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Salivary gland pathology

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https://www.readbyqxmd.com/read/29656683/clinicopathologic-analysis-of-2736-salivary-gland-cases-over-a-11-year-period-in-southwest-china
#1
S Y Shen, W H Wang, R Liang, G Q Pan, Y M Qian
OBJECTIVE: To investigate the epidemiological and clinicopathological characteristics of salivary gland tumors in southwest China in order to provide data for clinical diagnosis and other similar research. METHODS: Between March 2007 and December 2017, 2736 patients with salivary gland tumors were recruited, the clinical and pathological data were retrospectively analyzed. RESULTS: A total of 2736 patients had a ratio of males to females of about 1...
April 14, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29656342/prosaposin-and-its-receptors-are-differentially-expressed-in-the-salivary-glands-of-male-and-female-rats
#2
Farzana Islam, Md Sakirul Islam Khan, Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Kimiko Yamamiya, Naoto Kobayashi, Seiji Matsuda
Salivary glands produce various neurotrophins that are thought to regulate salivary function during normal and pathological conditions. Prosaposin (PSAP) is a potent neurotrophin found in several tissues and various biological fluids and may play roles in the regulation of salivary function. However, little is known about PSAP in salivary glands. As the functions of salivary glands are diverse based on age and sex, this study examines whether PSAP and its receptors, G protein-coupled receptor 37 (GPR37) and GPR37L1, are expressed in the salivary glands of rats and whether sex and aging affect their expression...
April 14, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29644928/salivary-gland-ultrasound-is-linked-to-the-autoimmunity-profile-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#3
Juan Carlos Nieto-González, Juan G Ovalles-Bonilla, Eduardo Estrada, Belén Serrano-Benavente, Julia Martínez-Barrio, Carlos M González-Fernández, Roberto González-Benítez, Cristina Vergara Dangond, Indalecio Monteagudo, Luis Collado Yurrita, Francisco Javier López-Longo
Objective Salivary gland ultrasound (SGU) is a reliable technique for assessing the salivary glands in patients with primary Sjögren's syndrome (pSS). The aim of this study was to elucidate the relationship between SGU findings and autoimmunity in patients with pSS. Methods Patients with pSS underwent an SGU assessment. The patients were classified into three groups according to their autoimmunity profile: the complete positive group (positive rheumatoid factor, antinuclear antibodies, and anti-Ro/anti-La antibodies), the partial seropositive group (positivity of at least one autoantibody but not all), and the seronegative group...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29627048/pathology-of-primary-tracheobronchial-malignancies-other-than-adenoid-cystic-carcinomas
#4
REVIEW
Darroch Moores, Paresh Mane
Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Squamous cell carcinoma and adenoid cystic carcinoma make up about two-thirds of adult primary tracheal tumors. Because of their predominantly local growth pattern, malignant salivary gland-type tumors show a better outcome than other histologic types.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29622119/routine-and-advanced-ultrasound-of-major-salivary-glands
#5
REVIEW
Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
Ultrasound is the preferred initial imaging modality in Europe and Asia for assessing the major salivary glands. In experienced hands, it is sensitive for a range of salivary pathologies, often diagnostic, and also a safe, cost-effective gatekeeper for further investigations as well as image-guided diagnostic biopsies and aspirations. This article reviews the scanning technique and normal sonographic anatomy of major salivary glands and overviews typical sonographic appearances of salivary pathologies, including infective and inflammatory conditions, sialolithiasis, and neoplasms...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29622118/imaging-of-inflammatory-disorders-of-salivary-glands
#6
REVIEW
Asim K Bag, Joel K Curé, Philip R Chapman, Aparna Singhal, Atif Wasim Haneef Mohamed
Sialadenitis is among the most common conditions that affect the salivary glands. Inflammation of the salivary glands occurs as the end result of a variety of pathologic conditions, including infectious, autoimmune, and idiopathic causes. Clinically, inflammation of the salivary gland causes pain and localized swelling. The presentation may be acute or chronic, and can be recurrent. Because there is significant overlap of underlying disease mechanisms and clinical presentations, radiologic evaluation often plays a significant role in evaluation...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29622116/imaging-of-submandibular-and-sublingual-salivary-glands
#7
REVIEW
Amit K Agarwal, Sangam G Kanekar
The submandibular and sublingual salivary glands are major salivary glands with a wide spectrum of pathologic conditions. The corresponding spaces along the floor of mouth have complex anatomy, best evaluated with cross-sectional imaging. The spectrum of diseases in these regions varies from simple infection to advanced malignancy, not just from the gland itself but also from the surrounding structures. The most common abnormalities in these spaces are inflammatory and infectious, and computed tomography is currently the most common imaging modality used...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29622115/imaging-of-pediatric-salivary-glands
#8
REVIEW
Elliott Friedman, Maria Olga Patiño, Unni K Udayasankar
Salivary gland diseases in children are uncommon, and the relative incidence of pathologies is different than in adults. This article presents a comprehensive review of congenital and acquired disorders that affect the major salivary glands in the pediatric population, highlighting the imaging findings that are important in defining the appropriate diagnosis or narrowing of the differential diagnosis.
