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Endometrium

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https://www.readbyqxmd.com/read/29348629/the-suppressive-role-of-calcium-sensing-receptor-in-endometrial-cancer
#1
Xiaoyan Xin, Xianqin Zeng, Dilu Feng, Teng Hua, Shuangge Liu, Shuqi Chi, Qinghua Hu, Hongbo Wang
Studies have shown that calcium sensing receptor (CaSR) is involved in the progressions of several human cancers. However, the role of CaSR in endometrial cancer remains unknown. This study provides a preliminary analysis of the CaSR effect on endometrial cancer development. Ectopic CaSR expression by lentiviral transfection (CaSR-OV) in Ishikawa cells significantly increased intracellular calcium ([Ca2+]i) levels and cell apoptosis. E-cadherin and β-catenin expression and complex formation at the membrane were increased in CaSR-OV Ishikawa cells relative to control Ishikawa cells (vector)...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347814/-customization-of-hormonal-contraception
#2
Vincenzo DE Leo, Antonio Cianci, Costantino DI Carlo, Valentina Cappelli, Franca Fruzzetti
In the last few years new oral contraceptives have been marketed showing a better safety profile for women. They are the result of important changes made to the old compounds. As far as the estrogenic component, with the aim of decreasing side effects, the dose of ethinyl estradiol has been reduced and synthetic estrogens have been replaced by natural estradiol, further improving the safety profile. Also the progestin component in the last years has been changed in terms of dose, endocrine and metabolic characteristics...
February 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29346527/progesterone-effects-on-extracellular-vesicles-in-the-sheep-uterus
#3
Gregory W Burns, Kelsey E Brooks, Eleanore V O'Neil, Darren E Hagen, Susanta K Behura, Thomas E Spencer
Progesterone (P4) acts via the endometrium to promote conceptus growth and implantation for pregnancy establishment. Many cells release extracellular vesicles (EVs) that are membrane-bound vesicles of endosomal and plasma membrane origin. In sheep, endometrial-derived EVs were found to traffic to the conceptus trophectoderm. Thus, EVs are hypothesized to be an important mode of intercellular communication by transferring select RNAs, proteins, and lipids between the endometrium and conceptus. Electron microscopy analysis found that the endometrial luminal and glandular epithelia were the primary source of EVs in the uterus of cyclic sheep...
January 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29345445/the-impact-of-high-progesterone-levels-on-the-day-of-hcg-administration-in-assisted-human-reproduction-treatments
#4
Michelli S Tanada, Ivan H Yoshida, Monise Santos, Caroline Z Berton, Elen Souto, Waldemar P de Carvalho, Emerson B Cordts, Caio P Barbosa
OBJECTIVE: Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. METHODS: The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration...
January 18, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29345024/being-pluripotent-bone-marrow-vsels-rather-than-hscs-have-the-potential-to-regenerate-other-adult-organs
#5
REVIEW
Deepa Bhartiya
Recent study by Deanne's group provides evidence that transplanted GFP positive bone marrow hematopoietic stem cells (HSCs) expressing CD45 do not regenerate the endometrium of irradiated mice. The results do not surprise us since global efforts to regenerate various organs by transplanting bone marrow (BM) mononuclear cells (presumably enriched for HSCs) have failed. HSCs can only regenerate/reconstitute BM as they are 'committed progenitors' that are specified from more primitive, CD45 negative stem cells...
January 18, 2018: Stem Cells
https://www.readbyqxmd.com/read/29334789/circular-rna-expression-in-ovarian-endometriosis
#6
Licong Shen, Yu Zhang, Wenjun Zhou, Zheng Peng, Xiaxia Hong, Yi Zhang
AIM: Circular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression. This study was carried out to identify the expression profile and role of circRNAs in endometriosis. MATERIALS & METHODS: Microarray assay was performed in four paired ovarian endometriomas and eutopic endometrium, followed by quantitative real-time RT-PCR in 24 paired samples. Bioinformatical algorithms were used to predict MREs, as well as ceRNA and KEGG pathway analysis...
