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Immunologic diseases

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https://www.readbyqxmd.com/read/30118804/porphyromonas-gingivalis-induces-exacerbated-periodontal-disease-during-pregnancy
#1
Xingyu Duan, Aislinn Hays, Wei Zhou, Nawar Sileewa, Satya Upadhyayula, Huizhi Wang, Shuang Liang
Although pregnant women are prone to gingival inflammation, its mechanism remains unclear. Animal models are ideal for investigating immunological mechanisms in the periodontal disease. A murine model for ligature-induced periodontal disease has been modified and utilized to determine the susceptibility to periodontal inflammation and tissue damage in pregnant mice. Expression of different inflammatory mediators in the gingivae was determined by quantitative real-time PCR (qPCR). Inflammatory bone loss was determined by measuring the distance from the cementoenamel junction to the alveolar bone crest (CEJ-ABC)...
August 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30118537/effects-of-non-surgical-periodontal-therapy-on-clinical-and-immunological-profile-and-oral-colonization-of-candida-spp-in-hiv-infected-patients-with-chronic-periodontitis
#2
Átila V V Nobre, Tábata L S Pólvora, Letícia R M Silva, Vanessa de O Teles, Kelly Vargas Villafuerte, Raphael J G da Motta, João H P Fortes, Gilberto A Silva, Ana Laura P Ranieri, Leandro D de Macedo, Karen M L Morejon, Benedito A L da Fonseca, Camila Tirapelli, Maria C P Saraiva, Mário Taba, Alan G Lourenço, Ana Carolina F Motta
BACKGROUND: After the introduction of antiretroviral therapy (ART), human immunodeficiency virus (HIV) infection has become a chronic controllable disease. For this reason, chronic conditions related to both HIV infection and senescence, such as chronic periodontitis (CP) need to be studied. This study investigated the impact of non-surgical periodontal therapy (NSPT) on clinical and immunological features of CP, and on oral colonization by Candida spp. in HIV-infected and non-HIV-infected individuals...
August 17, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30117744/heterologous-effects-of-infant-bcg-vaccination-potential-mechanisms-of-immunity
#3
Egle Butkeviciute, Christine E Jones, Steven G Smith
The current antituberculosis vaccine, BCG, was derived in the 1920s, yet the mechanisms of BCG-induced protective immunity and the variability of protective efficacy among populations are still not fully understood. BCG challenges the concept of vaccine specificity, as there is evidence that BCG may protect immunized infants from pathogens other than Mycobacterium tuberculosis - resulting in heterologous or nonspecific protection. This review summarizes the up-to-date evidence for this phenomenon, potential immunological mechanisms and implications for improved childhood vaccine design...
August 17, 2018: Future Microbiology
https://www.readbyqxmd.com/read/30116606/the-tree-shrew-as-a-model-for-infectious-diseases-research
#4
REVIEW
Runfeng Li, Mark Zanin, Xueshan Xia, Zifeng Yang
Despite major advances in medicine, infectious diseases still pose a significant threat to humanity. Mammalian models of disease have proved extremely useful in adding to the understanding of infectious diseases and the development of prophylactic and/or therapeutic interventions. Arguably the most important considerations of any animal model are (I) the similarity of the model to humans with respect to anatomy, physiology, immunology and disease progression, and (II) the expense of conducting experiments using the model organism...
July 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30116273/imbalanced-expression-of-th2-and-treg-cell-related-parameters-in-peripheral-blood-mononuclear-cells-in-patients-with-allergic-asthma
#5
Samane Hoseini-Shahrestanak, Nasrin Bazargan, Leila Rahimian, Maryam Nemati, Saeed Solaymani, Abdollah Jafarzadeh
Background: The imbalance between Th2 and Treg cells plays fundamental role in the pathogenesis of allergic asthma. The current study aimed at assessing the expression of some Th2 and Treg cell-related parameters in patients with allergic asthma. Material and Methods: The serum and peripheral blood mononuclear cell (PBMC) samples were collected from 30 patients with asthma and 36 healthy subjects. The serum levels of transforming growth factor (TGF)-β, interleukin (IL)-4, as well as the expression levels of GATA3 and FOXP3 genes in PBMCs were determined by the enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR), respectively...
