admitted to the Department of Gynecologic Oncology, Izmir Tepecik Training and Research Hospital between January 1983 and December 2012, were evaluated retrospectively...
2016: Ginekologia Polska
Chieko Sakae, Ken Yamaguchi, Noriomi Matsumura, Hidekatsu Nakai, Yumiko Yoshioka, Eiji Kondoh, Junzo Hamanishi, Kaoru Abiko, Masafumi Koshiyama, Tsukasa Baba, Aki Kido, Masaki Mandai, Ikuo Konishi
OBJECTIVE: To identify suitable diagnostic tools and evaluate the efficacy of sentinel lymph node (SLN) biopsy for inguinal lymph node metastasis in vulvar cancer. METHODS: Data from 41 patients with vulvar cancer were evaluated retrospectively, including magnetic resonance imaging (MRI) measurements, SLN biopsy status, groin lymph node metastasis, and prognosis. RESULTS: SLN biopsy was conducted in 12 patients who had stage I to III disease...
June 29, 2016: Journal of Gynecologic Oncology
Lisa Barbera, Lilian T Gien, Rinku Sutradhar, Gillian Thomas, Al Covens, Laurie Elit, Anthony Fyles, Eileen Rakovitch, Ying Liu, Mahmoud Khalifa
We conducted a population-based patterns of care study of vulvar carcinoma. This paper describes the changes in reporting based on pathology review. This is a retrospective population-based cohort study. We obtained all pathology records available from the provincial cancer registry for primary invasive squamous cell carcinoma of the vulva diagnosed between 1998 and 2007. Pathology reviews were conducted centrally by a group of gynecologic pathologists and were identified during abstraction. Corresponding original reports were matched to pathology review reports based on accession numbers...
August 10, 2016: International Journal of Gynecological Pathology
Domenico Ferraioli, Gery Lamblin, Patrice Mathevet, Jessika Hetu, Isabelle Berakdar, Frederic Beurrier, Nicolas Chopin
PURPOSE: Genital melanoma is a rare pathology. We present the experience of two comprehensive cancer centers in Lyon (France) in the management of genital melanoma in order to identify prognostic factors and optimal treatments. METHODS: Between April 1992 and Mars 2014, 16 patients with a primary genital melanoma were referred to our department. Nine patients presented a vaginal melanoma, six vulvar melanomas and only one cervical melanoma. The median dimension of the lesion was 33...
June 30, 2016: Archives of Gynecology and Obstetrics
Beatriz de Melo Maia, Iara Santana Rodrigues, Erica Mie Akagi, Nayra Soares do Amaral, Hui Ling, Paloma Monroig, Fernando Augusto Soares, George Adrian Calin, Rafael Malagoli Rocha
MiR-223-5p has been previously mentioned to be associated with tumor metastasis in HPV negative vulvar carcinomas, such as in several other tumor types. In the present study, we hypothesized that this microRNA would be important in vulvar cancer carcinogenesis and progression. To investigate this, we artificially mimicked miR-223-5p expression in a cell line derived from lymph node metastasis of vulvar carcinoma (SW962) and performed in vitro assays. As results, lower cell proliferation (p < 0.01) and migration (p < 0...
June 23, 2016: Oncotarget
Emily R Holthoff, Horace Spencer, Thomas Kelly, Steven R Post, Charles M Quick
Factors contributing to aggressive behavior in vulvar squamous cell carcinoma (vSCC) are poorly defined; however, a recent study has shown that vSCCs with an infiltrative pattern of invasion and fibromyxoid stroma are associated with worse outcomes than tumors with a pushing or nested pattern of invasion and lymphoplasmacytic stroma. Epithelial-mesenchymal transition (EMT) has been associated with tumor progression in a number of malignancies, and this study proposes that EMT contributes to tumor aggressiveness in this subset of vSCC...
October 2016: Human Pathology
Mouna Khmou, Najat Lamalmi, Abderrahmane Malihy, Lamia Rouas, Zaitouna Alhamany
BACKGROUND: Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small to medium-sized vessels with mural hyalinization. The indolent nature of the lesion is underscored by the uniformity of its constituent stromal cells, and their lack of nuclear atypia. Characterization by immunohistochemistry is helpful distinguishing Cellular angiofibroma from other mesenchymal lesions...
2016: BMC Clinical Pathology
Maaike C G Bleeker, Pascal J Visser, Lucy I H Overbeek, Marc van Beurden, Johannes Berkhof
BACKGROUND: The association between lichen sclerosus and vulvar squamous cell carcinoma (VSCC) has long been recognized, but large epidemiologic studies are lacking. METHODS: Data of women diagnosed with vulvar pathology in the Netherlands were retrieved from the Dutch Pathology Registry. All vulvar pathology reports of this historical cohort were reviewed to construct a research database, including 3,038 women with lichen sclerosus diagnosed between 1991 and 2011...
August 2016: Cancer Epidemiology, Biomarkers & Prevention
Mustafa Öztürk, Yakup Çil, Ferdi Kıncı, Hakan Çermik
BACKGROUND: Cystic lesions associated with the blockage of Bartholin gland ducts are frequently seen, but occurrence outside the normal vestibular localization is quite rare. CASE: A 16-year-old patient presented with a localized cystic lump approximately 4 cm in size on one of her labia minora. After an excision, she was diagnosed with an atypically localized Bartholin cyst. SUMMARY AND CONCLUSION: It is very difficult to make an early diagnosis for an atypically localized Bartholin cystic lesion in adolescence; it can be diagnosed only after a pathological examination...
