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Cervical pathology

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https://www.readbyqxmd.com/read/29350424/prevalence-of-high-grade-cervical-intraepithelial-neoplasia-in-women-with-persistent-high-risk-hpv-genotypes-and-negative-cytology
#1
M Macdonald, J Crossley, K Ellis, N Dudding, R Lyon, J H F Smith, J A Tidy, J E Palmer
INTRODUCTION: Primary HPV screening will be implemented into the English Cervical Screening Programme by 2019. Its impact upon women referred to colposcopy, with negative cytology but persistently positive high-risk HPV (hrHPV), remains unreported from UK Sentinel sites. HPV primary screening was introduced in Sheffield, UK in April 2013; this paper reports its impact on the service. METHODS: A retrospective cohort study was performed from June 2014 to July 2016 at the Jessop Wing Colposcopy Unit, Sheffield...
January 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29350325/evaluation-and-management-of-rotator-cuff-tears-a-primary-care-perspective
#2
REVIEW
Ross Mathiasen, Christopher Hogrefe
PURPOSE OF REVIEW: To provide a primary care perspective regarding the evaluation and management of shoulder pain and rotator cuff tears. RECENT FINDINGS: In the primary care setting, rotator cuff pathology is commonly encountered. Information regarding the risks of oral medications for the management of the associated pain keeps mounting. Partial-thickness rotator cuff tears remain difficult to diagnose with a single imaging modality. Musculoskeletal education in medical schools and non-orthopaedic residency and fellowship training programs continues to be an area for additional improvement...
January 19, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29344808/minimally-invasive-esophagectomy-with-thoracic-duct-resection-post-neoadjuvant-chemoradiotherapy-for-carcinoma-esophagus-impact-on-lymph-node-yield-and-hemodynamic-parameters
#3
Santosh Anand, Raja Kalayarasan, Sandip Chandrasekar, Senthil Gnanasekaran, Biju Pottakkat
BACKGROUND: Neoadjuvant therapy followed by surgery is the current recommended treatment for locally advanced esophageal carcinoma. Thoracic duct (TD) resection was indicated for radical mediastinal lymphadenectomy. However, TD resection can cause hemodynamic disturbances. The presence of metastasis in TD has not been previously studied. METHODS: Twenty-two patients who underwent minimally invasive esophagectomy with D2 lymphadenectomy after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma were analyzed...
January 18, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29333334/the-effect-of-the-2012-asccp-consensus-guideline-for-abnormal-cervical-cytology-on-resident-colposcopy-training
#4
Cori-Ann M Hirai, Bliss Kaneshiro, Mark K Hiraoka
The primary objective was to determine the theoretical number of colposcopies at a resident clinic if the 2012 American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines were applied. The secondary objective was to determine the actual number of colposcopies before and after the ASCCP guidelines. This was a two-part descriptive study. The first part applied the 2012 ASCCP guidelines to all pre-guideline colposcopy cases at a single resident clinic. These theoretical results were then compared to the actual number of colposcopies...
January 2018: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29330601/assessment-of-vestibular-evoked-myogenic-potentials-and-video-head-impulse-test-in-type-2-diabetes-mellitus-patients-with-or-without-polyneuropathy
#5
Mehmet Kalkan, Ali Bayram, Ferhat Gökay, Hasan Selçuk Cura, Cemil Mutlu
This study aimed to compare cervical vestibular-evoked myogenic potentials (cVEMP), ocular vestibular-evoked myogenic potentials (oVEMP) and video head impulse test (vHIT) results between patients with type 2 diabetes mellitus (DM) or diabetic polyneuropathy (DPN) and healthy controls to determine vestibular end-organ pathologies. The participants in the present study consisted of three groups: the type 2 DM group (n = 33 patients), the DPN group (n = 33 patients), and the age- and sex-matched control group (n = 35)...
January 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29325948/spinal-metastasis-resulting-from-atypical-thymic-carcinoid-a-case-report
#6
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325690/dose-volume-effects-in-pathologic-lymph-nodes-in-locally-advanced-cervical-cancer
#7
Warren Bacorro, Isabelle Dumas, Alexandre Escande, Sebastien Gouy, Enrica Bentivegna, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
OBJECTIVE: In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS: Patients with node-positive cervical cancer treated curatively with external beam radiotherapy (EBRT) and image-guided brachytherapy (IGABT) were identified. Nodal doses during EBRT, IGABT and boost were converted to 2-Gy equivalent (α/β = 10 Gy) and summed...
January 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29319946/medical-devices-hematology-and-pathology-devices-classification-of-a-cervical-intraepithelial-neoplasia-test-system-final-order
#8
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the CIN test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens...
