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Ovarial pathology

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https://www.readbyqxmd.com/read/28442026/neuromodulatory-effect-of-oestradiol-in-the-metabolism-of-ovarian-progesterone-and-oestradiol-during-dioestrus-ii-participation-of-the-superior-mesenteric-ganglion
#1
Adriana Vega Orozco, Cynthia Bronzi, Sandra Vallcaneras, Zulema Sosa, Marilina Casais
The aims of the present study were to determine: (1) whether oestradiol (E2) in the superior mesenteric ganglion (SMG) modifies the release of ovarian progesterone (P4), androstenedione (A2) and E2, the activity and gene expression of 3β-hydroxysteroid dehydrogenase (3β-HSD) and 20α-HSD and the expression of P450 aromatase (Cyp19a1) and (2) whether any such modifications are related to changes in ovarian nitric oxide (NO) and noradrenaline (NA) levels during dioestrus II. Using an ex vivo SMG-ovarian nervous plexus-ovary system, ovarian P4 release was measured following the addition E2 plus tamoxifen (Txf) (10-6M) to the ganglion, whereas A2, E2, NA and NO were measured following the addition of E2 alone...
April 26, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28415994/a-pathological-and-clinical-study-of-706-primary-tumours-of-the-ovary-in-the-largest-tertiary-hospital-in-ghana
#2
Patrick Kafui Akakpo, Leonard Derkyi-Kwarteng, Richard Kwasi Gyasi, Solomom Edward Quayson, Simon Naporo, Jehoram Tei Anim
BACKGROUND: Ovarian tumours are a leading cause of death in Ghana. Even though geographical and racial differences exist in the frequency, types and age distribution of primary ovarian tumours, information about the clinical and pathological characteristics of ovarian tumours in Ghana and its neighboring countries is scanty. We determined the frequency, age distribution, histopathological types and clinical features of primary ovarian tumours diagnosed at the Korle-Bu Teaching Hospital in Ghana to aid in the management of patients...
April 17, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28415950/ovarian-cystectomy-in-the-treatment-of-apparent-early-stage-immature-teratoma
#3
Ting Zhao, Yan Liu, Xiao Wang, Hao Zhang, Yuan Lu
Objective To investigate the role of ovarian cystectomy in patients with early-stage immature teratoma. Methods A retrospective review was undertaken on patients diagnosed pathologically with immature teratoma and with malignant lesions confined to the ovary. Patients were included if they had been treated between January 1997 and December 2015 at the Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China. Relevant demographic and clinical data were retrieved from the medical records. Results Forty-three patients were included in the study; 14 underwent ovarian cystectomy (group 1) and 29 underwent unilateral salpingo-oophorectomy (USO; group 2)...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28406767/homeostatic-model-assessment-for-insulin-resistance-homa-ir-a-better-marker-for-evaluating-insulin-resistance-than-fasting-insulin-in-women-with-polycystic-ovarian-syndrome
#4
Hafsa Majid, Qamar Masood, Aysha Habib Khan
OBJECTIVE: To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from January 2009 to September 2012. METHODOLOGY: Medical chart review of all women diagnosed with PCOS was performed...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28404483/anaconda-paramyxovirus-infection-in-an-adult-green-anaconda-after-prolonged-incubation-pathological-characterization-and-whole-genome-sequence-analysis
#5
Patrick C Y Woo, Paolo Martelli, Suk-Wai Hui, Candy C Y Lau, Joseph M Groff, Rachel Y Y Fan, Susanna K P Lau, Kwok-Yung Yuen
From July 2011 to June 2012, 31 out of 33 green anaconda juveniles from an oceanarium in Hong Kong died over a 12-month period. These anacondas were progeny of a female anaconda purchased from Japan and added to the collection in May 2011. The juvenile anacondas were born in July 2011. A novel paramyxovirus, named anaconda paramyxovirus (AnaPV), was isolated from these affected juvenile anacondas. In July 2015, one of the remaining two anacondas, that survived the cluster of fatal infections, died at the age of four...
April 9, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28401199/clinicopathology-of-epcam-and-egfr-in-human-epithelial-ovarian-carcinoma
#6
Jingying Zheng, Lijing Zhao, Yi Wang, Shuhua Zhao, Manhua Cui
The objective of this study was to explore the expression of EpCAM and EGFR in human epithelial ovarian cancer (EOC) and their correlation with clinicopathological parameters. The protein expression levels of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded specimens from 30 patients with epithelial ovarian carcinoma and 15 normal ovary tissues. Clinicopathological characteristics were gathered by retrospective review of the patients' files...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28394114/ovarian-teratoma-in-routine-biopsy-material-during-a-five-year-period
#7
Marina Kos, Jasmina Nikić, Tanja Leniček
Teratomas are tumors derived from germ cells, most frequently arising in the gonads. The aim of this study was to determine the number of ovarian teratomas diagnosed in the routine biopsy material at Ljudevit Jurak Clinical Department of Pathology, Sestre milosrdnice University Hospital Center during a 5-year period, as well as their clinical, gross and microscopic characteristics. Teratomas accounted for 48.6% (n=166) of primary ovarian tumors. The patient mean age was 34.74±12.37 years. Difference in the incidence of teratoma between the left and right ovary was not significant; bilateral teratoma was found in 13 patients...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28388912/environmental-pollutants-a-possible-etiology-for-premature-ovarian-insufficiency-a-narrative-review-of-animal-and-human-data
#8
REVIEW
Pauline Vabre, Nicolas Gatimel, Jessika Moreau, Véronique Gayrard, Nicole Picard-Hagen, Jean Parinaud, Roger D Leandri
BACKGROUND: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic...
