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https://www.readbyqxmd.com/read/30540846/evaluating-the-impact-of-meloxicam-oral-suspension-administered-at-parturition-on-subsequent-production-health-and-culling-in-dairy-cows-a-randomized-clinical-field-trial
#1
Daniel A Shock, David L Renaud, Steven M Roche, Robert Poliquin, Merle E Olson
Parturition is a painful event experienced by cows at the onset of lactation. This pain could lead to a reduced feed intake, altered metabolic and immunological status, and a host of other diseases that could seriously limit her productive herd lifespan. The objective of the current study was to assess the effect of administration of a single dose of oral meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on the production and health status of cows during their lactation. A total of 2,653 (1,009 meloxicam-treated and 1,644 untreated control) cows were enrolled across 20 herds in the provinces of Ontario and Quebec, Canada...
2018: PloS One
https://www.readbyqxmd.com/read/30539910/research-trends-of-macrophage-polarization-a-bibliometric-analysis
#2
Han Gao, Feng-Yan Huang, Zhi-Ping Wang
Background: Macrophage polarization is involved in the development of many diseases such as obesity, diabetes, and cancer. This study aimed to understand the trends and hotspots of macrophage polarization research. Methods: We searched through the Web of Science Core Collection database to obtain original articles in this research domain. CiteSpace, HistCite, and VOSviewer software were used to facilitate the analysis and visualization of scientific productivity and emerging trends...
December 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30539779/genetic-variants-in-rora-are-associated-with-asthma-and-allergy-markers-in-an-admixed-population
#3
Louise Correia Lima, Gerson de Almeida Queiroz, Ryan Dos Santos Costa, Neuza Maria Alcantara-Neves, Cíntia Rodrigues Marques, Gustavo Nunes de Oliveira Costa, Mauricio Lima Barreto, Camila Alexandrina Viana Figueiredo, Valdirene Leão Carneiro
Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA...
January 2019: Cytokine
https://www.readbyqxmd.com/read/30539376/emerging-immunotherapies-for-parkinson-disease
#4
REVIEW
Samis M A Zella, Judith Metzdorf, Emine Ciftci, Friederike Ostendorf, Siegfried Muhlack, Ralf Gold, Lars Tönges
Symptomatic treatment options for Parkinson disease have steadily improved, and individualized therapeutic approaches are becoming established for every stage of the disease. However, disease-modifying therapy with a causal approach is still unavailable. The central causative role of alpha-synuclein pathology, including its progressive spread to most areas of the CNS, has been widely recognized, and a strong involvement of immune responses has recently been discovered. New immunologic technologies have been shown to effectively prevent the progression of alpha-synuclein pathology in animal models...
December 11, 2018: Neurology and Therapy
https://www.readbyqxmd.com/read/30538706/glycans-as-key-checkpoints-of-t-cell-activity-and-function
#5
REVIEW
Márcia S Pereira, Inês Alves, Manuel Vicente, Ana Campar, Mariana C Silva, Nuno A Padrão, Vanda Pinto, Ângela Fernandes, Ana M Dias, Salomé S Pinho
The immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulation of both innate and adaptive immune responses with important implications in the pathogenesis of major diseases such as autoimmunity and cancer...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30538346/role-of-il-21-in-host-pathogenesis-in-experimental-visceral-leishmaniasis
#6
R Khatonier, A M Khan, P Sarmah, G U Ahmed
Visceral leishmaniasis (VL) is a major global health problem but still remains one of the neglected tropical diseases. Currently available chemotherapeutics are associated with severe toxicity and increased drug resistance. There is a need to explore for novel therapeutic strategies that could modulate host immune responses or work in synergy with chemotherapy of VL. Therefore, understanding the host immunological changes that play a vital role in disease pathology is a prerequisite for designing any interventions...
