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Dysbacteriosis

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https://www.readbyqxmd.com/read/30010471/oxidative-stress-and-nf-%C3%AE%C2%BAb-signaling-are-involved-in-lps-induced-pulmonary-dysplasia-in-chick-embryos
#1
Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang, Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count...
August 2, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29937879/oral-dysbacteriosis-in-type-2-diabetes-and-its-role-in-the-progression-to-cardiovascular-disease
#2
Ziad Nabee, Rajesh Jeewon, Prity Pugo-Gunsam
Background: Salivary changes and proliferation of specific bacterial communities are known to result in oral disease which may adversely impact on systemic conditions like diabetes and cardiovascular diseases. Objectives: This study reports on the changes in oral ecology of healthy and diseased adults and the possible role in disease causation. Methods: The study comprised 150 participants divided into control (healthy), diabetic and cardiac groups...
December 2017: African Health Sciences
https://www.readbyqxmd.com/read/29849602/the-use-of-complementary-and-alternative-medicine-is-less-frequent-in-patients-with-inflammatory-bowel-disease-than-in-patients-with-other-chronic-gastrointestinal-disorders
#3
Anna Fábián, Mariann Rutka, Tamás Ferenci, Renáta Bor, Anita Bálint, Klaudia Farkas, Ágnes Milassin, Kata Szántó, Zsuzsanna Lénárt, Ferenc Nagy, Zoltán Szepes, Tamás Molnár
Background and Aims: Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases. Materials and Methods: The use of herbs and botanicals, lifestyle modifications and mind/body therapies, patient satisfaction, and continuous use of conventional medicine were assessed with an anonymous questionnaire at a tertiary IBD unit in Hungary...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29784985/chronic-rhinosinusitis-with-nasal-polyps-is-characterized-by-dysbacteriosis-of-the-nasal-microbiota
#4
Thanit Chalermwatanachai, Ramiro Vilchez-Vargas, Gabriele Holtappels, Tim Lacoere, Ruy Jáuregui, Frederiek-Maarten Kerckhof, Dietmar H Pieper, Tom Van de Wiele, Mario Vaneechoutte, Thibaut Van Zele, Claus Bachert
Chronic rhinosinusitis with nasal polyp (CRSwNP) patients are often characterized by asthma comorbidity and a type-2 inflammation of the sinonasal mucosa. The mucosal microbiota has been suggested to be implicated in the persistence of inflammation, but associations have not been well defined. To compare the bacterial communities of healthy subjects with CRSwNP patients, we collected nasal swabs from 17 healthy subjects, 21 CRSwNP patients without asthma (CRSwNP-A), and 20 CRSwNP patients with co-morbid asthma (CRSwNP+A)...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772494/effects-of-ceftriaxone-induced-intestinal-dysbacteriosis-on-regulatory-t-cells-validated-by-anaphylactic-mice
#5
Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice...
July 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29748959/changes-in-intestinal-microbiota-affect-metabolism-of-ginsenoside-re
#6
Lei Zhang, Fei Li, Wang-Jun Qin, Chao Fu, Xiang-Lin Zhang
Ginsenoside Re, an active ingredient in Panax ginseng, is widely used as a therapeutic and nutriment. The intestinal microbiota plays crucial roles in modulating the pharmacokinetics and pharmacological actions of ginsenoside Re. The aim of this study was to explore the relationship between bacterial community variety and the metabolic profiles of ginsenoside Re. We developed two models with intestinal dysbacteriosis: a pseudo-germ-free model induced by a nonabsorbable antimicrobial mixture (ATM), and Qi-deficiency model established via over-fatigue and acute cold stress (OACS)...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29702281/intestinal-dysbacteriosis-potentiates-ovalbumin-induced-allergic-airway-inflammation-by-inhibiting-microrna-130a-to-upregulate-tumor-necrosis-factor-%C3%AE
#7
Lei Shi, Wei Yin, Zhiyu Zhang, Guanggang Shi
Allergic airway diseases (AAD), including chronic disorders such as allergic rhinitis, are resulted from complicated immunological interactions. Intestinal dysbacteriosis (ID) has been implicated in immune response to respiratory infections. We aimed to investigate the effect of ID on a mouse model of AAD, and the potential molecular factors involved. Ovalbumin (OVA) was employed to sensitize and challenge mice to elicit allergic inflammation in the upper as well as the lower airways. OVA-induced AAD model mice and control mice were raised with or without antibiotics treatment to establish the combinational AAD + ID mouse model...
July 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29701959/prebiotic-mannan-oligosaccharides-augment-the-hypoglycemic-effects-of-metformin-in-correlation-with-modulating-gut-microbiota
#8
Jialin Zheng, Heng Li, Xiaojuan Zhang, Min Jiang, Chunqin Luo, Zhenming Lu, Zhenghong Xu, Jinsong Shi
Type 2 diabetes (T2D) induced by obesity and high-fat diet is significantly associated with gut microbiota dysbacteriosis. Because the first line clinical medicine of metformin has several intestinal drawbacks, combination usage of metformin with a prebiotic of konjac mannan-oligosaccharides (MOS) was conceived and implemented aiming to investigate whether there were some intestinal synergetic effects and how MOS would function. Composite treatment of metformin and MOS demonstrated synergistic effects on ameliorating insulin resistance and glucose tolerance, also on repairing islet and hepatic histology...
