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https://www.readbyqxmd.com/read/30512201/already-enlight-tened-equipping-young-immunologists-with-a-combination-of-research-related-and-transferrable-competencies
#1
Rebecca Ludwig, Jochen Huehn
No abstract text is available yet for this article.
December 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30509957/cancer-immunity-and-gene-expression-data-a-quick-tool-for-immunophenotype-evaluation
#2
Masayuki Hirano
The rapid advancement of next generation sequencing technology has resulted in accumulation of many datasets in cancer clinical and research laboratories, many of which do not have bioinformaticians. Xu and colleagues developed a user-friendly web-based tool to define the tumor immunophenotype among patients with cancer. By uploading user-defined datasets on the web, it can systematically track, analyze, and visualize the status of anticancer immune activity and the proportion of tumor-infiltrating immune cells...
December 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/30502467/analysis-of-enzyme-activity-antibacterial-activity-antiparasitic-activity-and-physico-chemical-stability-of-skin-mucus-derived-from-amphiprion-clarkii
#3
Huan Wang, Wei Tang, Rui Zhang, Shaoxiong Ding
Recently, mucosal surfaces, especially fish skin and its secreted mucus, have attracted significant interest from immunologists. Amphiprion clarkii, a member of the family Pomacentridae, lives symbiosis with sea anemones and has a good resistance to common seawater bacterial diseases and parasites owing to the protection from its abundant skin mucus. In the present work, the activity of immune-related enzymes (lysozyme, protease, antiprotease, cathepsin B, alkaline phosphatase and peroxidase), the antibacterial activity against two Gram-positive bacteria and five Gram-negative bacteria, the antiparasitic activity against the pathogen of marine white spot disease (Cryptocaryon irritans theronts) and the physico-chemical stability (to pH and heat) of the skin mucus of A...
November 28, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30498006/rocking-the-world-of-innate-immunity-an-interview-with-luke-o-neill
#4
Luke A J O'Neill
Luke O'Neill is professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin, and his main research focus is innate immunity and its key output, inflammation. His work has explored the key sensors and mediators of infection, including the Toll-like receptors, inflammasomes and cytokines in the interleukin-1 (IL-1) family. Luke received the Royal Irish Academy Gold Medal for Life Sciences in 2012 and the European Federation of Immunology Societies Medal in 2014. He was elected a member of the European Molecular Biology Organisation (EMBO) in 2005 and a Fellow of the Royal Society in 2016...
November 29, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/30466768/update-on-advances-in-hematopoietic-cell-transplantation-for-primary-immunodeficiency-disorders
#5
REVIEW
Oded Shamriz, Shanmuganathan Chandrakasan
Hematopoietic stem cell transplantation (HSCT) in patients with primary immunodeficiency disorders (PIDDs) is being increasingly used as a curative option. Understanding the critical components, such as disease's nature and activity and pre-HSCT and post-HSCT patient care is key to a successful outcome. HSCT should be tailored to the underlying PIDD, as different PIDDs, such as severe combined immune deficiency, Treg dysfunction, and phagocytic disorders, have different transplant approaches. Therefore, successful HSCT in patients with PIDDs requires teamwork between immunologists and transplant physicians...
February 2019: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/30452901/updates-in-diagnostic-and-clinical-laboratory-immunology-from-the-30th-annual-meeting-of-the-association-of-medical-laboratory-immunologists-amli
#6
L Sarada Nandiwada, Evangelos Ntrivalas, Maurice R G O'Gorman
No abstract text is available yet for this article.
November 16, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/30423208/deep-ultraviolet-lasers-for-flow-cytometry
#7
William Telford, Thierry Georges, Clint Miller, Pascal Voluer
Modern flow cytometers require multiple laser wavelengths to excite the wide variety of fluorescent probes now available for high-dimensional analysis. Ultraviolet (UV) lasers (typically solid state 355 nm) have become a critical excitation source for the Brilliant Ultraviolet (BUV) series of polymer fluorochromes. The BUV dyes have pushed the number of fluorescent probes available for simultaneous analysis to nearly 30, allowing an unprecedented level of precision for immune cell analysis. However, immunologists are already seeking analyze more than 30 simultaneous parameters, requiring both new fluorochromes and corresponding laser wavelengths...
