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Raúl Alberto Jiménez-Castillo, Edgar Francisco Carrizales-Sepúlveda, Raymundo Vera-Pineda, José Luis Herrera-Elizondo, Alexis García-Sarreón, Alan Ledif Reyes-Mondragón, Elizabeth Mercado-Domínguez, Luis Javier Marfil-Rivera
Lyme disease is the most common tick-borne illness in North America. A 23-year-old female presented to our emergency department with a chief complaint of sudden dyspnea and chest pain. An electrocardiogram revealed a third degree heart block. She was a resident of the Northeast region of Mexico and referred a recent travel to an endemic area for Borrelia burgdorferi in the center of Mexico in the past weeks. Lyme carditis was diagnosed after enzyme linked immunosorbent assay for IgM antibodies against B. burgdorferi was reported positive and corroborated by a confirmatory immunoblot analysis...
December 6, 2018: Journal of Electrocardiology
Robert B Lochhead, David Ordoñez, Sheila L Arvikar, John M Aversa, Luke S Oh, Benton Heyworth, Ruslan Sadreyev, Allen C Steere, Klemen Strle
Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Ex vivo analysis of synovial tissue revealed high abundance of IFNγ-producing T cells and NK cells...
December 14, 2018: Cellular Microbiology
Sukanya Narasimhan, Carmen J Booth, Kathleen DePonte, Ming-Ji Wu, Xianping Liang, Subhasis Mohanty, Fred Kantor, Erol Fikrig
Ixodes scapularis vectors several pathogens including Borrelia burgdorferi, the agent of Lyme disease. Nymphal and larval stages, and the pathogens transmitted by I. scapularis are maintained in a zoonotic cycle involving rodent reservoir hosts, predominantly Peromyscus leucopus. Humans are not reservoir hosts, however, accidental encounters of infected ticks with humans, results in pathogen transmission to the human host. Laboratory models of non-reservoir hosts such as guinea pigs develop a strong immune response to tick salivary proteins and reject ticks upon repeated tick infestations...
December 3, 2018: Ticks and Tick-borne Diseases
Juan Carlos Garcia-Monco, Jorge L Benach
Lyme Borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis and cranial and radiculoneuritis) as these have withstood the test of time. We also discuss other manifestations that are less frequent. Stroke, as a manifestation of Lyme neuroborreliosis, is considered in the context of other infections. The summary of the literature regarding clinical outcomes of neuroborreliosis leads to its controversies. We also include new information on pathogenesis, and on the polymicrobial nature of tick-borne diseases...
December 10, 2018: Annals of Neurology
C Eldin, A Raffetin, K Bouiller, Y Hansmann, F Roblot, D Raoult, P Parola
Lyme disease is a tick-borne bacterial disease with polymorphic clinical manifestations (cutaneous, rheumatological, and neurological). In recent years the issue of the diagnosis of this infection has been highly publicized on the Internet and other media in Europe and America. Some patients and physicians may share the perception that the diagnosis of the infection is not reliable in France. We reviewed current European and American guidelines on Lyme disease and performed a methodological evaluation of all guidelines...
December 6, 2018: Médecine et Maladies Infectieuses
Caroline Millins, Eleanor R Dickinson, Petra Isakovic, Lucy Gilbert, Agnieszka Wojciechowska, Victoria Paterson, Feng Tao, Martin Jahn, Elizabeth Kilbride, Richard Birtles, Paul Johnson, Roman Biek
BACKGROUND: Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communities and dynamics. Using a landscape of islands and mainland sites we investigated how natural landscape fragmentation affects the prevalence and persistence of the zoonotic tick-borne pathogen complex Borrelia burgdorferi (sensu lato), which causes Lyme borreliosis...
December 4, 2018: Parasites & Vectors
Agustín Estrada-Peña, Sally Cutler, Aleksandar Potkonjak, Muriel Vassier-Tussaut, Wim Van Bortel, Hervé Zeller, Natalia Fernández-Ruiz, Andrei Daniel Mihalca
BACKGROUND: The bacteria of the group Borrelia burgdorferi s.l. are the etiological agents of Lyme borreliosis in humans, transmitted by bites of ticks. Improvement of control measures requires a solid framework of the environmental traits driving its prevalence in ticks. METHODS: We updated a previous meta-analysis of the reported prevalence of Borrelia burgdorferi s.l. in questing nymphs of Ixodes ricinus with a literature search from January 2010-June 2017. This resulted in 195 new papers providing the prevalence of Bb for 926 geo-referenced records...
December 4, 2018: International Journal of Health Geographics
Katarina Boršič, Rok Blagus, Tjaša Cerar, Franc Strle, Daša Stupica
Infected elderly people often present with signs and symptoms that differ from those in younger adults, but data on the association between patient age and presentation of early Lyme borreliosis (LB) are limited. In this study, the association between patient age (18⁻44 years, young vs. 45⁻64 years, middle-aged vs. ≥ 65 years, elderly) and disease course, microbiologic characteristics, and the long-term outcome of treatment was investigated prospectively in 1220 adult patients with early LB manifesting as erythema migrans (EM) at a single-center university hospital...
December 2, 2018: Journal of Clinical Medicine
Nadine A Vogt, Jan M Sargeant, Melissa C MacKinnon, Ali M Versluis
BACKGROUND: Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%. OBJECTIVES: To determine the efficacy of vaccines for prevention of Lyme disease in dogs in North America...
December 3, 2018: Journal of Veterinary Internal Medicine
John Patrik Matthias Burkhard, Kurt Lädrach, Tateyuki Iizuka, Stefan Gerber
Lyme borreliosis is a prevalent disease with a wide variety of clinical manifestations. However, only a few pertinent references are found in the dental literature. Considering the diversity of differential diagnoses, borreliosis-associated orofacial pain may be a challenge for treatment providers and patients alike. The aim of this case report is to emphasize the importance of a sound, structured medical history and assessment to identify severe cases early and to start interdisciplinary therapy if indicated...