January 2018: Tanaffos
https://www.readbyqxmd.com/read/30116241/spontaneous-remission-in-paroxysmal-nocturnal-hemoglobinuria-return-to-health-or-transition-into-malignancy
#6
Eva-Stina Korkama, Anna-Elina Armstrong, Hanna Jarva, Seppo Meri
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired syndrome characterized by intravascular hemolysis, thrombosis, and bone marrow failure. The disease is caused by a mutation in the PIG-A gene that leads to the lack of glycosylphosphatidylinositol-anchored complement regulatory molecules CD55 and CD59 on affected blood cell surfaces. In previous studies, spontaneous clinical remissions have been described. The disease manifestations are very heterogeneous, and we wanted to examine if true remissions and disappearance of the clone occur...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30116031/cerebrospinal-fluid-markers-of-inflammation-and-infections-in-schizophrenia-and-affective-disorders-a-systematic-review-and-meta-analysis
#7
Sonja Orlovska-Waast, Ole Köhler-Forsberg, Sophie Wiben Brix, Merete Nordentoft, Daniel Kondziella, Jesper Krogh, Michael Eriksen Benros
Infections and inflammatory processes have been associated with the development of schizophrenia and affective disorders; however, no study has yet systematically reviewed all available studies on cerebrospinal fluid (CSF) immune alterations. We aimed to systematically review the CSF immunological findings in schizophrenia spectrum and affective disorders. We identified all studies investigating CSF inflammatory markers in persons with schizophrenia or affective disorders published prior to March 23, 2017 searching PubMed, CENTRAL, EMBASE, Psychinfo, and LILACS...
August 16, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/30115734/a-phase-ib-ii-study-of-the-jak1-inhibitor-itacitinib-plus-nab-paclitaxel-and-gemcitabine-in-advanced-solid-tumors
#8
Gregory L Beatty, Safi Shahda, Thaddeus Beck, Nikhil Uppal, Steven J Cohen, Ross Donehower, Afshin Eli Gabayan, Albert Assad, Julie Switzky, Huiling Zhen, Daniel D Von Hoff
LESSONS LEARNED: Itacitinib in combination with nab -paclitaxel plus gemcitabine demonstrated an acceptable safety profile with clinical activity in patients with advanced solid tumors including pancreatic cancer.The results support future studies of itacitinib as a component of combination regimens with other immunologic and targeted small molecule anticancer agents. BACKGROUND: Cytokine-mediated signaling via JAK/STAT is central to tumor growth, survival, and systemic inflammation, which is associated with cancer cachexia, particularly in pancreatic cancer...
August 16, 2018: Oncologist
https://www.readbyqxmd.com/read/30115527/interferon-alpha-the-key-trigger-of-type-1-diabetes
#9
REVIEW
Angela Lombardi, Effie Tsomos, Sara S Hammerstad, Yaron Tomer
IFNα is a cytokine essential to a vast array of immunologic processes. Its induction early in the innate immune response provides a priming mechanism that orchestrates numerous subsequent pathways in innate and adaptive immunity. Despite its beneficial effects in viral infections IFNα has been reported to be associated with several autoimmune diseases including autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, primary biliary cholangitis, and recently emerged as a major cytokine that triggers Type 1 Diabetes...
August 13, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30115091/diagnostics-of-rare-disorders-whole-exome-sequencing-deciphering-locus-heterogeneity-in-telomere-biology-disorders
#10
Luca Trotta, Anna Norberg, Mervi Taskinen, Vivien Béziat, Sofie Degerman, Ulla Wartiovaara-Kautto, Hannamari Välimaa, Kirsi Jahnukainen, Jean-Laurent Casanova, Mikko Seppänen, Janna Saarela, Minna Koskenvuo, Timi Martelius
BACKGROUND: The telomere biology disorders (TBDs) include a range of multisystem diseases characterized by mucocutaneous symptoms and bone marrow failure. In dyskeratosis congenita (DKC), the clinical features of TBDs stem from the depletion of crucial stem cell populations in highly proliferative tissues, resulting from abnormal telomerase function. Due to the wide spectrum of clinical presentations and lack of a conclusive laboratory test it may be challenging to reach a clinical diagnosis, especially if patients lack the pathognomonic clinical features of TBDs...
