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Étienne Bénard-Séguin, Jason Kwok, Walter Liao, Stephanie Baxter
OBJECTIVE: To determine whether practice using an online fundus photograph program results in a long-term increase in proficiency with direct ophthalmoscopy skills in medical students. DESIGN: This study was a prospective medical education trial. Students were enrolled to participate in a voluntary Objective Structured Clinical Examination (OSCE) using 5 patients with ocular findings. Students who matched a minimum of 6 discs 16 months before the study were assigned to the intervention group and were compared with students who did not participate in the exercise...
October 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Anne F Alex, Maged Alnawaiseh, Peter Heiduschka, Nicole Eter
The development of in vivo retinal fundus imaging in mice has opened a new research horizon, not only in ophthalmic research. The ability to monitor the dynamics of vascular and cellular changes in pathological conditions, such as neovascularization or degeneration, longitudinally without the need to sacrifice the mouse, permits longer observation periods in the same animal. With the application of the high-resolution confocal scanning laser ophthalmoscopy in experimental mouse models, access to a large spectrum of imaging modalities in vivo is provided...
2019: Methods in Molecular Biology
Timothy H M Fung, Janine Abramson, Shalini Ojha, Roger Holden
No abstract text is available yet for this article.
November 2018: Ophthalmology
Peizeng Yang, Wen Yuan, Liping Du, Qingyun Zhou, Chaokui Wang, Zi Ye, Aize Kijlstra
PURPOSE: To characterise the ocular and extraocular findings in patients with relapsing polychondritis (RP) patients. DESIGN: Retrospective, longitudinal study. METHODS: A total number of 16 patients with ocular RP, seen in our tertiary uveitis referral centre over a time period of 10 years were included in this study. Routine ocular examinations such as best-corrected visual acuity, intraocular pressure, slit-lamp biomicroscopy, ophthalmoscopy and auxiliary examinations including ultrasound biomicroscopy, B-scanultrasonography, fundus fluorescein angiography and optical coherence tomography were performed...
October 12, 2018: British Journal of Ophthalmology
Milan Ivanišević
PURPOSE: Until Helmholtz's discovery of the ophthalmoscope, it was not possible to visualize the posterior pole of the eye in a living subject. The aim of this work is to emphasize the importance of the invention of the ophthalmoscope because the new era in ophthalmology began with it. METHODS: Available literature concerning this topic was studied, especially by getting in contact with institutes for history of medicine as well as medico-historians in Germany and other countries...
October 7, 2018: European Journal of Ophthalmology
Radka Andrysikova, Simon Pot, Simon Rüegg, Jitka Markova, Eliska Horackova, Filip Kolos, Katrin Voelter, Bernhard Spiess
OBJECTIVE: To screen a closed herd of the Old Kladruber Horses (OKH) for the prevalence of ocular disorders and report normal ocular variations. ANIMALS STUDIED: Two hundred and sixty-one horses, 122 Old Kladruber Gray Horses, and 139 Old Kladruber Black Horses owned by the National Stud Farm Kladruby nad Labem, Czech Republic, were included in the study with signalment and pedigree information recorded. PROCEDURES: Bilateral ocular examination of manually restrained horses was performed in a darkened environment by a single examiner (RA), using a portable slit-lamp biomicroscope, direct ophthalmoscope, and monocular indirect ophthalmoscopy using a Finnoff transilluminator and 20 D condensing lens...
October 5, 2018: Veterinary Ophthalmology
Carla N Urata, Livia S Mazzoli, Niro Kasahara
Purpose: Falls are very prevalent in the older population. Visually impaired elderly patients are prone to falls as the result of visual loss and ageing. The purpose of the study was to compare the fear of falling (FoF) between primary open angle glaucoma (POAG) and age-related macular degeneration (ARMD) patients who live in a developing country. Methods: This was a cross-sectional observational study. After a complete eye examination including measurement of best-corrected visual acuity, ophthalmoscopy, and automated visual field, all subjects completed the Fall Efficacy Scale International Brazil (FES-I-Brazil) questionnaire...