December 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/30538138/prospective-phase-ii-clinical-trial-of-autologous-haematopoietic-stem-cell-transplant-for-treatment-refractory-multiple-sclerosis
#7
John J Moore, Jennifer C Massey, Carole D Ford, Melissa L Khoo, John J Zaunders, Kevin Hendrawan, Yael Barnett, Michael H Barnett, Kain A Kyle, Robert Zivadinov, Kris C Ma, Sam T Milliken, Ian J Sutton, David D F Ma
BACKGROUND: Autologous haematopoietic stem cell transplantation (AHSCT) has been explored as a therapeutic intervention in multiple sclerosis (MS) over the last two decades; however, prospective clinical trials of the most common myeloablative conditioning regimen, BEAM, are limited. Furthermore, patient selection, optimal chemotherapeutic regimen and immunological changes associated with disease response require ongoing exploration. We present the outcomes, safety and immune reconstitution (IR) of patients with active, treatment refractory MS...
December 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30537794/immunotherapeutic-effects-of-%C3%AE-d-mannuronic-acid-on-il-4-gata3-il-17-and-rorc-gene-expression-in-the-pbmc-of-patients-with-inflammatory-bowel-diseases
#8
Hussaini Alhassan Mohammed, Ali Akbar Saboor-Yaraghi, Homayoun Vahedi, Ghordratollah Panahi, Gholamreza Hemmasi, Mir Saeed Yekaninejad, Abbas Mirshafiey
Inflammatory bowel diseases (IBD) are chronic relapsing immune-mediated disorders that result from an aberrant immunological response. IBD comprises of Crohn's disease (CD) and ulcerative colitis (UC). The precise aetiology of IBD has not been fully understood, however, recent studies support the hypothesis that patients with IBD have a dysregulated immune response to endogenous bacteria in the gastrointestinal tract (GIT). The increasing number of hospitalisation coupled with the high economic burden faced by IBD patients, calls for more concerted research efforts, to design a potent and credible treatment option for these strata of patients...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/30537479/simple-rapid-and-inexpensive-typing-of-common-hla-class-i-alleles-for-immunological-studies
#9
Soi Cheng Law, Oscar L Haigh, Carina M Walpole, Colm Keane, John Miles, Maher K Gandhi, Kristen J Radford, Raymond J Steptoe
Current HLA-typing methods are typically designed to provide exquisitely-detailed identification of multiple HLA-alleles to satisfy the requirements for organ and bone marrow transplantation or genetic studies. Many human immunological studies, on the other hand, focus around only a small number of HLA alleles that are abundant or of relevance to specific diseases. Consequently, for such studies, many HLA typing approaches are not cost-effective and are potentially complicated, slow and not easily performed in-house...
December 8, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/30536806/ruxolitinib-treatment-for-steroid-refractory-acute-and-chronic-graft-versus-host-disease-in-children-clinical-and-immunological-results
#10
Marta González Vicent, Blanca Molina, Jesús González de Pablo, Ana Castillo, Miguel Ángel Díaz
Ruxolitinib is a promising treatment for steroid refractory graft-versus-host disease (GvHD). However, data concerning effects on T cells are probably involved in increased risk of opportunistic infections. We analyzed clinical and immunological changes in children with GvHD taking ruxolitinib. Twenty-two children that underwent transplantation and received ruxolitinib were included. Ruxolitinib indication was acute and chronic GvHD in 13 and 9 patients, respectively. Overall response rate in acute GvHD and chronic GvHD was high, of 77% and 89%, respectively...
December 8, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/30536071/using-tree-shrews-tupaia-belangeri-as-a-novel-animal-model-of-liver-transplantation
#11
Bo Tang, Tao Wu, Shu-Feng Xiao, Jia-Yun Ge, Dong Wei, Chun-Man Li, Qiu-Hong Wang, Wang Zeng, Bi-Mang Fu, Jie Zhang
Liver transplantation (LT) is most effective and promising approach for end-stage liver disease. However, there remains room for further improvement and innovation, for example, to reduce ischemic reperfusion injury, transplant rejection and immune tolerance. A good animal model of LT is essential for such innovation in transplant research. Although rat LT model has been used since the last century, it has never been an ideal model because the results observed in rat may not be applied to human because these two species are genetically distinct from each other...
