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Christina Schwarz, Robin Sharma, Soon Keen Cheong, Matthew Keller, David R Williams, Jennifer J Hunter
Purpose: Infrared ultrashort pulse lasers are becoming increasingly popular for applications in the living eye. However, safety standards are not yet well established. Here we investigate retinal damage close to threshold for this pulse regime in the living macaque eye. Methods: Retinal radiant exposures between 214 and 856 J/cm2 were delivered to the photoreceptor layer with an ultrashort pulse laser (730 nm, 55 fs, 80 MHz) through a two-photon adaptive optics scanning light ophthalmoscope...
December 3, 2018: Investigative Ophthalmology & Visual Science
Matthew E Braza, Jonathon Young, Thomas A Hammeke, Scott E Robison, Dennis P Han, Clinton C Warren, Joseph Carroll, Kimberly E Stepien
Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally. Methods and Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure...
2018: BMJ Open Ophthalmology
Serena Fragiotta, Talia R Kaden, K Bailey Freund
Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes. Case presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination...
2018: International Journal of Retina and Vitreous
Antonia Kowallick, Charlotte Viola Fischer, Hans Hoerauf
PURPOSE: To investigate the feasibility and diagnostic benefit of routinely performed preoperative macular spectral-domain (SD-) optical coherence tomography (OCT) for the detection of macular pathology in patients with normal biomicroscopic funduscopy prior to cataract surgery. METHODS: Prospective, single center study. A total of 162 eyes of 123 consecutive patients referred for cataract surgery with a visual acuity better than 20/100, absence of macular symptoms such as metamorphopsia, no history of previous intravitreal procedures and a normal funduscopic appearance on biomicroscopy underwent an additional SD-OCT-examination prior to cataract surgery...
2018: PloS One
Daisuke Nagasato, Hitoshi Tabuchi, Hideharu Ohsugi, Hiroki Masumoto, Hiroki Enno, Naofumi Ishitobi, Tomoaki Sonobe, Masahiro Kameoka, Masanori Niki, Ken Hayashi, Yoshinori Mitamura
The aim of this study is to assess the performance of two machine-learning technologies, namely, deep learning (DL) and support vector machine (SVM) algorithms, for detecting central retinal vein occlusion (CRVO) in ultrawide-field fundus images. Images from 125 CRVO patients ( n =125 images) and 202 non-CRVO normal subjects ( n =238 images) were included in this study. Training to construct the DL model using deep convolutional neural network algorithms was provided using ultrawide-field fundus images. The SVM uses scikit-learn library with a radial basis function kernel...
2018: Journal of Ophthalmology
Charles E Granger, Qiang Yang, Hongxin Song, Kenichi Saito, Koji Nozato, Lisa R Latchney, Bianca T Leonard, Mina M Chung, David R Williams, Ethan A Rossi
Purpose: To characterize in vivo morphometry and multispectral autofluorescence of the retinal pigment epithelial (RPE) cell mosaic and its relationship to cone cell topography across the macula. Methods: RPE cell morphometrics were computed in regularly spaced regions of interest (ROIs) from contiguous short-wavelength autofluorescence (SWAF) and photoreceptor reflectance images collected across the macula in one eye of 10 normal participants (23-65 years) by using adaptive optics scanning light ophthalmoscopy (AOSLO)...
December 3, 2018: Investigative Ophthalmology & Visual Science
Mehrdad Afarid, Adel Attarzadeh, Mohsen Farvardin, Hossein Ashraf
This study was performed to determine the association amongst serum leptin level and anthropometric measures with the severity of Diabetic Retinopathy (DR) in subjects with type 2 Diabetes Mellitus (DM). This case-controlled study was conducted within a one-year period, during year 2016, at outpatient retina ophthalmology clinics of Shiraz, southern Iran. Eighty-three patients with type 2 DM, referring for ophthalmoscopy evaluation, were included. Anthropometric measures, serum leptin level, and baseline laboratory assessment was performed for all subjects...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
S V Saakyan, Ya V Parmon, A Yu Tsygankov, A G Amiryan, A M Burdennyy
The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Analysis of the genes GNAQ and GNA11 revealed two mutually exclusive mutations in the genes GNAQG183A and GNAQA209C showing genetic heterogeneity of the two tumor lesions...
2018: Vestnik Oftalmologii
A N Kulikov, T A Leongardt, D S Maltsev
PURPOSE: To describe a case of paracentral acute middle maculopathy (PAMM) from the perspective of multimodal visualization and characterize it using optical coherence tomography angiography (OCT-A). MATERIAL AND METHODS: Multimodal imaging of the eye structures was used to investigate the right eye of a patient with PAMM. Infrared scanning laser ophthalmoscopy (IR-SLO), scanning laser ophthalmoscopy in autofluorescence mode and fluorescein angiography (FAG) were performed with scanning laser ophthalmoscope F-10 ('Nidek Co', Japan)...
2018: Vestnik Oftalmologii
D S Ismailova, Y O Grusha, Yu V Abramova, P I Novikov, S S Danilov
One of the most common and potentially threatening manifestations of granulomatosis with polyangiitis (GPA) is orbital lesion. PURPOSE: To study the clinical course and prognosis of orbital lesions of various localization in GPA patients. Material and me-thods. The study included 226 patients with GPA, 74 of them with orbital lesion. Ophthalmic examination consisted of visual acuity test, biomicroscopy, ophthalmoscopy, exophthalmometry and ocular mobility test. Visualization was done using multislice computed tomography and/or magnetic resonance tomography and/or ultrasound examination...
2018: Vestnik Oftalmologii
Chrishan D Gunasekera, Peter Thomas
No abstract text is available yet for this article.
