Fang Zhou, Shufang Wang, Wenhong Lu, Xihua Chen, Shige Guo, Cong Lu, Xin Zhang, Jiangxu Wu, Siyu Wang, Zeyi Long, Bin He, Taifeng Zhuang, Xiangbo Xu
In women of childbearing age, extensive decidualization, shedding and remodeling of the endometrium during the menstrual cycle are fundamental for successful pregnancy. The role of prostaglandins (PGs) in menstruation has long been proposed in humans, and the rate-limiting enzyme cyclooxygenase was shown to play a key role in endometrial breakdown and shedding in a mouse menstrual-like model in our previous study. However, the specific types of PGs involved and their respective roles remain unclear. Therefore, our objective was to investigate the mechanism through which PGs regulate endometrial disintegration...
April 18, 2024: Reproductive Sciences