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Andrew W Francis, Ivy Zhu, Sidhiporn Borirakchanyavat, Daniel M Schwartz, David G Hwang
PURPOSE: To report a central retinal artery occlusion with cilioretinal artery sparing in a 48-year-old woman after laser-assisted in situ keratomileusis surgery. METHODS: Case history and clinical examination including best-corrected visual acuity, serum markers, slit-lamp biomicroscopy, indirect ophthalmoscopy, fundus photography, fluorescein angiography, and optical coherence tomography. RESULTS: A 48-year-old woman underwent routine laser-assisted in situ keratomileusis surgery in both eyes...
August 10, 2018: Retinal Cases & Brief Reports
Elaine M Wells-Gray, Stacey S Choi, Mark Slabaugh, Paul Weber, Nathan Doble
PURPOSE: To examine the microstructural changes in the inner nuclear layer (INL) and ganglion cell layer (GCL) in a primary open angle glaucoma (POAG) patient at 2 time points, 4 months apart. PATIENTS AND METHODS: This case-control study (one POAG patient and one normal control) used the single cell, three-dimensional volumetric imaging capability of an adaptive optics-optical coherence tomography-scanning laser ophthalmoscopy system to examine the inner retina...
August 7, 2018: Journal of Glaucoma
Brian A Darlow, Máximo Vento, Marc Beltempo, Liisa Lehtonen, Stellan Håkansson, Brian Reichman, Kjell Helenius, Gunnar Sjörs, Emilio Sigali, Shoo Lee, Akihiko Noguchi, Naho Morisaki, Satoshi Kusuda, Dirk Bassler, Laura San Feliciano, Mark Adams, Tetsuya Isayama, Prakesh S Shah, Kei Lui
BACKGROUND: Rates of retinopathy of prematurity (ROP) and ROP treatment vary between neonatal intensive care units (NICUs). Neonatal care practices, including oxygen saturation (SpO2) targets and criteria for the screening and treatment of ROP, are potential contributing factors to the variations. OBJECTIVES: To survey variations in SpO2 targets in 2015 (and whether there had been recent changes) and criteria for ROP screening and treatment across the networks of the International Network for Evaluating Outcomes in Neonates (iNeo)...
August 8, 2018: Neonatology
Robert N Weinreb, Jeffrey M Liebmann, George A Cioffi, Ivan Goldberg, James D Brandt, Chris A Johnson, Linda M Zangwill, Susan Schneider, Hanh Badger, Marina Bejanian
PURPOSE: To evaluate the effectiveness and safety of oral memantine as a potential neuroprotective agent in open-angle glaucoma (OAG) at risk for progression. DESIGN: Two randomized, double-masked, placebo-controlled, parallel-group, multicenter, 48-month studies identically designed, initiated 1 year apart, and completed in 2006. Protocol amendments included a 1-year extension (first study) and change in primary endpoint and analysis (second study). PARTICIPANTS: Patients (2298 total) with bilateral OAG; glaucomatous optic disc damage and visual field loss in 1 eye; glaucomatous optic disc damage and/or visual field loss in the contralateral eye (at screening), topically treated or untreated intraocular pressure (IOP) of 21 mmHg or less (at baseline); and at risk of glaucomatous progression (per prespecified criteria)...
August 3, 2018: Ophthalmology
Jianfei Liu, HaeWon Jung, Johnny Tam
Loss of cone photoreceptor neurons is a leading cause of many blinding retinal diseases. Direct visualization of these cells in the living human eye is now feasible using adaptive optics scanning light ophthalmoscopy (AOSLO). However, it remains challenging to monitor the state of specific cells across multiple visits, due to inherent eye-motion-based distortions that arise during data acquisition, artifacts when overlapping images are montaged, as well as substantial variability in the data itself. This paper presents an accurate graph matching framework that integrates (1) robust local intensity order patterns (LIOP) to describe neuron regions with illumination variation from different visits; (2) a sparse-coding based voting process to measure visual similarities of neuron pairs using LIOP descriptors; and (3) a graph matching model that combines both visual similarity and geometrical cone packing information to determine the correspondence of repeated imaging of cone photoreceptor neurons across longitudinal AOSLO datasets...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Phanthipha Wongwai, Sirinya Suwannaraj, Somkiat Asawaphureekorn
OBJECTIVES: To evaluate the diagnostic accuracy of a digital fundus photographic system that consists of taking fundus photographs by a trained technician using a RetCam® shuttle and interpreting fundus images by an expert to detect Retinotapthy of Prematurity requiring treatment (ROP-RT) which defined as type I ROP according to the Early Treatment for ROP study (ETROP). MATERIALS AND METHODS: One hundred infants were examined by (1) an expert ophthalmologist experienced in ROP care using indirect ophthalmoscopy; (2) digital wide-field imaging by a trained technician using a RetCam® shuttle and images were sent remotely for interpretation by two ophthalmologists experienced in ROP care (Reader A, and Reader B); and (3) local ophthalmologists using indirect ophthalmoscopy...