November 13, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/30417378/functions-of-adipose-resident-immune-subsets-and-the-impact-on-metabolic-syndrome
#8
EDITORIAL
Daniel M Altmann
There is a growing appreciation of the role in the aetiology of metabolic syndrome that is played by the interplay of diet, microbiota and the interactions of immune cells and adipose cells in visceral adipose tissue. Recent studies have highlighted the programmes, properties and roles of the specialized, resident immune subsets that are abundant in adipose tissue, which may be considered a newly identified lymphoid compartment for immunology research. The findings indicate important roles for resident T effector and regulatory cells, innate lymphoid cells (ILCs), invariant natural killer T (iNKT) cells and macrophages, among others...
December 2018: Immunology
https://www.readbyqxmd.com/read/30409091/whatever-happened-to-the-shwartzman-phenomenon
#9
Abdullah B Chahin, Jason M Opal, Steven M Opal
Ninety years ago, Gregory Shwartzman first reported an unusual discovery following the intradermal injection of sterile culture filtrates from principally Gram-negative strains from bacteria into normal rabbits. If this priming dose was followed in 24 h by a second intravenous challenge (the provocative dose) from same culture filtrate, dermal necrosis at the first injection site would regularly occur. This peculiar, but highly reproducible, event fascinated the microbiologists, hematologists, and immunologists of the time, who set out to determine the mechanisms that underlie the pathogenesis of this reaction...
November 2018: Innate Immunity
https://www.readbyqxmd.com/read/30405621/a-single-cell-sequencing-guide-for-immunologists
#10
REVIEW
Peter See, Josephine Lum, Jinmiao Chen, Florent Ginhoux
In recent years there has been a rapid increase in the use of single-cell sequencing (scRNA-seq) approaches in the field of immunology. With the wide range of technologies available, it is becoming harder for users to select the best scRNA-seq protocol/platform to address their biological questions of interest. Here, we compared the advantages and limitations of four commonly used scRNA-seq platforms in order to clarify their suitability for different experimental applications. We also address how the datasets generated by different scRNA-seq platforms can be integrated, and how to identify unknown populations of single cells using unbiased bioinformatics methods...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30400720/statistics-for-immunologists
#11
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2018: Current Protocols in Immunology
https://www.readbyqxmd.com/read/30340549/trial-reporting-in-immuno-oncology-trio-an-american-society-of-clinical-oncology-society-for-immunotherapy-of-cancer-statement
#12
Apostolia M Tsimberidou, Laura A Levit, Richard L Schilsky, Steven D Averbuch, Daniel Chen, John M Kirkwood, Lisa M McShane, Elad Sharon, Kathryn F Mileham, Michael A Postow
PURPOSE: To develop recommendations for clinical trial reporting that address the unique efficacy, toxicity, and combination and sequencing aspects of immuno-oncology (IO) treatments. METHODS: ASCO and the Society for Immunotherapy of Cancer (SITC) convened a working group that consisted of practicing medical oncologists, immunologists, clinical researchers, biostatisticians, and representatives from industry and government to develop Trial Reporting in Immuno-Oncology (TRIO) recommendations...
October 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/30339040/trial-reporting-in-immuno-oncology-trio-an-american-society-of-clinical-oncology-society-for-immunotherapy-of-cancer-statement
#13
Apostolia M Tsimberidou, Laura A Levit, Richard L Schilsky, Steven D Averbuch, Daniel Chen, John M Kirkwood, Lisa M McShane, Elad Sharon, Kathryn F Mileham, Michael A Postow
PURPOSE: To develop recommendations for clinical trial reporting that address the unique efficacy, toxicity, and combination and sequencing aspects of immuno-oncology (IO) treatments. METHODS: ASCO and the Society for Immunotherapy of Cancer (SITC) convened a working group that consisted of practicing medical oncologists, immunologists, clinical researchers, biostatisticians, and representatives from industry and government to develop Trial Reporting in Immuno-Oncology (TRIO) recommendations...