January 16, 2018: Epigenomics
https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#7
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29332562/the-delicate-balance-between-the-good-and-the-bad-il-1-proinflammatory-effects-in-endometriosis
#8
Justyna Sikora, Simone Ferrero, Aleksandra Mielczarek-Palacz, Zdzislawa Kondera-Anasz
BACKGROUND: Endometriosis is an inflammatory gynaecological disease with an associated chronic inflammation. Interleukin(IL)-1 is one of the most important immune and proinflammatory factors, produced mainly by monocytes and macrophages. Studies indicate the role of the cytokine from IL-1 family in endometrium-related disorders, particularly in endometriosis. METHODS: The information about the impact of cytokine from IL-1 cytokine family on the pathogenesis and development of endometriosis was obtained with an electronic literature search based on the PubMed and Medline databases, spanning the period of January 1950 to July 2017 and includes associated references in the published studies...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29329415/establishment-of-a-three-dimensional-model-to-study-human-uterine-angiogenesis
#9
Camille L Duran, Colette A Abbey, Kayla J Bayless
STUDY QUESTION: Can primary human uterine microvascular endothelial cells (UtMVECs) be used as a model to study uterine angiogenic responses in vitro that are relevant in pregnancy? SUMMARY ANSWER: UtMVECs demonstrated angiogenic responses when stimulated with proangiogenic factors, including sphingosine 1-phosphate (S1P), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), physiological levels of wall shear stress (WSS), human chorionic gonadotropin (hCG) and various combinations of estrogen and progesterone...
December 21, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29328024/endometrial-polyps-in-women-of-reproductive-age-clinical-and-pathogene-tic-variations
#10
N Kosei, N Zakharenko, D Herman
The aim of the study was to study the relationship between the morphofunctional characteristics of the endometrium, hormonal homeostasis and microbiocenosis of the reproductive system in patients with endometrial polyps. The study involved 130 patients aged 18-35 years: 34 patients with endometrial polyps, 30 patients with micropolyps, 36 patients with endometrial polyps and micropolyps, 30 healthy women of the control group. Hysteroscopy was performed for women who had been suspected for endometrial polyps and who had infertility or repeated recurrent miscarriages...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29325695/investigation-of-the-uterine-structural-changes-in-the-experimental-model-with-polycystic-ovary-syndrome-and-effects-of-vitamin-d-treatment-an-ultrastructural-and-immunohistochemical-study
#11
Yurdun Kuyucu, Latife Seyran Çelik, Özge Kendirlinan, Özgül Tap, Ufuk Özgü Mete
In this study, we aimed to investigate the structural changes seen in the endometrium in experimental PCOS rat model and the effects of vitamin D treatment on these changes at immunohistochemical and electron microscopic levels. 24 prepubertal female rats were divided into three groups. Two groups were injected with dehydroepiandrosterone and one of them was treated with 1,25(OH)2 D3 at the same time. The control group was injected with sesame oil. At the end of the 28th day, the blood samples were collected...
January 8, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29325014/cdkn1c-p57-one-of-the-determinants-of-human-endometrial-stromal-cell-decidualization
#12
Lan Wang, Hui Yang, Linli Hu, Dan Hu, Shuxia Ma, Xuejiao Sun, Liu Jiang, Jianyuan Song, Licheng Ji, Jackson Ferdinand Masau, Hanwang Zhang, Kun Qian
Decidualization is regulated by crosstalk of progesterone and the cAMP pathway. It involves extensive reprogramming of gene expression and includes a wide range of functions. To investigate how cell cycle regulatory genes drive the human endometrial stromal cell (ESC) exit cell cycle and enter differentiation, primary cultured ESC was treated with 8-Br-cAMP and MPA and cell cycle distribution was investigated by flow cytometry. High-throughput cell cycle regulatory gene expression was also studied by microarray...
January 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29324807/vegf-may-contribute-to-macrophage-recruitment-and-m2-polarization-in-the-decidua
#13
Karen C Wheeler, Manoj K Jena, Bhola S Pradhan, Neha Nayak, Subhendu Das, Chaur-Dong Hsu, David S Wheeler, Kang Chen, Nihar R Nayak
It is increasingly evident that cytokines and growth factors produced in the decidua play a pivotal role in the regulation of the local immune microenvironment and the establishment of pregnancy. One of the major growth factors produced in the decidua is vascular endothelial growth factor (VEGF), which acts not only on endothelial cells, but also on multiple other cell types, including macrophages. We sought to determine whether decidua-derived VEGF affects macrophage recruitment and polarization using human endometrial/decidual tissue samples, primary human endometrial stromal cells (ESCs), and the human monocyte cell line THP1...
