Sarah A Moore, Marian A Rollins-Raval, Jennifer M Gillette, Joseph E Kiss, Darrell J Triulzi, Mark H Yazer, Jasmeet S Paul, Christine M Leeper, Matthew D Neal, Jay S Raval
OBJECTIVES: Trauma-induced coagulopathy (TIC) occurs in a subset of severely injured trauma patients. Despite having achieved surgical hemostasis, these individuals can have persistent bleeding, clotting, or both in conjunction with deranged coagulation parameters and typically require transfusion support with plasma, platelets, and/or cryoprecipitate. Due to the multifactorial nature of TIC, targeted interventions usually do not have significant clinical benefits. Therapeutic plasma exchange (TPE) is a non-specific modality of removing and replacing a patient's plasma in a euvolemic manner that can temporarily normalize coagulation parameters and remove deleterious substances, and may be beneficial in such patients with TIC...
2024: Trauma Surgery & Acute Care Open