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29622110/cross-sectional-imaging-techniques-and-normal-anatomy-of-the-salivary-glands
#9
REVIEW
Christopher Atkinson, Joseph Fuller, Benjamin Huang
The salivary glands play an important role in digestion and oral hygiene, and give rise to a variety of benign and malignant pathologies. In suspected pathology, the goal of imaging is to confirm a lesion as being of salivary gland origin, narrow the list of differential considerations, define the extent of disease, and guide further management decisions. This review outlines the function, embryologic development, anatomy, and normal imaging features of the major salivary glands. The article also discusses imaging indications, the general approach to imaging the salivary glands, and the commonly used cross-sectional techniques used for evaluating the salivary gland...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29610392/personalized-oncogenomic-analysis-of-metastatic-adenoid-cystic-carcinoma-using-whole-genome-sequencing-to-inform-clinical-decision-making
#10
Manik Chahal, Erin Pleasance, Jasleen Grewal, Eric Zhao, Tony Ng, Erin Chapman, Martin R Jones, Yaoqing Shen, Karen L Mungall, Melika Bonakdar, Gregory A Taylor, Yussanne Ma, Andrew J Mungall, Richard A Moore, Howard Lim, Daniel Renouf, Stephen Yip, Steven J M Jones, Marco A Marra, Janessa Laskin
Metastatic adenoid cystic carcinomas (ACCs) can cause significant morbidity and mortality. Because of their slow growth and relative rarity, there is limited evidence for systemic therapy regimens. Recently, molecular profiling studies have begun to reveal the genetic landscape of these poorly understood cancers, and new treatment possibilities are beginning to emerge. The objective is to use whole-genome and transcriptome sequencing and analysis to better understand the genetic alterations underlying the pathology of metastatic and rare ACCs and determine potentially actionable therapeutic targets...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29609671/salivary-gland-diseases-presentation-and-investigation
#11
Jackie E Brown
A number of salivary gland diseases may present with a wide variety of symptoms to the general dental practitioner, or may appear as unexpected findings on dental radiographs. Careful clinical examination in combination with appropriate imaging will assist practitioners in identifying whether further investigation or referral is required. This article explores the main types of salivary gland diseases and their potential pathology.
March 1, 2018: Primary Dental Journal
https://www.readbyqxmd.com/read/29608903/the-efficacy-of-touch-smear-cytology-in-the-diagnosis-of-salivary-gland-cancers
#12
Seiji Hosokawa, Satoru Takebayashi, Yutaka Sasaki, Hiroyuki Mineta
PURPOSE: Methods for cytologic diagnosis, such as fine-needle aspiration (FNA) and touch smear (TS) cytology, have been frequently used for malignant tumor screening; however, false-negative cases often result in misdiagnosis. The purpose of this study was to investigate the causes of false-negative cases and methods to decrease the false-negative rate in salivary gland tumor TS cytology. MATERIALS AND METHODS: In this cross-sectional study, the authors examined pathologically confirmed salivary gland tumors in 127 cases in which FNA and TS cytology were performed before the operation or open biopsy at Numazu City Hospital (Numazu, Japan) from 2002 to 2016...
March 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29580041/galectin-3-serum-levels-could-help-clinicians-screen-for-salivary-gland-tumor-patients
#13
Azadeh Andisheh-Tadbir, Maryam Mardani, Mahyar Malekzadeh, Tayebe Amirbeigi Tafti, Bijan Khademi
Objective: To identify serum levels of galectin-3 in salivary gland cancer and healthy populations; a prospective analysis was performed on serum specimens from 105 patients with salivary gland cancer and 56 healthy persons. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure levels of galectin-3 (GAL-3). Serum levels were compared between patients with salivary gland tumors and healthy control. A total of 105 patients were enrolled in the study (55 men, 50 women). Result: Mean age was 45...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29569854/il-25-axis-is-involved-in-the-pathogenesis-of-human-primary-and-experimental-sj%C3%A3-gren-s-syndrome
#14
Giuliana Guggino, Xiang Lin, Aroldo Rizzo, Fan Xiao, Laura Saieva, Stefania Raimondo, Diana Di Liberto, Giuseppina Candore, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Dieli, Riccardo Alessandro, Giovanni Triolo, Liwei Lu, Francesco Ciccia
OBJECTIVE: To investigate the role of IL-25/IL-17RB axis in experimental Sjögren's syndrome (ESS) and in patients with primary Sjögren Syndrome (pSS) and pSS-associated lymphoma. METHODS: Expression of IL-25, IL-17RB, IL-17B and TRAF6 was analyzed on minor salivary glands (MSG) from pSS patients and on parotid glands from pSS-associated B cell non-Hodgkin lymphomas (NHL). IL-17RB expression and the frequencies of natural type 2 innate lymphoid cells (nILC2), inflammatory ILC2 (iILC2) and M2-polarized macrophages were assessed by flow cytometry in salivary gland mononuclear cells (SGMC) and peripheral blood mononuclear cells (PBMC)...
