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JOURNAL ARTICLE
Silvia Ricci, Valentina Guarnieri, Francesca Capitanini, Caterina Pelosi, Valeria Astorino, Silvia Boscia, Elisa Calistri, Clementina Canessa, Martina Cortimiglia, Francesca Lippi, Lorenzo Lodi, Sabrina Malvagia, Maria Moriondo, Giancarlo La Marca, Chiara Azzari
BACKGROUND: Inborn errors of immunity (IEIs) include 485 inherited disorders characterized by an increased susceptibility to life threatening infectious diseases, autoimmunity and malignant diseases with a high mortality rate in the first years of life. Severe Combined Immunodeficiency is the most severe of the IEIs and its detection should be a primary goal in a newborn screening (NBS) program. The term "actionable" has recently been used for all IEIs with outcomes that can be demonstrably improved through early specialized intervention...
April 16, 2024: Journal of Allergy and Clinical Immunology in Practice
#2
JOURNAL ARTICLE
Alexandra R Dvorscek
Mentorship refers to the guidance given by a mentor to a less experienced individual to enhance their professional and personal development. For graduate research students, seeking independent mentors external to their institution offers the rewarding opportunity to obtain objective guidance on a variety of work, study and life matters. This article outlines the steps taken to develop a professional society-based, international mentoring program of over 70 participants. This 6-month program aimed to connect graduate research students with more senior academic scientists in response to the limited networking opportunities imposed by the coronavirus disease 2019 (COVID-19) pandemic in Australia...
April 12, 2024: Immunology and Cell Biology
#3
JOURNAL ARTICLE
Steven T Chen, Yevgeniy R Semenov, Allireza Alloo, Daniel Q Bach, Allison Betof Warner, Amina Bougrine, Leeann Burton, Laura C Cappelli, Mariana Castells, Justine Cohen, Anna K Dewan, Riley Fadden, Lauren Guggina, Aparna Hegde, Victor Huang, Douglas B Johnson, Benjamin Kaffenberger, Daniela Kroshinsky, Shawn Kwatra, Bernice Kwong, Mario E Lacouture, Cecilia Larocca, Jonathan Leventhal, Alina Markova, Jon McDunn, Meghan J Mooradian, Jarushka Naidoo, Jennifer Choi, Vinod Nambudiri, Caroline A Nelson, Anisha B Patel, Julia Pimkina, Johnathan Rine, Krista M Rubin, Maxwell Sauder, Sheila Shaigany, Afreen Shariff, Ryan J Sullivan, Leyre Zubiri, Kerry L Reynolds, Nicole R LeBoeuf
With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often with important downstream consequences for the patient. Current guidelines lack clarity in terms of diagnostic criteria for D-irAEs. The goal of this project is to better define D-irAE for the purposes of identification, diagnosis, and future study of this important group of diseases...
April 10, 2024: Journal for Immunotherapy of Cancer
#4
JOURNAL ARTICLE
Diego Bagnasco, Luisa Brussino, Cesare Biagini, Lorenzo Cosmi, Eugenio De Corso, Ignazio La Mantia, Alberto Macchi, Giandomenico Maggiore, Andrea Matucci, Stefania Nicola, Giovanni Passalacqua, Livio Presutti, Veronica Seccia, Alessandra Vultaggio, Michele Riparbelli, Chiara Sartor, Paola Parronchi, Frank Rikki Mauritz Canevari
No abstract text is available yet for this article.
April 2024: World Allergy Organization Journal
#5
JOURNAL ARTICLE
Hugo W F Mak, Valerie Chiang, Elsie T S Chan, Elaine Lee, Jackie S H Yim, Dorothy L Y Lam, Philip H Li
BACKGROUND: Chronic spontaneous urticaria (CSU) is an immunologic condition with an estimated prevalence of 0.1%. For CSU that is poorly controlled despite the use of antihistamines, omalizumab is the only treatment approved and recommended by international guidelines. OBJECTIVE: Our aim was to outline the impact of treatment accessibility on CSU outcomes in the real world. METHODS: Serial data on adult patients with CSU receiving care for at least 6 months at a dedicated, immunologist-led urticaria clinic at Grantham Hospital in Hong Kong between 2018 and 2023 were analyzed...
May 2024: J Allergy Clin Immunol Glob
#6
REVIEW
Xiaojian Zhang, Hailian Wang, Qin Xie, Yang Zhang, Yixin Yang, Man Yuan, Yuqi Cui, Si-Yuan Song, Jianzhen Lv, Yi Wang
Xenotransplantation is emerging as a vital solution to the critical shortage of organs available for transplantation, significantly propelled by advancements in genetic engineering and the development of sophisticated immunosuppressive treatments. Specifically, the transplantation of kidneys from genetically engineered pigs into human patients has made significant progress, offering a potential clinical solution to the shortage of human kidney supply. Recent trials involving the transplantation of these modified porcine kidneys into deceased human bodies have underscored the practicality of this approach, advancing the field towards potential clinical applications...