August 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/30115075/significance-of-glomerular-fibrinogen-deposition-in-children-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#11
Fengying Wang, Lusheng Huang, Hangyun Tang, Xiaozhong Li, Xueming Zhu, Xingdong Wang
BACKGROUND: Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN. METHODS: Eighty-two patients with HSPN were enrolled retrospectively at the Children's Hospital of Soochow University from January 2015 to March 2017. Patients were divided into groups according to the presence or absence and intensity of glomerular Fib deposits, and clinical and pathological features were compared among the groups...
August 16, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30112621/associations-of-sport-participation-with-self-perception-exercise-self-efficacy-and-quality-of-life-among-children-and-adolescents-with-a-physical-disability-or-chronic-disease-a-cross-sectional-study
#12
Saskia J Te Velde, Kristel Lankhorst, Maremka Zwinkels, Olaf Verschuren, Tim Takken, Janke de Groot
BACKGROUND: Little evidence is available about how sports participation influences psychosocial health and quality of life in children and adolescents with a disability or chronic disease. Therefore, the aim of the current study is to assess the association of sports participation with psychosocial health and with quality of life, among children and adolescents with a disability. METHODS: In a cross-sectional study, 195 children and adolescents with physical disabilities or chronic diseases (11% cardiovascular, 5% pulmonary, 8% metabolic, 8% musculoskeletal/orthopaedic, 52% neuromuscular and 9% immunological diseases and 1% with cancer), aged 10-19 years, completed questionnaires to assess sports participation, health-related quality of life (DCGM-37), self-perceptions and global self-worth (SPPC or SPPA) and exercise self-efficacy...
August 15, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/30112245/contribution-of-imaging-in-diagnosis-of-primitive-cyst-hydatid-in-unusual-localization-pleura-a-report-of-two-cases
#13
Fatima Zahra Mrabet, Jihane Achrane, Yassir Sabri, Fatima Ezzahra El Hassani, Sanaa Hammi, Jamal Eddine Bourkadi
Hydatic disease has always been the most common in countries where large amount of sheep and cattle is raised, but increased travel and immigration have made this condition a serious worldwide public problem. Cyst hydatid may affect all parts of the human body like the heart, the bone marrow, the eye, the brain, the kidney, and the spermatic cord. Humans can become infested by accidentally ingesting the eggs that are passed in the feces from definitive hosts (usually a canid, such as a wolf, fox, or dog). Even in endemic countries, the primitive pleural hydatid cyst is exceptional, and it is very difficult to distinguish from other pleural and parietal cystic masses especially that in majority of cases the immunologic tests are negative...
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/30111407/-clinical-characteristics-and-prognosis-of-patients-with-variant-philadelphia-chromosome-positive-leukemia
#14
Xue-Ya Zhang, Shi-Xin Wu, Xi-Zhe Guo, Ya-Fei Guo, Jing-Xin Pan
OBJECTIVE: To study the clinical characteristics and prognosis of patients with variant Ph chromosome-positive leukemia. METHODS: The defection of morphology, cytogenetics, immunology and molecular biology was performed in 4 cares of variant Ph chromosome-positive leukemia, and the therepeuitics outcome of 4 patients was evaluated. RESULTS: Among 4 cases of variant Ph+ leukemia, 3 cases were patients with CML, including 1 case in chronic phase and 2 cases in accelerated phase; and 1 cases was patient with adult B acute lymphoblasric leukemia(B-ALL)...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30111338/anti-inflammatory-signaling-by-mammary-tumor-cells-mediates-prometastatic-macrophage-polarization-in-an-innovative-intraductal-mouse-model-for-triple-negative-breast-cancer
#15
Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere, Evelyne Meyer
BACKGROUND: Murine breast cancer models relying on intraductal tumor cell inoculations are attractive because they allow the study of breast cancer from early ductal carcinoma in situ to metastasis. Using a fully immunocompetent 4T1-based intraductal model for triple-negative breast cancer (TNBC) we aimed to investigate the immunological responses that guide such intraductal tumor progression, focusing on the prominent role of macrophages. METHODS: Intraductal inoculations were performed in lactating female mice with luciferase-expressing 4T1 mammary tumor cells either with or without additional RAW264...
