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Cervical pathology

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https://www.readbyqxmd.com/read/28647656/delayed-retroclival-and-cervical-spinal-subdural-hematoma-complicated-by-pre-existing-chiari-malformation-in-an-adult-trauma-patient
#1
Ha Nguyen, Hoon Choi, Shekar Kurpad, Hesham Soliman
INTRODUCTION: Traumatic spinal subdural hematoma involving the retroclival region and upper cervical spine is a rare pathology. To our knowledge, there have only been two prior cases in an adult trauma patient. We describe a patient with pre-existing Chiari 1 malformation, who recently sustained a unilateral Type 1 OCF (occipital condyle fracture) with associated disruption of the tectorial membrane and transverse ligament, that returned with a retroclival subdural hematoma extending down to C7, causing spinal cord compression and symptomatic obstructive hydrocephalus...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28646863/fine-mapping-host-genetic-variation-underlying-outcomes-to-mycobacterium-bovis-infection-in-dairy-cows
#2
S Wilkinson, S C Bishop, A R Allen, S H McBride, R A Skuce, M Bermingham, J A Woolliams, E J Glass
BACKGROUND: Susceptibility to Mycobacterium bovis infection in cattle is governed in part by host genetics. However, cattle diagnosed as infected with M. bovis display varying signs of pathology. The variation in host response to infection could represent a continuum since time of exposure or distinct outcomes due to differing pathogen handling. The relationships between host genetics and variation in host response and pathological sequelae following M. bovis infection were explored by genotyping 1966 Holstein-Friesian dairy cows at 538,231 SNPs with three distinct phenotypes...
June 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28646336/nogo-a-antibodies-enhance-axonal-repair-and-remyelination-in-neuro-inflammatory-and-demyelinating-pathology
#3
Benjamin V Ineichen, Sandra Kapitza, Christiane Bleul, Nicolas Good, Patricia S Plattner, Maryam S Seyedsadr, Julia Kaiser, Marc P Schneider, Björn Zörner, Roland Martin, Michael Linnebank, Martin E Schwab
Two hallmarks of chronic multiple sclerosis lesions are the absence of significant spontaneous remyelination and primary as well as secondary neurodegeneration. Both characteristics may be influenced by the presence of inhibitory factors preventing myelin and neuronal repair. We investigated the potential of antibodies against Nogo-A, a well-known inhibitory protein for neuronal growth and plasticity, to enhance neuronal regeneration and remyelination in two animal models of multiple sclerosis. We induced a targeted experimental autoimmune encephalomyelitis (EAE) lesion in the dorsal funiculus of the cervical spinal cord of adult rats resulting in a large drop of skilled forelimb motor functions...
June 23, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28646018/the-amyloid-precursor-protein-modulates-%C3%AE-2a-adrenergic-receptor-endocytosis-and-signaling-through-disrupting-arrestin-3-recruitment
#4
Fang Zhang, Mary Gannon, Yunjia Chen, Lufang Zhou, Kai Jiao, Qin Wang
The amyloid precursor protein (APP) has long been appreciated for its role in Alzheimer's disease (AD) pathology. However, less is known about the physiologic function of APP outside of AD. Particularly, whether and how APP may regulate functions of cell surface receptors, including GPCRs, remains largely unclear. In this study, we identified a novel direct interaction between APP and the α2A adrenergic receptor (α2AAR) that occurs at the intracellular domains of both proteins. The APP interaction with α2AAR is promoted by agonist stimulation and competes with arrestin 3 binding to the receptor...
June 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#5
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28644161/agreement-between-magnetic-resonance-imaging-and-pathologic-findings-in-the-tumor-size-evaluation-before-and-after-neoadjuvant-chemotherapy-treatment-a-prospective-study
#6
Jinlong Cheng, Yan Hou, Junnan Li, Wenjie Wang, Ye Xu, Chunyan Yang, Libing Ma, Harman S Dhillon, Margarita S Openkova, Xin Fan, Zhenzi Li, Kang Li, Ge Lou
OBJECTIVES: To compare the agreement between magnetic resonance imaging (MRI) results and postsurgical pathologic findings for tumor size evaluation in cervical cancer patients before and after neoadjuvant chemotherapy (NACT) treatment. METHODS: The study analyzed the agreement between pretreatment MRI results and postsurgical pathologic findings about the tumor size in 100 cervical cancer patients without NACT and 397 cervical cancer patients with NACT, respectively...
June 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28640908/evaluating-diagnostic-tests-for-bovine-tuberculosis-in-the-southern-part-of-germany-a-latent-class-analysis
#7
Valerie-Beau Pucken, Gabriela Knubben-Schweizer, Dörte Döpfer, Andreas Groll, Angela Hafner-Marx, Stefan Hörmansdorfer, Carola Sauter-Louis, Reinhard K Straubinger, Pia Zimmermann, Sonja Hartnack
Germany has been officially free of bovine tuberculosis since 1996. However, in the last years there has been an increase of bovine tuberculosis cases, particularly in the southern part of Germany, in the Allgäu region. As a consequence a one-time tuberculosis surveillance program was revisited with different premortal and postmortal tests. The aim of this paper was to estimate diagnostic sensitivities and specificities of the different tests used within this surveillance program. In the absence of a perfect test with 100% sensitivity and 100% specificity, thus in the absence of a gold standard, a Bayesian latent class approach with two different datasets was performed...