2024: Frontiers in Immunology
#7
JOURNAL ARTICLE
S I Pavlova
The gastrointestinal tract is a barrier, represented by dynamic and mutually regulating components (microbial, chemical, physical and immune) for the selective penetration of luminal contents into the internal environment. From the point of view of immunologists, even in a physiological condition, the epithelium of the intestinal wall is in a state of mild inflammation, which is explained by the constant invasion of antigens (food, microbial) and, in turn, the constant readiness of the immune system to respond...
2024: Voprosy Pitaniia
#8
EDITORIAL
Jacob S Yount
In this editorial, I share advice and general principles based on recent experiences as a mentor and evaluator for early-career microbiology and immunology faculty seeking promotion and tenure. I outline 10 recommendations covering research, service, teaching, and mentoring. In addition, I encourage nuanced conversations with colleagues to strategically navigate the unique promotion and tenure processes at different institutions. I hope that these practical tips will assist early-career faculty in attaining promotion and tenure, contributing to long-term scientific and career advances...
March 29, 2024: MBio
#9
REVIEW
A M Marra, C M Rossi, M A Piga, G Moroncini, M B Bilò
Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD)...
March 28, 2024: European Annals of Allergy and Clinical Immunology
#10
Yida Xing, Chengjun Zhuang, Qian Yu, Changyan Liu, Mingxi Xu, Lin Zhao, Xiaodan Kong
Extra-articular manifestations (EAMs) in ankylosing spondylitis (AS) are common and most extra-articular manifestations such as acute iritis and inflammatory bowel disease are positively correlated with disease activity of AS. Vasculitis is an extra-articular manifestation of AS. However cutaneous leukocytoclastic vasculitis (CLV) is uncommon in AS patients. In this article, we report a case of a 66-year-old female patient who has had AS for long time. Although the patient's articular manifestations were stable, the aortic aneurysm and CLV continued to occur sequentially...
March 30, 2024: Heliyon
#11
JOURNAL ARTICLE
Christopher Warren, Ruchi Gupta, Arpamas Seetasith, Robert Schuldt, Rongrong Wang, Ahmar Iqbal, Sachin Gupta, Thomas B Casale
BACKGROUND: Food allergies are serious and potentially life-threatening, and often place a large burden on patients and their caregivers, including impacts on quality of life. OBJECTIVE: To assess the real-world patient burden of food allergies, using self-reported data available from the Food Allergy Research & Education (FARE) Patient Registry (NCT04653324). METHODS: The FARE Patient Registry is voluntary and captures real-world experiences of adults and pediatric patients in the United States, and their caregivers, through a series of surveys assessing patient health and experiences with food allergies...
March 2024: World Allergy Organization Journal
#12
REVIEW
Yujie Shi, Eleanor E Bashian, Yingqin Hou, Peng Wu
Immunology was one of the first biological fields to embrace chemical approaches. The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered insurmountable. This review focuses on advances at the interface of chemistry and immunobiology over the past two decades that have not only opened new avenues in basic immunological research, but also revolutionized drug development for the treatment of cancer and autoimmune diseases...
March 13, 2024: Cell Chemical Biology
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JOURNAL ARTICLE
Payal Damani-Yokota, Matthias Eberl
Immunologists are very social people-they love to meet other immunologists and talk about immunology (and immunologists). Constantly! γδ T-cell researchers are no exception. On the contrary, as there are not so many of them compared to, say, researchers working on dendritic cells, they especially crave frequent interactions with like-minded scientists. This is where the technological solutions being developed during the coronavirus disease 2019 (COVID-19) pandemic come into play that have, almost overnight, allowed researchers to hold meetings and lectures online...
March 18, 2024: Immunology and Cell Biology
#14
REVIEW
Alexandra E Conway, Marylee Verdi, Marcus S Shaker, Jonathan A Bernstein, Claire C Beamish, Richard Morse, Juliette Madan, Michael W Lee, Gordon Sussman, Amer Al-Nimr, Matthew Hand, Daniel A Albert
Allergist-immunologists face significant challenges as experts in an ever-evolving field of neuroimmunology. Among these challenges is the increasingly frequent need to counsel patients with suspected mast cell-activation disorders about perceived comorbidities, which may include hypermobile Ehlers Danlos syndrome, amplified pain syndrome, fibromyalgia, burning sensation syndromes, migraines, irritable bowel syndrome, and postural orthostatic tachycardia syndrome. Patients may experience comorbid anxiety, panic disorder and depression associated with disturbed sleep, fatigue, and cognitive impairment that often worsen when their physical symptoms increase in severity...
March 16, 2024: Journal of Allergy and Clinical Immunology in Practice
#15
REVIEW
Isabel Graf, Christopher Urbschat, Petra C Arck
Communication via biological mediators between mother and fetus are key to reproductive success and offspring's future health. The repertoire of mediators coding signals between mother and fetus is broad and includes soluble factors, membrane-bound particles and immune as well as non-immune cells. Based on the emergence of technological advancements over the last years, considerable progress has been made toward deciphering the "communicatome" between fetus and mother during pregnancy and even after birth. In this context, pregnancy-associated chimerism has sparked the attention among immunologists, since chimeric cells-although low in number-are maintained in the allogeneic host (mother or fetus) for years after birth...