January 3, 2018: Federal Register
https://www.readbyqxmd.com/read/29318432/the-price-study-the-role-of-conventional-and-diffusion-weighted-magnetic-resonance-imaging-in-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery
#9
A L Valentini, M Miccò, B Gui, M Giuliani, E Rodolfino, A M Telesca, T Pasciuto, A Testa, M A Gambacorta, G Zannoni, V Rufini, A Giordano, V Valentini, G Scambia, R Manfredi
OBJECTIVES: To analyse the role of DW-MRI in early prediction of pathologically-assessed residual disease in locally-advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by radical surgery. METHODS: Between October 2010-June 2014, 108 women with histologically-proven cervical cancer were screened; 88 were included in this study. Tumour volume (TV) and ADCmean were measured before (baseline-MRI) and after 2 weeks of chemoradiotherapy (early-MRI)...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29318337/full-endoscopic-posterior-foraminotomy-surgery-for-cervical-disc-herniations
#10
REVIEW
M Komp, S Oezdemir, P Hahn, S Ruetten
OBJECTIVE: Surgery for cervical disc herniation with full-endoscopic posterior access. INDICATIONS: Cervical disc herniation and neuroforaminal pathology with radicular symptoms. CONTRAINDICATIONS: Neck pain alone, cervical myelopathy or pathologies with central nervous system symptoms, instabilities requiring correction/instabilities. SURGICAL TECHNIQUE: Introduction of a surgical tube to the facet joint at the level to be operated on...
January 9, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29315627/transfusion-support-for-transgender-men-of-childbearing-age
#11
James A Mays, Dina N Greene, Ryan A Metcalf, Monica B Pagano
BACKGROUND: To date, limited attention has been given to transgender recipients of blood components, particularly transgender men of childbearing age. Here, we highlight the essential information needed to provide transfusion support for this population. CASE REPORT: A 40-year-old transgender man, who retained his uterus and ovaries, presented with severe vaginal hemorrhage following biopsies for a cervical mass. He was admitted to the Gynecology unit and emergency blood was ordered...
January 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29314780/hpv-16-targeted-dna-vaccine-expression-the-role-of-purification
#12
Ana M Almeida, Joana Tomás, Patrícia Pereira, João A Queiroz, Fani Sousa, Ângela Sousa
DNA vaccines have come to light in the last decades as an alternative method to prevent many infectious diseases, but they can also be used for the treatment of specific diseases, such as cervical cancer caused by Human Papillomavirus (HPV). This virus produces E6 and E7 oncoproteins, which alter the cell cycle regulation and can interfere with the DNA repairing system. These features can ultimately lead to the progression of cervical cancer, after cell infection by HPV. Thus, the development of a DNA vaccine targeting both proteins arises as an interesting option in the treatment of this pathology...
January 5, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29313091/intradural-cervical-chordoma-with-diffuse-spinal-leptomeningeal-spread-case-report-and-review-of-the-literature
#13
Jing Zhang, Chuan-Ping Gao, Xue-Jun Liu, Wen-Jian Xu
PURPOSE: Chordoma is a low-grade malignant bone tumor derived from embryonic notochord remnants along the axial skeleton. About 50% of chordomas occur in the sacral vertebrae and 35% in the skull base. Most chordomas are extradural and cause extensive bone destruction. Intradural spinal tumors without bone involvement are rare. METHODS: We herein describe the clinical features of a patient with a chordoma as well as the imaging and pathological manifestations of the tumor...
January 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29312708/substernal-reconstruction-following-esophagectomy-operation-of-last-resort
#14
Jacob R Moremen, DuyKhanh P Ceppa, Karen M Rieger, Thomas J Birdas
Background: The posterior mediastinum is the preferred location for reconstruction following esophagectomy. Occasionally alternative routes are required. We examined patient outcomes of esophageal reconstruction in order to determine whether substernal reconstruction (SR) is an equivalent alternative to orthotopic placement. Methods: Following IRB approval, we performed a retrospective review of all patients who underwent an esophagectomy from 1988-2014. Only patients reconstructed with a gastric conduit and cervical anastomosis by either substernal or posterior mediastinal (PM) routes were included in the study...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311423/necrotizing-fasciitis-possible-profiles-of-professional-liability-with-reference-to-two-cases
#15
Gian Luca Marella, Enrico De Dominicis, Giovanni Battista Paliani, Giuseppe Santeusanio, Luigi Tonino Marsella, Saverio Potenza
Necrotizing fasciitis is one of the most dangerous complication of an abscess and it is still a disease with a high mortality. In this work, we decided to consider two cases: the first one concerns a male subject, aged 66, deceased because of a fatal necrotizing fasciitis associated to a cervical descending mediastinitis, which evolved from a primary peritonsillar abscess; the second is about a 50-year-old woman with a perineal abscess, then evolved into necrotizing fasciitis associated to a fatal septis shock...