September 2018: Translational Vision Science & Technology
Philipp L Müller, Maximilian Pfau, Matthias M Mauschitz, Philipp T Möller, Johannes Birtel, Petrus Chang, Martin Gliem, Steffen Schmitz-Valckenberg, Monika Fleckenstein, Frank G Holz, Philipp Herrmann
Purpose: To investigate the interreader and intermodality agreement for grading of retinal pigment epithelium (RPE) atrophy lesion size in ABCA4 -related retinopathy using green (GAF) and blue fundus autofluorescence (BAF) imaging. Methods: In this cross-sectional case series, 97 eyes of 49 patients with RPE atrophy secondary to ABCA4 -related retinopathy underwent GAF- (518 nm excitation light) and BAF- (488 nm excitation light) imaging using confocal scanning laser ophthalmoscopy (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany)...
September 2018: Translational Vision Science & Technology
Ruofan Connie Han, Joanna Monika Gray, Jennie Han, Robert E Maclaren, Jasleen Kaur Jolly
BACKGROUND: Macular Integrity Assessment (MAIA) microperimetry is increasingly used in clinical and research settings to assess point retinal sensitivity and fixation stability. Testing occurs under mesopic conditions, commonly after a period of dark adaptation. Our aim was to identify the minimum length of adaptation required to optimise microperimetry performance. METHODS: MAIA microperimetry using the 10-2 grid was performed on 40 right eyes of 40 healthy participants aged 18-73 with no ocular pathology and vision of at least 0...
September 29, 2018: British Journal of Ophthalmology
Cheol Hong Lim, Yong Hoon Lee, Yong Soon Kim, Hyun Sung Choi, Dong Seok Seo
BACKGROUND: Cyclohexanone is a chemical used in various industries and many workers are exposed to it. Therefore, in this study, we determined the toxicity of cyclohexanone in inhalation-exposed F344 rats and B6C3F1 mice, so as to apply the findings in hazard and risk assessments. METHODS: Ten male and 10 female rats and mice per test group were exposed to cyclohexanone vapors at 0, 100, 250, and 625 ppm concentrations for 6 h per day, 5 d per week, and for 13 weeks...
September 28, 2018: Inhalation Toxicology
(no author information available yet)
This erratum corrects an error in "Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy".
September 2018: Journal of Biomedical Optics
Beau B Bruce, Samuel Bidot, Rabih Hage, Lindsay C Clough, Caroline Fajoles-Vasseneix, Mikhail Melomed, Matthew T Keadey, David W Wright, Nancy J Newman, Valérie Biousse
We evaluated a web-based training aimed at improving the review of fundus photography by emergency providers. 587 patients were included, 12.6% with relevant abnormalities. Emergency providers spent 31 minutes (median) training and evaluated 359 patients. Median post-test score improvement was 6 percentage points (IQR: 2-14; p  = 0.06). Pre- vs. post-training, the emergency providers reviewed 45% vs. 43% of photographs; correctly identified abnormals in 67% vs. 57% of cases; and correctly identified normals in 80% vs...
October 2018: Neuro-ophthalmology
Miguel O Bernabeu, Yang Lu, Omar Abu-Qamar, Lloyd P Aiello, Jennifer K Sun
Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Microaneurysms (MAs), which are abnormal outpouchings of the retinal vessels, are early and hallmark lesions of DR. The presence and severity of MAs are utilized to determine overall DR severity. In addition, MAs can directly contribute to retinal neural pathology by leaking fluid into the surrounding retina, causing abnormal central retinal thickening and thereby frequently leading to vision loss. Vascular perfusion parameters such as shear rate (SR) or wall shear stress (WSS) have been linked to blood clotting and endothelial cell dysfunction, respectively in non-retinal vasculature...
2018: Frontiers in Physiology
Margaret A Wilczek, Aaron S Gold, Fiona J Ehlies, Timothy G Murray
SIGNIFICANCE: This case highlights the importance of using ultrasonography to evaluate an eye that has no clear view of the fundus. PURPOSE: Uveal melanoma stems from melanocytes found in the iris, ciliary body, and choroid, and it is the most common primary intraocular malignancy found in adults. The lesion is identified predominantly via fundus biomicroscopy and binocular indirect ophthalmoscopy. The authors present a unique case where visual evaluation of the fundus was not possible, and ultrasonography was used to assess the retina and choroid...