2018: PloS One
https://www.readbyqxmd.com/read/29322015/kingiodendron-pinnatum-a-pharmacologically-effective-alternative-for-saraca-asoca-in-an-ayurvedic-preparation-asokarishta
#14
Adangam Purath Shahid, Nanu Sasidharan, Sasidharan Salini, Jose Padikkala, Nair Meera, Achuthan Chathrattil Raghavamenon, Thekkekara Devassy Babu
Saraca asoca (Fabaceae) is a prime ingredient in Asokarishta, a well-known Ayurvedic preparation for gynecological ailments. Due to scarcity, adulteration or substitution of related raw drugs is a common practice in its preparation. The bark of Kingiodendron pinnatum (Roxb. ex DC.) Harms, morphologically similar to S. asoca (Asoka) is a widely used substitute. The present study aimed to evaluate the pharmacological effectiveness of K. pinnatum as an alternative for S. asoca in Asokarishta by determining the inhibitory effect of estrogen induced uterus endometrial thickening in immature female rats...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319820/embryo-implantation-war-in-times-of-love
#15
Nancy Ashary, Abhishek Tiwari, Deepak Modi
Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by the endometrium. We propose that embryo implantation involves a three step process: 1) identification of a receptive endometrium; 2) superimposition of a blastocyst-derived signature onto the receptive endometrium prior to implantation; and finally 3) breaching by the embryo and trophoblast invasion, culminating in decidualization and placentation...
January 8, 2018: Endocrinology
https://www.readbyqxmd.com/read/29317890/enterobius-vermicularis-in-the-endometrium-of-the-uterus-a-case-report
#16
Biserka Pigac, Silvija Mašić, Valentina Mašić
Enterobius vermicularis is an intestinal nematode of humans and the most common helminth infection. Main transmission path is direct contact between infected and uninfected person meaning ingestion of the eggs. Human infections are usually asymptomatic or manifest as perianal itching. Although ectopic locations are uncommon, Enterobius can occasionally be detected in appendix, kidney, male urinary tract and female genital tract. We present a case from Varaždin General Hospital, Varaždin, Croatia in 2012, involving a 90-yr-old female patient who underwent hysterectomy leading to accidental finding of E...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317550/fertility-sparing-treatment-of-endometrial-cancer-with-initial-infiltration-of-myometrium-by-resectoscopic-surgery-a-pilot-study
#17
Paolo Casadio, Francesca Guasina, Roberto Paradisi, Concetta Leggieri, Giacomo Caprara, Renato Seracchioli
Three women with a well-differentiated grade 1 endometrioid adenocarcinoma of the endometrium with minimal myometrial infiltration were treated with hysteroscopic resection and hormone therapy. The presence of myometrial infiltration has often been mentioned as an exclusion criterion for conservative management in young patients because of worsening cancer prognosis. The subsequent 5-year follow-up and the pregnancies achieved may confirm the choice of this temporary treatment and indicate a new option for fertility-sparing treatment in highly motivated patients...
January 9, 2018: Oncologist
https://www.readbyqxmd.com/read/29317175/premature-progesterone-rise-in-art-cycles
#18
REVIEW
B Lawrenz, L Melado, H M Fatemi
Premature rise of progesterone during the late follicular phase in stimulated IVF cycles is a frequent event and its effect on the endometrial receptivity and on the ART (Assisted Reproductive Technique) - outcome has become a matter of intense debate and research. An emerging body of evidence demonstrates that premature progesterone rise does have a negative impact on the outcome of the ART-success. Until now, the exact cause of progesterone elevation is not fully clear, however lately published studies points to the fact, that premature progesterone elevation might be caused by enhanced FSH stimulation...
January 6, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29317075/the-origin-of-endometriosis-associated-ovarian-cancer-from-uterine-neoplastic-lesions
#19
Elisabetta Garavaglia, Cristina Sigismondi, Stefano Ferrari, Massimo Candiani
Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Supporting this hypothesis, an higher incidence of synchronous precancerous and cancerous endometrial pathology in patients affected by ovarian endometrioid cancer associated with endometriosis was showed...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#20
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
January 5, 2018: Human Reproduction
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