June 13, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29689277/butyrate-ameliorated-nlrc3-protects-the-intestinal-barrier-in-a-gpr43-dependent-manner
#9
Di Cheng, Ji-Hao Xu, Jie-Yao Li, Si-Yi Wang, Ting-Feng Wu, Qi-Kui Chen, Tao Yu
BACKGROUND: Intestinal barrier dysfunctions are related to dysbacteriosis and chronic gut inflammation in type 2 diabetes. Although there is emerging evidence that the chronic gut inflammatory response is stimulated by nucleotide-binding oligomerization domain-like receptors (NLRs), the relationship and precise mechanism between NLRC3 and the colonic epithelial barrier remains largely elusive. METHODS: We investigated the function and mechanism of NLRC3 in the colonic tissues of diabetic mice and colonic epithelial cell lines...
July 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29530088/investigations-on-the-interplays-between-schistosoma-mansoni-praziquantel-and-the-gut-microbiome
#10
Pierre H H Schneeberger, Jean T Coulibaly, Gordana Panic, Claudia Daubenberger, Morgan Gueuning, Jürg E Frey, Jennifer Keiser
BACKGROUND: Schistosomiasis is a neglected tropical disease burdening millions of people. One drug, praziquantel, is currently used for treatment and control. Clinically relevant drug resistance has not yet been described, but there is considerable heterogeneity in treatment outcomes, ranging from cure to only moderate egg reduction rates. The objectives of this study are to investigate potential worm-induced dysbacteriosis of the gut microbiota and to assess whether a specific microbiome profile could influence praziquantel response...
March 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29440929/role-of-intestinal-flora-in-colorectal-cancer-from-the-metabolite-perspective-a-systematic-review
#11
REVIEW
Shuwen Han, Jianlan Gao, Qing Zhou, Shanshan Liu, Caixia Wen, Xi Yang
Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. In total, 57 articles were included after identification and screening. The pertinent literature on floral metabolites in colorectal cancer from three metabolic perspectives - including carbohydrate, lipid, and amino acid metabolism - was analyzed...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29429459/-clinical-effect-of-saccharomyces-boulardii-powder-combined-with-azithromycin-sequential-therapy-in-treatment-of-children-with-diarrhea-secondary-to-mycoplasma-pneumoniae-pneumonia
#12
RANDOMIZED CONTROLLED TRIAL
Qi-Fen Chen, Yi-Wei Zhang
OBJECTIVE: To investigate the clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in the treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia. METHODS: A total of 88 children with diarrhea secondary to Mycoplasma pneumoniae pneumonia between June 2015 and March 2017 were divided into control group and study group using a random number table, with 44 children in each group. The children in the control group were given routine treatment combined with azithromycin sequential therapy, and those in the study group were given oral Saccharomyces boulardii powder in addition to the treatment in the control group until the end of azithromycin sequential therapy...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29359291/-granulated-proctosigmoiditis-by-antibiotic-associated-infection-with-pseudomonas-aeruginosa
#13
Philipp Kapp, Wolfgang Meier, Roland Reinehr
HISTORY AND ADMISSION FINDINGS:  We report on the case of an elderly patient with persisting diarrhea. Few weeks previous of admission the patient had received antibiotic therapy because of respiratory infection. On admission he seemed exsiccated and feeble. EXAMINATIONS:  Macroscopic findings in colonoscopy showed proctosigmoiditis and membranous exsudations. Stool culture provided the evidence for an antibiotic-associated infection with pseudomonas aeruginosa...