August 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30111280/the-ratio-of-the-seroprevalence-to-the-egg-positive-prevalence-of-schistosoma-japonicum-in-china-a-meta-analysis
#16
Yao Deng, Chen Qiu, Huan Ding, Da-Bing Lu
BACKGROUND: Schistosomiasis, caused by Schistosoma japonicum, remains one of the most important parasitic diseases, and detection of S. japonicum infections in humans plays a crucial role in control and treatment. However, comparisons between the parasitological and the immunological examinations in the fields of China are lacking. Therefore we performed a meta-analysis to compare the seroprevalence of Schistosoma japonicum, as determined by IHA or ELISA, with coprological prevalence, as determined by Kato-Katz, and estimate the ratio of the serological to the egg-positive prevalence in order to evaluate the potential threat of egg-negative but worm-positive schistosomiasis...
August 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30110122/pleiotropic-effect-of-vitamin-d-in-cystic-fibrosis
#17
Teresa Grzelak, Klaudia Mikołajczyk
Cystic fibrosis - CF - is the most common recessively autosomally and inherited disorder in the Caucasian population. It is incurable, multi-systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is due to the fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure (caused by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food...
August 15, 2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/30109819/neuroimmune-communication-in-health-and-disease
#18
Colin Reardon, Kaitlin Murray, Alan E Lomax
The immune and nervous systems are tightly integrated, with each system capable of influencing the other to respond to infectious or inflammatory perturbations of homeostasis. Recent studies demonstrating the ability of neural stimulation to significantly reduce the severity of immunopathology and consequently reduce mortality have led to a resurgence in the field of neuroimmunology. Highlighting the tight integration of the nervous and immune systems, afferent neurons can be activated by a diverse range of substances from bacterial-derived products to cytokines released by host cells...
October 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/30109481/the-immunologic-role-of-il-17-in-psoriasis-and-psoriatic-arthritis-pathogenesis
#19
REVIEW
Andrew Blauvelt, Andrea Chiricozzi
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, along with the rationale for targeting the IL-17 cytokine family (IL-17A, IL-17F, and IL-17 receptor A) in the treatment of psoriasis and psoriatic arthritis. Emerging evidence indicates that major sources of IL-17A in patients with psoriatic disease are mast cells, γδ T cells, αβ T cells, and innate lymphoid cells in lesional skin and synovial fluid...
August 14, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/30108590/squamous-cell-carcinomas-of-the-head-and-neck-cancer-response-to-programmed-cell-death-protein-1-targeting-and-differential-expression-of-immunological-markers-a-case-report
#20
Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Abdulqadir Jeprel Japer Nashwan, Niloofar Allahverdi, Roopesh Krishnankutty, Shahab Uddin, Abdul Rehman Zar Gul, Mohammed Ussama Al Homsi, Said Dermime
Targeting the programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) pathway has been shown to enhance T cell-mediated antitumor immunity. Clinical responses are limited to subgroups of patients. The search for biomarkers of response is a strategy to predict response and outcome of PD-1/PD-L1 checkpoint intervention. The NY-ESO-1 cancer testis antigen has been considered as a biomarker in head and neck squamous cell carcinoma (HNSCC) patients and can induce both specific NY-ESO-1 antibody and T cells responses...
2018: Frontiers in Immunology
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