2017: PloS One
https://www.readbyqxmd.com/read/28640767/surgical-and-pathological-outcomes-of-laparoscopic-versus-abdominal-radical-hysterectomy-with-pelvic-lymphadenectomy-and-or-para-aortic-lymph-node-sampling-for-bulky-early-stage-cervical-cancer
#8
Tao Zhu, Xi Chen, Jianqing Zhu, Yaqing Chen, Aijun Yu, Lu Chen, Huafeng Shou, Meijuan Wu, Ping Zhang
BACKGROUND AND OBJECTIVES: The aim of this study was to compare the feasibility, morbidity, and recurrence rate of total laparoscopic radical hysterectomy (LRH) with those of abdominal radical hysterectomy (ARH) for bulky early-stage cervical cancer. METHODS: We performed a retrospective cohort study of 112 patients with stage IB1 or IIA2 cervical cancer in which the tumor diameter was 3 cm or greater. All patients underwent LRH (n = 30) or ARH (n = 82) with pelvic lymphadenectomy and/or para-aortic lymph node sampling between May 2011 and November 2014...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28639968/defining-the-cervical-transformation-zone-and-squamocolumnar-junction-can-we-reach-a-common-colposcopic-and-histologic-definition
#9
Olaf Reich, Sigrid Regauer, W G McCluggage, Christine Bergeron, Charles Redman
Quality assurance and research in colposcopy and cervical pathology require standardized terminologies and reporting. However, clinical and histologic definitions of the cervical transformation zone (TZ) and squamocolumnar junction (SCJ) vary considerably. We aimed to identify areas of agreement and areas where work is required to standardize the definitions of the TZ and the SCJ. We conducted a survey among the board members of the European Federation of Colposcopy member societies and members of the International Society of Gynecological Pathologists...
June 20, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28634755/rhabdomyosarcoma-of-the-lower-female-genital-tract-an-analysis-of-144-cases
#10
Dimitrios Nasioudis, Michail Alevizakos, Eloise Chapman-Davis, Steven S Witkin, Kevin Holcomb
PURPOSE: The aim of the present study was to elucidate the clinico-pathological characteristics of female patients with lower genital tract rhabdomyosarcoma (RMS) stratified by age group and investigate their prognosis, using a multi-institutional database. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1973-2013) and a cohort of females diagnosed with RMS of the lower genital tract (vulva, vagina, cervix) was drawn...
June 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28632647/high-osteogenic-potential-of-adipose-and-muscle-derived-mesenchymal-stem-cells-in-spinal-ossification-model-mice
#11
Xizhe Liu, Gentaro Kumagai, Kanichiro Wada, Toshihiro Tanaka, Toru Asari, Kazuki Oishi, Taku Fujita, Hiroki Mizukami, Ken-Ichi Furukawa, Yasuyuki Ishibashi
STUDY DESIGN: Basic experiments in a mouse model of ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE: To assess the osteogenic potential of mesenchymal stem cells (MSCs) obtained from muscle and adipose tissue in Tiptoe-walking (ttw) mice, in which cervical OPLL compresses the spinal cord and causes motor and sensory dysfunction. SUMMARY OF BACKGROUND DATA: In humans, MSCs have been implicated in the pathogenesis of cervical OPLL...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28629588/human-papillomavirus-and-its-testing-assays-cervical-cancer-screening-and-vaccination
#12
Yusheng Zhu, Yun Wang, Julie Hirschhorn, Kerry J Welsh, Zhen Zhao, Michelle R Davis, Sarah Feldman
Human papillomavirus (HPV) was found to be the causative agent for cervical cancer in the 1980s with almost 100% of cervical cancer cases testing positive for HPV. Since then, many studies have been conducted to elucidate the molecular basis of HPV, the mechanisms of carcinogenesis of the virus, and the risk factors for HPV infection. Traditionally, the Papanicolaou test was the primary screening method for cervical cancer. Because of the discovery and evolving understanding of the role of HPV in cervical dysplasia, HPV testing has been recommended as a new method for cervical cancer screening by major professional organizations including the American Cancer Society, American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28626767/closer-to-a-uniform-language-in-colposcopy-study-on-the-potential-application-of-2011-international-federation-for-cervical-pathology-and-colposcopy-terminology-in-clinical-practice
#13
Yanyun Li, Xiaoling Duan, Long Sui, Fengying Xu, Shuifang Xu, Hongwei Zhang, Congjian Xu
As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28625905/the-influence-of-mri-features-on-surgical-decision-making-in-degenerative-cervical-myelopathy-results-from-a-global-survey-of-aospine-international-members
#14
Aria Nouri, Allan R Martin, Anick Nater, Christopher D Witiw, So Kato, Lindsay Tetreault, Hamed Reihani-Kermani, Carlo Santaguida, Michael G Fehlings
OBJECTIVE: We conducted a survey to understand how specific pathologic features on MRI influence surgeons toward an anterior or posterior surgical approach in Degenerative Cervical Myelopathy (DCM) . METHODS: A questionnaire was sent out to 6,179 AOSpine International members via email. This included 18 questions on a 7-point Likert scale regarding how MRI features influence the respondent's decision to perform an anterior or posterior surgical approach. Influence was classified based on the mean and mode...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28624565/a-case-of-laterally-extended-high-positioned-chordoma-treated-using-the-high-cervical-retropharyngeal-approach