January 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29071167/16s-rdna-analysis-of-the-effect-of-fecal-microbiota-transplantation-on-pulmonary-and-intestinal-flora
#14
REVIEW
Tianhao Liu, Zhongshan Yang, Xiaomei Zhang, Niping Han, Jiali Yuan, Yu Cheng
This study aims to explore the effect of FMT on regulations of dysbacteriosis of pulmonary and intestinal flora in rats with 16S rDNA sequencing technology. A total of 27 SPF rats (3-4 weeks old) were randomly divided into three groups: normal control group (K), model control group (MX), and fecal microbiota transplantation group (FMT); each group contained nine rats. The OTU values of the pulmonary and intestinal flora of the MX group decreased significantly compared with the normal control group. After FMT, the OTU value of pulmonary flora increased, while the value of OTU in intestinal flora declined...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29019886/a-hospital-to-home-evaluation-of-an-enhanced-recovery-protocol-for-elective-pancreaticoduodenectomy-in-china-a-cohort-study
#15
RANDOMIZED CONTROLLED TRIAL
Wei Su, Fangyan Lu, Xiaoyu Zhang, Guogang Li, Wei Chen, Tao Ma, Shunliang Gao, Jianying Lou, Xueli Bai, Tingbo Liang
Enhanced recovery after surgery (ERAS) programs have been shown to decrease postoperative complications and hospital stay in pancreaticoduodenectomy. However, no studies concerned recovery after discharge except readmission. This study evaluated an ERAS program for pancreaticoduodenectomy from hospital to home.A prospective ERAS cohort undergoing elective pancreaticoduodenectomy was compared with a retrospective control group in terms of postoperative complications and hospital stay, and home recovery after discharge...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28757346/development-of-an-xbp1-agonist-hlj2-as-a-potential-therapeutic-agent-for-ulcerative-colitis
#16
HaiJing Zhang, ZhiHui Zhang, GuangMing Song, XiaoNan Tang, HuaChen Song, AnJun Deng, WenJie Wang, LianQiu Wu, Hailin Qin
There is a severe lack of effective treatments for ulcerative colitis (UC), a recurrent and intractable inflammatory bowel disease. The identification of valid targets and new drugs is an urgent need. In this study, we identified the XBP-1 agonist HLJ2 as a promising treatment candidate. In an in vivo mouse model of DSS-induced colitis, HLJ2 decreased weight loss, colon contracture, disease activity index (DAI), colon mucosa damage index (CMDI) and histopathological index (HI). HLJ2 also decreased myeloperoxidase (MPO) activity and reduced production of the inflammatory cytokines TNF-α, IL-1β, and IL-6...
November 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28668709/isomalto-oligosaccharides-a-prebiotic-functionally-augment-green-tea-effects-against-high-fat-diet-induced-metabolic-alterations-via-preventing-gut-dysbacteriosis-in-mice
#17
Dhirendra Pratap Singh, Jagdeep Singh, Ravneet Kaur Boparai, JianHua Zhu, Shrikant Mantri, Pragyanshu Khare, Romesh Khardori, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
High fat diet (HFD)-induced alterations in gut microbiota and resultant 'leaky gut' phenomenon promotes metabolic endotoxemia, ectopic fat deposition, and low-grade systemic inflammation. Here we evaluated the effects of a combination of green tea extract (GTE) with isomalto-oligosaccharide (IMOs) on HFD-induced alterations in mice. Male Swiss albino mice were fed with HFD (58% fat kcal) for 12 weeks. Systemic adiposity, gut derangement parameters and V3-V4 region based 16S rRNA metagenomic sequencing, ectopic fat deposition, liver metabolome analysis, systemic and tissue inflammation, and energy homeostasis markers along with gene expression analysis in multiple tissues were done in mice supplemented with GTE, IMOs or their combination...
September 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28652732/preparation-characterization-and-evaluation-of-amphotericin-b-loaded-mpeg-pcl-g-pei-micelles-for-local-treatment-of-oral-candida-albicans
#18
Li Zhou, Peipei Zhang, Zhuo Chen, Shaona Cai, Ting Jing, Huihui Fan, Fei Mo, Jiye Zhang, Rong Lin
Fatal Candida albicans infections in the mucosal system can occur in association with immune-compromised diseases and dysbacteriosis. Currently, amphotericin B (AmB) is considered to be the most effective antibiotic in the treatment of C. albicans infections, but its clinical application is limited by side effects and poor bioavailability. In order to use AmB in the local treatment of oral C. albicans infections, AmB/MPEG-PCL-g-PEI (monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine, MPP) micelles were prepared...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28610416/bacterial-vaginosis-and-cervical-intraepithelial-neoplasia-is-there-an-association-or-is-co-existence-incidental
#19
Pushpa Sodhani, Sanjay Gupta, Ruchika Gupta, Ravi Mehrotra
Objectives: To determine associations, if any, of bacterial vaginosis with cervical pre-neoplastic lesions and evaluate any effects of sub-categorization of smears with bacterial vaginosis. Methods: All cervico-vaginal smears reported as positive for bacterial vaginosis over a five-year period were reviewed and sub-categorized into ‘type I (dysbacteriosis)’ and ‘type II (pure Gardenerella infection)’ smears by two cytopathologists (PS, SG). The proportion of smears with healthy flora and pre-neoplastic lesions was compared with those having bacterial vaginosis in conjunction with such changes...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28418713/defence-factors-of-vaginal-lactobacilli
#20
REVIEW
S Kovachev
Accurate knowledge of the composition and ecology of the vaginal microbial environment in healthy women is necessary for understanding lactobacilli-dominated normal microbiota and the mechanisms by which it reduces disease risk. The vagina and its microbiota form a balanced ecosystem; any movement outside the normal range for this ecosystem of obligate and/or facultative microbes, termed dysbacteriosis, can lead to infection and disease. This review summarizes recent research on the vaginal ecosystem, the Lactobacillus species that dominate it, and the means by which they suppress the growth, development, and/or proliferation of pathogenic microbial species...
February 2018: Critical Reviews in Microbiology
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