December 2018: Current medical science
https://www.readbyqxmd.com/read/30535609/microbiome-and-gut-dysbiosis
#12
José E Belizário, Joel Faintuch
The gastrointestinal (GI) tract is the residence of trillions of microorganisms that include bacteria, archaea, fungi and viruses. The collective genomes of whole microbial communities (microbiota) integrate the gut microbiome. Up to 100 genera and 1000 distinct bacterial species were identified in digestive tube niches. Gut microbiomes exert permanent pivotal functions by promoting food digestion, xenobiotic metabolism and regulation of innate and adaptive immunological processes. Proteins, peptides and metabolites released locally and at distant sites trigger many cell signalling and pathways...
2018: Experientia. Supplementum
https://www.readbyqxmd.com/read/30534614/pre-obese-children-s-dysbiotic-gut-microbiome-and-unhealthy-diets-may-predict-the-development-of-obesity
#13
Simone Rampelli, Kathrin Guenther, Silvia Turroni, Maike Wolters, Toomas Veidebaum, Yiannis Kourides, Dénes Molnár, Lauren Lissner, Alfonso Benitez-Paez, Yolanda Sanz, Arno Fraterman, Nathalie Michels, Patrizia Brigidi, Marco Candela, Wolfgang Ahrens
It is widely accepted that the intestinal microbiome is connected to obesity, as key mediator of the diet impact on the host metabolic and immunological status. To investigate whether the individual gut microbiome has a potential in predicting the onset and progression of diseases, here we characterized the faecal microbiota of 70 children in a two-time point prospective study, within a four-year window. All children had normal weight at the beginning of this study, but 36 of them gained excessive weight at the subsequent check-up...
2018: Communications biology
https://www.readbyqxmd.com/read/30534474/organoid-technology-in-disease-modelling-drug-development-personalized-treatment-and-regeneration-medicine
#14
REVIEW
Hanxiao Xu, Ying Jiao, Shuang Qin, Weiheng Zhao, Qian Chu, Kongming Wu
Organoid technology bridges the gap between conventional two-dimensional cell line culture and in vivo models. The near-physiological technology can virtually recapitulates organ development and human diseases, such as infectious diseases, genetic abnormality and even cancers. In addition, organoids can more accurately predict drug responses, and serve as an excellent platform for drug development, including efficacy evaluation, toxicity testing and pharmacokinetics analysis. Furthermore, organoids can also be exploited to explore the possible optimized treatment strategies for each individual patient...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/30534006/combination-of-acquired-von-willebrand-syndrome-avws-and-glanzmann-thrombasthenia-in-monoclonal-gammopathy-of-uncertain-significance-mgus-a-case-report
#15
Elizabeth Sarah Mayne, Malcolm Tait, Barry Frank Jacobson, Evashin Pillay, Susan J Louw
Background: Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders. Case presentation: This case study reports an unusual clinical presentation of 2 acquired bleeding disorders, Acquired von Willebrand syndrome (disease) and Acquired Glanzmann's thrombasthenia, in an elderly patient with monoclonal gammopathy of uncertain significance...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/30533227/-first-in-man-case-report-of-selective-c-reactive-protein-apheresis-in-a-patient-with-acute-st-segment-elevation-myocardial-infarction
#16
Wolfgang Ries, Ahmed Sheriff, Franz Heigl, Oliver Zimmermann, Christoph D Garlichs, Jan Torzewski
C-reactive protein (CRP) may be causative in cardiovascular disease. As yet, no specific CRP inhibitor for human application has been described. A 69-year-old male was referred with ST segment elevation myocardial infarction (STEMI). Typical symptoms of chest pain started at 10.00 p.m. The patient was admitted to the hospital at 1.30 a.m. the next day. As ECG showed anterior wall myocardial infarction, the patient was immediately transferred to successful emergency angioplasty/drug-eluting- (DE-) stenting of the subtotally occluded left anterior descending artery...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/30533183/bioengineered-functional-humanized-livers-an-emerging-supportive-modality-to-bridge-the-gap-of-organ-transplantation-for-management-of-end-stage-liver-diseases
#17
REVIEW
Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Avinash Bardia, Syed Ameer Basha Paspala, Chaturvedula Tripura, Md Aejaz Habeeb, Aleem Ahmed Khan
End stage liver diseases (ESLD) represent a major, neglected global public health crisis which requires an urgent action towards finding a proper cure. Orthotropic liver transplantation has been the only definitive treatment modality for ESLD. However, shortage of donor organs, timely unavailability, post-surgery related complications and financial burden on the patients limits the number of patients receiving the transplants. Since last two decades cell-based therapies have revolutionized the field of organ/tissue regeneration...