#15
Kiyoshi Ito, Takuya Nakamura, Tatsuro Aoyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo
BACKGROUND: Several surgical approaches for the treatment of pathologies of the craniovertebral junction (CVJ) and high cervical regions have been reported. For the best postoperative results, selection of a surgical route to treat such pathologies should be based on a complete understanding of the approach. CASE DESCRIPTION: Here, we describe the case of a 64-year-old woman who presented with a 5-year history of motor and sensory disturbances in her right upper extremity...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28624026/the-prediction-of-the-treatment-response-of-cervical-nodes-using-intravoxel-incoherent-motion-diffusion-weighted-imaging
#16
Simona Marzi, Francesca Piludu, Giuseppe Sanguineti, Laura Marucci, Alessia Farneti, Irene Terrenato, Raul Pellini, Maria Benevolo, Renato Covello, Antonello Vidiri
PURPOSE: To investigate the predictive role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) parameters on cervical nodal response to chemo-radiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Patients with pathologically confirmed HNSCC were included in the present prospective study, having at least one positive cervical lymph node (LN). They received concomitant CRT and underwent three serial IVIM-DWI investigations: before, at mid-treatment and after treatment completion...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622488/dizziness-unsteadiness-visual-disturbances-and-sensorimotor-control-in-traumatic-neck-pain
#17
Julia Treleaven
Synopsis There is considerable evidence to support the importance of cervical afferent dysfunction in the development of dizziness, unsteadiness, visual disturbances and altered balance, eye, and head movement control following neck trauma, especially in those with persistent symptoms. However, there are other possible causes for these symptoms and secondary adaptive changes should also be considered in the process of differential diagnosis. Understanding the nature of these symptoms and the differential diagnosis of their potential origin is important for rehabilitation...
June 16, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28620930/prospective-multimodal-imaging-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery-the-price-prospective-imaging-of-cervical-cancer-and-neoadjuvant-treatment-study-the-role-of-ultrasound
#18
A C Testa, G Ferrandina, F Moro, T Pasciuto, M C Moruzzi, I De Blasis, F Mascilini, E Foti, R Autorino, A Collarino, B Gui, G F Zannoni, M A Gambacorta, A L Valentini, V Rufini, G Scambia
OBJECTIVE: Chemoradiation-based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC) -stage ≥ IB2 (except of IIA1)- but ultrasound variables used to predict neoadjuvant partial response are not well defined. The goal of this study was to prospectively analyze the potential role of transvaginal ultrasound (TVUS) in early predicting pathologically assessed residual disease in a large, single-institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery...
June 16, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28619043/effect-of-transcutaneous-electrical-stimulation-treatment-on-lower-urinary-tract-symptoms-after-class-iii-radical-hysterectomy-in-cervical-cancer-patients-study-protocol-for-a-multicentre-randomized-controlled-trial
#19
Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-Ting Cao, Xin Yang, Jing-Song Han, Yang-Feng Wu, Kathleen H Reilly, Jian-Liu Wang
BACKGROUND: Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders especially bladder dysfunction are common due to damaged vessels and nerve fibers following surgery. Transcutaneous electrical stimulation (TENS) treatment has been used to treat bladder disorders for many years, but its effect on cervical cancer patients, the best treatment time point and stimulated protocol, had never been assessed...
June 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28617687/preoperatively-assessable-clinical-and-pathological-risk-factors-for-parametrial-involvement-in-surgically-treated-figo-stage-ib-iia-cervical-cancer
#20
Emel Canaz, Eser Sefik Ozyurek, Baki Erdem, Merve Aldikactioglu Talmac, Ipek Yildiz Ozaydin, Ozgur Akbayir, Ceyhun Numanoglu, Volkan Ulker
OBJECTIVE: Determining the risk factors associated with parametrial involvement (PMI) is of paramount importance to decrease the multimodality treatment in early-stage cervical cancer. We investigated the preoperatively assessable clinical and pathological risk factors associated with PMI in surgically treated stage IB1-IIA2 cervical cancer. METHODS: A retrospective cohort study of women underwent Querleu-Morrow type C hysterectomy for cervical cancer stage IB1-IIA2 from 2001 to 2015...
June 14, 2017: International Journal of Gynecological Cancer
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