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Allergic diseases

Wannaporn Tongtako, Jettanong Klaewsongkram, Timothy D Mickleborough, Daroonwan Suksom
INTRODUCTION: Exercise training and vitamin C supplementation have both been recommended as an effective adjuvant treatment in the management of symptoms in patients with many diseases. However, its effects on rhinitis symptoms remain unclear. The aim of the present study was to determine the effects of exercise training alone, and in combination with vitamin C supplementation, on rhinitis symptoms in allergic rhinitis patients. METHODS: Twenty-seven rhinitis patients were randomized into 3 groups: control (CON; n = 8), exercise (EX; n = 9), and exercise combined with vitamin C (EX + Vit...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Zhiyong Yi, Zhipan Yi, Kai Huang, Yanqun Cao, Chuli Xiao, Yanwei Li, Quzhe Lu, Shuang Zhao, Wenqi Luo, Guanlan Liu
The aim of the present study was to investigate the effect of propofol on immunoglobulin (Ig)E-activated mast cell degranulation and explore the underlying mechanisms responsible. RBL-2H3 cells were treated with propofol for at a variety of concentrations and different amounts of time. Cell viability was assessed using an MTT assay and microRNA (miR)-221 expression was quantified using reverse transcription-quantitative polymerase chain reaction. RBL-2H3 cells were transfected with miR-221 mimic or a negative control and degranulation, including the release of β-hexosaminidase and histamine, was evaluated using an ELISA kit...
August 2018: Experimental and Therapeutic Medicine
Wenjie Gao, Jinying Li, Quanheng Li, Shuhua An
Cysteinyl leukotriene receptor 1 (CYSLTR1) serves a pivotal role in allergic reactions, which is one of the main causes of adenoid hypertrophy. The present study aimed to investigate the function of CYSLT1 within adenoid hypertrophy. A total of 40 patients with adenoid hypertrophy were recruited between January 2014 and January 2016 at the Children's Hospital of Hebei Province, China. The patients were divided into either the mild-moderate group or the severe group according to their disease severity. The expression of CYSLT1 in the adenoid tissue and whole blood of all patients and healthy controls was detected by reverse transcription-quantitative polymerase chain reaction...
August 2018: Experimental and Therapeutic Medicine
Samane Hoseini-Shahrestanak, Nasrin Bazargan, Leila Rahimian, Maryam Nemati, Saeed Solaymani, Abdollah Jafarzadeh
Background: The imbalance between Th2 and Treg cells plays fundamental role in the pathogenesis of allergic asthma. The current study aimed at assessing the expression of some Th2 and Treg cell-related parameters in patients with allergic asthma. Material and Methods: The serum and peripheral blood mononuclear cell (PBMC) samples were collected from 30 patients with asthma and 36 healthy subjects. The serum levels of transforming growth factor (TGF)-β, interleukin (IL)-4, as well as the expression levels of GATA3 and FOXP3 genes in PBMCs were determined by the enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR), respectively...
January 2018: Tanaffos
Eun-Jeong Kim, Yong-Keum Choi
Background: The purpose of this study was to examine whether allergic rhinitis is associated with periodontal disease in a representative sample of elderly Korean people that was adjusted for socio-demographic factors, oral and general health behaviors, and systemic health status. Methods: A total of 10,643 subjects who were between 20 and 59 years of age participated in the Korean National Health and Nutrition Examination Survey and underwent cross-sectional examination...
2018: BMC Ear, Nose, and Throat Disorders
Sinan Özçelik, İbrahim Kulaç, Mustafa Yazıcı, Esra Öcal
Aim: Studies on pediatric skin diseases in Turkey are not yet sufficient. It was aimed to characterize the prevalence of skin diseases, age and gender distribution in children living in the Erzincan region. Material and Methods: 10,115 children aged 0-16 years who reached to our outpatient clinic between 01.11.2014 and 30.11.2016 were included in the study. The frequency, age and gender distribution of the skin diseases were examined. The cases were divided into 4 groups; infantile period (0-2 years), preschool period (3-5 years), school period (6-11 years) and adolescence period (12-16 years)...
June 2018: Türk Pediatri Arşivi
Sachiko Hojo, Atsushi Mizukoshi, Kenichi Azuma, Jiro Okumura, Satoshi Ishikawa, Mikio Miyata, Masami Mizuki, Hideo Ogura, Kou Sakabe
BACKGROUND: Recently, with rapid changes in the Japanese lifestyle, the clinical condition of patients with multiple chemical sensitivity (MCS) may also have undergone change. Thus, we conducted a new survey for subjective symptoms, ongoing chemical exposures, the prevalence of allergic diseases, and presumed onset/trigger factors in patients with MCS and compared results with those of an old survey from ten years ago. METHODS: The new survey was conducted from 2012 to 2015 and the old survey was independently conducted from 1999 to 2003, meaning it was not a follow-up study...