April 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28379469/in-vivo-intrabursal-administration-of-bioactive-lipid-sphingosine-1-phosphate-enhances-vascular-integrity-in-a-rat-model-of-ovarian-hyperstimulation-syndrome-ohss
#9
Mariana Di Pietro, Natalia Pascuali, Leopoldina Scotti, Griselda Irusta, Diana Bas, María May, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Can the bioactive lipid sphingosine-1 phosphate (S1P) act as an endothelial barrier-enhancing molecule and, in turn, restore the vascular integrity and homeostasis in a rat model of ovarian hyperstimulation syndrome (OHSS). STUDY ANSWER: In vivo administration of S1P may prevent the early onset of OHSS and decrease its severity. WHAT IS KNOWN ALREADY: Although advances in the prediction and treatment of OHSS have been made, complete prevention has not been possible yet...
April 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28377131/bovine-herpesvirus-1-modified-live-virus-vaccines-for-cattle-reproduction-balancing-protection-with-undesired-effects
#10
Christopher C L Chase, Robert W Fulton, Donal O'Toole, Benjamin Gillette, Russell F Daly, George Perry, Travis Clement
Bovine herpesvirus 1 (BoHV-1) has long been associated with reproductive failure in cattle following infection of the ovary and/or fetus. Vaccination prior to breeding has been an effective approach to lessen the impact of BoHV-1 on reproduction. Prior studies in the 1980s and 1990s established the susceptibility of the ovary and particularly the corpus luteum (CL) to BoHV-1 infection. A series of studies at breeding time established that: (1) in naïve animals, the CL was the major target of BoHV-1 pathology; (2) CL lesions occurred within 4-9 days after estrus; (3) similar lesions was seen with BoHV-1 MLV vaccines; (4) ovarian lesions varied by the vaccine strain used; (5) progesterone decreased with or without CL lesions; and (6) following reactivation of BoHV-1 latent infection, ovaries could become reinfected in the face of BoHV-1 immunity...
March 23, 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28357110/identical-twins-with-mature-cystic-teratomas-treated-with-laparoscopic-surgery-two-case-reports
#11
Yasushi Mabuchi, Nami Ota, Aya Kobayashi, Yuko Tanizaki, Sawako Minami, Kazuhiko Ino
Mature cystic teratomas are the most common among all ovarian neoplasms, representing 30-40% of the cases. However, to the best of our knowledge, there have been only two reports of mature cystic teratomas occurring in identical twins to date. We herein report a case of identical twins with mature cystic teratomas who were treated with laparoscopic surgery. A 32-year-old woman was referred to our hospital due to a tumor in the right ovary. The patient underwent laparoscopic resection of the ovarian tumor and the pathological diagnosis was benign mature cystic teratoma...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28357094/high-grade-serous-ovarian-cancer-3-years-after-bilateral-salpingectomy-a-case-report
#12
Emi Sato, Kentaro Nakayama, Masako Ishikawa, Kohei Nakamura, Tomoka Ishibashi, Satoru Kyo
Although epithelial ovarian cancer commonly originates from the ovarian surface epithelium and/or ovarian inclusion cysts, it was recently proposed that high-grade serous ovarian cancer (HGSC) develops from the Fallopian tubes. In our department, we encountered a case of HGSC that contradicts the hypothesis of a tubal origin for HGSC. A 51-year-old postmenopausal woman had undergone hysterectomy, left oophorectomy and bilateral salpingectomy for uterine myoma. Three years later, the patient was diagnosed with stage IV ovarian cancer and underwent primary debulking surgery...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356029/oncogenic-role-of-set-i2pp2a-for-gynecologic-cancers
#13
Shi-Wen Jiang, Siliang Xu, Haibin Chen, Jiayin Liu, Ping Duan
SET (SE translocation, SET) is an evolutionarily conserved gene broadly expressed in various human tissues, especially in the gonadal and neural system. As a multitasking protein, SET is involved in essential cell processes such as histone modification, chromatin remodeling, DNA repair, gene transcription, and androgen synthesis. Recent studies showed that SET is overexpressed in breast cancers, ovary cancers and a variety of other malignancies. The strong correlation between SET expression levels and survival of ovarian cancer patients, and SET-mediated activation of androgen synthesis, strongly indicated that this factor may play a significant role in gynecologic cancers...