2018: PloS One
M Bieniasz, R Kieszek, M Kwapisz, K Jędrzejko, M Durlik, L Pączek, A Kwiatkowski
BACKGROUND: Transforming growth factor-β (TGF-β) is involved in the pathogenesis of hypertension and the development of hypertensive target organ damage. TGF-β may promote blood pressure elevation through several mechanisms. The identification of risk factors of hypertension in living kidney donors may provide proper postoperative management. OBJECTIVE: The objective of the study was to determine the serum TGF-β concentration in living kidney donors after nephrectomy...
July 2018: Transplantation Proceedings
Mufarriq Shah, Ayesha Noor, Gail M Ormsby, Fakir Amirul Islam, Colin Alex Harper, Jill Elizabeth Keeffe
BACKGROUND: The number of adults with diabetes is increasing worldwide and also the number of people with diabetic retinopathy (DR), a major complication of diabetes. Task sharing in eye care for people with diabetes could address the shortage in the number of ophthalmologists and increase access to eye care services. This study investigated the opinion of eye care professionals for a checklist of tasks, which are involved in DR management, to be possibly shared by optometrists and mid-level eye and health care workers with ophthalmologists...
July 27, 2018: International Journal of Health Planning and Management
Eric Bifolck, Andrew Fink, Daniel Pedersen, Tanya Gregory
Direct ophthalmoscopy is an integral part of the physical examination and is the most widely used technique to assess the fundus, especially in primary care. The gold standard slit-lamp technique is used in specialty clinics and in some EDs. Most medical professionals own smartphones, and a smartphone ophthalmoscope could bring the quality of a slit-lamp examination into primary care. Imaging techniques with smartphones are easy to learn and use, providing a significant step toward reversing the lack of confidence that students and clinicians have in traditional methods...
August 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
Luis Filipe Nakayama, Vinicius Campos Bergamo, Marina Lourenço de Conti, Lívia Bueno, Nilva Simeren Bueno de Moraes, Orlando Ambrogini
BACKGROUND: Inflammatory bowel disease is a systemic inflammatory disease classified as Crohn disease or ulcerative colitis. It could present extra intestinal findings, such as fever, weight loss, arthralgia, mucocutaneous lesions, hepatic, renal and ophthalmological involvement. Among ophthalmological findings, posterior segment findings are present in less than 1% of patients with inflammatory bowel disease, however, these findings could bring definitive visual impairment. OBJECTIVE: Our study objective was to evaluate ocular posterior segment findings is patients with inflammatory bowel disease, through retinal mapping, color fundus retinography, optical coherence tomography (OCT) and OCT angiography, and compare our results to literature...
April 2018: Arquivos de Gastroenterologia
Sunil Mamtora, Maria Teresa Sandinha, Amritha Ajith, Anna Song, David H W Steel
PURPOSE: The purpose of this study is to evaluate a commercially available smartphone ophthalmoscope, D-EYE, as compared with the direct ophthalmoscope when used by a cohort of final-year medical students in a prospective study. METHODS: Two-hundred fundal examinations were performed on the eyes of 10 mannequins featuring 5 unique fundal images by 20 final-year medical students from Newcastle University. Each student examined the five fundal images twice, once each with a direct ophthalmoscope and D-EYE in a random order...
July 24, 2018: Eye
Maho Nakamura, Tomohiro Yako, Yoshiki Kuse, Yuki Inoue, Anri Nishinaka, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
To determine the characteristics of the damages of the retinal pigment epithelium (RPE) and photoreceptors of pigmented mice induced by exposure to blue light emitting diode (LED) light, and to determine the mechanisms causing the damages. Exposure to blue LED light for 3 days induced retinal damage, and the characteristics of the damage differed from that induced by white fluorescent light exposure. Ophthalmoscopy showed that blue LED exposure for 3 days induced white spots on the retina, and histological examinations showed materials accumulated at the IS/OS junction of the photoreceptors...
July 21, 2018: Experimental Eye Research
Cindy W Christian, Alex V Levin
Child abuse can cause injury to any part of the eye. The most common manifestations are retinal hemorrhages (RHs) in infants and young children with abusive head trauma (AHT). Although RHs are an important indicator of possible AHT, they are also found in other conditions. Distinguishing the number, type, location, and pattern of RHs is important in evaluating a differential diagnosis. Eye trauma can be seen in cases of physical abuse or AHT and may prompt referral for ophthalmologic assessment. Physicians have a responsibility to consider abuse in the differential diagnosis of pediatric eye trauma...