August 13, 2018: International Journal of Hygiene and Environmental Health
Jason R Woloski, Deepa Burman, Olumuyiwa Adebona
Patients with suspected bites or skin rashes regularly present to their primary care physician. Common mite infections encountered in the primary care office include scabies, chiggers, grain itch, and allergic responses from dust mites. In fact, scabies is one of the 50 most prevalent diseases worldwide. Bed bugs are also becoming increasingly common, living in dark crevices, such as mattresses, feeding at night, and causing a maculopapular immune mediated allergic skin response in humans. Proper identification of the mite or bed bug is essential to guide treatment and eradication...
September 2018: Primary Care
Thierry Olivry, Emmanuel Bensignor, Claude Favrot, Craig E Griffin, Peter B Hill, Ralf S Mueller, Jon D Plant, Hywel C Williams
BACKGROUND: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical signs were validated later, there was little impact on standardizing outcome measures resulting in difficulties in comparing treatment efficacy between trials and impeding meta-analyses. RESULTS: Participants in the Outcome Measures subcommittee of the International Committee of Allergic Diseases of Animals (ICADA) collaborated for two years to develop a core outcome set (COS) for canine AD, the COSCAD...
August 16, 2018: BMC Veterinary Research
Li-Chi Chen, Mu-Hong Chen, Tung-Ping Su, Shih-Jen Tsai, Ya-Mei Bai, Cheng-Ta Li, Albert C Yang, Wen-Han Chang, Tzeng-Ji Chen
INTRODUCTION: Previous studies have suggested that both bipolar disorder and atopy are associated with an increased risk of stroke. However, the role of atopic diseases/diathesis in the risk of stroke among patients with bipolar disorder remains unclear. METHODS: Using Taiwan's National Health Insurance Research Database, we selected 55,593 patients with bipolar disorder between 2002 and 2008, divided them into patients with atopic diseases/diathesis (n = 21,050) and patients without atopic diseases/diathesis (n = 34,543), and observed them until the end of 2011...
2018: PloS One
Hiroki Sato, Terasu Honma, Takashi Owaki, Kentaro Tominaga, Junji Yokoyama, Shuji Terai
BACKGROUND: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology. PATIENTS AND METHODS: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Their symptoms, patterns of flares, and type of treatment were documented. The shift in peripheral blood eosinophil levels was also examined...
August 14, 2018: European Journal of Gastroenterology & Hepatology
Lacey B Robinson, Carlos A Camargo
Acid suppressant medications, such as proton pump inhibitors and histamine-2 receptor antagonists, are used often and throughout the lifespan. These medications have been linked to the development of a variety of allergic diseases. Areas covered: This review discusses prior studies investigating the association between acid suppressant medication exposure and the development of allergic diseases. We performed a thorough literature search to identify potentially relevant studies for inclusion. In summary, exposure to these medications prenatally, in childhood and in adulthood may increase the risk of allergic diseases...
August 16, 2018: Expert Review of Clinical Immunology
V I Butvilovskaya, O V Smoldovskaya, G U Feyzkhanova, M A Filippova, L V Pavlushkina, S A Voloshin, A Yu Rubina
Glycans and anti-glycan antibodies (AGAs) are essential for infiltration of inflammatory cells in various allergies. The glycocalyx structure of the cells is modified during disease progression, and this modification is possible to evaluate by assessment of AGAs. A printed glycan array with 55 immobilized glycans and immobilized antibodies to IgG, IgA, and IgM was used to study the changes in AGA profiles in bronchial asthma (BA). Levels of antibodies to certain glycans in BA patients statistically differed from levels in healthy donors (p < 0...
July 2018: Molekuliarnaia Biologiia
Parker F Duffney, Megan L Falsetta, Ashley R Rackow, Thomas H Thatcher, Richard P Phipps, Patricia J Sime
Chronic inflammation is an underlying feature of many diseases, including chronic obstructive pulmonary disease, rheumatoid arthritis, asthma, and multiple sclerosis. There is an increasing appreciation of the dysregulation of adaptive immunity in chronic inflammatory and allergic diseases. The discovery of specialized pro-resolving lipid mediators (SPMs) that actively promote the resolution of inflammation has opened new avenues for the treatment of chronic inflammatory diseases. Much work has been done focusing on the impact of SPMs on innate immune cells...