October 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Billie Beckwith-Cohen, Allison Hoffman, Gillian J McLellan, Richard R Dubielzig
Feline neovascular vitreoretinopathy (FNV) is a newly recognized rare condition affecting kittens and young domestic cats. This study investigated the clinical and pathologic findings in 22 cats with FNV. In affected cats, ophthalmoscopy of the fundus (when visible) revealed avascular peripheral retinae and epiretinal vascular membranes. Frequent nonspecific clinical findings were buphthalmos ( n = 21), medically uncontrollable glaucoma ( n = 22), and lenticular abnormalities ( n = 13). Anterior segment dysgenesis (ASD) was detected clinically in affected cats ( n = 6)...
September 16, 2018: Veterinary Pathology
Y Zhu, Y Song, Q Cai, Y Zhou, J J Li
Objective: To compare the differences in the central macular choroidal thickness (CMCT) between thyroid-associated ophthalmopathy (TAO) patients in active and inactive stages, and the healthy subjects used spectral-domain optical coherence tomography (SD-OCT) and assess the potential of using CMCT as an indicator for follow-up of TAO patients. Methods: Cross-sectional study. Eleven active stage TAO patients (22 eyes, active TAO group) and 21 inactive stage TAO patients (42 eyes, inactive TAO group) who received treatment at the Department of Ophthalmology, First People's Hospital of Nantong during January 2015 and December 2017 were enrolled...
September 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Zeynep Ozkurt, Selahattin Balsak, Yusuf Yildirim, Harun Yuksel, Ihsan Caca
Background: Red reflex screening is the primary but unheeded test for the detection of vision- and life-threatening eye conditions. Aims: To evaluate the red reflex of newborns, percentage of ocular diseases resulting in red reflex abnormality, and their relation with consanguinity in Southeast Turkey. Methods: Newborns (n = 1358) were examined with pencil light and direct ophthalmoscopy. Results: Eight hundred of these newborns were hospitalized in a rooming-in unit...
September 6, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Elina Karvonen, Katri Stoor, Marja Luodonpää, Pasi Hägg, Jaana Kuoppala, Timo Lintonen, Pasi Ohtonen, Anja Tuulonen, Ville Saarela
PURPOSE: To report the prevalence of glaucoma in the Northern Finland Birth Cohort (NFBC) Eye Study. METHODS: Subjects of the population-based Northern Finland 1966 Birth Cohort (NFBC), aged 45-49 years at the time of the field examination, were randomized to eye screening (50%) and control (50%) groups. The eye examination protocol included best corrected visual acuity (BCVA), measurements of intraocular pressure and central corneal thickness, Humphrey 24-2 perimetry, stereoscopic optic nerve head (ONH) and retinal nerve fibre layer (RNFL) photography and imaging with optical coherence tomography (OCT), scanning laser polarimetry (GDx) and scanning laser ophthalmoscopy (HRT)...
September 9, 2018: Acta Ophthalmologica
David Heiden, NiNi Tun, Frank N Smithuis, Jeremy David Keenan, Catherine E Oldenburg, Gary N Holland, W Lawrence Drew
Patients with AIDS-related cytomegalovirus (CMV) retinitis receiving combined antiretroviral therapy (cART), but not specific anti-CMV therapy, consistently showed active retinitis for several months. Delayed diagnosis and treatment of CMV retinitis may have severe consequences. Patients first entering care with advanced HIV infection and vulnerability to reactivation of latent CMV infection should be screened immediately for CMV retinitis by dilated indirect ophthalmoscopy and treated with specific anti-CMV therapy without delay, in addition to cART...
September 8, 2018: British Journal of Ophthalmology
Raymond Fong, Bruce E Silverstein, James H Peace, Jon I Williams, Jason L Vittitow
PURPOSE: To assess the safety and efficacy of a 0.38% submicron formulation of loteprednol etabonate (LE) gel for the treatment of postoperative inflammation and pain after cataract surgery. SETTING: Forty-five United States ophthalmology practices. DESIGN: Double-masked vehicle-controlled randomized parallel group study. METHODS: Patients 18 years of age or older with anterior chamber cells grade 2 or higher on day 1 after uncomplicated cataract surgery were randomized to 14 days of treatment with LE gel 2 times a day, LE gel 3 times a day, or vehicle...
October 2018: Journal of Cataract and Refractive Surgery
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