March 28, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28350328/vitamin-d-decreases-serum-vegf-correlating-with-clinical-improvement-in-vitamin-d-deficient-women-with-pcos-a-randomized-placebo-controlled-trial
#14
Mohamad Irani, David B Seifer, Richard V Grazi, Sara Irani, Zev Rosenwaks, Reshef Tal
Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathophysiology of polycystic ovary syndrome (PCOS) and may contribute to increased risk of ovarian hyperstimulation syndrome (OHSS) in affected individuals. Vitamin D (VitD) supplementation improves multiple clinical parameters in VitD-deficient women with PCOS and decreases VEGF levels in several other pathologic conditions. Unveiling the basic mechanisms underlying the beneficial effects of vitamin D on PCOS may enhance our understanding of the pathophysiology of this syndrome...
March 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28346042/decreased-expression-of-aldh5a1-predicts-prognosis-in-patients-with-ovarian-cancer
#15
Xun Tian, Yingyan Han, Lan Yu, Bo Luo, Zheng Hu, Xiong Li, Zongyuan Yang, Xin Wang, Wanqiu Huang, Hui Wang, Qinghua Zhang, Ding Ma
Aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) belongs to the superfamily of aldehyde dehydrogenases (ALDHs). However, the prognostic value of ALDH5A1 in ovarian cancer remains unclear. The aim of this study was to explore the relationship between ALDH5A1 and the prognosis of patients with ovarian cancer (OC). We compared the expression of ALDH5A1 in OC to that innormal controls, using GSE40595 profiling data. Tissue microarray analysis was conducted for192 OC patients, 14 adjacent normal ovary tissues, and 2 normal ovary tissues...
March 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28342361/giant-leiomyosarcoma-of-the-rectum-with-lymph-node-metastasis-a-case-report-and-review-of-the-literature
#16
Hiroyuki Anzai, Hiroaki Nozawa, Junichiro Tanaka, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Tetsuo Ushiku, Soichiro Ishihara, Toshimi Takano, Masashi Fukayama, Toshiaki Watanabe
INTRODUCTION: Leiomyosarcoma of the gastrointestinal tract is very rare, with a reported frequency of less than 0.1% of all malignancies of the colorectum. It is important to diagnose leiomyosarcoma definitively by immunohistochemical profiling of smooth muscle actin, desmin, and CD34. True leiomyosarcoma of the colorectum diagnosed by immunnohistochemical profiling is extremely rare that only 13 reports have been published in reviews of resected gastrointestinal mesenchymal tumors after 1998...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28333135/bre-modulates-granulosa-cell-death-to-affect-ovarian-follicle-development-and-atresia-in-the-mouse
#17
Cheung Kwan Yeung, Guang Wang, Yao Yao, Jianxin Liang, Cheuk Yiu Tenny Chung, Manli Chuai, Kenneth Ka Ho Lee, Xuesong Yang
The BRE (brain and reproductive expression) gene, highly expressed in nervous and reproductive system organs, plays an important role in modulating DNA damage repair under stress response and pathological conditions. Folliculogenesis, a process that ovarian follicle develops into maturation, is closely associated with the interaction between somatic granulosa cell and oocyte. However, the regulatory role of BRE in follicular development remains undetermined. In this context, we found that BRE is normally expressed in the oocytes and granulosa cells from the primordial follicle stage...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28330882/adiponectin-and-resistin-a-role-in-the-hypothalamo-pituitary-gonadal-axis
#18
Agnieszka Rak, Namya Mellouk, Pascal Froment, Joëlle Dupont
Adipokines, including adiponectin and resistin, are cytokines produced mainly by adipose tissue. They play a significant role in the metabolic functions that regulate insulin sensitivity and inflammation. Alteration of adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissue, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2, are present in various reproductive tissues in both sexes of different species...
March 22, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28327103/morphological-and-phenotypical-features-of-ovarian-metastases-in-breast-cancer-patients
#19
Inge T A Peters, Merle A van der Steen, Bertine W Huisman, Carina G J M Hilders, Vincent T H B M Smit, Alexander L Vahrmeijer, Cornelis F M Sier, J Baptist Trimbos, Peter J K Kuppen
BACKGROUND: Autotransplantation of frozen-thawed ovarian tissue is a method to preserve ovarian function and fertility in patients undergoing gonadotoxic therapy. In oncology patients, the safety cannot yet be guaranteed, since current tumor detection methods can only exclude the presence of malignant cells in ovarian fragments that are not transplanted. We determined the need for a novel detection method by studying the distribution of tumor cells in ovaries from patients with breast cancer...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28323956/hyperhomocysteinemia-promotes-insulin-resistance-and-adipose-tissue-inflammation-in-pcos-mice-through-modulating-m2-macrophage-polarization-via-estrogen-suppression
#20
Xinyu Qi, Bochun Zhang, Yue Zhao, Rong Li, Hsun-Ming Chang, Yanli Pang, Jie Qiao
It has been shown that serum homocycteine (Hcy) levels are higher in women with polycystic ovary syndrome (PCOS). However, the specific role of hyperhomocycteinemia (HHcy) in the development of PCOS has never been reported. Adipose tissue inflammation is featured by the infiltration of macrophages that plays a critical role in the pathogenesis of glucose and insulin intolerance. In this study, C57BL/6 mice were treated with dehydroepiandrosterone (DHEA) and/or high methionine diet to induce PCOS and HHcy mice models...
March 15, 2017: Endocrinology
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