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Cervical pathology

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https://www.readbyqxmd.com/read/28087391/clonal-cytogenetic-abnormalities-are-predictor-in-developing-non-hodgkin-lymphomas
#1
Ying Wang, Yi Xiao, Xiangyu Meng, Heng Zhang, Qinlu Li, Fankai Meng, Lifang Huang, Chunrui Li, Jianfeng Zhou
Pathological analysis is the cornerstone for diagnosing malignant lymphoma. Status of cytogenetic abnormalities is frequently left unexamined if no evidence of malignancy is found in pathological analysis. In this study, we presented 3 cases in which clonal cytogenetic abnormalities were detected but morphological alterations of the same tissue did not support malignant non Hodgkin lymphoma at the first lymph node biopsy. Case 1 is a 55-year-old female with lymphadenopathy neoplastic process confirmed by flow cytometry and polymerase chain reaction (PCR)...
January 10, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28079682/comparing-short-term-complications-of-inpatient-versus-outpatient-single-level-anterior-cervical-discectomy-and-fusion-an-analysis-of-6940-patients-using-the-acs-nsqip-database
#2
Ryan Khanna, Robert B Kim, Sandi K Lam, George R Cybulski, Zachary A Smith, Nader S Dahdaleh
STUDY DESIGN: Multicenter propensity score-adjusted retrospective cohort study. OBJECTIVE: To determine baseline 30-day complication rates for anterior cervical discectomy and fusion (ACDF) and compare clinical complications for patients undergoing single-level ACDFs between inpatient and outpatient settings. SUMMARY OF BACKGROUND DATA: ACDF remains the most common procedure in the treatment of a variety of cervical disc pathologies, making it a focus of quality improvement initiatives...
January 10, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28078481/defining-a-new-tumor-dimension-in-staging-of-papillary-thyroid-carcinoma
#3
Ping Wang, Yong Wang, Chundi Miao, Xing Yu, Haichao Yan, Qiuping Xie, Jaiswal Sanjay, Qunzi Zhao
BACKGROUND: Cervical lymph node metastasis is a vital factor associated with local recurrence in papillary thyroid carcinoma (PTC). Tumor size is used in the staging of PTC because it represents the tumor load. This study compared two methods of tumor size assessment to predict tumor behavior in the relationship between size and cervical node involvement for patients with PTC. METHODS: The study enrolled 1084 patients who underwent initial thyroid surgery and had a pathologic diagnosis of PTC between 2012 and 2014 at The Second Affiliated Hospital Zhejiang University School of Medicine...
January 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28078473/traumatic-atlantoaxial-rotatory-fixation-in-an-adult-patient
#4
María A García-Pallero, Cristina V Torres, Juan Delgado-Fernández, R G Sola
INTRODUCTION: Atlantoaxial rotational fixation (AARF) is a rare entity in adults, with only a few cases reported in the English literature and often associated with a traumatic mechanism. It is an underdiagnosed condition that must be taken into account in the initial assessment of all craniocervical trauma. Both diagnostic and therapeutic delay may be a potential cause of severe neurological damage or even death of the patient. The therapeutic management is controversial given the difficulty of achieving optimum stability and permanent reduction...