July 2, 2018: Journal of Clinical Investigation
Jesper Z Haeggström
Leukotrienes are powerful immune-regulating lipid mediators with established pathogenic roles in inflammatory allergic diseases of the respiratory tract - in particular, asthma and hay fever. More recent work indicates that these lipids also contribute to low-grade inflammation, a hallmark of cardiovascular, neurodegenerative, and metabolic diseases as well as cancer. Biosynthesis of leukotrienes involves oxidative metabolism of arachidonic acid and proceeds via a set of soluble and membrane enzymes that are primarily expressed by cells of myeloid origin...
July 2, 2018: Journal of Clinical Investigation
Süleyha Hilmioğlu-Polat, Seyedmojtaba Seyedmousavi, Macit Ilkit, Mohammad Taghi Hedayati, Ramazan Inci, Emel Tumbay, David W Denning
The current number of fungal infections occurring each year in Turkey is unknown. We estimated the burden of serious human fungal diseases based on the population at risk, existing epidemiological data from 1920 to 2017, and modelling previously described by the LIFE program Among the population of Turkey (80.8 million in 2017), approximately 1,785,811 (2.21%) people are estimated to suffer from a serious fungal infection each year. The model used predicts high prevalences of allergic fungal rhinosinusitis episodes (312,994 cases) (392/100,000), of severe asthma with fungal sensitization (42,989 cases) (53...
August 14, 2018: Mycoses
Fahad M Aldakheel, Jane E Bourke, Paul S Thomas, Melanie C Matheson, Michael J Abramson, Garun S Hamilton, Caroline J Lodge, Bruce R Thompson, Haydn E Walters, Katrina J Allen, Bircan Erbas, Jennifer L Perret, Shyamali C Dharmage, Adrian J Lowe
BACKGROUND: Asthma and allergic diseases are heterogeneous. Measurement of biomarkers in exhaled breath condensate (EBC) may help to discriminate between different phenotypes and may assist with clinical prognostication. OBJECTIVES: We aimed to assess associations between total nitric oxide products (NOx ) in EBC and different allergic phenotypes and lung function in young and middle-aged adults. METHODS: Cross-sectional analyses were nested within two Australian longitudinal studies, the Melbourne Atopy Cohort Study (MACS, mean age 17...
August 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Pierre Regenass, Dayana Abboud, François Daubeuf, Christine Lehalle, Patrick Gizzi, Stéphanie Riché, Muriel Hachet-Haas, François Rohmer, Vincent Gasparik, Damien Boeglin, Jacques Haiech, Tim Knehans, Didier Rognan, Denis Heissler, Claire Marsol, Pascal Villa, Jean-Luc Galzi, Marcel Hibert, Nelly Frossard, Dominique Bonnet
We previously reported small molecules that bind the chemokine CXCL12, not its cognate receptors CXCR4 or CXCR7, and neutralize its biological activity. These neutraligands encompass a chalcone chemotype, and suffer from limitations such as poor chemical stability, solubility and oral activity. Herein, we report a systematic structure-activity relationship study around the first neutraligand of CXCL12, Chalcone 4 (1) resulting in the discovery of pyrimidinone 57 (LIT-927), a novel neutraligand of CXCL12 which displays a higher solubility than 1...
August 14, 2018: Journal of Medicinal Chemistry
Jorge Sanchez, Andres Sánchez, Ricardo Cardona
Background: Epidemiological studies have shown that children who grow up on traditional farms are protected from allergic diseases. However, less is known about if the environment influences the pharmacotherapy in these patients. Objective: To compare the treatment of asthmatic and rhinitis children from urban and rural areas in Medellín, Colombia. Methods: During one year, we follow up a group of children (6 to 14 years) with diagnostic of asthma or rhinitis living for more than five years in urban or rural area...
June 30, 2018: Colombia Médica: CM
Naina Gour, Ursula Smole, Hwan-Mee Yong, Ian P Lewkowich, Nu Yao, Anju Singh, Edward Gabrielson, Marsha Wills-Karp, Stephane Lajoie
Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma pathogenesis. In susceptible individuals, allergen exposure triggers the activation of complement, a major arm of innate immunity, leading to the aberrant generation of the C3a anaphylatoxin. C3 and C3a have been shown to be important for the development of Th2 responses, yet remarkably, the mechanisms by which C3a regulates type 2 immunity are relatively unknown...
August 13, 2018: Mucosal Immunology
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