March 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29563362/difficulties-in-diagnosis-of-sialolithiasis-a-case-series
#15
Svitlana Veniaminivna Kolomiiets, Kristina Oleksandrivna Udaltsova, Tetiana Andriivna Khmil, Alina Mykolaiivna Yelinska, Olena Anatoliivna Pisarenko, Viktoriya Ihorivna Shynkevych
Sialolithiasis is one of the most common and extensively obstructive disorders of the major salivary glands. Here, we report 3 cases of sialolithiasis in the submandibular salivary gland showing symptomatic similarities to other dental and non-dental disorders of the maxillofacial area. How the various clinical features of this condition and findings on 3D-CT may lead to a misdiagnosis are also discussed. In the first case, that of a 45-year-old woman, a final diagnosis of a non-radiopaque submandibular sialolith allowed the initially indicated surgical extraction of a malerupted and semi-impacted right mandibular 3rd molar to be abandoned...
2018: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/29556963/proceedings-of-the-nashnp-companion-meeting-march-18th-2018-vancouver-bc-canada-salivary-neuroendocrine-carcinoma-an-overview-of-a-rare-disease-with-an-emphasis-on-determining-tumor-origin
#16
Rebecca D Chernock, Eric J Duncavage
Salivary neuroendocrine carcinomas are rare and the overwhelming majority is high-grade. The parotid gland is the most commonly involved site followed by the submandibular gland. Most arise de novo but rare examples occurring as a high-grade transformation of another type of salivary gland neoplasm exist. There is significant morphologic and immunophenotypic overlap with neuroendocrine carcinomas of other sites, especially the skin. Like cutaneous neuroendocrine (or Merkel cell) carcinomas, approximately three-fourths are cytokeratin 20 positive...
March 20, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29549722/serum-levels-of-selected-adipocytokines-in-benign-and-malignant-parotid-gland-tumor-patients
#17
Pawel Sowa, Maciej Misiolek, Boguslawa Orecka, Eugeniusz Czecior, Monika Adamczyk-Sowa
OBJECTIVES: The aim of this study was to evaluate serum levels of adiponectin, leptin, visfatin and IL-6 in patients with pleomorphic adenoma, Warthin's tumor and acinic cell carcinoma of the parotid gland. MATERIALS AND METHODS: Venous blood samples were collected from 30 patients with pleomorphic adenoma, 21 patients with Warthin's tumor and 8 patients with acinic cell carcinoma. Serum adiponectin, leptin, visfatin, IL-6 and CRP concentrations were determined...
March 14, 2018: Cytokine
https://www.readbyqxmd.com/read/29544756/cervical-lymph-node-metastatic-status-and-adjuvant-therapy-predict-the-prognosis-of-salivary-duct-carcinoma
#18
Kai Qian, Lu Di, Kai Guo, Xiaoke Zheng, Qinghai Ji, Zhuoying Wang
PURPOSE: Salivary duct carcinoma (SDC) is an aggressive malignancy that is not yet fully understood. We designed the present retrospective study to investigate the factors affecting the prognosis of SDC and the effects of adjuvant therapies on the clinical outcomes of patients. MATERIALS AND METHODS: Patients with SDC treated surgically from 2006 to 2016 were enrolled in the present retrospective cohort study. The demographic data, clinical pathologic characteristics, and follow-up results were recorded...
February 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29521047/expression-of-vegf%C3%A2-%C3%A2-%C3%A2-b-vegfr1-vegfr2-and-cd34-in-benign-and-malignant-tumors-of-parotid-glands
#19
Katarzyna J Błochowiak, Jerzy Sokalski, Magdalena B Bodnar, Dorota Trzybulska, Andrzej K Marszałek, Henryk Witmanowski
BACKGROUND: Vascular endothelial growth factor (VEGF) is an angiogenic factor and could be involved in the pathogenesis of salivary gland tumors. VEGF exerts its biological function by binding to its receptors, VEGFR1 and VEGFR2. An alternative splice variant of VEGF (VEGFxxxb) is an anti-angiogenic factor. Binding VEGF165b with VEGFR2 results in an impaired angiogenic response. The imbalance of VEGFxxx and VEGFxxxb isoforms can underpin pathological angiogenesis. OBJECTIVES: The purpose of this study was to evaluate and compare the expression of VEGF165b, VEGFR1, VEGFR2, and CD34 in benign and malignant parotid gland tumors and to explore the possible correlations between their expression and clinicopathological features of tumors...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29512140/autoimmune-pancreatitis-mouse-model
#20
Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Warren Strober, Masatoshi Kudo
Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disorder of the pancreas. However, extensive clinico-pathological analyses have revealed that AIP is, in reality, a pancreatic manifestation of a newly described systemic disease known as IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced local and systemic IgG4 antibody (Ab) responses as well as inflammation involving multiple organs, including the pancreas, bile ducts, and salivary glands. Although mice lack the IgG4 Ab subtype, autoimmune-prone MRL/Mp mice treated with repeated injection with polyinosinic-polycytidylic acid (poly (I:C)) provide an experimental model of AIP...
February 21, 2018: Current Protocols in Immunology
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