Read by QxMD icon Read


Stephen McGhee, Connie Visovksy, Cheryl Zambroski, Alan Finnegan
Over the past ten years there has been a significant rise in the number of people who present to emergency departments with Lyme disease. Although some patients remain asymptomatic many present with a rash around a previous tick bite and others may present with a range of debilitating symptoms that can be problematic if left untreated. Due to the growing prevalence of Lyme disease in the UK and the US this article gives an overview of the vector-borne condition and provides emergency nurses with information about the pathophysiology, prevention, presenting signs and symptoms and management...
August 9, 2018: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
Gerold Stanek
No abstract text is available yet for this article.
August 2018: Wiener Klinische Wochenschrift
Anna J Henningsson, Malin Lager, Rebecka Brännström, Ivar Tjernberg, Barbro H Skogman
Anti-Borrelia antibodies in the cerebrospinal fluid (CSF) are required for definite diagnosis of Lyme neuroborreliosis (LNB). However, children often present with early LNB, and antibody production in the CSF may not be demonstrated. Recent studies have suggested the chemokine CXCL13 to be an early marker for LNB. The aim of the study was to evaluate CXCL13 for laboratory diagnosis in pediatric LNB patients and to evaluate the association with pleocytosis in CSF, clinical features, and recovery. CSF samples were collected from LNB patients, classified as definite LNB (n = 44) or possible LNB (n = 22), and controls classified as non-LNB (n = 102) or other specific diagnoses (n = 23)...
August 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Pediatric Emergency Care
Katharine Christina Long, Keri Anne Cohn
Lyme disease is the most common vector-borne illness in North America, with the majority of cases occurring in the Northeast and upper Midwest. Lyme arthritis is the most prevalent manifestation of late-stage Lyme disease. Lyme arthritis typically presents as a monoarthritis or oligoarthritis in large joints such as the knee. Accompanying positive 2-tier Lyme serologies or polymerase chain reaction from synovial fluid/tissue is considered diagnostic for patients from an endemic area. The mainstay of initial treatment is a prolonged course of oral antibiotics...
August 2018: Pediatric Emergency Care
Sven Bergström, Johan Normark
The recent proposal of splitting the genus Borrelia into two genera in the newly formed family of Borreliaceae, i. e. Borrelia and Borreliella has motivated us to reflect upon how these organisms has been characterized and differentiated. This article therefore aims to take a closer look on the biology and virulence attributes of the two suggested genera, i. e. those causing Lyme borreliosis and relapsing fever borreliosis. Both genera have much in common with similar infection biological features. They are both characterized as bacterial zoonoses, transmitted by hematophagous arthropods with almost identical microbiological appearance...
August 3, 2018: Wiener Klinische Wochenschrift
Daša Stupica, Vera Maraspin, Petra Bogovic, Katarina Ogrinc, Rok Blagus, Tjaša Cerar, Franc Strle
Importance: Multiple erythema migrans (MEM) has been suggested as a risk factor for unfavorable antibiotic treatment outcome compared with solitary erythema migrans (EM). However, no direct comparison of early Lyme borreliosis manifested as MEM with solitary EM has been undertaken. Objective: To investigate the potential differences in clinical course and treatment outcome between MEM and solitary EM. Design, Setting, and Participants: This prospective cohort study was conducted from June 1, 2010, to October 31, 2015, at the University Medical Center Ljubljana, Slovenia...
August 1, 2018: JAMA Dermatology
Eugene D Shapiro, Gary P Wormser
No abstract text is available yet for this article.
August 2, 2018: JAMA: the Journal of the American Medical Association
Lisa K Blum, Julia Z Adamska, Dale S Martin, Alison W Rebman, Serra E Elliott, Richard R L Cao, Monica E Embers, John N Aucott, Mark J Soloski, William H Robinson
Lyme disease ( Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stronger serum reactivity to surface proteins and peptides from B. burgdorferi was also associated with faster resolution of clinical symptoms. Through molecular identifier-enabled antibody heavy-chain sequencing of bulk B cells and single-cell paired-chain antibody sequencing of blood plasmablasts, we characterized immunoglobulin gene usage patterns specific to B...
2018: Frontiers in Immunology
A Wagemakers, M C Visser, B de Wever, J W Hovius, N W C J van de Donk, E J Hendriks, L Peferoen, F F Muller, C W Ang
BACKGROUND: Infection with Borrelia burgdorferi sensu lato complex (B. b. sl) spirochetes can cause Lyme borreliosis, manifesting as localized infection (e.g. erythema migrans) or disseminated disease (e.g. Lyme neuroborreliosis). Generally, patients with disseminated Lyme borreliosis will produce an antibody response several weeks post-infection. So far, no case of neuroborreliosis has been described with persistently negative serology one month after infection. CASE PRESENTATION: We present a patient with a history of Mantle cell lymphoma and treatment with R-CHOP (rituximab, doxorubicine, vincristine, cyclofosfamide, prednisone), with a meningo-encephalitis, who was treated for a suspected lymphoma relapse...
August 2, 2018: BMC Infectious Diseases
Jong-Myon Bae
Lyme borreliosis (LB) is the most common tick-borne infectious disease in North America, and it was designated as a national notifiable infectious disease in Korea in December 2010. While no cases in Jeju-do were recorded from 2012 to 2016, a recent survey reported that the seroprevalence of Borrelia burgdorferi using enzyme-linked immunosorbent assays in horses in Jeju-do was 19.0% (95% confidence interval, 12.0 to 28.3%). This fact suggests that horses may be a potential reservoir of LB in Jeju-do and that individuals in close contact with horses may be a high-risk group...