October 19, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/30311672/the-real-danger-lies-in-the-failure-to-confront-fundamentals
#14
Melvin Cohn
Can we formulate a framework that would provide an agreed upon basis for discussions of immune behaviour? An attempt to do this is, in the end, the main goal of this essay. If you tell a physicist that you have invented a perpetual motion machine, he would not spend any time trying to reveal the flaw. Rather, he would shrug you off because in his framework, such a machine is an impossibility. However, immunologists lacking an agreed upon, preferably default, framework spend their time chasing into dead-end alleys or take refuge in descriptive empiricism...
December 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30301592/vector-immunity-and-evolutionary-ecology-the-harmonious-dissonance
#15
REVIEW
Dana K Shaw, Ann T Tate, David S Schneider, Elena A Levashina, Jonathan C Kagan, Utpal Pal, Erol Fikrig, Joao H F Pedra
Recent scientific breakthroughs have significantly expanded our understanding of arthropod vector immunity. Insights in the laboratory have demonstrated how the immune system provides resistance to infection, and in what manner innate defenses protect against a microbial assault. Less understood, however, is the effect of biotic and abiotic factors on microbial-vector interactions and the impact of the immune system on arthropod populations in nature. Furthermore, the influence of genetic plasticity on the immune response against vector-borne pathogens remains mostly elusive...
November 2018: Trends in Immunology
https://www.readbyqxmd.com/read/30295133/british-journal-of-biomedical-science-in-2018-what-have-we-learned
#16
Andrew Blann
In 2018 the British Journal of Biomedical Science published one guideline (in reproductive science) and 40 research articles in the various disciplines the comprise biomedical science. The latter were 24 original articles and 16 'In Brief' short reports. Of these, 23 are of note to only one of the sub-disciplines (seven each to biochemists and microbiologists, six to cell pathologists, and one each to cytologists, immunologists and reproductive scientists). Reflecting the increasing complexity of laboratory science, thirteen papers crossed one boundary (three papers each relevant to biochemists and immunologists, and to haematologists and biochemists), whilst four papers were relevant to three or more disciplines...
October 8, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30290932/clinical-issues-in-severe-asthma-consensus-and-controversies-on-the-road-to-precision-medicine
#17
Eugene R Bleecker, Reynold A Panettieri, Sally E Wenzel
As seen in this CME online activity (available at http://courses.elseviercme.com/708e), the various forms of asthma affect > 300 million people globally and > 25 million people in the United States. Asthma-related symptoms and exacerbations result in nearly 2 million ED visits annually, and many of these visits lead to inpatient hospital stays. There is an urgent need to improve the care of the estimated 5% to 15% of patients who have severe asthma. Importantly, studies have shown that severe asthma accounts for an outsized proportion of the disease-related morbidity, mortality, and health-care costs...
October 2018: Chest
https://www.readbyqxmd.com/read/30280610/stat1-and-stat3-mutations-important-lessons-for-clinical-immunologists
#18
Peter Olbrich, Alexandra F Freeman
The transcription factors signal transducer and activator of transcription (STAT) 1 and STAT3 fulfill fundamental functions in nonimmune and immune cells. The description and follow-up of patients with germline mutations that result in either loss-of-function or gain-of-function have contributed to our understanding of the pathophysiology of these regulators. Depending on the type of mutations, clinical symptoms are complex and can include infection susceptibility, immune dysregulation as well as characteristic nonimmune features...
October 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/30279600/cancer-immunologists-scoop-medicine-nobel-prize
#19
Heidi Ledford, Holly Else, Matthew Warren
No abstract text is available yet for this article.
October 2018: Nature
https://www.readbyqxmd.com/read/30275850/primary-immunodeficiency
#20
REVIEW
Christine McCusker, Julia Upton, Richard Warrington
Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). Although the clinical manifestations of PIDs are highly variable, many disorders involve an increased susceptibility to infection. Early consultation with a clinical immunologist is essential, as timely diagnosis and treatment are imperative for preventing significant disease-associated morbidity...
2018: Allergy, Asthma, and Clinical Immunology
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