August 2018: Pediatrics
Niharika Singh, Mukesh Jain, Durgasri Jaisankar, Tarun Sharma, Rajiv Raman
PURPOSE: To elucidate the clinical characteristics and surgical outcome of consecutive patients with bilateral simultaneous retinal detachment who reported to a tertiary eye care institution over a period of 10 years. METHODS: Retrospective interventional consecutive study of 168 eyes of 84 patients with bilateral simultaneous retinal detachment, observed by indirect ophthalmoscopy at the initial examination was performed. Demographic and clinical characteristics were collected before and after surgery...
July 17, 2018: Retina
Lydia Sauer, Karl M Andersen, Binxing Li, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: To describe different patterns of macular pigment (MP) seen in fluorescence lifetime imaging ophthalmoscopy (FLIO) and to analyze ex vivo fluorescence characteristics of carotenoids. Methods: A total of 31 eyes of young healthy subjects, 4 eyes from patients with albinism, 36 eyes with macular telangiectasia type 2 (MacTel), 24 eyes with retinitis pigmentosa, and 1 eye with a macular hole were included in this clinic-based, cross-sectional study. All subjects underwent Heidelberg Engineering FLIO and MP measurements (dual-wavelength autofluorescence)...
June 1, 2018: Investigative Ophthalmology & Visual Science
Katharina G Foote, Panagiota Loumou, Shane Griffin, Jia Qin, Kavitha Ratnam, Travis C Porco, Austin Roorda, Jacque L Duncan
Purpose: To evaluate foveal function in patients with inherited retinal degenerations (IRD) by measuring visual acuity (VA) after correction of higher-order aberrations. Methods: Adaptive optics scanning laser ophthalmoscopy (AOSLO) was used to image cones in 4 healthy subjects and 15 patients with IRD. The 840-nm scanning laser delivered an "E" optotype to measure AOSLO-mediated VA (AOSLO-VA). Cone spacing was measured at the preferred retinal locus by two independent graders and the percentage of cones below the average density of 47 age-similar healthy subjects was computed...
July 2, 2018: Investigative Ophthalmology & Visual Science
Songqi Gao, Tanu Parmar, Grazyna Palczewska, Zhiqian Dong, Marcin Golczak, Krzysztof Palczewski, Beata Jastrzebska
Continuous regeneration of the 11-cis-retinal visual chromophore from all-trans-retinal is critical for vision. Insufficiency of 11-cis-retinal arising from the dysfunction of key proteins involved in its regeneration can impair retinal health, ultimately leading to loss of human sight. Delayed recovery of visual sensitivity and night blindness caused by inadequate regeneration of the visual pigment rhodopsin, are typical early signs of this condition. Excessive concentrations of unliganded, constitutively active opsin and increased levels of all-trans-retinal, and its byproducts in photoreceptors also accelerate retinal degeneration following light exposure...
July 17, 2018: Molecular Pharmacology
Masaki Nakamura, Satoshi Katagiri, Takaaki Hayashi, Mayumi Yoshioka, Tadashi Nakano
PURPOSE: To describe two cases of paracentral acute middle maculopathy (PAMM) that occurred unilaterally after endovascular coil embolization. METHODS: Medical records including ophthalmic examinations of two PAMM cases were retrospectively reviewed. RESULTS: The first case was a 64-year-old woman with hyperlipidemia and chronic sinusitis. The second case was a 49-year-old man with hypertension, hyperlipidemia, tension headache, and vertigo...
July 13, 2018: Retinal Cases & Brief Reports
Geetha Srinivasan, Gudlavalleti Venkata Satyanarayana Murthy, Shalini Mohan, Kalaivani Mani, Praveen Vashist, Nina John, Viney Gupta, Ramanjit Sihota
PURPOSE: To study optic nerve head (ONH) characteristics using scanning laser ophthalmoscopy, Heidelberg retina tomograph (HRT), in an elderly population. METHODS: A population-based, cross-sectional study included 1460 eyes of 1460 consecutive, subjects >60 years, in North India. All subjects underwent a detailed ophthalmic evaluation and imaged on HRT. Stereometric parameters, Moorfields regression analysis (MRA) and discriminant function analysis were analyzed...
July 17, 2018: Ophthalmic Epidemiology
Michel Paques, Serge Meimon, Florence Rossant, David Rosenbaum, Sarah Mrejen, Florian Sennlaub, Kate Grieve
Adaptive optics (AO)-enhanced en face retinal imaging, termed here AO ophthalmoscopy (AOO) has reached a level of robustness which fuels its increasing use in research and clinical centers. Here we will review the contribution of clinical AOO to the understanding and monitoring of 1) age-related macular degeneration and 2) vascular diseases. The main contributions of AOO to the phenotyping of AMD are a better identification of drusen, a better delineation of the limits of atrophy, and the identification of novel features such as punctate hyperreflectivity and mobile melanin-containing clumps...
July 17, 2018: Progress in Retinal and Eye Research
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