October 2016: Journal of Pediatric and Adolescent Gynecology
Fatimah Alnafisah, Joanne Alfieri
Vulvar neoplasms represent four percent of all gynecological cancers. While most cases of vulvar neoplasms are benign, two percent of patients present with malignant disease. We present the case of a 37-year-old premenopausal female who presented to an outside institution with a lump in her left vulva, which had progressively enlarged to the size of an egg. A wide local excision of the left vulva was performed, and the pathology revealed a high-grade sarcoma, not otherwise specified (NOS), with negative margins...
2016: Curēus
R Saleeb, H Faragalla, G M Yousef, R Stewart, C J Streutker
INTRODUCTION: Previous publications have shown an increased incidence of various malignancies amongst renal transplant populations. The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. METHODS: After approval by the hospital's research ethic board, review of the records and pathology of the 1584 patients in the renal transplant clinic database patients was performed...
April 2016: Urology Annals
Lesley B Conrad, Steven A Conrad, David S Miller, Debra L Richardson, Siobhan Kehoe, Jayanthi S Lea
OBJECTIVES: Advanced vulvar cancers involving midline structures pose a therapeutic challenge. Our objectives were to review the management and outcomes, and identify factors influencing primary treatment modality. METHODS: Patients with midline vulvar cancers diagnosed from 1985 to 2012 were included in the analysis. Medical records were abstracted for demographics, clinico-pathological findings, treatment, and outcomes. Groin node status was defined by clinical findings or pathology...
July 2016: Gynecologic Oncology
M E Căpîlna, B Szabo, C R Nicolau, A Daniilidis, R M Neagoe, B Moldovan
PURPOSE OF INVESTIGATION: To analyze the prevalence of inguinofemoral lymph nodes metastases in clinical Stages IB-II vulva cancer. MATERIALS AND METHODS: Twenty-two patients with FIGO Stages IB-II FIGO vulva cancer with no clinically and imagistic evidence of nodes metastases were treated in the present clinic. The surgical procedures consisted in radical vulvectomy plus inguinofemoral lym- phadenectomy. RESULTS: The final pathological result was squamous carcinoma in 20 patients, vulva melanoma in one, and carcinosar- coma in one...
2016: European Journal of Gynaecological Oncology
Antonino Ditto, Giorgio Bogani, Fabio Martinelli, Violante Di Donato, Joel Laufer, Santiago Scasso, Valentina Chiappa, Mauro Signorelli, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: The aim of the study was to evaluate the surgical management and the role of different prognostic factors on survival outcomes of women affected by genital (i.e., vulvar and vaginal) melanoma. MATERIALS AND METHODS: Data of patients undergoing primary surgical treatment for genital melanoma were evaluated in this retrospective study. Baseline, pathological, and postoperative variables were tested to identify prognostic factors. Five-year disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox proportional hazards models...
July 2016: Journal of Lower Genital Tract Disease
Simona Pichler Sekulic, Miroslav Sekulic
Nodular fasciitis involving the vulva on physical examination can mimic a Bartholin gland lesion, and histologically can have overlapping features with more ominous mesenchymal pathologies. We describe a case in which a 52-year-old perimenopausal woman presents with a vulvar mass. After an initial biopsy and later excision, the myofibroblastic lesion was noted to have areas of differing cellularity, with compact nodule formations at the periphery. Immunohistochemical staining showed lesional cells to be positive for desmin, estrogen receptor, progesterone receptor, and smooth muscle actin, and negative for CD34, ALK-1, myogenin, caldesmon, S100, and wide spectrum (Oscar) cytokeratin...
March 18, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Ana Mercedes Victoria-Martínez, Laura Cubells-Sánchez, Lorena Martínez-Leborans, José Luis Sánchez-Carazo, Víctor Alegre de Miquel
We present a case report of a patient with epidermal inclusion cyst as a late complication of female genital mutilation (FGM). We describe the management of the patient, and a review of the literature. We report the clinical and pathological findings in a 37-year-old female patient from Nigeria, with a clitoral mass of 1 year duration. She declared to have an FGM since she was 5 years. The lesion was excised successfully with good cosmetic results. Histological examination revealed epidermal cyst with the presence of granular layer...
January 2016: Indian Journal of Dermatology
Mihae Song, Marina Chekmareva, Gloria Bachmann, Darlene Gibbon
BACKGROUND: Pilomatrix carcinomas are rare, frequently occurring in older male patients. We report a case of vulvar pilomatrix carcinoma in a 30-year-old woman, the second known reported case occurring on the external genitalia. CASE: A 30-year-old female originally presented at an outside institution for the management of an asymptomatic vulvar mass that was biopsied and read as invasive squamous cell carcinoma. Pathology review at our institution reclassified the vulvar mass as a low-grade pilomatrix carcinoma...
January 2016: Gynecologic Oncology Reports
Alessandro Buda, Tiziana Dell'Anna, Francesca Vecchione, Debora Verri, Giampaolo Di Martino, Rodolfo Milani
Sentinel lymph node (SLN) mapping is emerging as an effective method for surgical staging of different gynecologic malignancies. Near-infrared (NIR) technology using a fluorescent dye such as indocyanine green (ICG) represents an interesting and feasible method for SLN mapping even in traditional open surgeries by applying video telescope operating microscope (VITOM) system technology. We report our preliminary experience in 12 women who underwent surgical nodal staging for early-stage vulvar and uterine or cervical cancer...
May 2016: Journal of Minimally Invasive Gynecology
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