March 11, 2024: EMBO Molecular Medicine
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JOURNAL ARTICLE
Christopher O C Bellamy, Jacqueline G O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B Farris, Sandy Feng, Maria Isabel Fiel, Sandra E Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M Jackson, Elmar Jaeckel, Nigar A Khurram, Stuart J Knechtle, Drew Lesniak, Josh Levitsky, Geoff McCaughan, Catriona McKenzie, Claudia Mescoli, Rosa Miquel, Marta I Minervini, Imad Ahmad Nasser, Desley Neil, Maura F O'Neil, Orit Pappo, Parmjeet Randhawa, Phillip Ruiz, Alberto Sanchez Fueyo, Deborah Schady, Thomas Schiano, Mylene Sebagh, Maxwell Smith, Heather L Stevenson, Timucin Taner, Richard Taubert, Swan Thung, Pavel Trunecka, Hanlin L Wang, Michelle Wood-Trageser, Funda Yilmaz, Yoh Zen, Adriana Zeevi, Anthony J Demetris
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including non-invasive and tissue monitoring, immunosuppression optimisation and long-term structural changes. Potential revision of the rejection classification scheme to better accommodate and communicate late T cell-mediated rejection patterns and related structural changes, such as nodular regenerative hyperplasia, were discussed...
March 8, 2024: American Journal of Transplantation
#17
JOURNAL ARTICLE
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
March 1, 2024: Allergy and Asthma Proceedings:
#18
REVIEW
Stephen R Welch, Aura R Garrison, Dennis A Bente, Felicity Burt, Jake D'Addiego, Stephanie Devignot, Stuart Dowall, Kerstin Fischer, David W Hawman, Roger Hewson, Ali Mirazimi, Lisa Oestereich, Zati Vatansever, Jessica R Spengler, Anna Papa
The Third International Conference on Crimean-Congo Hemorrhagic Fever (CCHF) was held in Thessaloniki, Greece, September 19-21, 2023, bringing together a diverse group of international partners, including public health professionals, clinicians, ecologists, epidemiologists, immunologists, and virologists. The conference was attended by 118 participants representing 24 countries and the World Health Organization (WHO). Meeting sessions covered the epidemiology of CCHF in humans; Crimean-Congo hemorrhagic fever virus (CCHFV) in ticks; wild and domestic animal hosts; molecular virology; pathogenesis and animal models; immune response related to therapeutics; and CCHF prevention in humans...
February 28, 2024: Antiviral Research
#19
Nicola de Bortoli, Pierfrancesco Visaggi, Roberto Penagini, Bruno Annibale, Federica Baiano Svizzero, Giovanni Barbara, Ottavia Bartolo, Edda Battaglia, Antonio Di Sabatino, Paola De Angelis, Ludovico Docimo, Marzio Frazzoni, Manuele Furnari, Andrea Iori, Paola Iovino, Marco Vincenzo Lenti, Elisa Marabotto, Giovanni Marasco, Aurelio Mauro, Salvatore Oliva, Gaia Pellegatta, Marcella Pesce, Antonino Carlo Privitera, Ilaria Puxeddu, Francesca Racca, Mentore Ribolsi, Erminia Ridolo, Salvatore Russo, Giovanni Sarnelli, Salvatore Tolone, Patrizia Zentilin, Fabiana Zingone, Brigida Barberio, Matteo Ghisa, Edoardo Vincenzo Savarino
Eosinophilic esophagitis (EoE) is a chronic type 2-mediated inflammatory disease of the esophagus that represents the most common eosinophilic gastrointestinal disease. Experts in the field of EoE across Italy (i.e., EoETALY Consensus Group) including gastroenterologists, endoscopists, allergologists/immunologists, and paediatricians conducted a Delphi process to develop updated consensus statements for the management of patients with EoE and update the previous position paper of the Italian Society of Gastroenterology (SIGE) in light of recent evidence...
February 28, 2024: Digestive and Liver Disease
#20
REVIEW
Mutali Musa, Ekele Chukwuyem, Oluwasola Michael Ojo, Efioshiomoshi Kings Topah, Leopoldo Spadea, Carlo Salati, Caterina Gagliano, Marco Zeppieri
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder characterized by immune dysregulation and multi-organ involvement. In this concise brief review, we highlight key insights into Ocular Systemic Lupus Erythematosus (SLE), an intricate autoimmune disorder with diverse organ involvement. Emphasizing the formation of autoantibodies and immune complex deposition, we delve into the inflammation and damage affecting ocular structures. Clinical presentations, ranging from mild dry eye syndrome to severe conditions like retinal vasculitis, necessitate a comprehensive diagnostic approach, including clinical exams, serological testing, and imaging studies...
February 12, 2024: Journal of Clinical Medicine
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