July 2018: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
Alejandro Robles, James Fong, Jorge Cervantes
Lyme disease (LD) is a multisystemic inflammatory disease caused by pathogenic spirochetes, belonging to the genospecies complex Borrelia burgdorferi sensu lato (B.b.s.l.). Around the world, distinct species of Ixodes tick vectors transmit different species of Borrelia. Despite the rising recognition and occurrence of tick-borne disease in Latin America, serology has proven to be inconclusive in detecting suspected LD cases. Recently, new B.b.s.l. strains or new related species have been described in Brazil, Uruguay, and Chile...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Aris Garro, Jonathan Bennett, Fran Balamuth, Michael N Levas, Desiree Neville, John C Branda, Alexandra B Maulden, Paul M Lantos, Lise E Nigrovic
Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme linked immunoassays, but only 5 had positive IgG or IgM supplemental immunoblots (1.6%, 95% confidence interval 0.7-3.7%).
July 31, 2018: Pediatric Infectious Disease Journal
Hong-Bo Liu, Ran Wei, Xue-Bing Ni, Yuan-Chun Zheng, Qiu-Bo Huo, Bao-Gui Jiang, Lan Ma, Rui-Ruo Jiang, Jin Lv, Yun-Xi Liu, Fang Yang, Yun-Huan Zhang, Jia-Fu Jiang, Na Jia, Wu-Chun Cao
Northeastern China is a region of high tick abundance, multiple tick-borne pathogens and likely human infections. The spectrum of diseases caused by tick-borne pathogens has not been objectively evaluated in this region for clinical management and for comparison with other regions globally where tick-transmitted diseases are common. Based on clinical symptoms, PCR, indirect immunofluorescent assay and (or) blood smear, we identified and described tick-borne diseases from patients with recent tick bite seen at Mudanjiang Forestry Central Hospital...
August 1, 2018: Parasitology
Andrew J MacDonald
The distribution, abundance and seasonal activity of vector species, such as ticks and mosquitoes, are key determinants of vector-borne disease risk, and are strongly influenced by abiotic and habitat conditions. Despite the numerous species of tick vectors in the heavily populated North American West Coast, all but Ixodes pacificus, the primary vector of the Lyme disease spirochete, is poorly characterized with regard to seasonal activity patterns and fine scale drivers of distribution and abundance, particularly in heavily populated regions of southern California...
2018: PloS One
Umesh Sharma
A 45-year-old man was presented with 3 weeks of fever, chills, headache, myalgia and sweats after returning from a camping trip. He had multiple erythematous, blanching, non-target lesions on back and lower abdomen and oral pseudomembrane. He was empirically started on doxycycline for presumed Lyme disease and hydration for management of acute renal failure. Next day, he was started on vancomycin for worsening rash and coverage of methicillin-resistant Staphylococcus aureus skin infection and fluconazole for possible thrush and tested for HIV, syphilis, tick-borne diseases, arboviral panel, Epstein-Barr virus, rapid plasma reagin and rheumatoid factor...
July 30, 2018: BMJ Case Reports
Mattia E Chason, Maureen Monaghan, Jichuan Wang, Yao Cheng, Roberta L DeBiasi
We performed a retrospective study to determine the time frame for symptom resolution in 78 pediatric patients hospitalized with laboratory-confirmed early-disseminated or late-stage Lyme disease. The vast majority of the patients improved promptly after receiving appropriate antibiotics. Patients with a longer duration of arthritis before the institution of therapy experienced a longer time to recovery.
July 30, 2018: Journal of the Pediatric Infectious Diseases Society
Ameesh Isath, Deepak Padmanabhan, Niyada Naksuk, Danesh Kella, Paul Friedman
No abstract text is available yet for this article.
July 30, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Wojciech Łuczaj, Anna Moniuszko-Malinowska, Pedro Domingues, Maria Rosario Domingues, Ewa Gindzienska-Sieskiewicz, Elżbieta Skrzydlewska
OBJECTIVES: Distinguishing of rheumatoid arthritis (RA) and Lyme arthritis (LA) is difficult, because of similar symptoms. This presents a significant clinical problem since treatments are quite different in both diseases. We investigated the plasma phospholipid profiles of RA and LA patients versus healthy subjects to find metabolic changes responsible for differentiation of both diseases. METHODS: Plasma was collected from 9 RA, 9 LA, and 9 healthy subjects. Extracted lipids were analyzed using LC- MS/MS to characterize phospholipid profiles of RA, LA and healthy subjects...
July 27, 2018: Archives of Biochemistry and Biophysics
Emiliano Mori, Benoît Pisanu, Rudy Zozzoli, Emanuela Solano, Emanuela Olivieri, Davide Sassera, Matteo Montagna
Introduced Siberian chipmunks Eutamias sibiricus have been reported to be important reservoirs for human Lyme disease, as they may host high numbers of hard ticks carrying Borrelia spp. and other pathogens. In the present study, we assessed the prevalence of Borrelia spp. and other pathogenic bacteria in ectoparasite arthropod species infesting Siberian chipmunks and coexisting native small rodents. Small rodents were trapped with Sherman traps in Veneto (NE Italy), where the largest Italian populations of chipmunks occur...
July 30, 2018: Parasitology Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"