December 18, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29310838/a-leukemic-double-hit-follicular-lymphoma-associated-with-a-complex-variant-translocation-t-8-14-18-q24-q32-q21-involving-bcl2-myc-and-igh
#16
Daisuke Minakata, Kazuya Sato, Takashi Ikeda, Yumiko Toda, Shoko Ito, Kiyomi Mashima, Kento Umino, Hirofumi Nakano, Ryoko Yamasaki, Kaoru Morita, Yasufumi Kawasaki, Miyuki Sugimoto, Chihiro Yamamoto, Masahiro Ashizawa, Kaoru Hatano, Iekuni Oh, Shin-Ichiro Fujiwara, Ken Ohmine, Hirotoshi Kawata, Kazuo Muroi, Ikuo Miura, Yoshinobu Kanda
Double-hit lymphoma (DHL) is defined as lymphoma with concurrent BCL2 and MYC translocations. While the most common histological subtype of DHL is diffuse large B-cell lymphoma, the present patient had leukemic follicular lymphoma (FL). A 52-year-old man was admitted to our hospital due to general fatigue and cervical and inguinal lymph node swelling. The patient was leukemic and the pathological diagnosis of the inguinal lymph node was FL grade 1. Chromosomal analysis revealed a complex karyotype including a rare three-way translocation t(8;14;18)(q24;q32;q21) involving the BCL2, MYC, and IGH genes...
January 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29310409/analysis-of-diagnosis-and-treatment-of-complicated-cervical-severe-adhesion-atresia-after-removal-of-endometrial-stromal-nodule-a-case-report
#17
Rui Zhang, Pei Gu, Qi Liu, Bin Li, Wenpei Bai
RATIONALE: Endometrial stromal nodule (ESN) is a rare benign endometrial stroma tumor.Experiences are helpful for avoiding and treating similar postoperative complications (cervical adhesions and atresia). PATIENT CONCERNS: When appearing in the cervical, this tumor can easily lead to complications after the surgical resection. The diagnosis and postsurgery complication of a young woman's ESN was reported here. DIAGNOSES: The postoperative pathological diagnosis was ESN...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29309102/variations-in-progression-and-regression-of-precancerous-lesions-of-the-uterine-cervix-on-cytology-testing-among-women-of-different-races
#18
Daniel Martingano, Audrey Renson, Alison Jane Martingano, Francis X Martingano
Background: Although not incorporated into current cervical cancer screening guidelines, racial differences are known to persist in both occurrence of and outcomes related to cervical cancer. Objective: To compare the differences in progression and regression of precancerous lesions of the uterine cervix on cervical cytologic analysis among women of different races who adhered to cervical cancer screening recommendations and follow-up. Methods: Retrospective cohort study comparing differences in precancerous lesion diagnoses for patients receiving adequate evaluation according to the American Society for Colposcopy and Cervical Pathology guidelines...
January 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29307980/uterine-prolapse-should-hysterectomy-specimens-be-subjected-for-histopathological-examination
#19
Rupali Awale, Roma Isaacs, Shavinder Singh, Kavita Mandrelle
Context: Uterine prolapse accounts for one of the common gynecological problems in India. The excised uterus is not expected to have any pathological finding other than atrophic endometrium and may be an ulcer because of the prolapse. Aims: The aim of this study is to assess the hysterectomy specimen for unsuspected pathology. Subjects and Methods: The study is done over two and half years at a tertiary care hospital. Hysterectomy specimens done with a clinical indication of prolapse were included in the study...
October 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29301464/intervertebral-disc-degeneration-in-warmblood-horses-morphology-grading-and-distribution-of-lesions
#20
Wilhelmina Bergmann, Niklas Bergknut, Stefanie Veraa, Andrea Gröne, Hans Vernooij, Inge D Wijnberg, Willem Back, Guy C M Grinwis
Equine intervertebral disc degeneration is thought to be rare and of limited clinical relevance, although research is lacking. To objectively assess pathological changes of the equine intervertebral disc and their clinical relevance, description of the normal morphology and a practical, biologically credible grading scheme are needed. The objectives of this study are to describe the gross and histological appearance of the equine intervertebral discs and to propose a grading scheme for macroscopic degeneration...
January 1, 2018: Veterinary Pathology
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