December 10, 2018: Swiss Dental Journal
Alaa Badawi, Paul Arora, Darren Brenner
INTRODUCTION: Lyme disease-also known as Lyme borreliosis (LB)-is the most common vector-borne disease in North America and Europe. It may result in substantial morbidity, primarily from persistent Lyme arthritis (LA) that-although treatable-can develop into antibiotic-refractory LA (A-RLA). The aim of this study is to systematically review and evaluate a range of biomarkers for their potential predictive value in the development of A-RLA. METHODS: We conducted a systematic review of studies examining biomarkers among patients with A-RLA from MEDLINE via OVID, EMBASE and Web of Science databases and identified a total of 26 studies for qualitative analysis...
November 30, 2018: Infectious Diseases and Therapy
Travis J Bourret, William K Boyle, Amanda Zalud, Jesus G Valenzuela, Fabiano Oliveira, Job E Lopez
The relapsing fever spirochete Borrelia turicatae possesses a complex life cycle in its soft-bodied tick vector, Ornithodoros turicata. Spirochetes enter the tick midgut during a bloodmeal, and during the following weeks spirochetes disseminate throughout O. turicata. A population persists in the salivary glands allowing for rapid transmission to mammalian hosts during tick feeding. Little is known about the physiological environment within the salivary glands acini in which B. turicatae persists. In this study, we examined the salivary gland transcriptome of O...
November 29, 2018: Cellular Microbiology
William K Boyle, Ashley M Groshong, Dan Drecktrah, Julie A Boylan, Frank C Gherardini, Jon S Blevins, D Scott Samuels, Travis J Bourret
The pathogenic spirochete Borrelia burgdorferi senses and responds to changes in the environment, including changes in nutrient availability, throughout its enzootic cycle in Ixodes ticks and vertebrate hosts. This study examined the role of DnaK suppressor protein (DksA) in the transcriptional response of B. burgdorferi to starvation. Wild-type and dksA mutant B. burgdorferi strains were subjected to starvation by shifting cultures grown in rich complete medium, BSK II, to a defined mammalian tissue culture medium, RPMI 1640, for 6 h under microaerobic conditions (5% CO2 , 3% O2 )...
November 26, 2018: Journal of Bacteriology
Yang Wang, Rianne Esquivel, Seleeke Flingai, Zachary A Schiller, Aurélie Kern, Sangya Agarwal, Jacqueline Chu, Ami Patel, Katherine Sullivan, Megan C Wise, Kate E Broderick, Linden Hu, David B Weiner, Mark S Klempner
We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against Lyme disease. Plasmid DNA-encoded anti-OspA HuMAbs inoculated in mice achieved a serum antibody concentration of >6 μg/mL. Among mice injected with DNA-encoded monoclonal antibodies, 75%-77% were protected against an acute challenge by Borrelia-infected ticks...
November 21, 2018: Journal of Infectious Diseases
Igor Dumic, Edson Severnini
Lyme disease (LD) is the most common tick-borne disease in North America. It is caused by Borrelia burgdorferi and transmitted to humans by blacklegged ticks, Ixodes scapularis. The life cycle of the LD vector, I. scapularis , usually takes two to three years to complete and goes through three stages, all of which are dependent on environmental factors. Increases in daily average temperatures, a manifestation of climate change, might have contributed to an increase in tick abundance via higher rates of tick survival...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
Mateusz Markowicz, Gerold Stanek
The short commentary focuses on the diagnosis of Lyme borreliosis with special respect to serological testing. The methods of serological testing are summarized with strong recommendation to use the tests only in patients with sysmptoms consistent with Lyme borreliosis according to clinical case definitions. In the second part there is a brief discussion of the post-Lyme diesease syndrome and nonspecific complaints, as patients with such complaints are frequently suspected to have Lyme borreliosis. The published literature indicates that the aetiology of these symptoms might be based on multiple factors and not on the chronic infection with Borrelia...
November 22, 2018: Clinical Microbiology and Infection
Christine A James, David L Pearl, L Robbin Lindsay, Andrew S Peregrine, Claire M Jardine
In eastern North America, the blacklegged tick, Ixodes scapularis, is the vector for Borrelia burgdorferi sensu stricto and Anaplasma phagocytophilum, the causal agents for human and canine Lyme disease and anaplasmosis, respectively. The extensive range expansion of I. scapularis in Ontario is a growing veterinary and public health concern. However, there is limited information on the risk factors associated with I. scapularis carriage on dogs. Within an emerging area for Lyme disease risk in southeastern Ontario, we identified the tick species carried by dogs; determined the prevalence of B...
October 17, 2018: Ticks and Tick-borne Diseases
Carmen Silvia Molleis Galego Miziara, Virginia Aparecida Gelmeti Serrano, Natalino Yoshinari
Baggio-Yoshinari syndrome is an emerging, tick-borne, infectious disease recently discovered in Brazil. This syndrome is similar to Lyme disease, which is common in the United States of America, Europe and Asia; however, Brazilian borreliosis diverges from the disease observed in the Northern Hemisphere in its epidemiological, microbiological, laboratory and clinical characteristics. Polymerase chain reaction procedures showed that Baggio-Yoshinari syndrome is caused by the Borrelia burgdorferi sensu stricto spirochete...
November 14, 2018: Clinics
Alexis Lacout, Pierre Yves Marcy, Marie Mas, Christian Perronne
No abstract text is available yet for this article.
November 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Kevin Bouiller, Timothée Klopfenstein, Catherine Chirouze
No abstract text is available yet for this article.
November 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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