November 29, 2018: JAMA Ophthalmology
Juliette E McGregor, Lu Yin, Qiang Yang, Tyler Godat, Khang T Huynh, Jie Zhang, David R Williams, William H Merigan
The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However, uncovering the wiring of retinal circuitry responsible for this performance has been challenging due to the difficulty in recording receptive fields of foveal retinal ganglion cells (RGCs) in vivo. In this study, we use adaptive optics scanning laser ophthalmoscopy (AOSLO) to image the calcium responses of RGCs in the living primate, with a stable, high precision visual stimulus that allowed us to localize the receptive fields of hundreds of foveal ganglion cells...
2018: PloS One
Carlos M Dulanto-Reinoso, Maria Ana Martinez-Castellanos
In a newborn with candidemia, two retinal lesions were seen without external inflammatory signs or reaction in the anterior chamber or vitreous. However, handheld spectral domain-optical coherence tomography (HH SD-OCT) images show that one of the retinal lesions had a "firework display" projecting to the vitreous that was not identified in indirect ophthalmoscopy. This finding suggested a Candida endophthalmitis. HH SD-OCT findings allowed us to make an accurate diagnosis and, therefore, modified the decision-making process in the treatment of the pathology...
September 2018: Case Reports in Ophthalmology
Jan Lammer, Sonja G Karst, Michael M Lin, Michael Cheney, Paolo S Silva, Stephen A Burns, Lloyd Paul Aiello, Jennifer K Sun
Purpose: We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT). Methods: Diabetic participants underwent VA testing and AOSLO and SDOCT imaging of MAs. AOSLO images were graded for MA dimension, wall hyperreflectivity (WH), intraluminal hyperreflectivity (IH), and perfusion pattern...
November 1, 2018: Investigative Ophthalmology & Visual Science
Aslı Vural, İrfan Perente, İsmail Umut Onur, Erdem Eriş, Zeynep Seymen, Gülsüm Oya Hergünsel, Özgül Salihoğlu, Fadime Ulviye Yiğit
PURPOSE: To evaluate the efficacy of intravitreal aflibercept (IVA) in vascular and macular maturation in neonates with type 1 retinopathy of prematurity (ROP) and aggressive posterior retinopathy of prematurity (APROP). MATERIALS AND METHODS: Thirty-six eyes of 18 patients with type 1 ROP or APROP in zone I or posterior zone II were enrolled in our study. At baseline, only fluorescein angiography (FA) was performed. After IVA injection, both FA and optical coherence tomography (OCT) were performed after 6...
November 26, 2018: International Ophthalmology
Sanam Mozaffari, Volker Jaedicke, Francesco LaRocca, Pavan Tiruveedhula, Austin Roorda
Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a powerful tool for imaging the retina at high spatial and temporal resolution. In this paper, we present a multi-detector scheme for AOSLO which has two main configurations: pixel reassignment and offset aperture imaging. In this detection scheme, the single element detector of the standard AOSLO is replaced by a fiber bundle which couples the detected light into multiple detectors. The pixel reassignment configuration enables high resolution imaging with an increased light collection...
November 1, 2018: Biomedical Optics Express
Shyamanga Borooah, Chloe M Stanton, Joseph Marsh, Keren J Carss, Naushin Waseem, Pooja Biswas, Georgios Agorogiannis, Lucy Raymond, Gavin Arno, Andrew R Webster
BACKGROUND: Age-related macular degeneration (AMD) is a common sight threatening condition. However, there are a number of monogenic macular dystrophies that are clinically similar to AMD, which can potentially provide pathogenetic insights. METHODS: Three siblings from a non-consanguineous Greek-Cypriot family reported central visual disturbance and nyctalopia. The patients had full ophthalmic examinations and color fundus photography, spectral-domain ocular coherence tomography and scanning laser ophthalmoscopy...
December 2018: Ophthalmic Genetics
Fabienne Fierz, Chetan K Patel
No abstract text is available yet for this article.
November 12, 2018: Ophthalmology
Guillermo Cuervo, Carolina Garcia-Vidal, Mireia Puig-Asensio, Paloma Merino, Antonio Vena, Almudena Martín-Peña, José Miguel Montejo, Alba Ruiz, Fernando Lázaro-Perona, Jesús Fortún, Mario Fernández-Ruiz, Ana Isabel Suarez, Carmen Castro, Celia Cardozo, Carlota Gudiol, José María Aguado, Jose Ramón Paño, Javier Pemán, Miquel Salavert, José Garnacho-Montero, José Miguel Cisneros, Alex Soriano, Patricia Muñoz, Benito Almirante, Jordi Carratalà
We aimed to analyze whether the lack of inclusion of specific recommendations for the management of candidemia is an independent risk factor for early and overall mortality. Multicenter study of adult patients with candidemia in 13 hospitals. We assessed the proportion of patients on whom nine specific ESCMID and IDSA guidelines recommendations had been applied, and analyzed its impact on mortality. 455 episodes of candidemia were documented. Patients who died within the first 48 hours were excluded. Sixty-two percent of patients received an appropriate antifungal treatment...
November 10, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Riccardo Francesco Bellanca, Fabio Scarinci, Mariacristina Parravano
PURPOSE: To evaluate the role of multimodal imaging in the diagnosis and monitoring of patients with osteogenesis imperfecta complicated with choroidal neovascularization. CASE REPORT: A 28-year-old man, diagnosed with osteogenesis imperfecta, was referred 2 months after the appearance of central scotoma and metamorphopsia in the right eye. The patient underwent a complete ophthalmological evaluation including visual acuity examination as well as ophthalmoscopy, spectral-domain optical coherence tomography, optical coherence tomography angiography, fundus autofluorescence imaging, fluorescein angiography and microperimetry...
November 8, 2018: European Journal of Ophthalmology
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