January 11, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28072618/18f-fdg-pet-ct-versus-contrast-enhanced-ct-for-staging-and-prognostic-prediction-in-patients-with-salivary-gland-carcinomas
#5
Marn Joon Park, Jungsu S Oh, Jong-Lyel Roh, Jae Seung Kim, Jeong Hyun Lee, Soon Yuhl Nam, Sang Yoon Kim
PURPOSE: Salivary gland carcinoma (SGC) is rare tumor with various histological type and metastatic potential. Pretreatment detection of metastases can contribute to planning the appropriate treatment of SGC. Therefore, the present study evaluated the utility of F-FDG PET/CT versus contrast-enhanced CT for detection of metastases and prediction of outcomes in SGC patients. METHODS: Sixty-seven consecutive SGC patients who were prospectively evaluated by F-FDG PET/CT and contrast-enhanced CT and subsequently underwent surgery with or without postoperative radiotherapy/chemoradiotherapy were included...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28069683/targeted-deep-sequencing-reveals-full-methylation-profiles-of-multiple-hpv-types-and-potential-biomarkers-for-cervical-cancer-progression
#6
Pengyuan Liu, Marissa Iden, Samantha Fye, Yi-Wen Huang, Elizabeth Hopp, Chen Chu, Yan Lu, Janet S Rader
BACKGROUND: Invasive cervical cancer (ICC) and its premalignant phase (cervical intraepithelial neoplasia; CIN1-3) are distinguished by gynecological and pathological examination, yet no current methodologies can predict precancerous lesions that are destined to progress to ICC. Thus, development of reliable assays to assess patient prognosis is much needed. METHODS: HPV DNA methylation is significantly altered in cervical disease. Using an HPV-enrichment approach and next-generation DNA sequencing, methylation status was characterized in a case-case comparison of CIN (n = 2 CIN1; n = 2 CIN2; n = 20 CIN3) and ICC (n = 37) samples...
January 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28060456/significance-of-high-risk-hpv-detection-in-women-with-atypical-glandular-cells-on-pap-testing-analysis-of-1857-cases-from-an-academic-institution
#7
Stell Patadji, Zaibo Li, Dinesh Pradhan, Chengquan Zhao
BACKGROUND: The role of high-risk human papillomavirus (hrHPV) testing in women with various types of atypical glandular cells (AGC) on Papanicolaou (Pap) test is undetermined. METHODS: Herein, the authors retrospectively searched their pathology database for cases of AGC with concurrent hrHPV testing and histological follow-up results within 1 year between January 2008 and December 2013. RESULTS: Among 3709 AGC cases occurring during the study period, 2287 had concurrent Hybrid Capture 2 HPV testing results...
October 24, 2016: Cancer
https://www.readbyqxmd.com/read/28059690/accuracy-of-screening-tools-for-pap-smears-in-general-practice
#8
Catherine Harding, Alexa Seal, Louis Pilotto, Ken Mackey, Geraldine Duncan, Ronald Huynh, Robert McWilliam, Stephanie Blake
BACKGROUND: Data extraction tools (DETs) are increasingly being used for research and audit of general practice, despite their limitations.Objective This study explores the accuracy of Pap smear rates obtained with a DET compared to that of the Pap smear rate obtained with a manual file audit. METHOD: A widely available DET was used to establish the rate of Pap smears in a large multi-general practice (multi-GP) in regional New South Wales followed by a manual audit of patient files...
September 13, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28059093/expression-of-pd-l1-and-presence-of-cd8-positive-t-cells-in-pre-treatment-specimens-of-locally-advanced-cervical-cancer
#9
Emeka K Enwere, Elizabeth N Kornaga, Michelle Dean, Theodora A Koulis, Tien Phan, Maria Kalantarian, Martin Köbel, Prafull Ghatage, Anthony M Magliocco, Susan P Lees-Miller, Corinne M Doll
Several of the cancer immunotherapies under investigation or in clinical use target the programmed death-ligand 1/programmed death-1 (PD-L1/PD-1) signaling axis. PD-L1 expression in tumor samples has been used as a predictive marker for response to these therapeutics, and may also have independent prognostic utility when assessed along with immune cell markers. Our objectives were to assess the expression of PD-L1 in tumor specimens from a uniformly treated patient cohort with locally advanced cervical cancer, and to determine its prognostic significance along with the density of tumor-infiltrating T cells...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28056533/hemicrania-continua-in-carotid-artery-dissection-symptomatic-cases-or-linked-pathophysiology