November 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/30531533/rare-respiratory-diseases-in-the-icu-when-to-suspect-them-and-specific-approaches
#18
Aude Gibelin, Antoine Parrot, Muriel Fartoukh, Nicolas de Prost
PURPOSE OF REVIEW: A prompt identification of the cause of acute respiratory failure (ARF)/acute respiratory distress syndrome (ARDS) is required in order to initiate a targeted treatment. Yet, almost 10% of ARDS patients have no identified ARDS risk factor at ARDS diagnosis. Numerous rare causes of ARF have been reported in this setting. The purpose of this review is to delineate the main rare causes of ARF/ARDS and to provide clinicians with a pragmatic diagnostic work-up. RECENT FINDINGS: Recent epidemiological data have proposed the identification of a subgroup of ARDS patients lacking exposure to common risk factors...
December 5, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/30531316/hiv-controllers-suppress-viral-replication-and-evolution-and-prevent-disease-progression-following-intersubtype-hiv-1-superinfection
#19
Suwellen S D de Azevedo, Edson Delatorre, Fernanda H Côrtes, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G Veloso, Thiago Moreno L Souza, Mariza G Morgado, Gonzalo Bello
OBJECTIVE: To investigate the impact of intersubtype HIV-1 superinfection (SI) on viremia, reservoir reseeding, viral evolution, and disease progression in HIV controllers (HIC). DESIGN: Longitudinal analysis of two Brazilian HIC subjects (EEC09 and VC32) previously identified as dually infected with subtypes B and F1 viruses. METHODS: Changes in plasma viremia, total HIV-1 DNA levels, CD4 T cell counts and HIV-1 quasispecies composition were measured over time...
November 27, 2018: AIDS
https://www.readbyqxmd.com/read/30530592/composition-and-clinical-impact-of-the-immunologic-tumor-microenvironment-in-oral-squamous-cell-carcinoma
#20
Melanie Boxberg, Lena Leising, Katja Steiger, Moritz Jesinghaus, Aezlat Alkhamas, Marion Mielke, Nicole Pfarr, Carolin Götz, Klaus Dietrich Wolff, Wilko Weichert, Andreas Kolk
Immunotherapy shows promising results and revolutionizes treatment of oral squamous cell carcinoma (OSCC). The immunologic microenvironment might have prognostic/predictive implications. Morphologic immunologic parameters (inflammatory infiltrate, stromal content, and budding activity [BA] [potentially indicating epithelial-mesenchymal transition]) were evaluated in 66 human primary therapy-naive OSCCs. Intraepithelial/stromal tumor-infiltrating lymphocytes (TILs; CD3+ /CD4+ /CD8+ /CD4+ FOXP3+ /IL-17A+ ) were quantified, and ratios were calculated...
December 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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