#10
Roland Brilla, Matthias Pawlowski, Stefan Evers
Background Hemicrania continua (HC) -like headaches have been rarely reported as symptomatic headaches, including cases secondary to cervical artery dissection. Case series We present five cases of HC-like headaches following cervical artery dissection, in three cases with specific indomethacin response. In two cases, comorbidity of fibromuscular dysplasia (FMD) was noted. Conclusion Carotid artery dissection may result in an HC-like headache syndrome. A specific response to indomethacin does not rule out dissection as underlying pathology...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28056376/technical-note-a-preliminary-comparative-study-between-classical-and-interventional-radiological-approaches-for-multi-phase-post-mortem-ct-angiography
#11
Fatima-Zohra Mokrane, Frederic Savall, Laurent Dercle, Eric Crubezy, Norbert Telmon, Hervé Rousseau, Fabrice Dedouit
PURPOSE: Multi-phase post-mortem computed tomography angiography (MPMCTA) is a new diagnostic tool, used in forensic pathology. On the one hand, this technique allows a better and direct visualization of vascular and solid organ lesions. On the other hand, the invasiveness of the procedure-which requires surgical denudation (inguinal and/or cervical) and the insertion of surgical cannulas-leads to many relatives refusing scientific autopsies. Our hypothesis states that a minimally-invasive procedure combining interventional radiological techniques with MPMCTA (replacement of surgical cannulas by radiological catheters) will improve the approval rate of scientific autopsies by families...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28054557/kilohertz-frequency-nerve-block-enhances-anti-inflammatory-effects-of-vagus-nerve-stimulation
#12
Yogi A Patel, Tarun Saxena, Ravi V Bellamkonda, Robert J Butera
Efferent activation of the cervical vagus nerve (cVN) dampens systemic inflammatory processes, potentially modulating a wide-range of inflammatory pathological conditions. In contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system through the greater splanchnic nerve (GSN), and elevation of pro-inflammatory cytokines. Ideally, to clinically implement anti-inflammatory therapy via cervical vagus nerve stimulation (cVNS) one should selectively activate the efferent pathway...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050798/effects-of-long-term-vitamin-d-supplementation-on-regression-and-metabolic-status-of-cervical-intraepithelial-neoplasia-a-randomized-double-blind-placebo-controlled-trial
#13
Zahra Vahedpoor, Mehri Jamilian, Fereshteh Bahmani, Esmat Aghadavod, Maryam Karamali, Maryam Kashanian, Zatollah Asemi
We are not aware of any study examining the effects of long term vitamin D administration on regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1). This study was performed to evaluate the effects of long-term vitamin D administration on regression and metabolic status of patients with CIN1. This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with CIN1. CIN1 diagnosis was performed based on specific diagnostic procedures of biopsy, pathological diagnosis, and colposcopy...
January 3, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28050208/tonic-investigation-concept-of-cervico-vestibular-muscle-afferents
#14
Linda Josephine Dorn, Annabelle Lappat, Winfried Neuhuber, Hans Scherer, Heidi Olze, Matthias Hölzl
Introduction Interdisciplinary research has contributed greatly to an improved understanding of the vestibular system. To date, however, very little research has focused on the vestibular system's somatosensory afferents. To ensure the diagnostic quality of vestibular somatosensory afferent data, especially the extra cranial afferents, stimulation of the vestibular balance system has to be precluded. Objective Sophisticated movements require intra- and extra cranial vestibular receptors. The study's objective is to evaluate an investigation concept for cervico-vestibular afferents with respect to clinical feasibility...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28048882/su-f-p-25-dosimetric-changes-of-brainstem-caused-by-weight-loss-during-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma
#15
W Hu, C Yu, Y Cai, X Zhou, W Wang, H Yang
PURPOSE: To explore dosimetric effects of brainstem (BS) caused by weight loss during the course of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC). METHODS: Seventy-seven patients who were diagnosed with NPC by pathology biopsy have been enrolled. Every patients should receive weight measurement weekly and three times of computed tomography (CT) scans and replanning, at the 15th and 25th fraction during the treatment, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043576/immunohistochemical-findings-of-the-granulomatous-reaction-associated-with-tuberculosis
#16
Shirin Karimi, Masoud Shamaei, Mihan Pourabdollah, Makan Sadr, Mehrdad Karbasi, Arda Kiani, Moslem Bahadori
OBJECTIVE/BACKGROUND: The histological diagnosis of Mycobacterium tuberculosis (MTB) has long been a diagnostic challenge in the anatomical pathology field despite availability of different laboratory methods. Immunohistochemistry (IHC) could not only confirm granulomatous tissue involvement but also demonstrate MTB antigen immunolocalization. This study tries to clarify the details of IHC staining for MTB with pAbBCG. METHODS: A total of 50 patients undergoing simultaneous biopsy and tissue culture with positive tissue culture for MTB during 2005-2009 were selected from the MRC Department at Masih Daneshvari Hospital, Tehran, Iran...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042015/delayed-hemorrhage-from-an-iatrogenic-vertebral-artery-injury-during-anterior-cervical-discectomy-and-successful-endovascular-treatment-report-of-a-rare-case-and-literature-review
#17
William B Lo, Sanjoy Nagaraja, Amar Saxena
BACKGROUND: Anterior cervical discectomy is one of the commonest spinal surgeries. Although rare, iatrogenic vertebral artery injuries (VAIs) are potentially life-threatening. Risk factors are anatomical, operative and pathological. We report a rare case of iatrogenic vertebral artery injury during anterior cervical discectomy and successful endovascular treatment with no long term complications. Literature on all VAIs associated with anterior cervical discectomy and fusions is reviewed...
December 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28040666/post-mortem-ct-evaluation-of-atlanto-occipital-dissociation
#18
Mohammed Madadin, Ravindra Priyalal Samaranayake, Chris O'Donnell, Stephen Cordner
Atlanto-occipital dissociation injury is an important injury in forensic pathology practice. Radiological diagnosis of atlanto-occipital dissociation clinically is assessed by direct measurement of occipito-vertebral skeletal relationships. Different measurements may be used to diagnose atlanto-occipital dissociation, including the basion-dens interval (BDI) and basion-axial interval (BAI). It is not known whether the normal ante-mortem measurements of BDI and BAI described in the literature are applicable to post-mortem CT images of the occipito-cervical junction (OCJ) or whether these measurements could be affected by early post-mortem changes...
December 22, 2016: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28036070/young-hungarian-students-knowledge-about-hpv-and-their-attitude-toward-hpv-vaccination
#19
Bettina Claudia Balla, András Terebessy, Emese Tóth, Péter Balázs
(1) Background: Hungarys's estimated cervical cancer mortality was 6.9/100,000 in 2012, above the average of the EU27 countries (3.7/100,000) in the same year. Since 2014, the bivalent HPV vaccine has been offered to schoolgirls aged 12-13. (2) Methods: We conducted a cross-sectional study among 1022 high school seniors (492 girls, 530 boys) in 19 randomly selected schools in Budapest. Our anonymous questionnaire contained 54 items: basic socio-demographic data, knowledge about HPV infection/cervical cancer and HPV vaccination...
December 29, 2016: Vaccines
https://www.readbyqxmd.com/read/28028952/mastalgia-due-to-degenerative-changes-of-the-spine
#20
Okay Pirti, Aziz M Barlas, Serdar Kuru, Selim Temel, Mustafa K Urhan, Kemal Kismet, Adnan Hasanoglu, Osman Guler
BACKGROUND: Mastalgia is a common and enigmatic condition; the cause and optimal treatment are still inadequately defined. Cervical radiculopathy, which is the result of cervical nerve root pathology often caused by spaceoccupying lesions such as cervical disc herniation, spondylosis, or osteophytosis, is frequently encountered in physical therapy. OBJECTIVES: The aim of the study was to evaluate the incidence of vertebral pathologies in patients with non-cyclic mastalgia and the efficacy of conservative treatment of these pathologies on relieving breast pain...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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